Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial
ConclusionsThe therapeutic effect of ShenYanXiaoBai high dose group was better than the two other treated groups from the 5th week to the 7th week, the comparison had a significant difference. The therapeutic effect of benazepril group was better than the ShenYanXiaoBai low dose group in the 7 weeks and the comparison had a significant difference.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L.
ConclusionsUntil now, significant progress has been witnessed in phytochemistry and pharmacology of E. prostrata. Thus, some traditional uses has been well supported and clarified by modern pharmacological studies. Moreover, E. prostrata also showed therapeutic potential in some refractory diseases such as cancer, dementia and diabetes. But, present findings are still insufficient that cannot satisfactorily explain some mechanisms of action. More well-designed studies in vitro especially in vivo are required to establish links between the traditional uses and bioactivities, discover new skeletons and activity molecules, as...
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Immunoregenerative effects of the bionically cultured Sanghuang mushrooms (Inonotus sanghuagn) on the immunodeficient mice
This study aims to establish a practical protocol for culture, particularly for a bunch of production of Sanghuang mushrooms possibly to commercialize the cultured Sanghuang based on deep comparison of quality and pharmacological activities between the cultured and the wild Sanghuang.Materials and methodsA phylogenetic tree containing five strains of the wild Sanghuang was constructed using rDNA markers. Different temperatures and medium compositions were surveyed to develop a practical protocol for culture of the Sanghuang mushrooms. 5-fluorouracil was used to induce the immunodeficient mice. Chemotherapeutic components a...
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Phenolic constituents, pharmacological activities, quality control, and metabolism of Dracaena species: A review
ConclusionsDragon's blood is a valuable source of bioactive compounds, mainly flavonoids and their oligomers. Its potential therapeutic effects on different diseases are attractive, such as the notable effect on cardiovascular diseases. In future studies, there is an urgent need to test the effect of this extract on appropriate cell lines and animal models to analyze its ethnopharmacological applications; moreover, “composition−effect correlation” methods and omics technologies are demanded for identifying the effective material basis and therapeutic mechanisms before entering into clinical trials. Moreov...
Source: Journal of Ethnopharmacology - August 5, 2019 Category: Drugs & Pharmacology Source Type: research

Prediction of the mechanisms of action of shenkang in chronic kidney disease: A network pharmacology study and experimental validation
ConclusionsSK exerted a curative effect on CKD and CKD-related diseases by targeting different organs, regulating inflammation and proliferation processes, and inhibiting abnormal extracellular matrix accumulation. Thus, pharmacological network analysis with in vivo validation explained the potential effects and mechanisms of SK in the treatment of CKD. However, these findings need to be further confirmed with clinical studies.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Ginger essential oil and fractions against Mycobacterium spp.
ConclusionsIn general, GEO showed a mix of monoterpenes and sesquiterpenes and a better antimycobacterial activity than the semi-pure fractions. Cytotoxic effects of GEO and its fractions should be better investigated.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of traditional chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies
ConclusionLCS exerted potent anti-hepatitis effects against the infection of HBV. The above results demonstrated the first-hand experimental evidences for the anti-hepatitis B efficiency of LCS. Our study provides a basis for further exploration and development of this promising compound prescription to treat hepatitis B disease.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense
ConclusionsThe veratramine-type alkaloids from V. taliense may serve as new leads for the discovery of analgesic drugs.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Soluble yerba mate (Ilex Paraguariensis) extract enhances In vitro osteoblastic differentiation of bone marrow-derived mesenchymal stromal cells
ConclusionsTogether, these results help to explain the promoting effect on osteoblast differentiation produced by a low SYM concentration. However, a higher SYM concentration presented deleterious effects, including cytotoxicity, decreased ALP activity, increased cytokine production, decreased bone marker gene expression, increased MAPK signaling, and significant mineralization reduction. In conclusion, our results suggest a concentration-specific direct stimulatory effect of SYM on osteoblastic differentiation in vitro.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation
ConclusionsOur findings suggest that TGP improved OVA-induced allergic asthma in mice mainly by suppressing Ca2+ influx-dependent mast cell degranulation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Nigella sativa seed extract applicability in preparations against methicillin-resistant Staphylococcus aureus and effects on human dermal fibroblasts viability
ConclusionsThe observed effectiveness of N. sativa seed extracts against bacteria was found to be dominantly dependent on concentration of thymoquinone. Its efficiency against S. aureus isolates as well as results of cytotoxicity examination against human dermal fibroblasts indicate on its applicability as an antibacterial agent for topical use and motivates further research in this area.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Cyberecoethnopharmacolomics
ConclusionsEthnopharmacology has a major role to play in global health care if the relevant sciences and cutting-edge technologies can coalesce synergistically as a responsive, evidence-based health care practice.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension
ConclusionsThis study used the systems pharmacology approach to decipher the mechanisms of action of ORS for the treatment of hypertension. When hypertension drugs and ORS are used in combination for treatment, possible side effects should be considered because most hypertension drugs are related to the RAAS. The results of this study may provide clues to not only analyze the pharmacological activity of ORS for the treatment of hypertension but other diseases as well.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

