Six new dammarane-type triterpene saponins from Panax ginseng flower buds and their cytotoxicity
Publication date: Available online 30 December 2018Source: Journal of Ginseng ResearchAuthor(s): Ke-Ke Li, Sha-Sha Li, Fei Xu, Xiao-Jie GongAbstractBackgroundPanax ginseng has been used for a variety of medical purposes in eastern countries for more than two thousand years. From the extensive experiences accumulated in its long medication use history and the substantial strong evidences in modern researches, we know that ginseng has various pharmacological activities, such as anti-tumor, anti-diabetic, anti-oxidant and protecting cardiovascular system effects. The active chemical constituents of ginseng, ginsenosides, are ...
Source: Journal of Ginseng Research - December 30, 2018 Category: Complementary Medicine Source Type: research
Inhibitory Mechanism of Ginsenoside Rh3 on GM-CSF Expression in UVB-irradiated Murine SP-1 Keratinocytes
ConclusionIn summary, we found that ginsenoside Rh3 impeded UVB-induced GM-CSF production through repression of PKCδ and ERK phosphorylation in SP-1 keratinocytes. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 25, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator–activated receptor gamma in A549 cells
ConclusionsOur results demonstrate that ginsenoside Rf inhibits hypoxia induced-COX-2 expression and cellular migration, which are dependent on PPARγ activation. These results suggest that ginsenoside Rf has an antiinflammatory effect under hypoxic conditions. Moreover, docking analysis of ginsenoside Rf into the active site of PPARγ suggests that the compound binds to PPARγ in a position similar to that of known agonists. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 18, 2018 Category: Complementary Medicine Source Type: research
The Role of Ginsenoside Rb1, a potential natural glutathione reductase agonist, in preventing oxidative stress-induced apoptosis of H9C2 cells
ConclusionGRb1 is a potential natural GR agonist that protects against oxidative-stress-induced apoptosis of H9C2 cells. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 16, 2018 Category: Complementary Medicine Source Type: research
Korean red ginseng attenuates type 2 diabetic cardiovascular dysfunction in OLETF rats
We examined the protective potential of KRG against type 2 diabetic illnesses. The results exhibited that KRG showed significant antihyperglycemic and antioxidative effects in KRG-treated OLETF rats. And, our results proposed the amelioration of cardiac function through normalized ejection fraction, fractional shortening and vascular reactivity. Furthermore, histopathological abnormalities in the OLETF rats were prevented by KRG treatment. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 16, 2018 Category: Complementary Medicine Source Type: research
Korean red and black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress
ConclusionsJP5 and BG1 protect against oxidative stress and inflammation induced by heat stress and help maintain liver function by preventing liver damage. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 16, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rb2 suppresses the glutamate-mediated oxidative stress and neuronal cell death in HT22 cells
ConclusionOur results suggest that Rb2 possesses neuroprotective properties that suppress glutamate-induced neurotoxicity. The molecular mechanism of Rb2 is by suppressing the MAPKs activity and AIF translocation. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 15, 2018 Category: Complementary Medicine Source Type: research
New dammarane-type triterpenoid saponins from Panax notoginseng saponins
ConclusionThree new triterpenoid saponins (1-3) together with twenty-five known rare saponins (4-28) were isolated from PNS, except for the five main compounds (notoginsenoside R1 and ginsenoside Rg1, Rd, Re and Rb1). In addition, the HPLC fingerprint of PNS was established, and the peaks of the isolated compounds were marked. The study of chemical constituents and fingerprint were useful for the quality control of PNS. The study on antitumor activities showed that new compound 2 exhibited significant inhibitory activity against the tested cell lines. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 13, 2018 Category: Complementary Medicine Source Type: research
Synergistic anticancer effects of timosaponin AIII and ginsenosides in MG63 human osteosarcoma cells
ConclusionsThe results strongly suggest that the combination of TA3 and the two ginsenosides Rb1 and Rc may be a strong candidate for the effective antiosteosarcoma agent. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 4, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rf inhibits COX-2 induction via peroxisome proliferator-activated receptor gamma in A549 cells
ConclusionsOur results demonstrate that ginsenoside Rf inhibits hypoxia induced-COX-2 expression and cellular migration, which are dependent on PPARγ activation. These results suggest that ginsenoside Rf has an anti-inflammatory effect under hypoxic conditions. Moreover, docking analysis of ginsenoside Rf into the active site of PPARγ suggests that the compound binds to PPARγ in a position similar to that of known agonists. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - December 1, 2018 Category: Complementary Medicine Source Type: research
Ginseng for an eye: Effects of ginseng on ocular diseases
Publication date: Available online 30 November 2018Source: Journal of Ginseng ResearchAuthor(s): Jisu Kim, Su-Young Han, Hyeyoung MinAbstractThe sense of vision is the primary means by which we gather information from our surroundings, and vision loss, therefore, severely compromises the life of the affected individuals, their families, and society. Loss of vision becomes more frequent with age, and diabetic retinopathy, age-related macular degeneration, cataracts, and glaucoma are the major causes of vision impairment. To find active pharmacological compounds that might prevent or ameliorate the vision-threatening eye dis...
Source: Journal of Ginseng Research - December 1, 2018 Category: Complementary Medicine Source Type: research
Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study
ConclusionTherefore, combination therapy of Rg5 and chemotherapy drugs is a strategy for the adjuvant chemotherapy, which encourages further pharmacokinetic and clinical studies. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 26, 2018 Category: Complementary Medicine Source Type: research
Transcriptome analyses of the ginseng root rot pathogens Cylindrocarpon destructans and Fusarium solani to identify radicicol resistance mechanisms
Publication date: Available online 23 November 2018Source: Journal of Ginseng ResearchAuthor(s): Taiying Li, Jin-Hyun Kim, Boknam Jung, Sungyeon Ji, Mun Won Seo, You Kyoung Han, Sung Woo Lee, Yeoung Seuk Bae, Hong-Gyu Choi, Seung-Ho Lee, Jungkwan LeeAbstractBackgroundThe ascomycete fungi Cylindrocarpon destructans (Cd) and Fusarium solani (Fs) cause ginseng root rot and significantly reduce the quality and yield of ginseng. Cd produces the secondary metabolite radicicol, which targets the molecular chaperone Hsp90. Fs is resistant to radicicol, whereas other fungal genera associated with ginseng disease are sensitive to it...
Source: Journal of Ginseng Research - November 24, 2018 Category: Complementary Medicine Source Type: research
Development of ginseng powder using high hydrostatic pressure treatment combined with UV-TiO2 photocatalysis
ConclusionCombined processing of UVTP and HHP increased ginsenoside levels and enhanced the microbiological safety and physiological activity of GP. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 24, 2018 Category: Complementary Medicine Source Type: research
Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice
ConclusionGBHT prevents changes in lipid and carbohydrate metabolism in a HFD mouse model. Our findings provide evidence for the traditional use of GBHT as therapy for the management of metabolic syndrome. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 16, 2018 Category: Complementary Medicine Source Type: research
