Vancomycin-resistant enterococci isolates colonizing and infecting haematology patients: clonality, and virulence and resistance profile
ConclusionE. faecium was predominant, and infection isolates were more virulent than colonization isolates and harboured more often the gene gelE. Infections caused by VRE carrying the asa1 gene appeared to be associated with a fatal outcome. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Cleaning of inpatient nebuliser devices in cystic fibrosis patients-the urgent need for universal guidelines
Publication date: Available online 2 July 2018Source: Journal of Hospital InfectionAuthor(s): Jane Bell, John E. Moore, B. Cherie Millar (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Sternal surgical site infection in Egypt following coronary artery bypass graft surgery: Incidence and Risk factors
Publication date: Available online 6 July 2018Source: Journal of Hospital InfectionAuthor(s): Enjy Abdou, Matthew Westercamp, Samia Girgis, Moshira Sabry, Omar Sayyouh, Maha Talaat (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Comparison of national strategies to reduce methicillin-resistant Staphylococcus aureus (MRSA) infections in Japan and England
ConclusionPolicy interventions need to be relevant to local epidemiological trends, while acceptable within health system cultures and public expectations. Cross-national learning can help inform the right mix of interventions to create sustainable and resilient systems for future infection and economic challenges. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Molecular epidemiology and antimicrobial resistance of Clostridium difficile in a national geriatric hospital in Costa Rica
ConclusionBased on the abundance of strain types observed and their resistance to antibiotics in this geriatric hospital, these results contribute to a better overall understanding of the epidemiology of CDI worldwide, and to surveillance programmes targeting geriatric populations. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Editorial Board
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Routine screening for colonization by Gram-negative bacteria in neonates at intensive care units for the prediction of sepsis: systematic review and meta-analysis
ConclusionLimited evidence of very low quality exists regarding the prognostic value of neonatal screening for late-onset sepsis. Carefully planned and conducted prospective studies, including randomized trials, are needed to clarify the potential value of this measure for the prediction and prevention of late-onset sepsis. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

An evaluation of a toolkit for the early detection, management, and control of carbapenemase-producing Enterobacteriaceae: a survey of acute hospital trusts in England
ConclusionCPE prevention and control requires robust IPC measures. Successful implementation can be hindered by a complex set of factors related to their practical execution, insufficient resources and a lack of confidence in the effectiveness of the guidance. Future CPE guidance would benefit from substantive user involvement, processes for ongoing feedback, and regular guidance updates. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Is cohorting the only solution to control carbapenemase-producing Enterobacteriaceae outbreaks? A single-centre experience
ConclusionUnderstanding ward variables associated with CPE spread can help design suitable solutions. Colonization pressure and antibiotic consumption seems to be driving in-hospital transmission, along with caregiver:patient ratio. In presence of high colonization pressure, dedicated healthcare workers for managing CPE patients should be implemented. Co-ordination between ICT and antimicrobial stewardship team is also crucial to prevent CPE spread. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Impact of active surveillance and infection control measures on carbapenem-resistant Gram-negative bacterial colonization and infections in intensive care
ConclusionEnhanced infection control measures including enhanced hand hygiene, active surveillance combined with contact precautions, education, audits and feedback policies and interventions could reduce CRKP and CRPA in endemic areas. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Clinical factors predicting persistent carriage of Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae among patients with known carriage
ConclusionThe results suggest that patients with KPC-producing CRE in clinical specimens who are using carbapenem, particularly those with multiple and prolonged hospitalizations, are more likely to remain carriers after six months of initial acquisition. This information is useful for coordinating strategies for pre-emptive isolation by predicting the CRE carriage status appropriately, and ensuring active surveillance through risk factor stratification. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Nosocomial transmission of carbapenem-resistant Klebsiella pneumoniae in an Italian university hospital: a molecular epidemiological study
ConclusionsA high incidence of KPC-Kp in patients with invasive infections was recorded at an Italian university hospital compared with the incidence measured before 2015. This study confirmed the importance of the KPC-3 carbapenemase variant, as reported by other Italian studies. High mortality and comorbidity rates appear to be associated with KPC-Kp infection. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Resistance patterns of Enterobacteriaceae in urines are similar in symptomatic and asymptomatic patients
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): A. Romero Palacios, F. Al Dhufairi, C. Ellis, D. Smyth, L.M.D. Mieusement, A. McGeer, D. MertzSummaryAntibiograms of urine cultures are being used to guide empiric treatment for urinary tract infections (UTIs). However, roughly 50% of urine cultures are from patients with asymptomatic bacteriuria (ABU). It is unclear whether Enterobacteriaceae in ABU patients have similar resistance patterns as UTI patients. Hence, we aimed to compare the antimicrobial resistance patterns in patients with ABU to patients with symptomatic UTI. W...
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Duodenoscopy: an amplifier of cross-transmission during a carbapenemase-producing Enterobacteriaceae outbreak in a gastroenterology pathway
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): C. Bourigault, F. Le Gallou, N. Bodet, N. Musquer, M.-E. Juvin, S. Corvec, N. Ferronnière, S. Wiesel, J. Gournay, G. Birgand, M. Le Rhun, D. LepelletierSummaryCarbapenemase-producing Klebsiella pneumoniae (OXA-48 CPE) were identified in five patients who underwent an endoscopy with the same duodenoscope in October 2015. The endoscope was the only epidemiological link between these cases. A transient contamination of the duodenoscope following a failure in the disinfection process may have been the cause of transmission. ...
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

