Diurnal Variation of Retinal Vessel Density in Healthy Human Eyes
Conclusions:
There was a small increase in ONH VD, but not macular VD, in the evening compared with the morning in healthy human eyes. As the observed difference was within the measurement variability, our results suggest the timing of OCT-A examination does not affect retinal VD measurements. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Novel Insights: Original Studies Source Type: research
Physical Activity and Cardiovascular Fitness During Childhood and Adolescence: Association With Retinal Nerve Fibre Layer Thickness in Young Adulthood
Precis:
Higher physical working capacity (PWC) at age 17 was associated with thicker peripapillary retinal nerve fiber layer (pRNFL) at age 20, suggesting a mechanistic link between cardiovascular fitness and neuroretinal integrity.
Purpose:
Physical activity and cardiovascular fitness have been linked with lower odds of developing glaucoma. We tested the hypothesis that early beneficial effects of physical activity and cardiovascular fitness can be observed by measuring the pRNFL thickness in young healthy adults.
Methods:
The Raine Study is a longitudinal study that has followed a cohort since before th...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Novel Insights: Original Studies Source Type: research
Deep Learning-based Diagnosis of Glaucoma Using Wide-field Optical Coherence Tomography Images
Purpose:
(1) To evaluate the performance of deep learning (DL) classifier in detecting glaucoma, based on wide-field swept-source optical coherence tomography (SS-OCT) images. (2) To assess the performance of DL-based fusion methods in diagnosing glaucoma using a variety of wide-field SS-OCT images and compare their diagnostic abilities with that of conventional parameter-based methods.
Methods:
Overall, 675 eyes, including 258 healthy eyes and 417 eyes with glaucoma were enrolled in this retrospective observational study. Each single-page wide-field report (12×9 mm) of wide-field SS-OCT imaging provides diff...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Novel Insights: Original Studies Source Type: research
Outcomes of Primary Trabeculectomy From Two Same-centre Cohorts 10 Years Apart
Precis:
Trabeculectomy can effectively lower intraocular pressure (IOP). A more junior surgeon profile is emerging. Mitomycin C (MMC) has replaced 5-fluorouracil (5-FU) intraoperatively with comparable success rates and a decrease in postoperative antimetabolite administration.
Purpose:
We compare 2-year outcomes for primary trabeculectomy in 2 cohorts, 10 years apart, performed at a large UK teaching hospital.
Methods:
Consecutive case series of trabeculectomies at Manchester Royal Eye Hospital between 2004-2005 (Cohort 1/C1) and 2014-2015 (Cohort 2/C2). Preoperative and postoperative data was collected ...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
Slow Coagulation Transscleral Cyclophotocoagulation for Postvitrectomy Patients With Silicone Oil–induced Glaucoma
Precis:
Slow coagulation transscleral cyclophotocoagulation (TSCPC) is an effective and safe glaucoma surgery in patients with medically uncontrolled silicone oil (SO)-induced glaucoma.
Purpose:
The purpose of this study was to report the outcomes of slow coagulation continuous wave TSCPC in patients with medically uncontrolled secondary glaucoma following pars plana vitrectomy (PPV) and intravitreal SO injection.
Patients and Methods:
This retrospective study enrolled patients with medically uncontrolled glaucoma secondary to PPV with SO injection who underwent TSCPC using slow coagulation TSCPC settings...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
Efficacy, Safety, and Retreatment Benefit of Micropulse Transscleral Cyclophotocoagulation in Glaucoma
Precis:
Micropulse transscleral cyclophotocoagulation (MP-TSCPC) with a 120-second setting reduces intraocular pressure (IOP) with a 6-month success of 45.5%. Only late (>6 mo) failure seem to present a benefit for retreatment.
Purpose:
The purpose of this study was to assess MP-TSCPC efficacy, safety, factors of success, and retreatment benefit in open-angle glaucoma.
Patients and Methods:
A retrospective consecutive case series study. We included patients with open-angle glaucoma who were naive of a cycloablative procedure and underwent MP-TSCPC at 2000 mW for 120 seconds between May 1, 2017, and Oc...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
Two-Year Experience With Latanoprostene Bunod in Clinical Practice
Precis:
We retrospectively reviewed records of patients prescribed latanoprostene bunod 0.024% (LBN) to assess its efficacy and safety in a real-world clinical setting. LBN was efficacious in lowering intraocular pressure (IOP) and had a favorable safety profile.
Purpose:
The aim of this study was to evaluate the usage of LBN, the first topical nitric oxide-donating prostaglandin analog (PGA) for reducing IOP, in clinical practice.
Patients and Methods:
Retrospective review identified patients prescribed LBN by 5 glaucoma specialists at an academic center from January 2018 to November 2019. Fifty-six pati...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
Detecting Progression in Patients With Different Clinical Presentations of Primary Open-angle Glaucoma
Conclusions:
While both RNFLT and VF parameters showed comparable abilities to identify progression across the different classifications, RNFLT assessment may be better suited to monitor progression, particularly among patients with elevated intraocular pressure and those who present with only GVF defect at baseline. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
The Association Between Intraocular Pressure and Visual Field Worsening in Treated Glaucoma Patients
Precis:
In treated eyes with mild/suspect glaucoma, intraocular pressure (IOP) increments are associated with worsening mean deviation (MD) once IOP reaches the 20s. In moderate/advanced eyes, IOP increments are associated with worse visual field (VF) performance across the entire IOP range.
Purpose:
The purpose of this study was to describe the relationship between mean treated IOP and VF worsening and understand how this relationship is affected by glaucoma severity and IOP range.
Methods:
A total of 1446 eyes of 869 treated glaucoma patients with at least 5 longitudinal reliable VF tests and IOP measur...
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Glaucoma Care: Original Studies Source Type: research
Response to Letter to the Editor: Early-onset Exfoliation Syndrome: A Literature Synthesis
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Correspondence Source Type: research
Letter to the Editor: Early-onset Exfoliation Syndrome: A Literature Synthesis
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Correspondence Source Type: research
Response to Letter to the Editor: Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Correspondence Source Type: research
Letter to the Editor: Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma
No abstract available (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Correspondence Source Type: research
Tube Obstruction of a Nonvalved Glaucoma Drainage Device by a Dislocated Soemmering’s Ring
The authors report a case of tube obstruction of a nonvalved glaucoma drainage device (Aurolab aqueous drainage implant; AADI) with a dislocated Soemmering’s ring (SR) leading to a postoperative intraocular pressure (IOP) spike after an initial IOP reduction. A 24-year-old man with bilateral aphakia, bilateral secondary glaucoma developed corneal decompensation in the left eye. The IOP in the left eye was 22 mm Hg with 3 topical IOP-lowering medications (timolol 0.5%, brimonidine 0.2%, and latanoprost 0.005%). To control the IOP before performing a penetrating keratoplasty, AADI was implanted. A good bleb and an IOP ...
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Case Reports Source Type: research
Tenon Cyst Patch Graft for Ahmed Glaucoma Valve Tube Exposure: Case Series Report
Conclusion:
The use of a Tenon cyst autograft for the surgical repair of a tube exposure is valuable, as it involves using autologous scar tissue that is available in eyes that have undergone AGV implantation. The patch autograft is technically easy to harvest, and represents a significantly lower cost when compared with other available options. (Source: Journal of Glaucoma)
Source: Journal of Glaucoma - August 1, 2021 Category: Opthalmology Tags: Case Reports Source Type: research
