Candida albicans interaction with Gram-positive bacteria within interkingdom biofilms
Publication date: Available online 2 November 2019Source: Journal de Mycologie MédicaleAuthor(s): Clément Bernard, Marion Girardot, Christine ImbertAbstractCandida albicans is a commensal of the human body and an opportunistic pathogen frequently responsible for nosocomial bloodstream infections. Most of these infections are linked to the development of a biofilm in or on implanted medical devices. C. albicans cells have the capacity to interact with bacteria within biofilms, especially by the way of chemical or metabolic indirect interactions and/or direct physical contacts involving specifically the yeast or hyphal for...
Source: Journal of Medical Mycology - November 3, 2019 Category: Biology Source Type: research
Editorial Board
Publication date: September 2019Source: Journal de Mycologie Médicale, Volume 29, Issue 3Author(s): (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 23, 2019 Category: Biology Source Type: research
Genotyping of Candida albicans isolates from oropharyngeal candidiasis in head and neck cancer patients in Iran: Molecular epidemiology and SAP2 gene expression
ConclusionWe found few genetically-related as well as identical isolates among the 32 Candida strains which indicated low cross-contaminations among the patients. There was no relationship between C. albicans MLST profiles and their geographic distribution, cancer type and SAP2 gene expression. This lack of correlation was possibly due to the small understudy population; hence, finding more relevance requires studies with a higher number of samples. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 19, 2019 Category: Biology Source Type: research
African Histoplasmosis in a Guinea Bissau Patient with HIV-2: Case Report and Review
We present the case of a 30-year-old Bissau-Guinean man with HIV-2 infection known for 16 years, irregularly treated, admitted with two weeks of fever, diarrhoea and cutaneous lesions. Examination revealed multiple subcutaneous nodes, Molluscum contagiosum-like lesions, generalized lymphadenopathy and painful palpation of the left iliac fossa. Laboratory tests showed severe nonhaemolytic anaemia and CD4+ count of 9/mm3, with normal creatinine and hepatic enzymes. Chest roentgenogram was unremarkable and a research for Mycobacterium tuberculosis by GeneXpert® was negative. Nonetheless, given the lack of further diagnostic ...
Source: Journal of Medical Mycology - October 19, 2019 Category: Biology Source Type: research
Evolution of fungemia in an italian region
Conclusions: No particular changes in terms of species distribution and antifungal susceptibility patterns was noted. However, surveillance programs are needed to monitor trends in antifungal resistance, steer stewardship activities, orient empirical treatment. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 16, 2019 Category: Biology Source Type: research
Refractory sporotrichosis due to Sporothrix brasiliensis in Argentina: case report, molecular identification and in vitro susceptibility pattern to antifungal drugs
Conclusions: this study contributed to the molecular epidemiology of Sporothrix species in Argentina and the characterization of the in vitro susceptibility pattern of S. brasiliensis isolates recovered from a cat and two humans involved in this case of zoonotic and refractory sporotrichosis. Bearing in mind the concept of “one health”, the experience described in the present study highlights the need for future strategies for sporotrichosis treatment, control and prevention. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 16, 2019 Category: Biology Source Type: research
Frequency, virulence factors and antifungal susceptibility of Candida parapsilosis species complex isolated from patients with candidemia in the central region of Argentina
Conclusions: We report a high frequency of isolation of C.orthopsilosis in candidemia patients of central region. Data on the prevalence, virulence capability and antifungal susceptibility of C. parapsilosis complex provide new epidemiological information about these cryptic species in Argentina. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 16, 2019 Category: Biology Source Type: research
Impact of Iron Chelators on Growth and Expression of Iron-Related Genes of Cryptococcus species
Conclusion: Synergistic antifungal activity of combination DFO and AMB was observed in Cryptococcus. Relatively increased CFT1 and CFT2 expression may be associated with the effect of DFO that inhibits the growth of fungi. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 13, 2019 Category: Biology Source Type: research
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Publication date: September 2019Source: Journal de Mycologie Médicale, Volume 29, Issue 3Author(s): (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 5, 2019 Category: Biology Source Type: research
CV2 / Ours de la rédaction - Editorial Board
Publication date: September 2019Source: Journal de Mycologie Médicale, Volume 29, Issue 3Author(s): (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - October 5, 2019 Category: Biology Source Type: research
Epidemiological profile of eumycetomas in Rabat, Morocco, over 40 years
The objective of our work is to establish their epidemiological, clinical and mycological profile in our Moroccan context. Therefore, we conducted a retrospective study, extending from 1975 to 2019, compiling all cases of eumycetomas that were diagnosed in the parasitology-mycology laboratory of the Ibn Sina University Hospital of Rabat. The diagnosis, based on the swabbing of exudates and eventual grains or the study of biopsies, included the direct examination of 30% KOH mounts, the realization of appositions colored by May-Grünwald-Giemsa and the incubation on 3 Sabouraud media at 27° and 37 °C. In 44 years, 12...
Source: Journal of Medical Mycology - October 4, 2019 Category: Biology Source Type: research
A computational study targeting the mutated L321F of ERG11 gene in C. albicans, associated with fluconazole resistance with bioactive compounds from Acacia nilotica
ConclusionThe findings of the study emphasize that kaempferol, apigenin and catechin from A. nilotica seem to possess a promising inhibitory effect against the wild and mutated ERG11 of C. albicans suggesting ERG11 as the best target to combat fluconazole resistant C. albicans with further in vivo validation targeting the same. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - September 28, 2019 Category: Biology Source Type: research
Epidemiological profile of eumycetomas in Rabat, Morocco, over 40 years. Profil épidémiologique des eumycétomes à Rabat, au Maroc, sur plus de 40 ans
The objective of our work is to establish their epidemiological, clinical and mycological profile in our Moroccan context. Therefore, we conducted a retrospective study, extending from 1975 to 2019, compiling all cases of eumycetomas that were diagnosed in the parasitology-mycology laboratory of the Ibn Sina University Hospital of Rabat. The diagnosis, based on the swabbing of exudates and eventual grains or the study of biopsies, included the direct examination of 30% KOH mounts, the realization of appositions colored by May-Grünwald-Giemsa and the incubation on 3 Sabouraud media at 27° and 37°C. In 44 years, 12 cases ...
Source: Journal of Medical Mycology - September 25, 2019 Category: Biology Source Type: research
A new mutation in the SQLE gene of Trichophyton mentagrophytes associated to terbinafine resistance in a couple with disseminated tinea corporis
We report two cases of tinea corporis resistant to systemic terbinafine in a 60-year-old man and his wife, a 51 year-old-woman. Both patients had multiple diffuse erythematous annular scaly plaques and T. mentagrophytes was isolated in culture. Systemic treatment with terbinafine in combination with topical terbinafine and then topical ketoconazole failed to improve the disease after 8 weeks. The broth microdilution tests performed to evaluate the antifungal sensitivity of the T. mentagrophytes isolate revealed a high MIC for terbinafine but a low MIC for posaconazole and itraconazole. An A1223T point mutation leading to a...
Source: Journal of Medical Mycology - September 25, 2019 Category: Biology Source Type: research
Biochemical and cellular activity of chemically synthesized elastase inhibitor (S-AFUEI) from Aspergillus fumigatus
ConclusionAs S-AFUEI strongly inhibited cytotoxicity induced by elastase in human-derived cells, it could prove beneficial for the treatment of pulmonary aspergillosis. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - September 24, 2019 Category: Biology Source Type: research
