Characterization of two excipient interaction degradation products in oseltamivir phosphate powder for oral suspension by MS and NMR
AbstractOseltamivir phosphate is widely used to treat and prevent influenza, and are available in the form of capsules, powder for oral suspension, pediatric solutions, and granules. Because of the amino group, oseltamivir is easy to react with the excipients of the formulation to generate drug-excipient interaction impurities. In this research, two degradation products in a commercial oseltamivir phosphate powder for oral suspension due to interaction between API and citrate were investigated. They were characterized to be 3-((-6-acetamido-3-(ethoxycarbonyl)-5-(pentan-3-yloxy)cyclohex-3-en-1-yl)carbamoyl)-3-hydroxypentane...
Source: Journal of Mass Spectrometry - November 27, 2022 Category: Chemistry Authors: Beiyang Yao,
Yiqun Guo,
Qifeng Xie,
Manhua Jiang,
Fuzhou Sun,
Yanping Zhao,
Guoying Tan,
Jiaxiang Sun,
Fangfang Huang,
Xuezhi Song,
Jinsong You Tags: RESEARCH ARTICLE Source Type: research
Quantitative analysis capability of DIUTHAME mass spectrometry verified by acetylcholinesterase enzyme ‐catalyzed reaction assays
In this study, the quantitative analysis capability of DIUTHAME was verified by applying DIUTHAME to enzyme-catalyzed reaction measurements, which are also used for HTS. Quantitative DIUTHAME-MS was conducted on various conditions of acetylcholinesterase-catalyzed reaction solutions containing cow milk as a substitute of biological media. Even for the enzyme-catalyzed reaction solutions containing complex additives that make the quantitative analysis extremely difficult, DIUTHAME based on the through hole structure enables quantitative measurements of the analytes by applying the reaction solutions to the back side of the ...
Source: Journal of Mass Spectrometry - November 25, 2022 Category: Chemistry Authors: Yasuhide Naito Tags: RESEARCH ARTICLE Source Type: research
Antibacterial activity against enterovirulent Escherichia coli strains from Bacillus amyloliquefaciens B31 and Bacillus subtilis subsp. subtilis C4: MALDI ‐TOF MS profiling and MALDI TOF/TOF MS structural analysis on lipopeptides mixtures
AbstractIn this work, twoBacillus strains isolated from honey (Bacillus subtilis subsp.subtilis C4; access code HQ828992) and from a waste of an artisanal tannery (Bacillus amyloliquefaciens B31; access code KP893752) were evaluated in order to determine their antibacterial activity against five enteropathogenicEscherichia coli strains. The number of viable cultivable cells of the different strains ofE. coli analyzed was determined by plate count. The crude cell-free supernatants of bothBacillus strains exerted anti-E. coli activities, whereas only the lipopeptide fraction of B31 had significantE. coli inhibition. Th...
Source: Journal of Mass Spectrometry - November 25, 2022 Category: Chemistry Authors: Sergio Fernando Huarachi,
Gabriela Petroselli,
Rosa Erra ‐Balsells,
Marcela Carina Audisio Tags: RESEARCH ARTICLE Source Type: research
Development of electrostatic ‐induced charge detector for multiturn time‐of‐flight mass spectrometer By Ken‐ichi Bajo, Jun Aoki, Morio Ishihara, Shizuho Furuya, Masahiro Nishimura, Miwa Yoshitake and Hisayoshi Yurimoto
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - November 23, 2022 Category: Chemistry Authors: Ken ‐ichi Bajo,
Jun Aoki,
Morio Ishihara,
Shizuho Furuya,
Masahiro Nishimura,
Miwa Yoshitake,
Hisayoshi Yurimoto Tags: COVER STORY Source Type: research
Cover Picture
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - November 23, 2022 Category: Chemistry Tags: COVER PICTURE Source Type: research
On the Importance of Color in Mass Spectrometry Imaging
AbstractMass spectrometry imaging (MSI) data visualization relies on heatmaps to show the spatial distribution and measured abundances of molecules within a sample. Non-uniform color gradients such as jet are still commonly used to visualize MSI data, increasing the probability of data misinterpretation and false conclusions. Also, the use of non-uniform color gradients and the combination of hues used in common colormaps makes it challenging for people with color vision deficiencies (CVDs) to visualize and accurately interpret data. Here we present best practices for choosing a colormap to accurately display MSI data, imp...
