The Lung Microbiome
J Immunol. 2024 Apr 15;212(8):1269-1275. doi: 10.4049/jimmunol.2300716.ABSTRACTAlthough the lungs were once considered a sterile environment, advances in sequencing technology have revealed dynamic, low-biomass communities in the respiratory tract, even in health. Key features of these communities-composition, diversity, and burden-are consistently altered in lung disease, associate with host physiology and immunity, and can predict clinical outcomes. Although initial studies of the lung microbiome were descriptive, recent studies have leveraged advances in technology to identify metabolically active microbes and potential...
Source: Journal of Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Jay H Lipinksi Piyush Ranjan Robert P Dickson David N O'Dwyer Source Type: research
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J Immunol. 2024 Apr 15;212(8):1255. doi: 10.4049/jimmunol.2490001.NO ABSTRACTPMID:38560812 | DOI:10.4049/jimmunol.2490001 (Source: Journal of Immunology)
Source: Journal of Immunology - April 1, 2024 Category: Allergy & Immunology Source Type: research
A Retrospective Analysis of Leadership, Awardees, and Member Gender Representation of the Canadian Society for Immunology
We present these findings as well as our recommendations to enhance inclusivity. These include a more comprehensive collection and secure storage of self-identification data, emphasis on EDI as an essential component of all annual meeting activities, and innovative measures of outreach, collaboration, and leadership with the aim of making the CSI a model for improving EDI in other professional research societies.PMID:38560813 | DOI:10.4049/jimmunol.2300711 (Source: Journal of Immunology)
Source: Journal of Immunology - April 1, 2024 Category: Allergy & Immunology Authors: Melina Messing Dominique M Gatti Siavash Mashhouri Sabryna Nantel Saki Sultana Lauren P Westhaver Kamala D Patel Aaron J Marshall S M Mansour Haeryfar Craig N Jenne Ninan Abraham Heather J Melichar Kelly M McNagny Yanet Valdez Tejeira Source Type: research
Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy
J Immunol. 2024 Mar 29:ji2300672. doi: 10.4049/jimmunol.2300672. Online ahead of print.ABSTRACTHIV-1 infection greatly alters the NK cell phenotypic and functional repertoire. This is highlighted by the expansion of a rare population of FcRγ- NK cells exhibiting characteristics of traditional immunologic memory in people with HIV (PWH). Although current antiretroviral therapy (ART) effectively controls HIV-1 viremia and disease progression, its impact on HIV-1-associated NK cell abnormalities remains unclear. To address this, we performed a longitudinal analysis detailing conventional and memory-like NK cell characteristi...
Source: Journal of Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Renee R Anderko Allison E DePuyt Rhianna Bronson Arlene C Bullotta Evgenia Aga Ronald J Bosch R Brad Jones Joseph J Eron John W Mellors Rajesh T Gandhi Deborah K McMahon Bernard J Macatangay Charles R Rinaldo Robbie B Mailliard Source Type: research
Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy
J Immunol. 2024 Mar 29:ji2300672. doi: 10.4049/jimmunol.2300672. Online ahead of print.ABSTRACTHIV-1 infection greatly alters the NK cell phenotypic and functional repertoire. This is highlighted by the expansion of a rare population of FcRγ- NK cells exhibiting characteristics of traditional immunologic memory in people with HIV (PWH). Although current antiretroviral therapy (ART) effectively controls HIV-1 viremia and disease progression, its impact on HIV-1-associated NK cell abnormalities remains unclear. To address this, we performed a longitudinal analysis detailing conventional and memory-like NK cell characteristi...
Source: Journal of Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Renee R Anderko Allison E DePuyt Rhianna Bronson Arlene C Bullotta Evgenia Aga Ronald J Bosch R Brad Jones Joseph J Eron John W Mellors Rajesh T Gandhi Deborah K McMahon Bernard J Macatangay Charles R Rinaldo Robbie B Mailliard Source Type: research
Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy
J Immunol. 2024 Mar 29:ji2300672. doi: 10.4049/jimmunol.2300672. Online ahead of print.ABSTRACTHIV-1 infection greatly alters the NK cell phenotypic and functional repertoire. This is highlighted by the expansion of a rare population of FcRγ- NK cells exhibiting characteristics of traditional immunologic memory in people with HIV (PWH). Although current antiretroviral therapy (ART) effectively controls HIV-1 viremia and disease progression, its impact on HIV-1-associated NK cell abnormalities remains unclear. To address this, we performed a longitudinal analysis detailing conventional and memory-like NK cell characteristi...
Source: Journal of Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Renee R Anderko Allison E DePuyt Rhianna Bronson Arlene C Bullotta Evgenia Aga Ronald J Bosch R Brad Jones Joseph J Eron John W Mellors Rajesh T Gandhi Deborah K McMahon Bernard J Macatangay Charles R Rinaldo Robbie B Mailliard Source Type: research
Correction: DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells
J Immunol. 2024 Mar 27:ji2400135. doi: 10.4049/jimmunol.2400135. Online ahead of print.ABSTRACTPellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs). Abs for DX5 and CD49b bind the same m...
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Daniel G Pellicci Kirsten J L Hammond Jonathan Coquet Konstantinos Kyparissoudis Andrew G Brooks Katherine Kedzierska Rachael Keating Stephen Turner Stuart Berzins Mark J Smyth Dale I Godfrey Source Type: research
Correction: Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses
J Immunol. 2024 Mar 27:ji2400134. doi: 10.4049/jimmunol.2400134. Online ahead of print.ABSTRACTPaidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.PMID:38536099 | DOI:10.4049/jimmunol.2400134 (Source: Journal of Immunology)
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Ramesh K Paidi Malabendu Jana Rama K Mishra Debashis Dutta Kalipada Pahan Source Type: research
Correction: DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells
J Immunol. 2024 Mar 27:ji2400135. doi: 10.4049/jimmunol.2400135. Online ahead of print.ABSTRACTPellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs). Abs for DX5 and CD49b bind the same m...
