Unravelling the genome sequence of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae ST11 isolated from a bloodstream infection
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Juan Xu, Zhao Zhao, Yumei Ge, Fang He (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - March 3, 2020 Category: Infectious Diseases Source Type: research

Genome sequence of a multidrug-resistant Erysipelothrix rhusiopathiae ZJ carrying several acquired resistance genes
Publication date: Available online 28 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Ju Gu, Yun-xia Li, Chang-wen Xu, Xian-jun Xie, Ping Li, Guang-xu Ma, Chang-wei Lei, Jin-xin Liu, An-yun Zhang (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - March 1, 2020 Category: Infectious Diseases Source Type: research

Investigation of pre-clinical pharmacokinetic parameters of atovaquone nanosuspension prepared using pH based precipitation method and its pharmacodynamic properties in a novel artemisinin combination
Publication date: Available online 29 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Harsha Kathpalia, Siddhesh Juvekar, Krishnapriya Mohanraj, Mrunal Apsingekar, Supriya Shidhaye (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - March 1, 2020 Category: Infectious Diseases Source Type: research

In vitro activity of ceftolozane–tazobactam and ceftazidime–avibactam against clinical isolates of meropenem-non-susceptible Pseudomonas aeruginosa: A two-centre study
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Hasan Cenk Mirza, Elvan Hortaç, Aylin Altay Koçak, M. Hamiyet Demirkaya, Buket Yayla, Aylin Üsküdar Güçlü, Ahmet Başustaoğlu (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - March 1, 2020 Category: Infectious Diseases Source Type: research

High-level aminoglycoside resistance and distribution of aminoglycoside resistance genes among Enterococcus spp. clinical isolates in Tehran, Iran
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): V. Sharifzadeh Peyvasti, A. Mohabati Mobarez, F. Shahcheraghi, N. Khoramabadi, N. Razaz Rahmati, R. Hosseini Doust (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 28, 2020 Category: Infectious Diseases Source Type: research

Virulence and antimicrobial resistance profiles of Escherichia coli encoding mcr gene from diarrhoeic weaned piglets in Korea during 2007–2016
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Kyung-Hyo Do, Ho-Eun Park, Jae-Won Byun, Wan-Kyu Lee (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 28, 2020 Category: Infectious Diseases Source Type: research

In vitro activity of Fosfomycin against mucoid and non-mucoid Pseudomonas aeruginosa strains
ConclusionsOur data suggest that fosfomycin has good effect against mucoid and non-mucoid strains of P. aeruginosa and automated systems can be implemented in clinical microbiology laboratories to assess fosfomycin with rapid and reproducible results. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 24, 2020 Category: Infectious Diseases Source Type: research

High genetic diversity in methicillin-susceptible Staphylococcus pseudintermedius in dogs in Europe
Publication date: Available online 22 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Marisa Haenni, Farid El Garch, Christine Miossec, Jean-Yves Madec, Didier Hocquet, Benoit Valot (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 24, 2020 Category: Infectious Diseases Source Type: research

Domestic and game pigeons as reservoirs for Escherichia coli harboring antimicrobial resistance genes
ConclusionsAn alarming rate of phenotypic resistance was observed in this study. Many isolates were positive for the screened resistance genes. According to the phylogenetic background, most resistant isolates belonged to the commensal phylo-types, representing significant role of commensal strains as a source of resistance genes. These findings highlight the role of pigeon as disseminator of resistant E. coli strains. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 24, 2020 Category: Infectious Diseases Source Type: research

Antibiotic resistance and molecular characteristics of methicillin-resistant Staphylococcus epidermidis recovered from hospital personnel in China
ConclusionsIn this study, the majority of MRSE belonged to cluster II domain of CC2. The ST59-IV was a dominant clone among isolates recovered from hospital personnel. Determination of new MLST types confirmed the genetic diversity of these isolates. These observations highlight the need to review the infection control strategies to reduce the carriage of MRSE among hospital personnel. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 24, 2020 Category: Infectious Diseases Source Type: research

Prospective infection surveillance and systematic screening for vancomycin-resistant enterococci in hematologic and oncologic patients – findings of a German tertiary care center
ConclusionsThe prospective surveillance and active screening for VRE was very useful to determine the true ratio of intestinal colonization to infection and thus helps to shape infection control management. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 22, 2020 Category: Infectious Diseases Source Type: research