Source: Journal of Mass Spectrometry - November 22, 2022 Category: Chemistry Authors: Kevan T. Knizner,
Russell R. Kibbe,
Kenneth P. Garrard,
Jamie R. Nu ñez,
Christopher R. Anderton,
David C. Muddiman Tags: RESEARCH ARTICLE Source Type: research
Method validation and clinical application for the quantification of Lopinavir, Efavirenz and Ritonavir in breast milk using LC ‐MS/MS
AbstractA liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been validated for quantification of three antiretroviral drugs (efavirenz (EFV), lopinavir (LPV), and ritonavir RTV)) from human breast milk. The samples were extracted employing protein precipitation method using methanol as precipitating agent. The supernatant was evaporated and reconstituted before injecting into the chromatograph and separated on a biphenyl column. Calibration curves for the three tested antiretroviral drugs were linear (r≥0.999) over the range examined. The inter- and intra-day coefficients of variation (CV) were ≤15% ...
Source: Journal of Mass Spectrometry - November 18, 2022 Category: Chemistry Authors: F. Fraissinet,
A. A. Oumar,
P. Seraissol,
M. C. Cere,
M. Lavit,
E. Chatelut,
P. Gandia Tags: RESEARCH ARTICLE Source Type: research
Development and validation of multiresidue method for organophosphorus pesticides in lanolin using gas chromatography –tandem mass spectrometry
AbstractLanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in lanolin. The present study describes a single novel hyphenated gas chromatography –tandem mass spectrometry (GC-MS/MS) technique for the quantification of 14 organophosphorus (OP) pesticides (tecnazene, propetamphos, diazinon, dichlofenthion, chlorpyrifos methyl, fenchlorphos, malathion, chlorpyrifos, pirimiphos ethyl, bromophos ethyl, tetrachlorvinphos, ethion, phosalone, a...
Source: Journal of Mass Spectrometry - November 12, 2022 Category: Chemistry Authors: Neha Gupta,
Rakhi Singh,
Sumant Kumar Nayak,
Mukul Das,
Kulsum Jan Tags: RESEARCH ARTICLE Source Type: research
Antibacterial activity against enterovirulent Escherichia coli strains from Bacillus amyloliquefaciencs B31 and Bacillus subtilis subsp. subtilis C4. MALDI ‐TOF MS profiling and MALDI TOF/TOF MS structural analysis on lipopeptides mixtures.
AbstractIn this work twoBacillus strains isolated from honey (Bacillus subtilis subsp.subtilis C4; access code HQ828992) and from a waste of an artisanal tannery (Bacillus amyloliquefaciens B31; access code KP893752), were evaluated in order to determine their antibacterial activity against five enteropathogenicEscherichia coli strains. The number of viable cultivable cells of the different strains ofE. coli analyzed was determined by plate count. The crude cell free supernatants of bothBacillus strains exerted anti-E. coli activities, while only the lipopeptide fraction of B31 had significantE. coli inhibition. The lipope...
Source: Journal of Mass Spectrometry - November 12, 2022 Category: Chemistry Authors: S. F. Huarachi,
G. Petroselli,
R. Erra ‐Balsells,
M. C. Audisio Tags: RESEARCH ARTICLE Source Type: research
Quantitative Analysis Capability of DIUTHAME Mass Spectrometry Verified by Acetylcholinesterase Enzyme ‐Catalyzed Reaction Assays
In this study, the quantitative analysis capability of DIUTHAME was verified by applying DIUTHAME to enzyme-catalyzed reaction measurements, which are also used for HTS. Quantitative DIUTHAME-MS was conducted on various conditions of acetylcholinesterase-catalyzed reaction solutions containing cow milk as a substitute of biological media. Even for the enzyme-catalyzed reaction solutions containing complex additives that make the quantitative analysis extremely difficult, DIUTHAME based on the through hole structure enables quantitative measurements of the analytes by applying the reaction solutions to the back side of the ...