A multi-disciplinary educational programme for the management of a carbapenem-resistant Klebsiella pneumoniae outbreak: an Italian experience
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): M. Fattorini, D. Rosadini, G. Messina, C. Basagni, A. Tinturini, M.F. De Marco (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Close long-term contacts between individuals with discordant colonization status of carbapenem-resistant Enterobacteriaceae do not result in bacterial transmission
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): S. Borgmann, B. Rieß, Y. Pfeifer (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

First case of New Delhi metallo-β-lactamase-1 of the same pulsotype of multi-drug-resistant Klebsiella pneumoniae in Minas Gerais, Brazil
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): I.R. Gonçalves, P.A. Campos, M.L. Ferreira, S. Royer, L.G. Machado, B.F. Araújo, V.V.P. Almeida, D.W.F. Batistão, P.P. Gontijo-Filho, R.M. Ribas (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Response to ‘The start of another infection prevention learning curve: reducing healthcare-associated Gram-negative bloodstream infections’
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): A. Joseph, V. Weston, T. Boswell (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Reply to Joseph et al.
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): M.H. Wilcox (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Community-acquired Clostridium difficile: epidemiology, ribotype, risk factors, hospital and intensive care unit outcomes, and current and emerging therapies
ConclusionCommunity-acquired CDI represents a growing public health threat and burden on healthcare systems. A multi-disciplinary approach will be required to stem the tides. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus, L. casei, and L. rhamnosus strains: assessing the evidence
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): L.V. McFarland, N. Ship, J. Auclair, M. MilletteSummaryClostridium difficile infection (CDI) has become the leading healthcare-associated infection and cause of outbreaks around the world. Although various innovative treatments have been developed, preventive strategies using multi-faceted infection control programmes have not been successful in reducing CDI rates. The major risk factor for CDI is the disruption of the normally protective gastrointestinal microbiota, typically by antibiotic use. Supplementation with specific pr...
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Clostridium difficile classification overestimates hospital-acquired infections
ConclusionCurrent guidelines for classifying C. difficile infections overestimate the proportion of cases acquired in hospital in all model scenarios. To reduce misclassification bias, an infection should be classified as being acquired prior to admission if symptoms begin within five days of admission. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Examining the epidemiology and microbiology of Clostridium difficile carriage in elderly patients and residents of a healthcare facility in southern Ontario, Canada
ConclusionC. difficile colonization by ACF and LTCF residents was common, despite a low apparent incidence of CDI. The association with PPI provides further evidence of the potential importance of this widely used drug class in C. difficile colonization. Wide genetic diversity was present, highlighting the likelihood of multiple unidentified routes of C. difficile acquisition. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Cost-effectiveness analysis of oral probiotics for the prevention of Clostridium difficile-associated diarrhoea in children and adolescents
ConclusionFrom the perspective of the medical system, oral probiotics as a preventive strategy for CDAD in hospitalized children and adolescents receiving a therapeutic course of antibiotics reduced the risk of CDAD and represents a cost-saving strategy. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Clearance of carbapenem-resistant Enterobacteriaceae vs vancomycin-resistant enterococci carriage after faecal microbiota transplant: a prospective comparative study
ConclusionCRE and VRE clearance rates were not significantly different in this study, possibly due to the small sample size, but a trend was observed. These data should be confirmed by larger cohorts and randomized trials. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Active surveillance for carbapenem-resistant Enterobacteriaceae, vancomycin-resistant enterococci and toxigenic Clostridium difficile among patients transferred from long-term care facilities in Korea
Publication date: August 2018Source: Journal of Hospital Infection, Volume 99, Issue 4Author(s): J-H. Hwang, J.S. Park, E. Lee, J.Y. Bae, K-H. Song, P.G. Choe, W.B. Park, J.H. Bang, E.S. Kim, S.W. Park, N.J. Kim, M. Oh, H.B. KimSummaryA 10-month active surveillance study was conducted to assess carriage of carbapenemase-producing Enterobacteriaceae (CPE), vancomycin-resistant enterococci (VRE) and toxigenic Clostridium difficile colonization among patients transferred to hospital from long-term care facilities (LTCFs). Four (1.4%) patients with carbapenem-resistant Enterobacteriaceae (none of which were CPE), 59 (21%) pati...
Source: Journal of Hospital Infection - July 10, 2018 Category: Infectious Diseases Source Type: research

