A case of successful treatment with eltrombopag for severe immune-related thrombocytopenia induced by atezolizumab:Case report
J Med Invest. 2023;70(3.4):516-520. doi: 10.2152/jmi.70.516.ABSTRACTImmune checkpoint inhibitors (ICIs) have shown impressive anti-tumor effects against multiple types of malignancies. Among the wide variety of immune-related adverse events (irAEs), immune-related thrombocytopenia (ITP) is relatively rare but often clinically significant and life-threatening. However, the appropriate treatment for severe ITP has not been determined. We herein report an 82-year-old male patient with non-small-cell lung cancer who developed severe ITP three weeks after starting the third course of atezolizumab. The initial combination therap...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Saki Harada Takeshi Imakura Seidai Sato Hiroshi Nokihara Yasuhiko Nishioka Source Type: research
Repeated shunt dysfunction due to Barium allergy that was difficult to differentiate from shunt infection
J Med Invest. 2023;70(3.4):521-523. doi: 10.2152/jmi.70.521.ABSTRACTWe encountered a case of repeated shunt dysfunction caused by barium allergy. The patient was a 60-year-old male who underwent ventricular peritoneal shunting for hydrocephalus following subarachnoid hemorrhage due to a ruptured aneurysm;however, it malfunctioned many times. A patch test performed after the third reconstruction was positive for barium. To the best of our knowledge, this is the first case report of shunt malfunction due to barium allergy. The patch test is useful in cases of suspected allergy-related dysfunction. We recommend the introducti...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Asami Kikuchi Shigeomi Yokoya Hideki Oka Hiroshi Ohno Akihiko Hino Source Type: research
A novel computed tomography-based three-column MLP classification of intertrochanteric fracture
CONCLUSION: This novel 3DCT-based MLP classification system for intertrochanteric fractures is comprehensive, and reproducible with good agreement. It is based on proximal femur biomechanic characteristics and traumatic mechanism, contributing to formulating more reasonable treatment protocols involving various late-model internal fixation devices. J. Med. Invest. 70 : 524-529, August, 2023.PMID:37940544 | DOI:10.2152/jmi.70.524 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Qi-Long Jiang Yan Li Xin-Wen Bai Yu Deng Hao Hong Jun Li Yong Cao Xiao-Yu Peng Source Type: research
Technologies, Physician's Caring Competency, and Patient Centered Care:A Systematic Review
This study aimed to conduct a systematic review to clarify patient understanding, understanding of caring concepts, understanding of technology, competency to express compassion, appropriate involvement in caring, and ethical and moral attitudes and responses toward patients. This systematic review was conducted through an electronic search across PubMed, Google Scholar, MEDLINE, and Science Direct. Authors independently appraised the methodological quality of the studies using the Mixed Method Appraisal Tool. A narrative synthesis approach was used to present these findings. Nine studies met the inclusion criteria and qua...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Leah Anne Christine L Bollos Yueren Zhao Gil P Soriano Tetsuya Tanioka Hideki Otsuka Rozzano Locsin Source Type: research
Immune response evaluation after Sputnik V vaccination in Sari healthcare population
CONCLUSION: Sputnik V vaccine can lead to a protective response against COVID-19 infection in high percentage of the population. J. Med. Invest. 70 : 317-320, August, 2023.PMID:37940513 | DOI:10.2152/jmi.70.317 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Ahmad Najafi Hossien Jalali Yousef Noshi Mehrad Mahdavi Mohammad Reza Mahdavi Amiri Source Type: research
Effects of activation with a Ca ionophore and roscovitine on the development of human oocytes that failed to fertilize after ICSI
CONCLUSIONS: Sequential treatment with an Ca ionophore and roscovitine activates oocytes that remain unfertilized after ICSI. In TESE-ICSI, the activation rate tended to be increased by the co-administration of roscovitine with a Ca ionophore. J. Med. Invest. 70 : 321-324, August, 2023.PMID:37940514 | DOI:10.2152/jmi.70.321 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Ayako Suto Yuya Yano Yuri Yamamoto Hiroki Noguchi Asuka Takeda Shota Yamamoto Tomohiro Kagawa Kanako Yoshida Kenji Hinokio Akira Kuwahara Toshiyuki Yasui Takeshi Iwasa Source Type: research
Early enteral nutrition with arginine compensates for negative nitrogen balance in patients undergoing curative total gastrectomy
J Med Invest. 2023;70(3.4):325-333. doi: 10.2152/jmi.70.325.ABSTRACTThe effects of early enteral arginine-rich nutrition (EAN) were analyzed among patients undergoing curative-intent total gastrectomy for gastric cancer. There were 19 patients in this prospective study, all randomly assigned to either a parenteral nutrition (PN) group or an EAN group for the first seven days after surgery. The EAN group received 1.8-fold greater arginine (10.1 g/day) compared with the PN group, which was administered through an enteral tube inserted into the jejunal loop. Both groups were provided almost identical amounts of total amino ac...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Yasuko Okamoto Takanori Sakaguchi Yoshito Ikematsu Toshikazu Kanai Kazuhisa Hirayama Hiroaki Tamura Tadataka Hayashi Yoshiro Nishiwaki Hiroyuki Konno Katsunori Aoki Source Type: research
A comparison of reoperation rates after single-level anterior cervical discectomy and fusion (ACDF) between the procedures with and without anterior plate fixation
