q value and parent energy optimization using a low voltage ionization approach increases resolution in linear ion trap mass spectrometry
AbstractIn this work, the isolation step in the linear ion trap was performed using different “q values” conditions at a low Collision Induced Dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and Low Voltage Ionization (LVI) near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performa...
Source: Journal of Mass Spectrometry - July 26, 2022 Category: Chemistry Authors: Simone Madama,
Ermelinda Falletta,
Amir Mohammad Malvandi,
Kevin Arzoni,
Carlo Brogna,
Marco Varelli,
Matteo Bertelli,
Matteo Conti,
Martina Larini,
Federico Guidugli,
Pietro Traldi,
Simone Cristoni Tags: RESEARCH ARTICLE Source Type: research
Novel Matrix Strategies for Improved Ionization and Spatial Resolution Using IR ‐MALDESI Mass Spectrometry Imaging
AbstractIn mass spectrometry imaging (MSI) applications of infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), an exogenous ice layer is the gold standard for an energy-absorbing matrix. However, the formation of the ice matrix requires additional time and instrument hardware, so glycerol was investigated herein as an alternative to the ice matrix to potentially improve spatial resolution and ionization, while decreasing experiment time. Glycerol solutions of varying concentrations were sprayed over top of rat liver tissue sections for analysis by IR-MALDESI, and compared to the typical ice matr...
Source: Journal of Mass Spectrometry - July 21, 2022 Category: Chemistry Authors: Russell R. Kibbe,
Allyson L. Mellinger,
David C. Muddiman Tags: RESEARCH ARTICLE Source Type: research
Cover Picture
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 19, 2022 Category: Chemistry Tags: COVER PICTURE Source Type: research
Whole blood analysis for medical diagnostics by GC ‐MS with Cold EI By Benny Neumark, Oneg Elkabets, Gabi Shefer, Assaf Buch, Naftali Stern and Aviv Amirav
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 19, 2022 Category: Chemistry Authors: Aviv Amirav Tags: COVER STORY Source Type: research
Design considerations for a cycloidal mass analyzer using a focal plane array detector
We present derivations and calculations used to determine the volume of homogeneous electric and magnetic fields needed to contain the ion trajectories and explore the relationship between electric and magnetic field homogeneity on resolving power using finite element analysis (FEA) simulations. A set of equations relating the electric field homogeneity to the geometry of the electric sector electrodes was developed by fitting homogeneity values from 78 different FEA models. Finally, a sequence of steps is suggested for designing a cycloidal mass analyzer employing an array detector. (Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 19, 2022 Category: Chemistry Authors: Kathleen L. Horvath,
Elettra L. Piacentino,
Rafael Bento Serpa,
Tanouir Aloui,
Raul Vyas,
Yuriy Zhilichev,
Jesko Windheim,
Maria Luisa Sartorelli,
Charles B. Parker,
M. Bonner Denton,
Michael E. Gehm,
Jeffrey T. Glass,
Jason J. Amsden Tags: RESEARCH ARTICLE Source Type: research
Whole blood analysis for medical diagnostics by GC ‐MS with Cold EI By Benny Neumark, Oneg Elkabets, Gabi Shefer, Assaf Buch, Naftali Stern and Aviv Amirav
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 19, 2022 Category: Chemistry Authors: Aviv Amirav Tags: COVER STORY Source Type: research
Cover Picture
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 19, 2022 Category: Chemistry Tags: COVER PICTURE Source Type: research
Design Considerations for a Cycloidal Mass Analyzer using a Focal Plane Array Detector
We present derivations and calculations used to determine the volume of homogeneous electric and magnetic fields needed to contain the ion trajectories and explore the relationship between electric and magnetic field homogeneity on resolving power using finite element analysis (FEA) simulations. A set of equations relating the electric field homogeneity to the geometry of the electric sector electrodes was developed by fitting homogeneity values from 78 different FEA models. Finally, a sequence of steps is suggested for designing a cycloidal mass analyzer employing an array detector. (Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - July 2, 2022 Category: Chemistry Authors: Kathleen L. Horvath,
Elettra L. Piacentino,
Rafael Bento Serpa,
Tanouir Aloui,
Raul Vyas,
Yuriy Zhilichev,
Jesko Windheim,
M. Luisa Sartorelli,
Charles B. Parker,
M. Bonner Denton,
Michael E. Gehm,
Jeffrey T. Glass,
Jason J. Amsden Tags: RESEARCH ARTICLE Source Type: research
Whole Blood Analysis for Medical Diagnostics by GC ‐MS with Cold EI
This study covers a new method and related instrumentation for whole blood analysis for medical diagnostics. Two μL whole blood samples were collected using "minimal invasive" diabetes lancet, and placed on a thin glass rod mounted on a newly designed BloodProbe. The BloodProbe with the whole blood sample was inserted directly into a ChromatoProbe mounted on the GC inlet, and thus no sample preparation was in volved. The analysis was performed within 10 minutes using a GC-MS with Cold EI that is based on interfacing GC and MS with supersonic molecular beams (SMB) along with electron ionization of vibrationally cold sample...
Source: Journal of Mass Spectrometry - July 1, 2022 Category: Chemistry Authors: Benny Neumark,
Oneg Elkabets,
Gabi Shefer,
Assaf Buch,
Naftali Stern,
Aviv Amirav Tags: RESEARCH ARTICLE Source Type: research
Sequential paired covariance for improved visualization of mass spectrometry imaging datasets
In this study, we present a new approach for improving image quality and visualization of tissue features by application of sequential paired covariance (SPC). This approach was demonstrated using previously published tissue datasets such as rat brain and human prostate with different biomolecules like metabolites andN-linked glycans. Data transformation by SPC improved ion images resulting in increased smoothing of biological features compared with commonly used normalization approaches. (Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - June 23, 2022 Category: Chemistry Authors: Crystal L. Pace,
Kenneth P. Garrard,
David C. Muddiman Tags: RESEARCH ARTICLE Source Type: research
Sequential Paired Covariance for Improved Visualization of Mass Spectrometry Imaging Datasets
In this study, we present a new approach for improving image quality and visualization of tissue features by application of sequential paired covariance (SPC). This approach was demonstrated using previously published tissue datasets such as rat brain and human prostate with different biomolecules like metabolites and N-linked glycans. Data transformation by SPC improved ion images resulting in increased smoothing of biological features compared to commonly used normalization approaches. (Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - June 13, 2022 Category: Chemistry Authors: Crystal L. Pace,
Kenneth P. Garrard,
David C. Muddiman Tags: RESEARCH ARTICLE Source Type: research
Electrospray ionization –tandem mass spectrometric study of fused nitrogen‐containing ring systems
AbstractFour fused nitrogen-containing ring systems were investigated by electrospray ionization –tandem mass spectrometry: Pyridazino-indoles, pyridazino-quinolines, a pyrimido-quinoline derivative and pyrimido-cinnolines. Fragmentation patterns of these compounds are discussed and compared. Several characteristic cross-ring fragments were formed mainly on the pyridazine and pyrimidine rings of the ring systems. The connected Cl, NO2, Me, Ph and more extended heterocyclic substituents influenced the fragmentation. (Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - June 9, 2022 Category: Chemistry Authors: G ábor Krajsovszky,
Borbála Dalmadiné Kiss,
Krisztina Ludányi,
István M. Mándity,
Dóra Bogdán Tags: RESEARCH ARTICLE Source Type: research