Performance of Polymyxin B Etest® in a setting of high prevalence of KPC-producing Klebsiella pneumoniae
ConclusionsThe considerable number of resistant isolates in this study allowed an accurate estimation of VME rates and, consequently, a more comprehensive assessment in susceptibility testing for polymyxins. Etest® did not meet fully acceptance criteria for the FDA requirements. Our data do not support the use of this commercial method for determining PMB MICs in carbapenem-resistant Enterobacterales populations. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 21, 2020 Category: Infectious Diseases Source Type: research

Infectious diseases and antimicrobial prescribing online spaced education for junior doctors
ConclusionsOnline spaced education in infectious diseases and antimicrobial prescribing was feasible, acceptable and effective for junior doctors. It has potential to reduce inappropriate antimicrobial prescribing and warrants further investigation. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 21, 2020 Category: Infectious Diseases Source Type: research

Systematic Review and Meta-analysis to Estimate the Antibacterial Treatment Effect of Nitrofurantoin for a Non-Inferiority Trial in Uncomplicated Urinary Tract Infection
ConclusionThe corresponding treatment effect estimate for nitrofurantoin was 26.8%, which supports a conservative non-inferiority margin of 12.5% and is consistent with the recently published draft FDA guidance. The findings from this systematic review and meta-analysis inform future antibacterial trials by providing non-inferiority margin justification. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Revealing antibiotic resistance in therapeutic and dietary probiotic supplements
ConclusionsThe findings showed the presence of antibiotic resistance in probiotic bacteria isolated from commercially available dietary supplements. As multidrug resistance is a serious emerging issue and the risk of drug resistant gene transfer to commensals or pathogens of the gut is inevitable, the safety of probiotics has become a major criterion of interest. The findings of this study would serve as a platform for further screening and characterization of the determinants of antibiotic resistance and the genetic mechanisms of resistance. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Distribution of emm types and macrolide resistance determinants among group A streptococci in the Middle East and North Africa
Publication date: Available online 18 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Rayane Rafei, Malaik Hawli, Marwan Osman, Fouad Dabboussi, Monzer HamzeAbstractThis review aimed to provide an updated scenario of the Group A Streptococcus (GAS) epidemiology in the Middle Eastern and North African (MENA) region with a special spotlight on the most prevalent emm types and macrolide resistance profiles. While the burden of invasive GAS infections is elusive to assess in the MENA region, the GAS prevalence ranged from 2.5% to up 42.4% in pharyngitis patients and from 2.4% to up 35.4% in healthy ca...
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Genome and Transcriptome Analysis of A. baumannii's “Transient” Increase in Drug Resistance under Tigecycline Pressure
ConclusionTigcycline induced changes in the expression of some related genes in A. baumannii, which may be the main reason for its increased drug resistance. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from North India region
ConclusionOverexpression in efflux pump transporter genes together with mutations in ERG11 pave the way to fluconazole resistance among C. tropicalis. To the best of our knowledge this is the first study on C. tropicalis fluconazole resistance mechanism from North India region. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar
ConclusionsA. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Patterns of polymyxin B use in eight major cities of China in its first year of use
Publication date: Available online 19 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Zhenwei Yu, Lingyan Yu, Jianping Zhu (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Transmitted drug resistance mutations and trends of HIV-1 subtypes in treatment-naïve patients: A single-centre experience
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Laura Mazzuti, Taulant Melengu, Francesca Falasca, Marianna Calabretto, Eleonora Cella, Massimo Ciccozzi, Ivano Mezzaroma, Giancarlo Iaiani, Martina Spaziante, Gabriella d’Ettorre, Caterina Fimiani, Vincenzo Vullo, Guido Antonelli, Ombretta TurrizianiAbstractObjectivesTransmitted drug resistance (TDR) and HIV-1 genetic diversity may affect treatment efficacy and clinical outcomes. Here we describe the circulating viral subtypes and estimate the prevalence of drug resistance among antiretroviral therapy (ART)-naïve...
Source: Journal of Global Antimicrobial Resistance - February 19, 2020 Category: Infectious Diseases Source Type: research

