3-Year Outcomes of XEN Implant Compared With Trabeculectomy, With or Without Phacoemulsification for Open Angle Glaucoma
Précis: Trabeculectomy (TRAB) surgery reduces the intraocular pressure (IOP) more than the XEN45 implant over 3 years. There is no difference in the number of antiglaucoma medications between the 2 procedures. The decision to perform either TRAB or XEN45 implantation must be evaluated on a case-by-case basis, taking into account the high rate of needling of the XEN45. Purpose: The aim of this study was to compare the differences between the efficacy and safety of the XEN45 implant and TRAB, either alone or in combination with phacoemulsification (PHACO), in patients with open angle glaucoma (OAG) at 36 months. ...
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

A Myopic Normative Database for Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography
Précis: The purpose of this study was to determine changes in optical coherence tomography (OCT) color codes after applying a myopic normative database. The diagnostic performance of the retinal nerve fiber layer analysis improved with the use of this database. Purpose: To evaluate the peripapillary retinal nerve fiber layer (pRNFL) OCT color codes based on a newly generated myopic normative database in comparison to the built-in normative database. Materials and Methods: A total of 371 subjects were included in this validation study in an attempt to generate a myopic normative database. Eighty myopic gl...
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

Systemic Barriers in Receiving Electronically Prescribed Glaucoma Medications
Conclusions: Approximately a third of electronically prescribed glaucoma medications were not received by patients within a month of refill request due to the need for prior authorization, insurance coverage, and pharmacy availability. A mechanism to alert providers and to address these barriers to medication access may minimize treatment interruption and disease progression. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

Effects of Exercise on Optic Nerve and Macular Perfusion in Glaucoma and Normal Subjects
Précis: Using optical coherence tomography angiography, we found an increase in the blood flow in regional macular without significant changes in the optic disk in patients with glaucoma after a moderate exercise regime. Purpose: To investigate the effect of moderate exercise on optic nerve and macular perfusion in glaucoma patients. Methods: Overall, 25 eyes of 25 patients with primary open angle glaucoma and 22 eyes of 22 normal subjects were included in the glaucoma and control groups, respectively. Foveal avascular zone parameters, whole and regional vessel density (VD) in the superficial layer of ma...
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers
Précis: The earlier a person quits smoking the more likely is the optic nerve be spared from damage. Purpose: To investigate the effect of smoking cessation on visual field (VF) progression in glaucoma. Methods: Primary open angle glaucoma patients with a minimum of 3 years follow-up and 5 VFs were included. Linear mixed models were used to investigate the effects of smoking on the rates of 24-2 VF mean deviation loss after adjusting for confounding factors. Cox proportional hazard regression was used to identify whether different levels of smoking intensity were associated with VF progression with respe...
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study
Conclusions: Geographic variation in the prevalence of self-reported glaucoma and its strong association with preexisting systemic chronic diseases were observed, suggesting that in addition to ophthalmological examinations, regular physical examinations are necessary for glaucoma patients, especially in areas of high incidence. Appropriate strategies to improve preventive measures for glaucoma are recommended for the Chinese population. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Original Studies Source Type: research

United States Medicare Reimbursement Trends for Glaucoma Procedures: 2000–2020
Conclusions: The US Medicare reimbursement for glaucoma procedures in the United States showed a significant decline between 2000 and 2020. These findings may be relevant to understanding changing practice patterns for glaucoma care. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Perspective Article Source Type: research

Primary Open Angle Glaucoma Prevalence in Europe: A Systematic Review and Meta-Analysis
Conclusion: POAG is a neurodegenerative disease that affects a large proportion of the older European population. In the future, the prevalence of POAG is expected to grow in Europe because of the progressive aging populations of Western countries. Future high-quality epidemiological studies for the evaluation of POAG prevalence rates are warranted. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - October 1, 2022 Category: Opthalmology Tags: Novel Glaucoma Insights: Review Article Source Type: research

Response to Letter to the Editor: Self-Identified Black Race as a Risk Factor for Intraocular Pressure Elevation and Iritis Following Prophylactic Laser Peripheral Iridotomy
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: Correspondence Source Type: research

Letter to the Editor: Self-Identified Black Race as a Risk Factor for Intraocular Pressure Elevation and Iritis Following Prophylactic Laser Peripheral Iridotomy
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: Correspondence Source Type: research

Gonioscopy-Assisted Transluminal Trabeculotomy Following Failed iStent Surgery
We describe 4 cases of eyes initially treated with phacoemulsification and iStent trabecular microbypass (Glaukos Corporation). These patients subsequently required further surgery and were successfully treated with the removal of the iStent device followed by gonioscopy-assisted transluminal trabeculotomy (GATT), using the iTrack catheter (Ellex Medical Lasers Ltd). Three of the cases had prior first-generation iStent (G1), and 1 had prior second-generation iStent (G2). This case series demonstrates that in selected cases, a further angle procedure in the form of a GATT can show efficacy and durability in the medium term....
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: New Glaucoma Insights: Brief Report Source Type: research

Repeatability and Reproducibility of 4.5 by 4.5 mm Peripapillary Optical Coherence Tomography Angiography Scans in Glaucoma and Non-Glaucoma Eyes
Conclusions: Among nonglaucomatous and glaucomatous eyes, the majority of peripapillary OCTA vessel parameters from 4.5×4.5 mm scans had greater intrasession repeatability than intersession reproducibility. There was a greater agreement for the commercially developed quantification parameters than for their custom quantification counterparts. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: New Glaucoma Insights: Original Studies Source Type: research

Effect of Optic Disc Tilt on the Measurement of Peripapillary Vessel Density Using Optical Coherence Tomography Angiography
Précis: Eyes with tilted disc (TD) had significantly lower peripapillary vessel density (pVD) and lower long-term measurement reproducibility in optical coherence tomography angiography (OCTA). After adjusting for confounding factors, disc tilt still contributed to the reduction of pVD in most sectors. Purpose: The purpose of this study was to investigate the effect of optic disc tilt on the measurement of sectoral pVD by OCTA and on the long-term measurement reproducibility. Materials and Methods: This retrospective observational case-control study included 70 healthy eyes. Average and 8-sector pVDs and...
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: New Glaucoma Insights: Original Studies Source Type: research

Association of Polymorphisms at the SIX1/SIX6 Locus With Normal Tension Glaucoma in a Korean Population
Conclusion: The current study found that SIX1-SIX6 locus rs10483727 and rs33912345 polymorphisms were significantly associated with NTG risk in the Korean population. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: New Glaucoma Insights: Original Studies Source Type: research

Short-Term Efficacy and Safety of Open Conjunctiva Ab Externo XEN45 Gel Stent Implantation in Glaucoma Patients
This study aims to determine the safety and efficacy of the open conjunctiva ab externo approach to XEN45 stent implantation. Materials and Methods: Retrospective chart review of all patients between July 2018 and March 2020 who underwent XEN45 implantation. IOP and the number of glaucoma medications were measured at the preoperative, 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months postoperative appointments. The primary outcome of this study is the number of cases achieving complete success at 12 months postoperatively. Results: Forty-four eyes of 44 patients were included. Mean preoperative IOP wa...
Source: Journal of Glaucoma - September 1, 2022 Category: Opthalmology Tags: New Glaucoma Insights: Original Studies Source Type: research