The effects of Jilin sika Deer's (Cervus dybowski) tendon liquid supplementation on endurance drop jumps performance, biochemistry profile of free boxing players
ConclusionsTD supplementation leads to better physiological adaptation in free boxing players and has the potential for use as a nutrient supplement toward a variety of benefits for endurance athletes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs?
ConclusionsPre-clinical in vitro and in vivo animal experiments failed to yield any promising drug leads. However, if the recent randomised controlled trials can be independently replicated in well-designed and executed clinical trials it might indicate that A. afra contain powerful ‘prodrugs’. Future research on A. afra should therefore focus on reproducing the randomised controlled trials and on artificially metabolising A. afra extracts/compounds in order to identify the presence of any ‘prodrugs’.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacology of the club moss subfamily Huperzioideae (Lycopodiaceae, Lycopodiophyta): A phylogenetic and chemosystematic perspective
ConclusionHuperzioideae club mosses have interesting pharmaceutical potential supported by ethnopharmacological investigations. Bioprospecting of these plants should be preceded by careful plant identification to produce consistent and reproducible data. We expect that DNA barcoding and LC-MS-based chemical fingerprinting could facilitate and improve ethnopharmaceutical studies in selection of club moss taxa.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity
ConclusionsTogether, the results herein obtained show that EuL presented anti-inflammatory activity by decreasing the influx of PMN to the inflamed tissue, as well as the cytokine IL-1β level. This anti-inflammatory activity was also accompanied by significant anti-hypersensitive effect. The effects presented by EuL seem not to be correlated with an antioxidant activity. However other extract chemical compounds could be responsible for its important anti-inflammatory effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

The protection of indolealkylamines from LPS-induced inflammation in zebrafish
ConclusionsOverall, the mechanism underlying the anti-inflammatory activity of IAAs probably attributed to their capability to suppress NF-κB and MAPKs inflammatory pathway. Meanwhile, IAAs could also interfere the metabolism of SM, Cer and PC probably by regulating LBP, PLA2, CERK, SMPD and SGMS.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes
Publication date: Available online 30 July 2019Source: Journal of EthnopharmacologyAuthor(s): T. Olabisi Obafemi, M. Tolulope Olaleye, Afolabi C. AkinmoladunAbstractEthnopharmacological relevanceMiracle fruit plant (Synsepalum dulcificum) has many applications in folk medicine. The leaves are used traditionally to treat diabetes and other diseases. The antidiabetic potential of Synsepalum dulcificum leaves in rats has been studied but the mechanisms involved are yet to be elucidated.AimThe present study aimed to provide insight into the antidiabetic mechanisms of methanol and flavonoid-rich leaf extracts of Synsepalum dulc...
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Hyphenated chromatography detection and compound-target-disease investigation on herb-pair Chuanxiong Rhizoma - Xiangfu Rhizoma
ConclusionsOur work successfully explained the compatible mechanism of CR-XR Yaodui, which exert ‘multi-components, multi targets’ in treating Qizhi and Xueyu Zheng.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

The freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb possess hypoglycemic, hypolipidemic and hypoinsulinemic on type 2 diabetes rat model
This study investigated the antihyperglycaemic, antidyslipidemic and antihyperinsulinemic activity of the freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb (RME) in an animal model of type 2 diabetes mellitus.MethodsType 2 diabetes was induced by dietary manipulation for 56 days via (high fat- high fructose diet) and intraperitoneal administration of streptozocin (30 mg/kg). Forty freshly-weaned Sprague Dawley rats were randomly assigned into the negative control (high fat/high fructose diet), low dose test (50mg/kg RME, high dose test (100mg/kg RME and positive control (Pioglitazone, 20mg/kg) group...
Source: Journal of Ethnopharmacology - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

Plants utilized as medicines by residents of Quilombo da Fazenda, Núcleo Picinguaba, Ubatuba, São Paulo, Brazil: A participatory survey
ConclusionsThe participatory method identified a large number of factors that influence medicinal plant use: the patient's blood type; the condition of the plant and the disease (hot-cold system); the route of administration and dosage; the preventive uses of the plants; and the influence of other factors, such as the sun, the moon and dew. The participatory approach is useful for gaining insight on the decision processes of medicinal plant use in traditional societies, and also for those communities wanting to document their knowledge with or without the participation of the academy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 27, 2019 Category: Drugs & Pharmacology Source Type: research

Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation
ConclusionsTGP alleviates the symptoms of psoriasis-like guinea pigs and mice, and the possible mechanism may relate to inhibit T helper 17 (TH17) cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

The protection of indolealkylamines on LPS-induced inflammation in zebrafish
ConclusionsOverall, the mechanism underlying the anti-inflammatory activity of IAAs probably attributed to their capability to suppress NF-κB and MAPKs inflammatory pathway. Meanwhile, IAAs could also interfere the metabolism of SM, Cer and PC by regulating LBP, PLA2, CERK, SMPD and SGMS.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Ameliorative influence of cnestis ferruginea vahl ex DC (connaraceae) root extract on kainic acid-induced temporal lobe epilepsy in mice: Role of oxidative stress and neuroinflammation
Conclusionfindings from this study showed that Cnestis ferruginea root extract ameliorated KA-induced TLE through enhancement of antioxidant defense mechanism and attenuation of neuro-inflammatory transcription factors. Thus, could possibly be a potential phytotherapeutic agent in the management of temporal lobe epilepsy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Cynanchum bungei Decne and its two related species for “Baishouwu”: A review on traditional uses, phytochemistry, and pharmacological activities
ConclusionsCB, CA and CW collectively known as Baishouwu are valuable medicinal herbs with multiple pharmacological activities. The traditional use for nourishing liver is closely associated with the hepatoprotective activity. The available literature performs that various of the activity of Baishouwu can be attributed to acetophenones and C21-steroids. It is high time that more efforts should be focused on the underlying mechanisms of their beneficial bioactivities and the structure activity relationship of the constituents, as well as their potential synergistic and antagonistic effects. The proper toxicology evaluation ...
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Unveiling the bioactive potential of the essential oil of a Portuguese endemism, Santolina impressa
ConclusionsOur results validate the main traditional use ascribed to S. impressa, namely its anti-inflammatory effect. In addition, an antifungal potential is pointed out, thus corroborating the antimicrobial uses and adding new value to an endemic species poorly recognized by the industry.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

The fruit of Crataegus pinnatifida ameliorates memory deficits in β-amyloid protein-induced Alzheimer's disease mouse model
ConclusionsCollectively, these experimental findings demonstrated that CPE could be a candidate for development of AD therapy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 24, 2019 Category: Drugs & Pharmacology Source Type: research

Characterization of the hot and cold medicinal properties of traditional Chinese herbs by spontaneous photon emission ratio of mice
ConclusionsWe have developed a novel and promising approach to quantitatively investigate herbal properties and we propose that SE ratio defined in this study can serve as a sensitive parameter to characterize the cold and hot medicinal properties of traditional Chinese herbs.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 24, 2019 Category: Drugs & Pharmacology Source Type: research