Ceftaroline versus Vancomycin in The Treatment of Methicillin-resistant Staphylococcus aureus in an Experimental MRSA Meningitis Model
Publication date: Available online 14 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sinan Mermer, Tuncer Turhan, Elif Bolat, Sohret Aydemir, Tansu Yamazhan, Husnu Pullukcu, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy, Oguz Resat SipahiAbstractObjectivesHerein, we aimed to compare the antibacterial activity of ceftaroline and vancomycin in the treatment of MRSA meningitis in experimental rabbit meningitis model.MethodsWe compared the antibacterial activity of ceftaroline with vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 433...
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Impact of narrow-spectrum penicillin V on the oral and faecal resistome in a young child treated for otitis media
ConclusionsFollowing penicillin V, we observed a remarkable enrichment of the aecal resistome, indicating that even narrow-spectrum antibiotics may have important consequences in selecting for a more resistant microbiome. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Genomic characterisation of a multidrug-resistant Mycoplasma hominis isolate recovered from a synovial fluid sample in China
ConclusionThis study reports the first genome sequence of a multidrug-resistant M. hominis isolate in China. These data may help to understand the genomic features and antimicrobial resistance mechanisms of this pathogen. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Prospective multicenter study on azole resistance in aspergillus isolates from surveillance cultures in haematological patients in italy
ConclusionsIn this study, theAspergillus azole resistance rate was 1% (3/292). In addition to A. fumigatus sensu stricto, A. lentulus and A. awamori azole resistant were identified. Therefore, it is important a correct identification at species level to better address a rapid therapy, to understand quickly the shift towards cryptic species and to have an updated knowledge of the local epidemiology. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Emergence of NDM-4 and OXA-181 carbapenemase-producing Klebsiella pneumoniae
Publication date: Available online 13 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Jin Seok Kim, Chae-Kyu Hong, Sang-Hun Park, Young-Hee Jin, Sunghee Han, Hee Soon Kim, Joo-Hyun Park, Byung-Noe Bae, Ju-Young Chung, Tae-Hee Han, Jib-Ho Lee, Sang-Me Lee, Young-Hee Oh (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Evaluation of the performance of Acuitas® ResistomeTest and the Acuitas Lighthouse® Software for the detection of β-lactamase producing microorganisms
ConclusionsThe OpGenAcuitas® Resistome Test is an efficient molecular tool that can identify resistance threats in health care institutions with high diagnostic accuracy and be integrated into targeted surveillance protocols. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Lamivudine-resistant HIVM184V is Durably Suppressed with Dolutegravir plus Lamivudine Dual Therapy in Humanized Mice
Publication date: Available online 13 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sandra Medina-Moreno, Juan C. Zapata, Fatah Kashanchi, Nhut M. Le, Said Hassounah, Thibault Mesplede, Maureen Oliveira, Charles C. Davis, Alonso Heredia (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Isolation and whole genome sequencing of a new type of linezolid-resistant Enterococcus faecalis from two cases of infective endocarditis after renal transplantation
Publication date: Available online 13 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Pengtao Bao, Zengzhen Zhang, Weiguo Zhao, Ying Jiang, Di Wang (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Mechanisms of fosfomycin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae
CONCLUSIONSThefosA3 gene is the primary mechanism of fosfomycin resistance in CRKP and can be transmitted widely by plasmid in hospitals. Mutations in murA and glpT were found in fosfomycin-resistant fosA3-negative CRKP. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Antimicrobial stewardship in patients with acute bacterial skin and skin structures infections: an international Delphi consensus
ConclusionsThis Delphi survey provided useful indicators for the implementation of antimicrobial stewardship principles in the clinical management of ABSSSI and offers interesting elements of discussion about the barriers existing in Europe for the optimal implementation of antimicrobial stewardship programs. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Cross-resistance of isoniazid, para-aminosalicylic acid and pasiniazid against isoniazid-resistant Mycobacterium tuberculosis isolates in China
ConclusionTaken together, these results demonstrate that PAS resistance and mutations in thekatG gene, inhA promoter or oxyR–ahpC intergenic region in INH-resistant M. tuberculosis have little effect on pasiniazid susceptibility. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Whole genome sequence of blaNDM and blaKPC co-producing Klebsiella pneumoniae isolate KSH203 with capsular serotype K25 belonging to ST11 from China
ConclusionIn this study, we illustrate the whole genome sequence of high biofilm-forming capacity, hypermucoviscous K. pneumoniae isolate KSH203 with capsular serotype K25 belonging to ST11 isolated from a patient in China, which carried a large number of antimicrobial resistance genes and virulence-associated genes. Future studies are needed to be aware of dissemination of this type of strain among environmental, animal and human isolates. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 15, 2020 Category: Infectious Diseases Source Type: research

