Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of immunosuppressive CD4+ T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3 (FOXP3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particul...
Source: Journal of Genetics and Genomics - February 20, 2020 Category: Genetics & Stem Cells Source Type: research
Disruptor of telomeric silencing 1-like (DOT1L) is involved in breast cancer metastasis via transcriptional regulation of MALAT1 and ZEB2
Publication date: 20 December 2019Source: Journal of Genetics and Genomics, Volume 46, Issue 12Author(s): Yang Duan, Xingyan Zhang, Lihong Yang, Xu Dong, Zhanye Zheng, Yiming Cheng, Hao Chen, Bei Lan, Dengwen Li, Jun Zhou, Chenghao Xuan (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - February 15, 2020 Category: Genetics & Stem Cells Source Type: research
Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines
Publication date: Available online 13 February 2020Source: Journal of Genetics and GenomicsAuthor(s): Xin Liu, Xiu-Jie Wang (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - February 14, 2020 Category: Genetics & Stem Cells Source Type: research
Defining endogenous barcoding sites for CRISPR/Cas9-based cell lineage tracing in zebrafish
In this study, we characterized 78 high-quality endogenous sites in the zebrafish genome that can be used as CRISPR/Cas9-based barcoding sites. The 78 sites are all highly expressed in most of the cell types according to single-cell RNA sequencing (scRNA-seq) data. Hence, the barcoding information of the 78 endogenous sites is recovered by the available scRNA-seq platforms, enabling simultaneous characterization of cell type and cell lineage information. (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - February 7, 2020 Category: Genetics & Stem Cells Source Type: research
Glycolysis regulates gene expression by promoting the crosstalk between H3K4 trimethylation and H3K14 acetylation in Saccharomyces cerevisiae
Publication date: Available online 11 December 2019Source: Journal of Genetics and GenomicsAuthor(s): Yinsheng Wu, Shihao Zhang, Xuanyunjing Gong, Qi Yu, Yuan Zhang, Mingdan Luo, Xianhua Zhang, Jerry L. Workman, Xilan Yu, Shanshan LiAbstractCells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth. However, how cells transduce nutrient availability to appropriate gene expression response via histone modifications remains largely unknown. Here, we report that glucose specifically induces histone H3K4 trimethylation (H3K4me3), an evolutionarily conserved histone covalent mod...
Source: Journal of Genetics and Genomics - February 2, 2020 Category: Genetics & Stem Cells Source Type: research
Identification of potential cross-protective epitope between 2019-nCoV and SARS virus
Publication date: Available online 30 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Tianyi Qiu, Tiantian Mao, Yuan Wang, Mengdi Zhou, Jingxuan Qiu, Jianwei Wang, Jianqing Xu, Zhiwei Cao (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - January 31, 2020 Category: Genetics & Stem Cells Source Type: research
Arabidopsis EED1 encoding a plant-specific nuclear protein is essential for early embryogenesis
Publication date: Available online 30 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Mai Yang, Chun Yan, Megan Griffith, Jinping Zhao, Yongbiao Zhang, Daoxin Xie, Jianbin Yan (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - January 31, 2020 Category: Genetics & Stem Cells Source Type: research
Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs
Publication date: Available online 29 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Fenghua Zhang, Xianmei Li, Mudan He, Ding Ye, Feng Xiong, Golpour Amin, Zuoyan Zhu, Yonghua SunAbstractThe CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in zebrafish. Despite this technology is efficient for generating different mutations, one of the main drawbacks is low survival rates during embryogenesis when knocking out some embryonic lethal genes. To overcome this problem, we developed a novel strategy using a combination of CRISPR/Cas9 mediated gene kn...
Source: Journal of Genetics and Genomics - January 30, 2020 Category: Genetics & Stem Cells Source Type: research
Engineering T cells for immunotherapy of primary human hepatocellular carcinoma
Publication date: Available online 28 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Leidy D. Caraballo Galva, Lun Cai, Yanxia Shao, Yukai HeAbstractLiver cancers, majority of which are primary hepatocellular carcinoma (HCC), continue to be on the rise in the world. Furthermore, due to the lack of effective treatments, liver cancer ranks the 4th most common cause of male cancer deaths. Novel therapies are urgently needed. Over last few years, immunotherapies, especially the checkpoint blockades and adoptive cell therapies of engineered T cells, have demonstrated a great potential for treating malignant tumo...
