Ginsenoside Rg3 reduces the adhesion, invasion and intracellular survival of Salmonella enterica serovar Typhimurium
ConclusionRg3 could be considered as a supplement agent to prevent S. Typhimurium infection.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 23, 2019 Category: Complementary Medicine Source Type: research

Korean Red Ginseng Aqueous Extract Improves Markers of Mucociliary Clearance by Stimulating Chloride Secretion
ConclusionRGAE augments ASL depth and CBF by stimulating Cl- secretion through CaCC, which suggests therapeutic potential in both CF and non-CF CRS.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 14, 2019 Category: Complementary Medicine Source Type: research

Identification of N,N’,N’’-Triacetylfusarinine C as a key metabolite for Root Rot disease virulence in American Ginseng
ConclusionsThe identification of the siderophore produced by Ilyonectria gives us further insight into the root rot disease that heavily affects ginseng crop yields. This research identifies a molecular pathway previously unknown for ginseng root rot and could lead to new disease treatment options.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 14, 2019 Category: Complementary Medicine Source Type: research

Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase–dependent mechanism
ConclusionGinsenoside Mc1 decreases oxidative stress and increases cell viability in H9c2 cells and the heart tissue isolated from HFD-fed mice via an AMPK-dependent mechanism, suggesting its potential as a novel therapeutic agent for oxidative stress–related cardiac diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 14, 2019 Category: Complementary Medicine Source Type: research

Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss
ConclusionG-Rf markedly reversed depression-like behavioral changes and exhibited protective effect against the astrocyte ablation in the PFC induced by L-AAA. These protective properties suggest that G-Rf might be a therapeutic agent for major depressive disorders. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - September 11, 2019 Category: Complementary Medicine Source Type: research

Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its anti-inflammatory and anti-oxidant activities
ConclusionThese results provide that KRGE could prevent DHEA-induced PCOS via anti-inflammatory and anti-oxidant activities. Thus, KRGE may be used in preventive and therapeutic strategies for PCOS-like symptoms.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 27, 2019 Category: Complementary Medicine Source Type: research

Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMPK-dependent mechanism
ConclusionGinsenoside Mc1 decreases oxidative stress and increases cell viability in H9c2 cells and the heart tissue isolated from HFD-fed mice via an AMPK-dependent mechanism, suggesting its potential as a novel therapeutic agent for oxidative stress-related cardiac diseases. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 27, 2019 Category: Complementary Medicine Source Type: research

Antidepressant effects of ginsenoside Rf on behavioral change in glial degeneration model of depression by reversing glial loss
ConclusionG-Rf markedly reversed depressive-like behavioral changes and exhibited protective effect against the astrocyte ablation in PFC induced by L-AAA. These protective properties suggest that G-Rf might be a therapeutic agent for major depressive disorder.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 23, 2019 Category: Complementary Medicine Source Type: research

Effects of red ginseng on the elastic properties of human skin
Publication date: Available online 21 August 2019Source: Journal of Ginseng ResearchAuthor(s): Moon Young Park, Se Jik Han, Donggerami Moon, Sangwoo Kwon, Jin-Woo Lee, Kyung Sook KimAbstractBackgroundRed ginseng contains components that can be used in skincare to delay the aging process, including microelements, vitamins, essential oils, and fatty acids. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis.MethodsHuman dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using at...
Source: Journal of Ginseng Research - August 22, 2019 Category: Complementary Medicine Source Type: research

Novel enzymatic elimination method for the chromatographic purification of ginsenoside Rb3 in an isomeric mixture
ConclusionsHerein, we demonstrated a novel enzymatic elimination-combined purification method for the chromatographic purification of ginsenoside Rb3. This method can also be applied to purify other isomeric glycoconjugates in mixtures.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 18, 2019 Category: Complementary Medicine Source Type: research

20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway
ConclusionThe findings indicate that 20(S)-GRh2 exhibits beneficial effects against T-ALL through the PI3K/Akt/mTOR pathway and could be a natural product of novel target for T-ALL therapy. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 18, 2019 Category: Complementary Medicine Source Type: research

Simultaneous quantification of six nonpolar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection
ConclusionIt was confirmed that nonpolar ginsenosides known to be specific components of red ginseng were present at substantial concentrations in the HR or RH of white ginseng. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 15, 2019 Category: Complementary Medicine Source Type: research

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling
ConclusionCellular molecular analysis suggests that Rg3(S) specifically reverses the replicative senescence of HDFs by modulating Akt-mTOR-Sirtuin signaling to promote the biogenesis of mitochondria.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 15, 2019 Category: Complementary Medicine Source Type: research

Analysis of oligosaccharides from Panax ginseng by using solid-phase permethylation method combined with UHPLC-Q-Orbitrap/MS
ConclusionA solid-phase methylation method combined with LC-MS/MS was successfully applied to analyze the oligosaccharides in ginseng extracts, which provides the possibility for holistic evaluation of ginseng oligosaccharides. The comparison of oligosaccharide composition of white ginseng and red ginseng could help to understand the differences in pharmacological activities between these two kinds of ginseng samples from the perspective of glycans. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - August 10, 2019 Category: Complementary Medicine Source Type: research

Till 2018: a survey of biomolecular sequences in genus Panax
Publication date: Available online 20 June 2019Source: Journal of Ginseng ResearchAuthor(s): Vinothini Boopathi, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun YangAbstractGinseng is popularly known to be the king of ancient medicines and is used widely in most of the traditional medicinal compositions due to its various pharmaceutical properties. Numerous studies are being focused on this plant's curative effects to discover their potential health benefits in most human diseases, including cancer— the most life-threatening disease worldwide. Modern pharmacological research has focused mainly on ginsenosides,...
Source: Journal of Ginseng Research - August 8, 2019 Category: Complementary Medicine Source Type: research