Compound selected by in silico methodologies bloking the C. albicans adhesion and biofilm process on abiotic surface
The objective of the present study was to evaluate whether the small molecule F2768-0318, which was selected by in silico methodologies against NT-Als3 domain, will be able to block the C. albicans adhesion on abiotic and biotic surfaces. F2768-0318 was assessed in tests of biofilm formation and adhesion on abiotic surfaces (polystyrene plates) and adherence on biotic surfaces, including human endocervical (HeLa) cells, human umbilical vein endothelial cells (HUVEC), and fresh buccal epithelial cells (BEC). Our results showed a good performance of F2768-0318 in reducing the adhesion and biofilm formation of C. albicans on ...
Source: Journal of Medical Mycology - February 13, 2020 Category: Biology Source Type: research

Ex vivo nail infection as an effective preclinical method for screening of new topical antifungals
This study concludes that the ex vivo porcine hoof model is an effective alternative method for preclinical screening of drugs or new topical compounds developed to combat onychomycosis. Further studies are need to compare the permeability of porcine hooves with human nails permeability. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - February 10, 2020 Category: Biology Source Type: research

Sino-orbital infection caused by Schizophyllum commune - rare presentation of a basidiomycetous fungus
Publication date: Available online 30 January 2020Source: Journal de Mycologie MédicaleAuthor(s): M. Kaur, J. Chander, N. Singla, A. Das, S. Sood, J. Guarro (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - February 8, 2020 Category: Biology Source Type: research

2020: a new year for Medical Mycology and medical mycologists
Publication date: Available online 31 January 2020Source: Journal de Mycologie MédicaleAuthor(s): (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - February 2, 2020 Category: Biology Source Type: research

Evaluation of the Performance of DiaSorin Molecular Pneumocystis jirovecii-CMV Multiplex Real-Time PCR Assay from Bronchoalveolar Lavage Samples
This study indicated that the DiaSorin Molecular PJ-CMV multiplex real-time PCR assay has higher sensitivity than direct IFA for detection of P. jirovecii and provides rapid detection of PJ and CMV infection in BAL samples. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - February 2, 2020 Category: Biology Source Type: research

Comparison of in vitro antifungal activity of novel triazoles with old antifungal agents against dermatophyte species caused tinea pedis
Conclusion: The novel triazoles are promising candidates for the treatment of tinea pedis caused by Trichophyton and Epidermophyton species. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 31, 2020 Category: Biology Source Type: research

Sino-orbital infection caused by Schizophyllum commune- rare presentation of a basidiomycetous fungus
Publication date: Available online 30 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Mandeep Kaur, Jagdish Chander, Nidhi Singla, Arjun Das, Sunandan Sood, Josep Guarro (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 31, 2020 Category: Biology Source Type: research

Preparation, characterization and antidermatophytic activity of free- and microencapsulated cinnamon essential oil
Publication date: Available online 24 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Regina Yasuko Makimori, Eliana Harue Endo, Julia Watanabe Makimori, Erica Benassi Zanqueta, Tania Ueda-Nakamura, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Benedito Prado Dias FilhoAbstractEssential oils (EO) are effective natural antimicrobials but are susceptible to oxidation. Microencapsulation improves EO stability, reduces toxicity, and controls release. The aim of this study was preparation, characterization and antidermatophytic activity of free and microencapsulated cinnamon essential oil (MP). MP were prepare...
Source: Journal of Medical Mycology - January 26, 2020 Category: Biology Source Type: research

Pulmonary infection due to Acrophialophora fusispora in a patient with underlying mixed connective tissue disease and chronic pulmonary aspergillosis: a case report and review of literature
Publication date: Available online 22 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Arghadip Samaddar, Anuradha Sharma, Twishi ShrimaliAbstractAcrophialophora fusispora is a soil-borne fungus rarely implicated in human infections. Here, we report a case of pulmonary infection due to A. fusispora in a 59-year-old male who presented with productive cough and gradually progressive dyspnoea for 20 days. He had a past history of pulmonary tuberculosis and was a known case of chronic obstructive pulmonary disease for past five years. He was diagnosed with mixed connective tissue disease and had been receiving oral...
Source: Journal of Medical Mycology - January 23, 2020 Category: Biology Source Type: research

Simultaneous detection of Aspergillus nidulans, Aspergillus luchuensis and Lichtheimia sp. in a bovine abortion
This report describes an abortion case in a Chianina cow due to Aspergillus nidulans, Aspergillus luchuensis and Lichtheimia sp. diagnosed by histology, cytology, culture and molecular assays. A mixed infection due to more than one fungus in abortion is rarely demonstrated. To our knowledge, this is the first case of bovine abortion caused by co-infection with three different moulds. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 20, 2020 Category: Biology Source Type: research

Anti-Cryptococcal activity of a furanone derivative–antibiofilm and opsonophagocytic potential
Publication date: Available online 18 January 2020Source: Journal de Mycologie MédicaleAuthor(s): Sudarshan Singh Rathore, Thiagarajan Raman, Cheepurupalli Lalitha, Manikandan Ramar, Arumugam Munusami, Jayapradha RamakrishnanAbstractCryptococcus neoformans, an encapsulated fungal pathogen is evolving as a major threat to immune-compromised patients and rarely to healthy individuals also. The cell wall bound capsular polysaccharide, melanin pigment and biofilm formation are major virulence factors that are known to contribute to cryptococcal meningitis. In the present study, a furanone derivative, (E)-5-benzylidenedihydrof...
Source: Journal of Medical Mycology - January 20, 2020 Category: Biology Source Type: research

Antioxidant and Antifungal activities of marrubiin, extracts and essential oil from Marrubium vulgare L. against pathogenic dermatophyte strains
Conclusion: In our study, we conclude that M.vulgare and marrubiin can be used as natural antioxidants and antifungal agent for treatment of skin dermatophyte infections. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 12, 2020 Category: Biology Source Type: research

Fungal keratitis caused by a rare pathogen, Colletotrichum gloeosporioides, in an east coast city of China
Conclusions: We report the rare keratitis caused by C. gloeosporioides in eastern China, which has not been published. Suddenly ocular trauma and old surgical intervention may be the risk factors associated with Colletotrichum keratitis. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 8, 2020 Category: Biology Source Type: research

Simultaneous detection of Aspergillus nidulans, Aspergillus luchuensis and Lichtheimia ramosa in a bovine abortion
This report describes an abortion case in a Chianina cow due to Aspergillus nidulans, Aspergillus luchuensis and Lichtheimia ramosa diagnosed by histology, cytology, culture and molecular assays. A mixed infection due to more than one fungus in abortion is rarely demonstrated. To our knowledge, this is the first case of bovine abortion caused by co-infection with three different moulds. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 8, 2020 Category: Biology Source Type: research

Vanillin confers antifungal drug synergism in Candida albicans by impeding CaCdr2p driven efflux
Conclusion: Van being a potent inhibitor of CaCdr2p and chemosensitizing drug of resistant C. albicans warrants further studies to be exploited as effective antifungal agent. (Source: Journal of Medical Mycology)
Source: Journal of Medical Mycology - January 8, 2020 Category: Biology Source Type: research