Draft genome sequence of a multidrug-resistant KPC–2 and SRT–2 co–producing Serratia marcescens strain isolated from a hospitalized patient in Chile
ConclusionsHere we report the genome of the first KPC-positive and multidrug-resistant S. marcescens strain identified in Chile, which co-harboured several ARGs. The genome sequence of S. marcescens UCO-366 provides an insight into the antibiotic-resistance characteristics in this species in this country, and offers important data for further genomic studies on this critical priority pathogen. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Minocycline, Focused on mechanisms of resistance, antibacterial activity, and clinical effectiveness; Back to Future
Publication date: Available online 12 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Arezoo Asadi, Milad Abdi, Ebrahim Kouhsari, Pegah Panahi, Mohammad Sholeh, Nourkhoda Sadeghifard, Taghi Amiriani, Alireza Ahmadi, Abbas Maleki, Mehrdad GholamiAbstractThe increase of crisis in multidrug-resistant (MDR) or extensively drug-resistant (XDR) microorganisms leads to appealing therapeutic options. During the last 30 years, minocycline has been a wide-spectrum antimicrobial agent, effective against MDR gram-positive and-negative bacterial infections. Alike other tetracyclines, mechanism of action of min...
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Escherichia coli resistant to fosfomycin from urinary tract infections: Detection of the fosA3 gene in Spain
ConclusionsOur study shows that fosfomycin-resistantE. coli strains are isolated in the majority of the cases in elderly people with complicated UTIs and belong the pandemic ST131 clone. To our knowledge, we describe, for the first time in Spain, the gene fosA3, which alerts for a future dissemination that should be monitored. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Unravelling the genome sequence of NDM-1- and KPC-2-co-producing Klebsiella pneumoniae ST11 isolated from a bloodstream infection
ConclusionsIn summary, we report the genome sequence of a K. pneumoniae ST11 clinical strain co-carrying blaNDM-1 and blaKPC-2 from Hangzhou, China. The genome sequence of CRKP380 can be used as a reference sequence for future comparative genomic analysis, including acquisition and mobilization of carbapenem resistance genes. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Prevalence of blaKPC-2 harboring Klebsiella pneumoniae ST290 in a tertiary hospital in China
Publication date: Available online 12 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Nana Kong, Gang Li, Chuanxin Yang, Xiaotong Wang, Mei Cao, Long Zhang, Muzhen Sun, Linlin Xiao, Quhao Wei (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Bioinformatic analysis of genes of Streptomyces xinghaiensis (fradiae) ATCC 19609 with a focus on mutations conferring resistance to oligomycin A and its derivatives
ConclusionsWe discovered a new oligomycin resistance mechanism involving a pathway that repairs double strand breaks in DNA known as non-homologuous end joining (NHEJ). (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Recurrence of urinary tract infections with ESBL–producing Escherichia coli are caused by homologous strains among which clone ST131–O25b is dominant
ConclusionsIn ESBL-E. coli RUTI, most recurrences were caused by the initial infecting strain. The high frequency of the multidrug-resistant fimH30Rx subclone and its association with multiple recurrences warrants further attention and early detection of this subclone in patients at risk of developing RUTI with ESBL-producing E. coli. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Draft genome sequencing and annotation of a low-virulence Morganella morganii strain CQ-M7, a multidrug-resistant isolate from the giant salamander in China
ConclusionIt is believed that this is the first draft genome of Chinese giant salamander original Morganella morganii strain harbouring multiple antibiotic resistance genes in China. The reported genome sequence could provide insights into antibiotic resistance mechanisms and control strategies of Morganella morganii. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Evaluation of disc diffusion tests and agar screening for predicting mecA-mediated oxacillin resistance in Staphylococcus lugdunensis revealed a cefoxitin-susceptible, mecA-positive S. lugdunensis clonal complex 27 clone
ConclusionsThese findings highlight the need to evaluate phenotypic methods using mecA-positive S. lugdunensis with different oxacillin resistance phenotypes. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 14, 2020 Category: Infectious Diseases Source Type: research

