Guizhi Fuling Wan for uterine fibroids: A systematic review of in vivo studies
ConclusionNoting the unevenly distributed covariates of animal model types, experimental evidence suggested that GFW may be a promising intervention for the management of uterine fibroids in animal models. Future natural product studies should be optimised by reporting the voucher specimen. More studies on composition and providing evidence of the involvement of relevant cell signalling pathways are required.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

Marantodes pumilum (Blume) Kuntze (Kacip Fatimah) stimulates uterine contraction in rats in post-partum period
ConclusionsThese findings support the claims that MPE help to firm the uterus and pave the way for its use as a uterotonic agent after delivery.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

Antihyperlipidemic effect of iridoid glycoside deacetylasperulosidic acid isolated from the seeds of Spermacoce hispida L. - A traditional antiobesity herb
This study was aimed to validate the traditional claim and to identify the antihyperlipidemic principle in the seeds of Spermacoce hispida using bioassay guided fractionation method.MethodsBioassay monitored fractionation of the aqueous extract from Spermacoce hispida seeds was carried out using triton WR 1339 induced hyperlipidemic animals. It yielded deacetylasperulosidic acid (DAA) as the active ingredient. Pharmacokinetic properties of DAA were predicted using DataWarrior and SwissADME tools. In vitro antiobesity and antihyperlipidemic effects of DAA were evaluated in 3T3L1 preadipocytes and HepG2 cells, respectively. ...
Source: Journal of Ethnopharmacology - August 18, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibitory activity of Scorzonera latifolia and its components on enzymes connected with healing process
Publication date: Available online 17 August 2019Source: Journal of EthnopharmacologyAuthor(s): Esra Küpeli Akkol, Karel Šmejkal, Ekin Kurtul, Mert Ilhan, Fatma Tuğçe Güragac, Gülçin Saltan Çitoğlu, Özlem Bahadır Acıkara, Josef Cvačka, Miloš BuděšínskýAbstractEthnopharmacological relevanceScorzonera latifolia (Fisch. & Mey.) DC. (Asteraceae)grows naturally in Eastern Anatolia, northeastern Iran, and Caucasus. Latex of S. latifolia roots is used in Turkish folk medicine for its analgesic effects, externally to cure infertility in women, an...
Source: Journal of Ethnopharmacology - August 18, 2019 Category: Drugs & Pharmacology Source Type: research

Plinia cauliflora (Mart.) Kausel: A comprehensive ethnopharmacological review of a genuinely Brazilian species
ConclusionThis review summarizes research on the traditional use, phytochemistry, biological activities, and toxicology of P. cauliflora. Although P. cauliflora possesses significant biological activities, much of its ethnomedicinal use has not been scientifically evaluated. Well-designed pharmacological and toxicological assays and randomized clinical trials are still needed to validate its ethnopharmacological use as an herbal medicine.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 16, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnobotanical uses, secondary metabolites and biological activities of Mashua (Tropaeolum tuberosum Ruíz & Pavón)
ConclusionsT. tuberosum has been tested for various biological activities and the extracts (tubers in particular) demonstrated a promising potential as an antibacterial, antioxidant, anti-inflammatory and inhibitors of benign prostatic hyperplasia. A lack of alignment between the ethno-medicinal uses and existing biological screenings was observed, indicating the need to explore its potential for the treatment against respiratory affections, urinary affections and blood diseases. Likewise, it is necessary to analyse deeply the relationship that exists between the different tuber colours of T. tuberosum and its use for the ...
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Research on mechanism of charred hawthorn on digestive through modulating “brain-gut” axis and gut flora
ConclusionThe above study showed that hawthorn decoction coupled with the odor of charred hawthorn effectively alleviate HC-DID in rats by regulating the “Brain-Gut” axis and gut flora. Odor treatment of hawthorn could be a potential therapeutic approach for HC-DID.Graphical abstractTraditional Chinese medicine decoction of hawthorn (raw hawthorn and charred hawthorn) regulated the body weight, food intake, gastrointestinal motility and abnormal secretion of brain-gut peptides in rats with high-calorie-diet-induced dyspepsia, and the odor of charred hawthorn also had good curative effect for it. Moreover, the i...
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