Source: Journal of Mass Spectrometry - November 11, 2022 Category: Chemistry Authors: Yasuhide Naito Tags: RESEARCH ARTICLE Source Type: research
Studies of pure and nitrogen gas mixed xenon ECR plasma: Signature of abundance dependent unusual trends in isotope anomaly
We report the effect of N2 gas-mixing in the xenon electron cyclotron resonance (ECR) plasma, and abundance-dependent novel, exciting and unusual trends of the isotope anomaly. The xenon plasma was produced using a 10 GHz all-permanent-magnet NANOGAN ECR ion source, and the charge state distributions of naturally abundant six stable xenon isotopes with and without N2 gas-mixing (at 25%, 50%, and 75%) were recorded. The intensity ratio of the heavier to lighter isotope, where the heavier isotope is less abundant, showed a clear signature of the isotope anomaly as explained by the linear Landau wave damping theory. Contrary ...
Source: Journal of Mass Spectrometry - November 4, 2022 Category: Chemistry Authors: Puneeta Tripathi,
Shushant Kumar Singh,
Pravin Kumar Tags: RESEARCH ARTICLE Source Type: research
Dissolve ‐Spin: Desalting Oligonucleotides for MALDI MS Analysis
AbstractDesalting oligonucleotides (ONs) for matrix assisted laser desorption ionization mass spectrometry (MALDI MS) analysis was achieved using a simple dissolve-spin approach. The ON is dissolved in an organic solvent. Insoluble salts are removed by centrifugation. ONs are highly polar molecules, and are generally believed insoluble in organic solvents with moderate polarity such as acetonitrile (ACN), 1,4-dioxane, ethyl acetate and THF. However, we found that in the presence of a suitable proton source such as pyridinium chloride, a quantity of ON that is sufficient for MALDI MS analysis could be dissolved. Because ino...
Source: Journal of Mass Spectrometry - October 31, 2022 Category: Chemistry Authors: Alexander Apostle,
Shiyue Fang Tags: RESEARCH ARTICLE Source Type: research
Development and validation of multiresidue method for organophosphorous pesticides in lanolin using Gas chromatography ‐ tandem mass spectrometry
AbstractLanolin also known as wool wax is derived from sheep, has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in Lanolin. The present study describes a single novel hyphenated gas chromatography tandem mass spectrometry (GC-MS/MS) technique for the quantification of 14 organophosphorous (OP) pesticides (Tecnazene, Propentamphos, Diazinon, Dichlofenthion, Chlorpyrifos methyl, Fenchlorphos, Malathion, Chlorpyrifos, Pirimphos ethyl, Bromophos ethyl, Tetrachlorvinphos, Ethion, Phosalone and Couma...
Source: Journal of Mass Spectrometry - October 29, 2022 Category: Chemistry Authors: Neha Gupta,
Rakhi Singh,
S. K. Nayak,
Mukul Das,
Kulsum Jan Tags: RESEARCH ARTICLE Source Type: research
Development of electrostatic ‐induced charge detector for multiturn time‐of‐flight mass spectrometer
AbstractWe developed an autocorrelation function to resolve the overtaking problem in a multiturn time-of-flight mass spectrometer (TOF –MS). The function analyzes the characteristic period for one lap of each ion packet and derives a mass spectrum from a signal pulse train composed of multiturn ion packets. To detect the ion pulse train, a new non-destructive ion detector was developed and installed in the multiturn orbit of MULT UM-S II. This detector is composed of an electrostatically induced charge detector, a preamplifier, and a digitizer. The electrostatic noises are smaller than the single-ion signals owing to th...
Source: Journal of Mass Spectrometry - October 26, 2022 Category: Chemistry Authors: Ken ‐ichi Bajo,
Jun Aoki,
Morio Ishihara,
Shizuho Furuya,
Masahiro Nishimura,
Miwa Yoshitake,
Hisayoshi Yurimoto Tags: RESEARCH ARTICLE Source Type: research