Comparison of national strategies to reduce methicillin-resistant Staphylococcus aureus (MRSA) infections in Japan and England
ConclusionPolicy interventions need to be relevant to local epidemiological trends, while acceptable within health system cultures and public expectations. Cross-national learning can help inform the right mix of interventions to create sustainable and resilient systems for future infection and economic challenges. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 7, 2018 Category: Infectious Diseases Source Type: research

Sternal surgical site infection in Egypt following coronary artery bypass graft surgery: Incidence and Risk factors
Publication date: Available online 6 July 2018Source: Journal of Hospital InfectionAuthor(s): Enjy Abdou, Matthew Westercamp, Samia Girgis, Moshira Sabry, Omar Sayyouh, Maha Talaat (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 6, 2018 Category: Infectious Diseases Source Type: research

Characteristics of antimicrobial stewardship programmes in rural East Texas hospitals
Publication date: Available online 4 May 2018Source: Journal of Hospital InfectionAuthor(s): J.C. Cho, R.L. Dunn, F.S. Yu, G.A. Loredo, B.J. BrazillSummaryIntroductionAntimicrobial stewardship programmes (ASPs) serve as the primary method to prevent and manage the development of antimicrobial resistance. Rural settings may lack the recommended personnel and resources needed to provide antimicrobial stewardship services.MethodsAn electronic survey was distributed via e-mail to pharmacy directors or antimicrobial stewardship programme directors of licensed hospitals within Public Health Region 4/5N of East Texas.ResultsSixty...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Characterizations of handwashing sink activities in a single hospital medical intensive care unit
ConclusionSeveral non-hand hygiene activities took place regularly in ICU handwashing sinks; these may provide a mechanism for nosocomial transmission and promotion of bacterial growth in the drain. Redesigning hospital workflow and sink usage may be necessary as it becomes apparent that sink drains may be a reservoir for transmission of multidrug-resistant bacteria. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Thirteen-year Experience with Universal Staphylococcus aureus Nasal Decolonisation Prior to Cardiac Surgery: a quasi-experimental study
Publication date: Available online 5 May 2018Source: Journal of Hospital InfectionAuthor(s): Adrien Lemaignen, Laurence Armand-Lefevre, Gabriel Birgand, Guillaume Mabileau, Isabelle Lolom, Walid Ghodbane, Pierre Dilly Marie, Patrick Nataf, Jean-Christophe LucetSummaryIntroductionSternal wound infection (SWI) after cardiac surgery is a severe complication. Among preventive measures, pre-operative decolonisation of nasal carriage of Staphylococcus aureus has recently been shown to be beneficial. In this quasi-experimental study, we assessed the effect of decolonisation on the incidence of S. aureus-associated SWI during 19-y...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Addressing the controversy of 100% hand hygiene compliance: can alcohol rub consumption data serve as a useful proxy validator?
Publication date: Available online 5 May 2018Source: Journal of Hospital InfectionAuthor(s): M.A. Borg, A. Brincat (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Do safety engineered devices reduce needlestick injuries?
ConclusionThe application of SEDs has not led to a reduction in NSIs. The majority of NSIs caused by a needle with an SED can be prevented by stimulation of safe needle disposal, proper use of SEDs, and provision of feedback to manufacturers to keep improving product design. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease?
Publication date: Available online 7 May 2018Source: Journal of Hospital InfectionAuthor(s): D.A. Enoch, R. Santos, C.J. Phillips, C. Micallef, M.E. Murphy, S.H. Aliyu, D. Massey, N.M. BrownSummaryAll courses of fidaxomicin use in the study hospital were reviewed. It was used for first recurrence (six times), second recurrence (eight times) and one case of third recurrence. One patients received fidaxomicin as first-line treatment. Eight patients initially responded to therapy; of these, three patients were asymptomatic at 90 days, three patients remained asymptomatic at 30 days, and two patients had recurrences five and n...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Invasive device-associated infections caused by Pseudomonas aeruginosa in critically ill patients: evolution over 10 years
