A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities
Publication date: Available online 14 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Nabila Brahmi-Chendouh, Simona Piccolella, Giuseppina Crescente, Francesca Pacifico, Lila Boulekbache, Sabrina Hamri-Zeghichi, Salah Akkal, Khodir Madani, Severina PacificoAbstractNowadays, advanced extraction techniques and highly sensitive metabolic profiling methods are effectively employed to get new information on plant chemical constituents. Among them wild medicinal plants or their parts, with large and ancient use in folk medicine, are investigated for their potential functional use and cultivation. In this context...
Source: Journal of Food and Drug Analysis - January 15, 2019 Category: Food Science Source Type: research
Corrigendum to “Investigation of borneols sold in Taiwan by chiral gas chromatography” [J Food Drug Anal 26 (2018) 348–352]
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): Tsung-Jung Ho, Chien-Che Hung, Tzenge-Lien Shih, Lih-Ming Yiin, Hao-Ping Chen (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research
Authorship & Conflicts of Interest Statement
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research
Checklist
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research
Editorial Board
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research
Instructions to Authors
Publication date: January 2019Source: Journal of Food and Drug Analysis, Volume 27, Issue 1Author(s): (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 13, 2019 Category: Food Science Source Type: research
Reduction of aluminum ion neurotoxicity through a small peptide application – NAP treatment of Alzheimer's disease
The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Complete proteomic techniques were implemented. Four proteins were identified as up-regulated with aluminum ion treatment, CBP80/20-dependent translation initiation factor (CTIF), Early endosome antigen 1 (EEA1), Leucine-rich repeat neuronal protein 4 (LRRN4) and Phosphatidylinositol 3-kinase regulatory subunit beta (PI3KR2). Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuropr...
Source: Journal of Food and Drug Analysis - January 12, 2019 Category: Food Science Source Type: research
Direct and rapid characterization of illicit drugs in adulterated samples using thermal desorption electrospray ionization mass spectrometry
In this study, thermal desorption electrospray ionization mass spectrometry (TD-ESI/MS), an AMS technique, was utilized to efficiently characterize illicit drugs spiked in samples including drinks, powders, and jelly candies. To perform sensitive analysis, the mass analyzer was operated in multiple reaction monitoring mode to monitor the molecular and fragment ions of the target analytes. The time required to complete a typical TD-ESI/MS analysis was less than 30 s. The limits of detection (LODs) for illicit drugs were found to be 100 ppb in drinks, 100–1000 ppb in instant powders, and 1.3–6.5 ng/mm2 on stamp surfa...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research
Nelumbo nucifera leaves extract attenuate the pathological progression of diabetic nephropathy in high-fat diet-fed and streptozotocin-induced diabetic rats
Publication date: Available online 8 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Huan-Wei Chen, Mon-Yuan Yang, Tung-Wei Hung, Yun-Ching Chang, Chau-Jong WangAbstractDiabetic nephropathy is not only a common and severe microvascular complication of diabetes mellitus but also the leading cause of renal failure. Lotus (Nelumbo nucifera) possesses antioxidative and anticancer properties. The present study aimed to investigate the antidiabetic and renoprotective effects of N. nucifera leaf extract (NLE) in a rat model of type 2 diabetic mellitus. Male Sprague–Dawley rats with type 2 diabetes induced by a h...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research
Glycoproteomic identification of novel plasma biomarkers for oral cancer
In this study we aim to discover novel core-fucosylated glycoprotein biomarkers for oral cancer diagnosis with glycoproteomic approaches. First, forty plasma samples obtained from the Human Bioinformation Bank of NCKUH were subjected to AAL (Aleuria aurantia lectin) affinity chromatography. Core-fucosylated proteins were collected and applied for LC-MS/MS followed by electrophoresis. Fourteen proteins were identified, and expression levels of proteins in plasma were verified by western blot. Expression levels of some glycoproteins were elevated in the oral cancer group, including ceruloplasmin, haptoglobin, and leucin-rich...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research
Using gas chromatography and mass spectrometry to determine 25-hydroxyvitamin D levels for clinical assessment of vitamin D deficiency
In this study, gas chromatography coupled mass spectrometry with trimethylsilyl derivatization (TMS-GC-MS) is the most suitable protocol for quantitative analyses of 25(OH)D3. Performance of method was evaluated and compared with liquid chromatography and immunoassay. Method validation has been carried out with plasma specimens. The limit of quantitation of TMS-GC-MS method is 1.5 ppb with good linear correlation. Furthermore, the dietary intake and nutritional status of vegetarian and non-vegetarians in Taiwan were assessed by our validated method. As a result, this vitamin D nutrition survey demonstrates that most Taiwa...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research
Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene
Publication date: Available online 8 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Ming-Hui Yang, Chia-Hung Yen, Chen-Chung Liao, Jung-Hsien Hung, Xiu-Ting Lai, Yi-Ming Arthur ChenAbstractGlycine N-methyltransferase (GNMT) protein is highly expressed in certain tissues, such as liver, pancreas, and prostate. GNMT serves multiple roles which include a methyl group transfer enzyme and a liver tumor suppressor. Benzo(a)pyrene (BaP), a family member of polycyclic aromatic hydrocarbon (PAH), is a known environmental carcinogen found in coal tar, tobacco smoke, barbecued food and incomplete combustion of auto f...
Source: Journal of Food and Drug Analysis - January 9, 2019 Category: Food Science Source Type: research
Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers
This study confirmed discovery-phase features of the urine metabolome of bladder cancer patients and verified their importance for further study.Graphical abstract (Source: Journal of Food and Drug Analysis)
Source: Journal of Food and Drug Analysis - January 8, 2019 Category: Food Science Source Type: research
Risk of adverse cardiovascular events with use of inhaled long-acting bronchodilators in management of chronic obstructive pulmonary disease
Publication date: Available online 7 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Meng-Ting Wang, Jyun-Heng Lai, Chen-Liang Tsai, Jun-Ting LiouAbstractInhaled long-acting bronchodilators, including long-acting β2 agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are the mainstay therapy in the treatment of chronic obstructive pulmonary disease (COPD), a disease that poses a heavy burden on morbidity and mortality worldwide. Use of LABAs and LAMAs in patients with COPD, however, has been concerned about an increased risk of adverse cardiovascular events, despite inconsistent findings report...
Source: Journal of Food and Drug Analysis - January 8, 2019 Category: Food Science Source Type: research
Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care
Publication date: Available online 3 January 2019Source: Journal of Food and Drug AnalysisAuthor(s): Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai, Fang-Rong Chang, Jentaie Shiea, Chi-Wei LeeAbstractThe unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray laser desorption ionization mass spectrometry (ELDI/MS) has been successfully used to characterize ...
Source: Journal of Food and Drug Analysis - January 4, 2019 Category: Food Science Source Type: research