CONCLUSION: Anterior cervical plating may have a negative impact on the adjacent segment integrity, resulting in an increased reoperation rate after a single-level ACDF at relatively shorter postoperative time points. J. Med. Invest. 70 : 334-342, August, 2023.PMID:37940516 | DOI:10.2152/jmi.70.334 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Nobuaki Tadokoro Katsuhito Kiyasu Naoki Aoyama Shuhei Mizobuchi Masahiko Ikeuchi Kazunobu Kida Toshikazu Tani Yusuke Kasai Source Type: research
Role of Nrf2 signaling in development of hepatocyte-like cells
In this study, we investigated the activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) on hADSCs undergoing differentiation to HLC (hepatocyte-like cells). Our three-step differentiation protocol was applied for 21 days (Step 1:day 1-6, Step2:day 6-11, Step3:day 11-21). Our results show that significant nuclear translocation of Nrf2 occurred from day 11 until the end of HLC differentiation. Nuclear translocation of Nrf2 and CYP3A4 activity in the GSK3 inhibitor-treated group was obviously higher than that in Activin A-treated groups at day 11. The maturation of HLCs was delayed in Nrf2-siRNA group compared...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Chie Takasu Shuhai Chen Luping Gao Yu Saito Yuji Morine Tetsuya Ikemoto Shinichiro Yamada Mitsu Shimad Source Type: research
Post-meal endogenous insulin secretion was significantly lower in head than in body/tail cancer of the pancreas
CONCLUSION: Characteristically, pancreatic head cancer was associated with decreased endogenous insulin secretion as compared to body/tail cancer. J. Med. Invest. 70 : 350-354, August, 2023.PMID:37940518 | DOI:10.2152/jmi.70.350 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Hirotaka Shichijo Toshio Hosaka Fumie Takewaki Yoshikazu Sumitani Hitoshi Ishida Kazuki Yasuda Source Type: research
Assessment of multiple domains of pain following BNT162b2 mRNA COVID-19 vaccination
J Med Invest. 2023;70(3.4):355-360. doi: 10.2152/jmi.70.355.ABSTRACTPain at the injection site is the most frequent reaction among COVID-19 vaccine recipients, but its characteristics were not fully described yet. The purpose of this study was to investigate multiple domains of pain following BNT162b2 mRNA vaccination. We included 107 subjects undergoing primary shot of the vaccination twice into deltoid muscle with a 3-week interval. They completed 6 sessions of pain assessments, one before the first and second dose (1-0, 2-0), and 1st/7th day after the first and second dose (1-1/1-7, 2-1/2-7). Pain visual analog scale (V...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Masashi Izumi Toru Morimoto Shota Oda Dai Ohishi Yoshihiro Hayashi Takahiro Shimokawa Kazuki Ozaki Anzu Nakamae Ryota Saito Yoshiki Fujii Naoki Komatsu Hiromi Seo Masahiko Ikeuchi Source Type: research
Early Prediction of Radiotherapeutic Efficacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using < sup > 18 < /sup > F-FLT and < sup > 18 < /sup > F-FDG PET/CT
This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Tamaki Otani Hitoshi Ikushima Yoshimi Bando Michiko Yamashita Kenmei Kuwahara Hideki Otsuka Kazuya Kondo Hirokazu Miyoshi Source Type: research
How many times can patients tolerate reoperation for the local recurrence of colorectal cancer in terms of complications?
We examined the postoperative complications classified as Clavien?Dindo IIIb. The positive rates of the complications were 0 (0.0%), 0 (0.0%), 2 (13.3%), 3 (37.5%), and 0 (0.0%) for the primary, 1st recurrent, 2nd recurrent, 3rd recurrent, and 4th recurrent operation group (p=0.027), respectively. It is important to exercise caution in handling cases exceeding two reoperations (exceeding three reoperations including the primary operation). J. Med. Invest. 70 : 369-376, August, 2023.PMID:37940521 | DOI:10.2152/jmi.70.369 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Koji Komori Takashi Kinoshita Yusuke Sato Akira Ouchi Seiji Ito Tetsuya Abe Kazunari Misawa Yuichi Ito Seiji Natsume Eiji Higaki Tomonari Asano Masataka Okuno Hironori Fujieda Satoshi Oki Tsukasa Aritake Kakeru Tawada Satoru Akaza Hisahumi Saito Kiyoshi N Source Type: research
Validation of a dietary balance score in middle-aged and older community-dwelling Japanese
This study assessed the validity of dietary balance scores (DBSs) by investigating the association between DBSs and nutrient adequacy (NA) in two Japanese populations. The participants were 65 community-dwelling Japanese from Tokushima Prefecture and 2,330 community-dwelling Japanese from Aichi Prefecture. Based on food frequency questionnaires or 3-day dietary records, we obtained 18 food groups. The NA score integrates nine beneficial nutrients and two nutrients that should be limited. We calculated four different DBSs: DBS1 consisted of five food groups (score range:0?20), DBS2 consisted of nine food groups (score range...
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Mariko Nakamoto Tsuzuri Nagashima Yukiko Tanaka Satomi Ono Yuki Iwasaki Akiko Nakamoto Shu Zhang Kaori Kinoshita Kanae Furuya Tomoko Imai Rei Otsuka Tohru Sakai Source Type: research
Assessment of dyspnea, ADL, and QOL in the perioperative period in lung cancer patients treated with minimally invasive surgery
CONCLUSIONS: Impairments in health conditions and symptoms persisted for 6 months after surgery despite its minimally invasive nature. J. Med. Invest. 70 : 388-402, August, 2023.PMID:37940523 | DOI:10.2152/jmi.70.388 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 8, 2023 Category: General Medicine Authors: Zhang Linwan Kazuya Kondo Takae Bando Naoya Kawakita Hiroaki Toba Yoshie Imai Hiromitsu Takizawa Source Type: research