Source: Journal of Genetics and Genomics - January 28, 2020 Category: Genetics & Stem Cells Source Type: research
Molecular feature and therapeutic perspectives of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)
Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of CD4+ T cells with distinct immunosuppressive, are vital for maintaining immune homeostasis in healthy people. FOXP3 (Forkhead box protein P3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg. The expression, post-translational modifications and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg in vivo. In particul...
Source: Journal of Genetics and Genomics - January 25, 2020 Category: Genetics & Stem Cells Source Type: research
Rapid and specific isolation of intact mitochondria from Arabidopsis leaves
Publication date: Available online 21 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Lilan Luo, Yajun He, Qian Xu, Wenhui Lyu, Jijun Yan, Peiyong Xin, Dahan Zhang, Jinfang Chu, Jiayang Li, Hong Yu (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - January 21, 2020 Category: Genetics & Stem Cells Source Type: research
Disruptor of telomeric silencing 1–like (DOT1L) is involved in breast cancer metastasis via transcriptional regulation of MALAT1 and ZEB2
Publication date: Available online 17 December 2019Source: Journal of Genetics and GenomicsAuthor(s): Yang Duan, Xingyan Zhang, Lihong Yang, Xu Dong, Zhanye Zheng, Yiming Cheng, Hao Chen, Bei Lan, Dengwen Li, Jun Zhou, Chenghao Xuan (Source: Journal of Genetics and Genomics)
Source: Journal of Genetics and Genomics - January 15, 2020 Category: Genetics & Stem Cells Source Type: research
Structural and immunogenomic insights for B cell receptor activation
Publication date: Available online 9 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Yangyang Feng, Yu Wang, Shaocun Zhang, Kabeer Haneef, Wanli LiuAbstractB cells express B-cell receptors (BCRs) which recognize antigen to trigger signaling cascades for B cell activation and subsequent antibody production. BCR activation has a crucial influence on B cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past a few years. Here, we summarized the models that have been proposed to explain BCR activation, including the cross-linkin...
Source: Journal of Genetics and Genomics - January 11, 2020 Category: Genetics & Stem Cells Source Type: research
MpbR, an essential transcriptional factor for Mycobacterium tuberculosis survival in the host, modulates PIM biosynthesis and reduces innate immune responses
Publication date: Available online 28 December 2019Source: Journal of Genetics and GenomicsAuthor(s): Yugang Li, Weihui Li, Zhiwei Xie, Hui Xu, Zheng-Guo HeAbstractMycobacterium tuberculosis possesses unique cellular envelope components that contribute to bacterial escape from host immune surveillance. Phosphatidylinositol mannosides (PIMs) and their higher derivatives are important molecules implicated in host-pathogen interactions in the course of tuberculosis. However, the biosynthetic regulation of these specific lipids and its effect on the bacterial fate in the infected host remain unclear. Here, we show that a hypot...
Source: Journal of Genetics and Genomics - December 30, 2019 Category: Genetics & Stem Cells Source Type: research
Genome-wide evolution analysis reveals low CpG contents of fast-evolving genes and identifies antiviral microRNAs
Publication date: Available online 23 December 2019Source: Journal of Genetics and GenomicsAuthor(s): Wen-Hong Zu, Hang Zhang, Xun Lan, Xu TanAbstractNoncoding RNAs play important roles in many biological processes and provide material for evolutionary adaptations beyond protein-coding genes, such as in the arms race between host and pathogen. However, currently, a comprehensive high-resolution analysis of primate genomes that includes the latest annotated noncoding RNAs is not available. Here we developed a computational pipeline to estimate the selections that act on noncoding regions based on comparisons with a large nu...
Source: Journal of Genetics and Genomics - December 24, 2019 Category: Genetics & Stem Cells Source Type: research