Publication date: Available online 8 May 2018Source: Journal of Hospital InfectionAuthor(s): F. Álvarez-Lerma, P. Olaechea-Astigarraga, M. Palomar-Martínez, M. Catalan, X. Nuvials, R. Gimeno, M.P. Gracia-Arnillas, I. Seijas-Betolaza, ENVIN-HELICS Study GroupSummaryInvasive device-associated infections caused by Pseudomonas aeruginosa over 10 years (2007–2016) were assessed based on data from the ENVIN-HELICS registry (200 Spanish intensive care units). P. aeruginosa was the leading pathogen except in the last two years in which there was a slight decrease, with Escherichia coli as the leading aetio...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Evaluating a neonatal intensive care unit MRSA surveillance programme using agent-based network modelling
ConclusionsAn effective MRSA surveillance programme needs to balance resource availability with potential for harm due to longer colonization periods and opportunity for development of invasive disease. While more frequent monitoring led to greater use of a decolonization regimen, it also reduced the likelihood of isolation rooms being available. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Unmasking leading to a healthcare worker Mycobacterium tuberculosis transmission
ConclusionExposure most likely occurred during an aerosol-generating procedure (AGP) which was done in accordance with national guidance at that time without using respiratory protection. Enhanced control measures were implemented following the outbreak. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Response to Aho Glele et al.
Publication date: Available online 11 May 2018Source: Journal of Hospital InfectionAuthor(s): E. Shaw, L. Gavalda (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Clinical and Molecular Epidemiologic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Infection/Colonization among Neonates in China
ConclusionsMost of the CR-KPN isolated from neonates produced NDM-1 and were highly homologous. Fosfomycin-containing regimens were efficient for CR-KPN infection in neonates, as well as the meropenem/panipenem-containing combination regimen. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Investigation of the efficacy of alcohol-based solutions on adenovirus serotypes 8, 19 and 37, common causes of epidemic keratoconjunctivitis, after an adenovirus outbreak in hospital
ConclusionThe alcohol-based solutions tested in this study were not found to be sufficiently effective against adenovirus serotypes. Further studies to investigate the efficiency of different alcohol-based solutions are required. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Assessing hand hygiene attitudes of inpatient nursing personnel in a US military hospital
This study described frequency of hand hygiene within a fixed US military facility, in participants wearing a military uniform and hospital-provided scrubs. The median frequency of hand hygiene reported in both uniforms was 10 per hour. However, two-thirds of staff indicated that the military uniform decreased their ability to perform hand hygiene. Stakeholders should re-evaluate policies requiring wear of long-sleeved military uniforms by nursing staff to facilitate hand hygiene. Non-military facilities may also consider the impact of long-sleeved garments on hand hygiene. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Impact of extended-spectrum β-lactamases and carbapenem-resistant Gram-negative infections on sepsis mortality at the emergency department: a cohort study
Publication date: Available online 22 May 2018Source: Journal of Hospital InfectionAuthor(s): S. Sabino, H. Monroy, C. Jara, O. Lopez, F. Ramos, D.R. Falci, M.H. Rigatto (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Effect of copper-impregnated composite bed linens and patient gowns on healthcare-associated infection rates in six hospitals
Publication date: Available online 24 May 2018Source: Journal of Hospital InfectionAuthor(s): J.P. ButlerSummaryBackgroundHospital linens and patient gowns are frequently touched and contaminated, and may contribute to endogenous, indirect-contact, and aerosol transmission of nosocomial-related pathogens. Recently Sentara Healthcare adopted biocidal copper oxide-impregnated linens across its hospitals.AimTo assess whether the replacement of the linens resulted in the reduction of healthcare-associated infection (HCAI).MethodsRates of HCAI caused by Clostridium difficile and multidrug-resistant organisms (MDROs) were compar...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

