Chicken UFL1 Restricts Avian Influenza Virus Replication by Disrupting the Viral Polymerase Complex and Facilitating Type I IFN Production
In this study, we first identified chUFL1 as a negative regulator of AIV replication by enhancing innate immunity and disrupting the assembly of the viral polymerase complex. Mechanistically, chUFL1 interacted with chicken stimulator of IFN genes (chSTING) and contributed to chSTING dimerization and the formation of the STING-TBK1-IRF7 complex. We further demonstrated that chUFL1 promoted K63-linked polyubiquitination of chSTING at K308 to facilitate chSTING-mediated type I IFN production independent of UFMylation. Additionally, chUFL1 expression was upregulated in response to AIV infection. Importantly, chUFL1 also intera...
Source: Journal of Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Weiqiang Li Yu Lin Xiyi Wang Huixing Yang Yangbao Ding Zuxian Chen Zhuoliang He Junsheng Zhang Luxiang Zhao Peirong Jiao Source Type: research
The Dysregulated IL-23/TH17 Axis in Endometriosis Pathophysiology
J Immunol. 2024 Mar 11:ji2400018. doi: 10.4049/jimmunol.2400018. Online ahead of print.ABSTRACTEndometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the development and differentiation of TH17 cells, driving TH17 cells toward a pathogenic profile. In a variety of inflammatory and autoimmune disorders, TH17 cells secrete proinflammatory cytokines, including IL-17, contributing to disease pathophysiology. Our studies and others have implicated IL-17 and TH17 cell dysregulation in endometriosis, which is assoc...
Source: Journal of Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Danielle J Sisnett Katherine B Zutautas Jessica E Miller Harshavardhan Lingegowda Soo Hyun Ahn Alison McCallion Olga Bougie Bruce A Lessey Chandrakant Tayade Source Type: research
The Dysregulated IL-23/TH17 Axis in Endometriosis Pathophysiology
J Immunol. 2024 Mar 11:ji2400018. doi: 10.4049/jimmunol.2400018. Online ahead of print.ABSTRACTEndometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the development and differentiation of TH17 cells, driving TH17 cells toward a pathogenic profile. In a variety of inflammatory and autoimmune disorders, TH17 cells secrete proinflammatory cytokines, including IL-17, contributing to disease pathophysiology. Our studies and others have implicated IL-17 and TH17 cell dysregulation in endometriosis, which is assoc...
Source: Journal of Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Danielle J Sisnett Katherine B Zutautas Jessica E Miller Harshavardhan Lingegowda Soo Hyun Ahn Alison McCallion Olga Bougie Bruce A Lessey Chandrakant Tayade Source Type: research
The Dysregulated IL-23/TH17 Axis in Endometriosis Pathophysiology
J Immunol. 2024 Mar 11:ji2400018. doi: 10.4049/jimmunol.2400018. Online ahead of print.ABSTRACTEndometriosis is a chronic inflammatory disease in which endometrial-like tissue grows ectopically, resulting in pelvic pain and infertility. IL-23 is a key contributor in the development and differentiation of TH17 cells, driving TH17 cells toward a pathogenic profile. In a variety of inflammatory and autoimmune disorders, TH17 cells secrete proinflammatory cytokines, including IL-17, contributing to disease pathophysiology. Our studies and others have implicated IL-17 and TH17 cell dysregulation in endometriosis, which is assoc...
Source: Journal of Immunology - March 11, 2024 Category: Allergy & Immunology Authors: Danielle J Sisnett Katherine B Zutautas Jessica E Miller Harshavardhan Lingegowda Soo Hyun Ahn Alison McCallion Olga Bougie Bruce A Lessey Chandrakant Tayade Source Type: research
Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction
J Immunol. 2024 Mar 8:ji2300839. doi: 10.4049/jimmunol.2300839. Online ahead of print.ABSTRACTmAbs to MHC class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding of epitopic sites seen by a set of anti-MHC-I mAb, we determined X-ray crystal structures of four complexes of anti-MHC-I Fabs bound to peptide/MHC-I/β2-microglobulin (pMHC-I). An anti-H2-Dd mAb, two anti-MHC-I α3 domain mAbs, and an anti-β2-microglobulin mAb bind pMHC-I at sites consistent with earlier mutational and functional experiments, and the structures exp...
