Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms
ConclusionResearch found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 26, 2019 Category: Complementary Medicine Source Type: research
Acremonidin E produced by Penicillium sp. SNF123, a fungal endophyte of Panax ginseng, has anti-melanogenic activities
ConclusionThis study demonstrates that acremonidin E, a bioactive metabolite derived from a fungal endophyte of P. ginseng, can inhibit melanin synthesis by downregulating tyrosinase, illuminating the potential utility of microorganisms associated with P. ginseng for cosmetic ingredients.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 22, 2019 Category: Complementary Medicine Source Type: research
Gastroprotective effects of the non-saponin fraction of Korean red ginseng through COX-1 upregulation
ConclusionThese results suggest that NSF has gastroprotective effects on gastritis and colitis in in vivo mouse models through COX-1 upregulation.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 16, 2019 Category: Complementary Medicine Source Type: research
Effect of Co-administration of Enriched Korean Red Ginseng (Panax Ginseng) and American Ginseng (Panax Quinquefolius L) on Cardiometabolic Outcomes in Type 2 Diabetes: A Randomized, Controlled Trial
ConclusionCo-administration of Rg3-KRG+AG is an effective add-on for improving BP along with attaining favorable cardiometabolic outcomes in individuals with type 2 diabetes. Ginseng derivatives may offer clinical utility when included in the polypharmacy and lifestyle treatment of diabetes.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 15, 2019 Category: Complementary Medicine Source Type: research
Gypenoside XVII protects against Myocardial Ischemia and Reperfusion Injury by inhibiting ER Stress-induced Mitochondrial Injury
ConclusionGP-17 inhibits I/R-induced mitochondrial injuryby delaying the onset of ER stress through the PI3K/AKT and P38 signaling pathways. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 15, 2019 Category: Complementary Medicine Source Type: research
Compound K improves skin barrier function by increasing SPINK5 expression
ConclusionsOur data showed that CK contributes to improving skin barrier function in UVB-irradiated and DNCB-induced atopic dermatitis-like models through SPINK5. These results suggest that therapeutic attempts with CK might be useful in treating barrier-disrupted diseases.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 15, 2019 Category: Complementary Medicine Source Type: research
Glycosyltransformation of ginsenoside Rh2 to two novel ginsenosides by recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
ConclusionThis is the first report on the synthesis of two novel ginsenosides, namely glucosyl-ginsenoside Rh2 and diglucosyl-ginsenoside Rh2 from Rh2 by utilizing recombinant glycosyltransferase isolated from L. rhamnosus. Moreover, diglucosyl-ginsenoside Rh2 might be a new candidate for treatment of inflammation, obesity and skin whiting, and especially for anticancer.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 15, 2019 Category: Complementary Medicine Source Type: research
Purification of ginseng rare sapogenins 25-OH-PPT and its mechanism of hypoglycemic, anti-inflammatory and lipid-lowering activities
ConclusionResearch found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food.Graphical abstract (Source: ...
Source: Journal of Ginseng Research - November 9, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via NMDA receptor modulation in mice
ConclusionThese results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating NMDAR overexpression in the hippocampus.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - November 8, 2019 Category: Complementary Medicine Source Type: research
Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid–induced HepG2 cells and high-fat/high-fructose diet-fed mice
ConclusionOur results indicate that BG may be a potential therapeutic agent for the prevention of NAFLD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 24, 2019 Category: Complementary Medicine Source Type: research
Korean Red Ginseng prevents posttraumatic stress disorder–triggered depression-like behaviors in rats via activation of the serotonergic system
ConclusionOur findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 22, 2019 Category: Complementary Medicine Source Type: research
Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium
ConclusionRg3 could be considered as a supplement agent to prevent S. Typhimurium infection.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 11, 2019 Category: Complementary Medicine Source Type: research
Ameliorative Effects of Black Ginseng on Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 cells and High-Fat/High-Fructose Diet-Fed Mice
ConclusionOur results indicate that BG may be a potential therapeutic agent for the prevention of NAFLD.Graphical abstract (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 5, 2019 Category: Complementary Medicine Source Type: research
Identification of N,N′,N″-triacetylfusarinine C as a key metabolite for root rot disease virulence in American ginseng
ConclusionThe identification of the siderophore produced by Ilyonectria gives us further insight into the root rot disease that heavily affects ginseng crop yields. This research identifies a molecular pathway previously unknown for ginseng root rot and could lead to new disease treatment options. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 1, 2019 Category: Complementary Medicine Source Type: research
Korean red ginseng prevents post-traumatic stress disorder-triggered depression-like behaviors in rats via activation of the serotonergic system
ConclusionOur findings suggest that KRG has an antidepressant effect in rats subjected to SPS and may represent an effective use of traditional medicine for the treatment of PTSD.Graphical abstractKorean red ginseng administration significantly reversed the depression-like behavioral abnormalities in the forced swimming test. Biochemical alterations in the hippocampus including changes in levels of 5-HT were consistent with the behavioral results . (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - October 1, 2019 Category: Complementary Medicine Source Type: research
