Stability of glyoxal- and methylglyoxal-modified hemoglobin on dried blood spot cards as analyzed by nanoflow liquid chromatography tandem mass spectrometry
In this study, we examine the stability of these modifications of hemoglobin stored on DBS cards at room temperature or 4 °C in the ambient air. After hemoglobin was extracted from the DBS cards, it was digested by trypsin and analyzed by nanoflow liquid chromatography coupled with nanospray ionization tandem mass spectrometry. The results show that the extents of all these PTMs are stable within 14 and 21 days when stored on DBS at room temperature and at 4 °C, respectively. Extraction of globin from DBS cards is mostly advantageous for hemolytic blood samples. This assay is sensitive as only a quarter of a DBS card c...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research
Development of biomarkers of genitourinary cancer using mass spectrometry-based clinical proteomics
Publication date: Available online 27 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Yi-Ting Chen, Cheng-Han Tsai, Chien-Lun Chen, Jau-Song Yu, Ying-Hsu ChangAbstractProstate, bladder and kidney cancer are the three most common types of genitourinary cancer in the world. Of these, prostate and bladder cancers are within the top 10 most common cancers in men. Notably, kidney cancer causes no obvious symptoms in the early stages. To satisfy clinical-management requirements, researchers have developed numerous biomarkers by applying proteomic approaches using clinical serum, urine and tissue specimens, as wel...
Source: Journal of Food and Drug Analysis - October 27, 2018 Category: Food Science Source Type: research
Identification of bacteria in juice/lettuce using magnetic nanoparticles and selected reaction monitoring mass spectrometry
This study presents an accurate means for bacterial identification in food matrixes using MS. The analysis time is less than 90 min and the minimum concentration of E. coli detected was 5 × 103 CFU/mL. The interaction between bacteria and the magnetic nanoparticles was electrostatic and nonspecific, in contrast to immunoassays which require specific antibodies. The targeted peptide analysis focuses on the bacterial markers, thus significantly simplifying the analysis and leading to an accurate identification of bacteria.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 26, 2018 Category: Food Science Source Type: research
Simultaneous quantification combined with multivariate statistical analysis of multiple chemical markers of Wu Ji Bai Feng Pill by UHPLC–MS/MS
In conclusion, the established method offered speedy and sensitive determination for 20 compounds and is helpful for chemical standardization of commercial WJBFP products.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 25, 2018 Category: Food Science Source Type: research
CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β, Wnt and STAT3 signaling pathways
Publication date: Available online 25 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): In-Yu Lin, Yi-Shiou Chiou, Li-Ching Wu, Chen-Yu Tsai, Chiung-Tong Chen, Wu-Chang Chuang, Ming-Chung Lee, Ching-Che Lin, Ting-Ting Lin, Ssu-Ching Cheng, Min-Hsiung Pan, Nianhan MaAbstractCCM111 is an aqueous extract of Antrodia cinnamomea (AC) that has exhibited anti-liver fibrosis functions. However, the detailed mechanisms of AC action against liver fibrosis have not been elucidated yet. The present research showed that CCM111 significantly lowered the levels of the hepatic enzyme markers glutamate oxaloacetate transamina...
Source: Journal of Food and Drug Analysis - October 25, 2018 Category: Food Science Source Type: research
Applications of cyclic peptide nanotubes (cPNTs)
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Wei-Hsien Hsieh, Jiahorng LiawAbstractSelf-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and f...
Source: Journal of Food and Drug Analysis - October 9, 2018 Category: Food Science Source Type: research
Novel technologies in detection, treatment and prevention of substance use disorders
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Hichem Moulahoum, Figen Zihnioglu, Suna Timur, Hakan CoskunolAbstractSubstance use disorders are a widely recognized problem, which affects various levels of communities and influenced the world socioeconomically. Its source is deeply embedded in the global population. In order to fight against such an adversary, governments have spared no efforts in implementing substance abuse treatment centers and funding research to develop treatments and prevention procedures. In this review, we will discuss the use of immunological...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Rapid screening of sulfonamides in dietary supplements based on extracted common ion chromatogram and neutral loss scan by LC-Q/TOF-mass spectrometry
In this study, a rapid screening method was developed for detection and confirmation of 35 sulfonamides in supplements by ultra-high performance liquid chromatography quadrupole/time of flight mass spectrometry. For effective extraction of sulfonamides from dietary supplements, four extraction protocols including HLB and WAX solid-phase extraction, Quick Easy Cheap Effective Rugged and Safe method, and pH-controlled liquid–liquid extraction were evaluated, and pH-controlled liquid–liquid extraction method was shown to be the most effective with high recovery efficiency and low matrix effect. Rapid separation of 35 sulf...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
In vivo pro-angiogenic effects of dracorhodin perchlorate in zebrafish embryos: A novel bioactivity evaluation platform for commercial dragon blood samples
In this study, we used zebrafish embryos as a platform to demonstrate the in vivo pro-angiogenic activity of dracorhodin perchlorate, the chemically synthesized analog of dracorhodin. By using this platform, three different commercial dragon blood samples were also examined. Our results clearly show that even though the commercial dragon blood samples had similar amounts of dracorhodin, they showed highly variable biological activity, such as pro-angiogenic effects and toxicity. In short, an in vivo activity assay platform for rapidly examining the biological activity of commercial dragon blood samples was successfully e...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Determination of sulfamonomethoxine in tilapia (Oreochromis niloticus × Oreochromis mossambicus) by liquid chromatography-tandem mass spectrometry and its application pharmacokinetics study
This study investigated the pharmacokinetic properties and tissue distribution of SMM and its major metabolite N4-acetyl sulfamonomethoxine (AC-SMM) in tilapia after a single dose of 100 mg kg−1 body weight of orally administered SMM. Blood and tissues were collected between 0.5 and 192 h with 14 total sampling time points. SMM was rapidly absorbed, and extensively distributed in the bile and liver through systemic circulation. Enterohepatic circulation of SMM was observed in the tilapia body. Acetylation percentages were 45% (blood), 90% (liver), 62% (kidney), 98% (bile), and 52% (muscle). High concentrations of AC-S...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Applications of cyclic peptide nanotubes
Publication date: Available online 28 September 2018Source: Journal of Food and Drug AnalysisAuthor(s): Wei-Hsien Hsieh, Jiahorng LiawAbstractSelf-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and f...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Instructions to Authors
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Novel inspection of sugar residue and origin in honey based on the 13C/12C isotopic ratio and protein content
Publication date: Available online 1 October 2018Source: Journal of Food and Drug AnalysisAuthor(s): Chun-Ting Chen, Bor-Yann Chen, Yu-Shin Nai, Yuan-Mou Chang, Kuan-Hua Chen, Yue-Wen ChenAbstractRegarding the honey industry, market prices are strongly affected by the origin and composition of products. In particular, the adulteration of honey can be divided into cases of honey being mixed with artificial syrup, the different origin of the adulteration and the presence of cane sugar residue. Unfortunately, recent studies mentioned that most honey is mixed with artificial syrups. Thus, determining such unnaturally present s...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry
In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standard...
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
Keyword Index
Publication date: October 2018Source: Journal of Food and Drug Analysis, Volume 26, Issue 4Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - October 4, 2018 Category: Food Science Source Type: research