Source: Journal of Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Lisa F Boyd Jiansheng Jiang Javeed Ahmad Kannan Natarajan David H Margulies Source Type: research
Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction
J Immunol. 2024 Mar 8:ji2300839. doi: 10.4049/jimmunol.2300839. Online ahead of print.ABSTRACTmAbs to MHC class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding of epitopic sites seen by a set of anti-MHC-I mAb, we determined X-ray crystal structures of four complexes of anti-MHC-I Fabs bound to peptide/MHC-I/β2-microglobulin (pMHC-I). An anti-H2-Dd mAb, two anti-MHC-I α3 domain mAbs, and an anti-β2-microglobulin mAb bind pMHC-I at sites consistent with earlier mutational and functional experiments, and the structures exp...
Source: Journal of Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Lisa F Boyd Jiansheng Jiang Javeed Ahmad Kannan Natarajan David H Margulies Source Type: research
Experimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction
J Immunol. 2024 Mar 8:ji2300839. doi: 10.4049/jimmunol.2300839. Online ahead of print.ABSTRACTmAbs to MHC class I (MHC-I) molecules have proved to be crucial reagents for tissue typing and fundamental studies of immune recognition. To augment our understanding of epitopic sites seen by a set of anti-MHC-I mAb, we determined X-ray crystal structures of four complexes of anti-MHC-I Fabs bound to peptide/MHC-I/β2-microglobulin (pMHC-I). An anti-H2-Dd mAb, two anti-MHC-I α3 domain mAbs, and an anti-β2-microglobulin mAb bind pMHC-I at sites consistent with earlier mutational and functional experiments, and the structures exp...
Source: Journal of Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Lisa F Boyd Jiansheng Jiang Javeed Ahmad Kannan Natarajan David H Margulies Source Type: research
PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection
In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a pro...
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kaitlin A Read Stephanie A Amici Sadaf Farsi Madeline Cutcliffe Bella Lee Chan-Wang Jerry Lio Hsin-Jung Joyce Wu Mireia Guerau-de-Arellano Kenneth J Oestreich Source Type: research
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J Immunol. 2024 Mar 15;212(6):931. doi: 10.4049/jimmunol.2390027.NO ABSTRACTPMID:38437647 | DOI:10.4049/jimmunol.2390027 (Source: Journal of Immunology)
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Source Type: research
PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection
In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a pro...
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kaitlin A Read Stephanie A Amici Sadaf Farsi Madeline Cutcliffe Bella Lee Chan-Wang Jerry Lio Hsin-Jung Joyce Wu Mireia Guerau-de-Arellano Kenneth J Oestreich Source Type: research
Top Reads
J Immunol. 2024 Mar 15;212(6):931. doi: 10.4049/jimmunol.2390027.NO ABSTRACTPMID:38437647 | DOI:10.4049/jimmunol.2390027 (Source: Journal of Immunology)
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Source Type: research
PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection
In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a pro...
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kaitlin A Read Stephanie A Amici Sadaf Farsi Madeline Cutcliffe Bella Lee Chan-Wang Jerry Lio Hsin-Jung Joyce Wu Mireia Guerau-de-Arellano Kenneth J Oestreich Source Type: research
Top Reads
J Immunol. 2024 Mar 15;212(6):931. doi: 10.4049/jimmunol.2390027.NO ABSTRACTPMID:38437647 | DOI:10.4049/jimmunol.2390027 (Source: Journal of Immunology)
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Source Type: research
PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection
In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production. Supporting a potential mechanism, we observe elevated surface expression of IL-2Rα on non-T regulatory effector PRMT5-deficient T cells. Notably, IL-2 signaling is known to negatively impact Tfh differentiation. Collectively, our findings identify PRMT5 as a pro...
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Authors: Kaitlin A Read Stephanie A Amici Sadaf Farsi Madeline Cutcliffe Bella Lee Chan-Wang Jerry Lio Hsin-Jung Joyce Wu Mireia Guerau-de-Arellano Kenneth J Oestreich Source Type: research
Top Reads
J Immunol. 2024 Mar 15;212(6):931. doi: 10.4049/jimmunol.2390027.NO ABSTRACTPMID:38437647 | DOI:10.4049/jimmunol.2390027 (Source: Journal of Immunology)
Source: Journal of Immunology - March 4, 2024 Category: Allergy & Immunology Source Type: research