Bauhinia forficata link, a Brazilian medicinal plant traditionally used to treat cardiovascular disorders, exerts endothelium-dependent and independent vasorelaxation in thoracic aorta of normotensive and hypertensive rats
ConclusionsThis study shows, for the first time, the vasorelaxant effect of EAButF from B. forficata leaves, an effect that may be attributed to the modulation of vascular tone through nitric oxide/soluble guanylate cyclase pathway, and potassium channels. The bioactive kaempferitrin and kaempferol seem to be important for the effects observed with the fraction. Finally, preparations obtained from the leaves of B. forficata may be interesting candidates for new or complementary strategies regarding cardiovascular diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 24, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-asthmatic effects of lepidii seu Descurainiae Semen plant species in ovalbumin-induced asthmatic mice
ConclusionLDS alleviated eosinophilic inflammation by inhibiting Th2 cell differentiation, and DSE was more effective in attenuating allergic lung inflammation than LAE.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

A review of pharmacological and clinical studies on the application of Shenling Baizhu San in treatment of Ulcerative colitis
ConclusionAlthough SLBZS has achieved some success in the treatment of UC, there are still some scientific gaps. There is a lack of uniform standards for constructing UC animal models, and some methods of modeling through environmental and dietary interventions are not reproducible, and there is a lack of uniform dosing regimen standards. SLBZS doses follow the tradition and lack toxicological validation. Therefore, more specific toxicological research models are essential. The clinical application of SLBZS requires reassessment and standardization. Although all clinical research reports randomly assigned patients to diffe...
Source: Journal of Ethnopharmacology - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Publisher's note
Publication date: 5 October 2019Source: Journal of Ethnopharmacology, Volume 242Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Transcriptomic-proteomics-anticoagulant bioactivity integrated study of Pheretima guillemi
ConclusionThis study illuminated the therapeutic potency of P. guillelmi for antithrombus and provide a new strategy to investigate animal drugs of Chinese materia medica.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Lignans from Schisandra sphenanthera protect against lithocholic acid-induced cholestasis by pregnane X receptor activation in mice
ConclusionThese results clearly demonstrated the lignans from Schisandra sphenanthera exert hepatoprotective effects against LCA-induced cholestasis by activation of PXR. These lignans may provide an effective approach for the prevention and treatment of cholestatic liver injury.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 21, 2019 Category: Drugs & Pharmacology Source Type: research

Characterization of active anticoagulant fraction and a fibrin(ogen)olytic serine protease from leaves of Clerodendrum colebrookianum, a traditional ethno-medicinal plant used to reduce hypertension
ConclusionThe potent in vivo anticoagulant and antithrombotic effects of AAFCC suggests its pharmacological significance as herbal anticoagulant drug for the prevention and/or treatment of hyperfibrinogenemia- and thrombosis associated cardiovascular disorders.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 20, 2019 Category: Drugs & Pharmacology Source Type: research

Total ginsenosides extract induce autophagic cell death in NSCLC cells through activation of endoplasmic reticulum stress
ConclusionOur findings suggested that TGS could induce autophagic cell death in NSCLC cells through activation of endoplasmic reticulum stress, disclosing another characteristic of TGS-induced cell death and a novel mechanism of TGS and its derived preparations in clinical treatment of cancer patients.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 19, 2019 Category: Drugs & Pharmacology Source Type: research

Ginger essential oil and fractions against Mycobacterium spp
ConclusionsIn general, GEO showed a mix of monoterpenes and sesquiterpenes and a better antimycobacterial activity than the semi-pure fractions. Cytotoxic effects of GEO and its fractions should be better investigated.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 19, 2019 Category: Drugs & Pharmacology Source Type: research

Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study
ConclusionsThus, CHM may help prevent T2DM-related complications in patients with PCOS. Further clinical and pharmacological analysis based on these findings is expected in the future.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 19, 2019 Category: Drugs & Pharmacology Source Type: research

Bioactivity-guided isolation of flavonoids from Urtica dioica L. and their effect on endometriosis rat model
ConclusionsThe present study demonstrated that aerial parts of U. dioica exhibited promising activity in the endometriosis rat model due to its flavonoids.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 19, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs
ConclusionA six-dimension in-vitro screening platform has been developed and successfully applied to find RS as a potential herb that would influence the co-administrated OS in rats. Although co-administered RS could inhibit OS hydrolysis during absorption and increase the absorbed fraction of OS, which lead to the increased ratio of OS concentration versus that of OSA in both rat plasma and urine, the anti-virus effect of OS was not influenced by co-administered RS.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 19, 2019 Category: Drugs & Pharmacology Source Type: research