In-hospital infective endocarditis following transcatheter aortic valve replacement: a cross sectional study of National Inpatient Sample database in the United States
Publication date: Available online 25 May 2018Source: Journal of Hospital InfectionAuthor(s): Ilhwan Yeo, Luke K. Kim, Sun O. Park, S. Chiu WongSummaryBackgroundWhile the utilization of transcatheter aortic valve replacement (TAVR) for patients with severe aortic stenosis has been increasing, in-hospital infective endocarditis (IE) following TAVR has not been well-described.AimTo identify in-hospital IE following TAVR.MethodsUsing the National Inpatient Sample database, we identified all patients who underwent TAVR between 2012 and 2014. Multivariate logistic regression was performed to identify the predictors of in-hospit...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Frequent MRSA nasal colonization among hospitalized children and their parents in Angola and São Tomé and Príncipe
ConclusionHospitalized children and their parents are important reservoirs of MRSA. Infection control measures should focus on parents to minimize the spread of MRSA to the community. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

High carriage rate of extended-spectrum beta-lactamase-producing Enterobacteriaceae among patients admitted for surgery in Tanzanian hospitals with low rate of endogenous surgical site infections
This study investigated the magnitude of EPE carriage among surgical patients at the time of admission and discharge, and linked the carried EPE genotypes to those from SSI.MethodsEPE were confirmed among isolates from rectal and wound/pus swabs using VITEK-2. PCR and sequencing were performed to detect beta-lactamase genes. Multilocus sequence typing was employed to determine the genotypes of EPE isolates.ResultsAmong 930 patients enrolled, the EPE carriage was significantly higher on discharge than admission (36.4% vs. 23.7%, P
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Impact of intensive care unit relocation and role of tap water on an outbreak of Pseudomonas aeruginosa expressing OprD-mediated resistance to imipenem
ConclusionRelocation of the ICU was associated with a marked decrease in P. aeruginosa strains resistant to imipenem. The polyclonal character of PA-OprD strains isolated from patients and the absence of tap-water-to-patient contamination highlight the complexity of the environmental impact on the endogenous colonization/infection with P. aeruginosa. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

A measles outbreak in a refugee community in Jeddah City, Saudi Arabia
Publication date: Available online 30 May 2018Source: Journal of Hospital InfectionAuthor(s): N. Al-Abdullah (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Adaptive microbial response to low level benzalkonium chloride exposure
Publication date: Available online 31 May 2018Source: Journal of Hospital InfectionAuthor(s): Günter KampfSummaryBenzalkonium chloride (BAC) is a commonly used active agent in healthcare, e.g. in surface disinfectants, disinfectant cleaners or sometimes also in skin antiseptics. Aim of the review was to evaluate the potential of bacteria to adapt to low level BAC exposure. A maximum 4-fold MIC increase was found in most of the 57 evaluated bacterial species. A strong adaptive, mostly stable, MIC change was described in strains or isolates of Pantoea spp, Enterobacter spp., S. saprophyticus or E. coli (up to 500-fold, ...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research

Healthcare-associated Infections: The Hallmark of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) With Review of the Literature
Publication date: Available online 1 June 2018Source: Journal of Hospital InfectionAuthor(s): Jaffar A. Al-Tawfiq, Paul G. AuwaerterAbstractThe Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a coronavirus capable of causing acute respiratory illness. Laboratory confirmed MERS-CoV cases may be asymptomatic, have mild disease or life-threatening infection with a high case fatality rate. There are three patterns of transmission: sporadic community cases from presumed non-human exposure, family clusters arising from contact with the infected family index case, and healthcare-acquired infections among patients and f...
Source: Journal of Hospital Infection - July 5, 2018 Category: Infectious Diseases Source Type: research