Diol-Ginsenosides from Korean Red Ginseng Delay the Development of Type 1 Diabetes in Diabetes-Prone BioBreeding Rats
ConclusionDiol-GF, but not Triol-GF, significantly delayed the development of insulitis and T1D in DP-BB rats. The anti-diabetogenic action of Diol-GF may result from the decrease in cytokine production and increase in β-cell resistance to cytokine/free radical-induced cytotoxicity. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 12, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derived neurotrophic factor upregulation
ConclusionILTHS induced oxidative stress responses and inflammatory molecules, which can lead to impaired neurogenesis and ultimately neuronal death, whereas, KRG, being the antioxidant, inhibited neuronal damage and increased cell viability. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 11, 2019 Category: Complementary Medicine Source Type: research
Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
ConclusionOur study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of “fireness” related to KRG. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 8, 2019 Category: Complementary Medicine Source Type: research
Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study
ConclusionTopical application of GEF promotes mouse hair growth through HFDPC proliferation. GEF could be one of the main components of ginseng that promotes hair growth and could be used to treat human alopecia.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 7, 2019 Category: Complementary Medicine Source Type: research
Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with Red ginseng
ConclusionThe gut microbiota may play an important role in the bioavailability of the non-polar RG ginsenosides by affecting the biotransformation of the ginsenosides.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 6, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng increases defective pol gene in peripheral blood mononuclear cells of HIV-1-infected patients; inhibition of its detection during ginseng-based combination therapy
ConclusionThe proportion of Δpol depends on template size as well as KRG treatment. HAART decreases the detection of Δpol.Graphical abstractInternal deletion in the pol gene (Δpol) can be induced by taking Korean Red Ginseng (KRG) and the proportion of Δpol increases with a longer target size of PCR. In both 1.2-kb and 3.0-kb targeting PCR, the Δpol was significantly lower during ginseng based combination therapy (GCT; KRG plus HAART) and HAART than in the KRG treatment period. The reason for this might be the reduction of Δpol detection by limit dilution effect. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 6, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng extract ameliorates melanogenesis in humans and induces antiphotoaging effects in ultraviolet B–irradiated hairless mice
ConclusionTherefore, we conclude that KRG is an excellent skin whitening and antiaging product. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - June 1, 2019 Category: Complementary Medicine Source Type: research
Structural characteristics of a red ginseng acidic polysaccharide, rhamnogalacturonan-I, with immunostimulating activity from red ginseng
This study aimed to characterize the immunostimulatory and structural properties of the red ginseng acidic polysaccharide (RGAP; Panax ginseng Meyer), a polysaccharide fraction (RGP-AP) isolated from red ginseng via hot water extraction, followed by amylase and, subsequently, pectinase digestion and ethanol precipitation. Next, a complex acidic polysaccharide (RGP-AP-I) was purified to homogeneity from RGP-AP via size-exclusion chromatography using Sephadex G-100. Peritoneal macrophages stimulated using RGP-AP-I significantly augmented the production of various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosi...
Source: Journal of Ginseng Research - May 30, 2019 Category: Complementary Medicine Source Type: research
Quinetides: diverse post-translational modified peptides of ribonuclease-like storage protein from Panaxquinquefolius as markers for differentiating Ginseng species
ConclusionWe provide specific information on PQ peptides, and propose the clinical application of peptide markers to distinguish PQ from P. ginseng.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 30, 2019 Category: Complementary Medicine Source Type: research
Metabolomes and transcriptomes revealed the saponin distribution in root tissues of Panax quinquefolius and Panax notoginseng
ConclusionsThese results provided the visual and quantitative profiles of and confirmed the pivotal transcripts of CYPs and UGTs regulating the saponin distribution in the root tissues of P. quinquefolius and P. notoginseng.Graphical abstractIn this study, saponin distribution were differed in the root tissues of Panax quinquefolius and Panax. notoginseng, respectively. Saponin contents were related to the expression levels of transcripts of root tissues. Among GDPS1, CYP51, CYP64, and UGT11 were significantly correlated with the contents of Rg1, Re, Rc, Rb2, and Rd in P. quinquefolius. CYP74, CYP89, CYP100, CYP103, CYP109...
Source: Journal of Ginseng Research - May 29, 2019 Category: Complementary Medicine Source Type: research
Genetic diversity among cultivated and wild Panax ginseng populations revealed by high-resolution microsatellite markers
ConclusionGinseng has a relatively high level of genetic diversity and cultivated and wild groups have similar levels of genetic diversity. Collectively, our data demonstrate that current breeding populations have abundant genetic diversity for breeding of elite ginseng cultivars. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 26, 2019 Category: Complementary Medicine Source Type: research
Korean red ginseng alleviates neuroinflammation and promotes cell survival in intermittent heat stress-induced rat brain by suppressing oxidative stress via ER-β and BDNF upregulation
ConclusionILTHS induced oxidative stress responses and inflammatory molecules, which can lead to impaired neurogenesis and ultimately neuronal death, whereas, KRG, being the antioxidant inhibited neuronal damage and increased cell viability. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 24, 2019 Category: Complementary Medicine Source Type: research
Safety and anti-fatigue effect of Korean Red Ginseng: A randomized, double-blind, and placebo-controlled clinical trial
ConclusionsOur study revealed that KRG has a potent anti-fatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of “fireness” related to KRG. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 22, 2019 Category: Complementary Medicine Source Type: research
Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS
ConclusionThis study provides the first-ever comprehensive report on NZ-grown wild simulated P. ginseng. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 21, 2019 Category: Complementary Medicine Source Type: research
Radix et Rhizoma Ginseng chemoprevents both initiation and promotion of cutaneous carcinoma by enhancing cell-mediated immunity and maintaining redox homeostasis
ConclusionAccording to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets and links. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - May 21, 2019 Category: Complementary Medicine Source Type: research
