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The Latest Research Advances of Danggui Buxue Tang as an Effective Prescription for Various Diseases: A Comprehensive Review
AbstractDanggui Buxue Tang (DBT) is composed ofAstragali Radix andAngelicae Sinensis Radix in a weight ratio of 5:1. The recipe of the decoction is simple, and DBT has been widely used in the treatment of blood deficiency syndrome for more than 800 years in China. Studies on its chemical constituents show that saponins, flavonoids, volatile oils, organic acids, and polysaccharides are the main components of DBT. Many techniques such as third-generation sequencing, PCR-denaturing gradient gel electrophoresis, and HPLC-MS have been used for the quality control of DBT. DBT has a wide range of biological activities, including ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Myeloid-derived Suppressor Cells Activate Liver Natural Killer Cells in a Murine Model in Uveal Melanoma
ConclusionAll these findings first revealed that MDSCs accumulated in liver metastasis of intraocular melanoma could activate the NK cells to produce an effective anti-tumor immune response. Thus, the MDSCs ’ performance in different tumor models would need more investigation to boost current immunotherapy modalities. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells
ConclusionOur findings indicated that PAD2 plays a role in ER homeostasis maintenance and apoptosis prevention. Therefore, targeting PAD2 with BB-Cl-A could represent a novel therapeutic strategy for treating AML. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

The Pathway of China ’s Integrated Delivery System: Based on the Analysis of the Medical Consortium Policies
AbstractWith the deepening of China ’s health-care reform, an integrated delivery system has gradually emerged with the function of improving the efficiency of the health-care delivery system. For China’s integrated delivery system, a medical consortium plays an important role in integrating public hospitals and primary care facil ities. The first medical consortium policy issued after the COVID-19 pandemic apparently placed hope on accelerating the implementation of a medical consortium and tiered health-care delivery system. This paper illustrates the possible future pathway of China’s medical consortium through re...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Attention and Intervention of Oncologists on Oxaliplatin-induced Adverse Reactions in Mainland China: A Cross-sectional Internet-based Survey
ConclusionOur findings indicate that oncologists in mainland China are concerned about OXA-induced ADRs, but the reporting of ADRs still needs to be strengthened. Therefore, training and educational programs are urgently needed to improve the risk management of OXA-induced ADRs among oncologists. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Relationship between Coronary Artery Tortuosity and Cardiorespiratory Fitness in Patients without Obstructed Coronaries
ConclusionThe results indicate that increasing severity of CAT is strongly associated with female gender and E/A ratio and is not directly correlated with decreasing CRF. Further research with a larger patient population and a longer follow-up time is required to fully comprehend the impact of CAT on CRF. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Increased CAP37 Expression in Stable Chronic Obstructive Pulmonary Disease
ConclusionOur findings indicated that neutrophil-derived CAP37 may be involved in airway inflammation and fibrosis in COPD via affecting the bronchial epithelial cells, and fibroblasts, thus suggesting a possible role of CAP37 in the development and progression of COPD. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

All-trans Retinoic Acid-incorporated Glycol Chitosan Nanoparticles Regulate Macrophage Polarization in Pg-LPS-Induced Inflammation
ConclusionThe present study confirms that RA-GC can promote the M2 polarization of macrophages in an inflammatory environment, and proposes this as a promising target for the clinical treatment of Pg-LPS-related diseases. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

TRIB3 Interacts with STAT3 to Promote Cancer Angiogenesis
ConclusionOur study provides insights into cancer angiogenesis and offers a potential therapeutic strategy for TRIB3-overexpressed cancer. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

Ten-year Time-trend Analysis of Dyslipidemia Among Adults in Wuhan
ConclusionThis study demonstrated that dyslipidemia is on the rise in men, and more emphasis should be provided for the screening of dyslipidemia in young males for the primary prevention of cardiovascular and renal diseases. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research

The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer
ConclusionDown-regulation of TRAT1 expression was associated with an unfavorable prognosis and immune infiltration of NSCLC. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 2, 2022 Category: Research Source Type: research

Impact of Antimicrobial Stewardship Programs on Antibiotic Use and Drug Resistance: Analysis of Data from Maternal and Child Health Care Hospitals in Hubei Province, China
ConclusionASPs have positive effects on antibiotic use and drug resistance in 85 maternity hospitals (maternal and child health care hospitals). (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 2, 2022 Category: Research Source Type: research

Analysis of Common Respiratory Infected Pathogens in 3100 Children after the Coronavirus Disease 2019 Pandemic
ConclusionThe prevention and control measures for the COVID-19 pandemic effectively changed the epidemiological features of common respiratory tract infectious diseases in pediatric children. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 2, 2022 Category: Research Source Type: research

Gadolinium Enhances Dual-energy Computed Tomography Scan of Pulmonary Artery
ConclusionGd-CTPA is recommended to patients who are unsuitable for receiving an iodine-based CTPA. Furthermore, a turbo flash scan could surpass a dual-energy scan without consideration for virtual monoenergetic imaging. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - September 30, 2022 Category: Research Source Type: research

Non-glomerular Tip Lesion Focal Segmental Glomerulosclerosis as a Negative Predictor in Idiopathic Membranous Nephropathy
ConclusionThe non-GTL FSGS lesion was a novel negative predictor in IMN and should be taken into account in the management of IMN. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - September 30, 2022 Category: Research Source Type: research