Influence of organic anion transporter 1/3 on the pharmacokinetics and renal excretion of ginkgolides and bilobalide
ConclusionThe findings indicated that ginkgolide A, B and bilobalide are excreted via OAT1/3-mediated transport in the kidney and OAT1/3 inhibitor significantly influence the PK ginkgolides and bilobalide.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

Study of the aqueous extract of Aloe vera and its two active components on the Wnt/β-catenin and Notch signaling pathways in colorectal cancer cells
ConclusionIn conclusion, this study showed that Aloe vera extract and its active component aloin activated the Wnt/β-catenin pathway and inhibited the Notch pathway in the presence of Wnt3a. While another active component, aloesin, activated the Wnt/β-catenin pathway and inhibited the Notch signaling pathway independent of Wnt3a. Given that Wnt/β-catenin and Notch pathway are closely associated with the progression of CRC, these findings would be helpful to better understand the colonic carcinogenicity of Aloe vera.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

α-Glucosidase inhibitory activity and in vivo antihyperglycemic effect of secondary metabolites from the leaf infusion of Ocimum campechianum mill
ConclusionsThe results confirm both the traditional use of O. campechianum and the importance of the leaf infusion as a potential source of antihyperglycemic agents. The isolation of 5-demethyl nobiletin (1) and 5-demethyl sinensetin (2) from O. campechianum and other Ocimum spp. suggests that polymethoxyflavones can be considered chemotaxonomical markers for the genus.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

Cang-ai volatile oil improves depressive-like behaviors and regulates DA and 5-HT metabolism in the brains of CUMS-induced rats
Publication date: Available online 16 July 2019Source: Journal of EthnopharmacologyAuthor(s): Bojun Chen, Jijun Li, Yuhuan Xie, Xi Ming, Gang Li, Jinjin Wang, Meng Li, Xiaohong Li, Lei XiongAbstractEthnopharmacological relevanceCang-ai volatile oil (CAVO) is a traditional Chinese medicine (TCM) inhalational preparation for the treatment of some depressive and emotive disorders.Aim of the studyThis research aimed to evaluate the efficiency and possible mechanism of intranasal CAVO administration on depression in chronic unpredictable mild stress (CUMS)-induced rats compared to lavender volatile oil (LVO) treatment after CUM...
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition
ConclusionsThis study showed that antifibrogenic effect of β-carboline alkaloids was due to inhibiting the initial of inflammation through NF-kb/p65 pathway and reversing the process of EMT.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

8 years post-marketing surveillance between Asari Radix and hepatocellular carcinoma: Nationwide population-based evidence against an association
ConclusionsPost-marketing surveillance showed that Asari Radix has no relationship with HCC development at an intake of under 200 g. The study is persuasive in furthering our knowledge of the maximum allowable amount of Asari Radix.Graphical abstractStudy design for the non-HBV/HCV, HBV, and HCV cohorts. HBV, hepatitis B virus; HCV, hepaptitis C virus; HCC, hepatocellualr carcinoma; TCM, traditional Chinese medicine; NHIRD, National Health Insurance Research Database. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 17, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of Panax ginseng supplementation on blood lipid profile. A meta-analysis and systematic review of clinical randomized trials
ConclusionsPG extract may induce an improvement in blood lipid profile mainly by a reduction in total and LDL-cholesterol levels.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 16, 2019 Category: Drugs & Pharmacology Source Type: research

Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury
ConclusionThis research is the first to clarify that iridoid glycosides and phenol compounds are the substance basis of the hepatoprotective activity of the EAFVC. Establish rapid and effective method for the determination of main seven compounds, which is vital for the quality control of V. ciliata. These main compounds could be chosen to the analytical marker of V. ciliata. The strong activity of EAFVC and its isolated compounds on relieving the drug-induced liver injury provided the further scientific data for the traditional use and deep development of this Tibetan Medicine. In addition, PASS Online prediction, an effe...
Source: Journal of Ethnopharmacology - July 14, 2019 Category: Drugs & Pharmacology Source Type: research