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Daniel G Pellicci Kirsten J L Hammond Jonathan Coquet Konstantinos Kyparissoudis Andrew G Brooks Katherine Kedzierska Rachael Keating Stephen Turner Stuart Berzins Mark J Smyth Dale I Godfrey Source Type: research
Correction: Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses
J Immunol. 2024 Mar 27:ji2400134. doi: 10.4049/jimmunol.2400134. Online ahead of print.ABSTRACTPaidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.PMID:38536099 | DOI:10.4049/jimmunol.2400134 (Source: Journal of Immunology)
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Ramesh K Paidi Malabendu Jana Rama K Mishra Debashis Dutta Kalipada Pahan Source Type: research
Correction: DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells
J Immunol. 2024 Mar 27:ji2400135. doi: 10.4049/jimmunol.2400135. Online ahead of print.ABSTRACTPellicci, D. G., K. J. L. Hammond, J. Coquet, K. Kyparissoudis, A. G. Brooks, K. Kedzierska, R. Keating, S. Turner, S. Berzins, M. J. Smyth, and D. I. Godfrey. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J. Immunol. 175: 4416-4425. Fig. 2A of this article contains flow cytometry comparing C57BL/6 WT mice and CD1d-/- mice for αβTCR versus DX5 or αβTCR versus CD49b staining in mouse thymus, spleen, liver, bone marrow, and peripheral lymph nodes (PLNs). Abs for DX5 and CD49b bind the same m...
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Daniel G Pellicci Kirsten J L Hammond Jonathan Coquet Konstantinos Kyparissoudis Andrew G Brooks Katherine Kedzierska Rachael Keating Stephen Turner Stuart Berzins Mark J Smyth Dale I Godfrey Source Type: research
Correction: Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses
J Immunol. 2024 Mar 27:ji2400134. doi: 10.4049/jimmunol.2400134. Online ahead of print.ABSTRACTPaidi, R. K., M. Jana, R. K. Mishra, D. Dutta, and K. Pahan. 2021. Selective inhibition of the interaction between SARS-CoV-2 spike S1 and ACE2 by SPIDAR peptide induces anti-inflammatory therapeutic responses. J. Immunol. 207: 2521-2533.In the original Supplemental Fig. 2C, the "Control" image was duplicated from the "Spike S1 (heat inactivated)" image due to an error during figure preparation. The supplemental figure has been corrected in the online version of the article.PMID:38536099 | DOI:10.4049/jimmunol.2400134 (Source: Journal of Immunology)
Source: Journal of Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Ramesh K Paidi Malabendu Jana Rama K Mishra Debashis Dutta Kalipada Pahan Source Type: research
Antibody-Suppressor CXCR5+CD8+ T Cells Are More Potent Regulators of Humoral Alloimmunity after Kidney Transplant in Mice Compared to CD4+ Regulatory T Cells
In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR). We examined quantity of peripheral blood, splenic and graft-infiltrating CD8+ TAb-supp, and CD4+ Tregs in KTx recipients and found that high alloantibody-producing CCR5 knockout KTx recipients have significantly fewer post-transplant peripheral blood and splenic CD8+ TAb-supp, as well as fewer splenic and graft-infiltrating CD4+ Tregs compared with wild-ty...
Source: Journal of Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Jing L Han Jason M Zimmerer Qiang Zeng Sachi Chaudhari Anjali Satoskar Mahmoud Abdel-Rasoul Hope Uwase Christopher K Breuer Ginny L Bumgardner Source Type: research
The Role of Coinhibitory Receptors in B Cell Dysregulation in SARS-CoV-2-Infected Individuals with Severe Disease
In this study, when analyzing critically ill COVID-19 patients versus those with mild disease, we observed a significant reduction in total and memory B cell subsets but an increase in naive B cells. Moreover, B cells from COVID-19 patients displayed impaired effector functions, evidenced by diminished proliferative capacity, reduced cytokine, and Ab production. This functional impairment was accompanied by an increased apoptotic potential upon stimulation in B cells from severely ill COVID-19 patients. Our further studies revealed the expansion of B cells expressing coinhibitory molecules (PD-1, PD-L1, TIM-1, VISTA, CTLA-...
Source: Journal of Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Suguru Saito Najmeh Bozorgmehr Wendy Sligl Mohammed Osman Shokrollah Elahi Source Type: research
Antibody-Suppressor CXCR5+CD8+ T Cells Are More Potent Regulators of Humoral Alloimmunity after Kidney Transplant in Mice Compared to CD4+ Regulatory T Cells
In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR). We examined quantity of peripheral blood, splenic and graft-infiltrating CD8+ TAb-supp, and CD4+ Tregs in KTx recipients and found that high alloantibody-producing CCR5 knockout KTx recipients have significantly fewer post-transplant peripheral blood and splenic CD8+ TAb-supp, as well as fewer splenic and graft-infiltrating CD4+ Tregs compared with wild-ty...
Source: Journal of Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Jing L Han Jason M Zimmerer Qiang Zeng Sachi Chaudhari Anjali Satoskar Mahmoud Abdel-Rasoul Hope Uwase Christopher K Breuer Ginny L Bumgardner Source Type: research