Prevalence of the β-lactamase and Antibiotic Resistant Pseudomonas aeruginosa in the Arab Region
ConclusionThis review shows that there is increasing prevalence of β-lactamase producing P. aeruginosa in some countries in the Arab region. This is a major cause of concern as this implies that more and more instances of multidrug resistance are emerging in this area. This leads to an overall negative impact on the health concerns and amounts to increasing difficulty in combating disease. It is recommended that awareness about antibiotic use and abuse be made a priority and measures of curbing unchecked use of prescription antibiotics be put into place. Effective screening methods to detect cases of resistance at the...
Source: Journal of Global Antimicrobial Resistance - February 12, 2020 Category: Infectious Diseases Source Type: research

Mutation in trxB leads to auranofin resistance in Staphylococcus aureus
Publication date: Available online 8 February 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Haoran Chen, Yanyan Liu, Zhou Liu, Jiabin Li (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 9, 2020 Category: Infectious Diseases Source Type: research

Transmission of multidrug-resistant Campylobacter jejuni to children from different sources in Pakistan
This study aimed to determine the prevalence, antibiotic resistance patterns and source tracking of clinical C. jejuni isolates from paediatric diarrhoeal patients in Pakistan.MethodsA total of 150 stool samples from children were processed for the presence of C. jejuni using culture, biochemical tests and species-specific PCR. Antibiotic susceptibility of the isolates was determined by the disc diffusion method, and metallo-β-lactamase (MBL) producers were detected using gene-specific PCR. Source tracking was performed using source-predictive PCR.ResultsC. jejuni was present in 54.6% of the processed samples. More th...
Source: Journal of Global Antimicrobial Resistance - February 5, 2020 Category: Infectious Diseases Source Type: research

Emergence of carbapenemase-producing Enterobacteriaceae in Malawi
Publication date: March 2020Source: Journal of Global Antimicrobial Resistance, Volume 20Author(s): Joseph M. Lewis, Rebecca Lester, Madalitso Mphasa, Rachel Banda, Thomas Edwards, Nicholas R. Thomson, Nicholas Feasey (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - February 5, 2020 Category: Infectious Diseases Source Type: research

In Vitro Synergy with Fosfomycin Plus Doxycycline Against Linezolid and Vancomycin-resistant Enterococcus faecium
ConclusionsThe combination of fosfomycin and doxycycline should be evaluated further with additional LRVREF isolates. In vivo studies should also be performed prior to usage in clinical situations. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - January 31, 2020 Category: Infectious Diseases Source Type: research

Whole genome sequence of a blaNDM, blaKPC co-producing Klebsiella pneumoniae isolate KSH203 with capsular serotype K25 that belongs to ST11 from China
ConclusionsIn this study, we mainly show the whole genome sequence of a high biofilm formation ability, hypermucoviscous K. pneumoniae isolate KSH203 with capsular serotype K25 that belongs to ST11 from a patient in China, which carried a large number of resistance genes and virulence-associated genes. Future studies are needed to vigilant this type of strain disseminate among environmental, animal and human. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - January 31, 2020 Category: Infectious Diseases Source Type: research

Synthetic multi-antibiotic resistant plasmids in plant-associated bacteria from agricultural soils
Publication date: Available online 30 January 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Silvina Brambilla, Romina Frare, Margarita Stritzler, Gabriela Soto, Carolina Berini, Cintia Jozefkowicz, Nicolás AyubAbstractObjectivesUnlike higher organisms such as domestic animals and cultivated plants, which display a robust reproductive isolation andlimited dispersal ability, microbes exhibit an extremely promiscuous gene flow and can rapidly disperse across the planet by multiple ways. Thus, microbial plasmids, including synthetic replicons, containing antibiotic resistance genes are a serious risk ...
Source: Journal of Global Antimicrobial Resistance - January 31, 2020 Category: Infectious Diseases Source Type: research

Genomic characterization of a multidrug-resistant Mycoplasma hominis recovered from a synovial fluid sample in China
ConclusionOur study report the first genome sequence of a multidrug-resistant M. hominis isolate in China. These data may help to understand the genomic features and antimicrobial resistance mechanisms of this pathogen. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - January 30, 2020 Category: Infectious Diseases Source Type: research