Role of Korean Ginseng and Ginsenosides in the Modulation of Platelet Functions and Cardiovascular Diseases
Publication date: Available online 21 May 2019Source: Journal of Ginseng ResearchAuthor(s): Muhammad Irfan, Minki Kim, Man Hee RheeAbstractCardiovascular diseases prevail among modern societies and underdeveloped countries, and a high mortality rate has also been reported by the World Health Organization affecting millions of people worldwide. Hyperactive platelets are the major culprits in thrombotic disorders. A group of drugs is available to deal with such platelet-related disorders; however, sometimes, side effects and complications caused by these drugs outweigh their benefits. Ginseng and its nutraceuticals have been...
Source: Journal of Ginseng Research - May 21, 2019 Category: Complementary Medicine Source Type: research
Korean Red ginseng extract ameliorates melanogenesis in humans and induces anti-photo aging effects in ultraviolet B-irradiated hairless mice
ConclusionTherefore, we conclude that KRG is an excellent skin whitening and antiaging product.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 15, 2019 Category: Complementary Medicine Source Type: research
Structural characteristics of a RGAP (red ginseng acidic polysaccharide), rhamnogalacturonan I with immuno-stimulating activity from red ginseng
This study aimed to characterize the immunostimulatory and structural properties of red ginseng acidic polysaccharide (RGAP; Panax ginseng Meyer), a polysaccharide fraction (RGP-AP) isolated from red ginseng via hot water extraction followed by amylase and, subsequently, pectinase digestion and ethanol precipitation. Next, a complex acidic polysaccharide (RGP-AP-I) was purified to homogeneity from RGP-AP via size-exclusion chromatography using Sephadex G-100. Peritoneal macrophages stimulated using RGP-AP-I significantly augmented the production of various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis fac...
Source: Journal of Ginseng Research - May 15, 2019 Category: Complementary Medicine Source Type: research
Proteomic Studies of putative molecular signatures for Biological Effects by Korean Red Ginseng
ConclusionThe DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targets of interest to include the potential functions of KRG. Furthermore, we validated the potential molecular targets of the functions, representatively LCN2, CRAMP, and HLA-DQB1 by western blotting. These results may provide molecular signature candidates to elucidate the mechanisms of the immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery of the molecular function of KRG.Graphical abst...
Source: Journal of Ginseng Research - May 11, 2019 Category: Complementary Medicine Source Type: research
Ginsenosides analysis of New Zealand grown forest Panax ginseng using LC-QTOF-MS/MS
ConclusionThis study provides the first ever comprehensive report on NZ grown wild simulated P. ginseng.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 3, 2019 Category: Complementary Medicine Source Type: research
Amino acid, fatty acid, and carbohydrate metabolomic profiles with ginsenoside-induced insecticidal efficacy against Ostrinia furnacalis (Guenee)
ConclusionsPDS decreased the consumption index, relative growth rate, approximate digestibility, conversion of ingested and digested food in 3rd instar larvae of O. furnacalis in a dose-dependent manner. PDS decreased 15 free amino acids, 16 free fatty acids, and 5 carbohydrates and increased the levels of palmitoleic acid, palmitic acid, and 9-octadecenoic acid in 3rd instar larvae. The activity of detoxification-related enzymes, such as AChE, GST, CYP540, CarE, TH, ACP and ALP, was reduced in a dose-dependent manner in 3rd instar larvae exposed to PDS. These data confirmed the inhibitory effect of PDS against growth, foo...
Source: Journal of Ginseng Research - April 29, 2019 Category: Complementary Medicine Source Type: research
Overexpression of ginseng cytochrome P450 CYP736A12 alters plant growth and confers phenylurea herbicide tolerance in Arabidopsis
ConclusionPgCYP736A12 does not respond to the well-known secondary metabolite elicitor JA, which suggests that it may not function in ginsenoside biosynthesis. Heterologous overexpression of PgCYP736A12 reveals that this gene is actually involved in herbicide metabolism. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 20, 2019 Category: Complementary Medicine Source Type: research
Appropriate nitrogen application enhances saponin synthesis and growth mediated by optimizing root nutrient uptake ability
ConclusionAppropriate N fertilizer rates could optimize both root architecture and nutrient uptake efficiency, then promote both the accumulation of dry matter and the synthesis of saponins. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 18, 2019 Category: Complementary Medicine Source Type: research
Metabolomic Understanding of Intrinsic Physiology in Panax ginseng During Whole Growing Seasons
ConclusionThis study highlights the intrinsic metabolic characteristics of ginseng plants and their associations with climate changes during their growth. It provides important information not only for better understanding of metabolic phenotype of ginseng, but also for quality improvement of ginseng through modification of cultivation. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 18, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons
ConclusionTaken together, our results suggest that ginsenoside Rk1 might be a novel component contributable to the development of ginseng-based therapeutic treatments for neurodegenerative diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 15, 2019 Category: Complementary Medicine Source Type: research
20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
ConclusionPPD promotes NSC proliferation and neural differentiation in vitro via activation of the Wnt/GSK-3β/β-catenin pathway by targeting GSK-3β, potentially having great significance for the treatment of neurodegenerative diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 12, 2019 Category: Complementary Medicine Source Type: research
Remarkable impact of amino acids on ginsenoside transformation from fresh ginseng to red ginseng
ConclusionAmino acids can remarkably affect the acidity of P. ginseng sample by altering the pH value. They were the main influential factors for the ginsenoside transformation. These results are useful in elucidating why and how steaming induces the structural change of ginsenoside in P. ginseng, and also provides an effective and green approach to regulate the ginsenoside conversion using amino acids during the steaming process. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - April 11, 2019 Category: Complementary Medicine Source Type: research
20(S)-protopanaxadiol promotes the migration, proliferation and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
ConclusionPPD promotes NSC proliferation and neural differentiation in vitro via activation of the Wnt/GSK-3β/β-catenin pathway by targeting GSK-3β, potentially having great significance for the treatment of neurodegenerative diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 26, 2019 Category: Complementary Medicine Source Type: research
Panax ginseng–derived fraction BIOGF1K reduces atopic dermatitis responses via suppression of mitogen-activated protein kinase signaling pathway
ConclusionsBIOGF1K attenuated the AD response, hence supporting its use as a promising and natural approach for treating AD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 20, 2019 Category: Complementary Medicine Source Type: research
Korean red ginseng enhances cardiac hemodynamics on doxorubicin-induced toxicity in rats
ConclusionThese mean that KRG mitigates myocardial damage by modulating the hemodynamics, histopathological, and oxidative stress related to DOX-induced cardiomyopathy in rats. The results of the present study showed protective effects for KRG on cardiac toxicity. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - March 15, 2019 Category: Complementary Medicine Source Type: research