An animal research and a chemical composition analysis of a Chinese prescription for pulmonary fibrosis: Yangfei Huoxue Decoction
ConclusionThe experiment results revealed that the vascularized VEGF, inflammatory factor expression of IL-1β was restrained by YHD.The UPLC/QTOF-MSE method, an automatic database screening platform and the characteristic MS fragmentation patterns have efficiently facilitated the post data process, so we test for the identification of major components in YHD by this technology, more than seven or more active ingredients, the results showed that YHD contained a total of 55 components, including 11 lignans, 12 flavonoids, 7 tanshinones, 9 organic acid, 5 polyphenols, 4 anthraquinones, 5 senkyunolides and 2 others. Based...
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
ConclusionThe microfractionation protocol developed in this study enabled time-efficient screening of many plants species, using a small quantity of sample material. In addition, microfractionation served as a guiding tool for identifying individual antimicrobial compounds. Through this process, flavonoids were isolated from Derris scandens, out of which dalpanithin and vicenin-3 showed activity in the low micromolar range. The high hit rate for in vitro antibacterial properties from this ethnopharmacologically guided sample collection gives credence to the Sri Lankan traditional herbal medicine as a source for drug discov...
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic compounds that improve liver cell glucose homeostasis
Publication date: Available online 15 August 2019Source: Journal of EthnopharmacologyAuthor(s): Pierre B. Kasangana, Hoda M. Eid, Abir Nachar, Tatjana Stevanovic, Pierre S. HaddadAbstractEthnopharmacological relevanceWe recently reported that ethanol extract of Myrianthus arboreus P. Beauv. root bark demonstrated antidiabetic activity by modulating hepatocyte glucose homeostasis. This activity was associated significantly to the ethyl acetate (EAc) fraction. The current study sought to identify the active compounds responsible of the antidiabetic effect of M. arboreus in the EAc fraction using bioassay-directed sub-fractio...
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: 28 October 2019Source: Journal of Ethnopharmacology, Volume 243Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 15, 2019 Category: Drugs & Pharmacology Source Type: research

A selection of eleven plants used as traditional Polynesian cosmetics and their development potential as anti-ageing ingredients, hair growth promoters and whitening products
ConclusionsA prospective approach of plants used traditionally for cosmetic purposes in French Polynesia gave insight on their development potential when paired with the appropriate multidisciplinary data. The eleven plants presented show promise in being developed sustainably as natural anti-aging or hair care products and as skin brightening agents.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnozoological practices in Rodrigues island of the Mascarene archipelago
ConclusionRodriguans were found to possess valuable knowledge on a plethora of ABR. It is believed that the present documentation will serve to record and present this vanishing knowledge to the scientific community before it is further eroded from the island. Given the dearth of primary published information on zootherapeutic practices in Rodrigues, this study opens new avenues for biomedicine development in an attempt to develop alternative therapies or complement existing ones.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnoveterinary remedies used in the Algerian steppe: Exploring the relationship with traditional human herbal medicine
ConclusionsTraditional veterinary knowledge is still key to sheep and goat herders in the Algerian steppe, but a knowledge transmission gap seems to exist between older and younger generations, and ethnoveterinary practices may disappear in the near future. Treatments for human and animal care overlap to a large extent, and a causal relationship possibly exists for, at least, some of them. However, overall a smaller number of remedies are used to treat animals than humans and for less therapeutic applications. This difference in the diversity of therapeutic applications and remedies should be the object of future research....
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation
ConclusionThis study rendered a preliminary overview of anti-cholinesterase activity from diverse Malaysian botanical families in which provided the medical relevance toward these native plant species, especially ones with limited ethnobotanical record or practice.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Viburnum pichinchense methanol extract exerts anti-inflammatory effects via targeting the NF-κB and caspase-11 non-canonical inflammasome pathways in macrophages
ConclusionThis study demonstrated Vp-ME has the anti-inflammatory activity via targeting NF-κB and caspase-11 non-canonical inflammasome pathways in macrophage-mediated inflammatory responses, suggesting Vp-ME could be developed as anti-inflammatory ethnopharmacological remedies to prevent and treat inflammatory diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Lippia alnifolia essential oil induces relaxation on Guinea-pig trachea by multiple pathways
ConclusionsLippia alnifolia essential oil has spasmolytic activity on guinea-pig isolated trachea and its mechanism of action possibly involves the activation of multiple signal transduction pathways, that culminate in the potassium channels activation and cytosolic calcium reduction.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Tongsaimai reverses the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats
In conclusion, STM could reverse the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice
Publication date: Available online 12 August 2019Source: Journal of EthnopharmacologyAuthor(s): A.B. Olorukooba, S. OdomaAbstractEthnopharmacological relevanceUapaca togoensis is a medicinal plant used traditionally in Africa for the treatment of rheumatism, epilepsy, cough, pneumonia, vomitting and fever. Previously, the analgesic activity of its methanol stem bark extract has been scientifically demonstrated. However, the mechanism responsible for this activity remains to be investigated.Aim of the studyTo elucidate the possible mechanism(s) through which the methanol stem bark extract of Uapaca togoensis (MEUT) exhibits...
Source: Journal of Ethnopharmacology - August 12, 2019 Category: Drugs & Pharmacology Source Type: research

From plant selection by elephants to human and veterinary pharmacopeia of mahouts in Laos
ConclusionBeyond a mere reproduction of elephant self-medication behaviours observed, the human or veterinary medicinal cares derived from these observations are the result of complex arrangements integrating all available medicinal and conceptual resources into elaborate preparations.We recommend that mahouts' knowledge about traditional medicinal care given to elephants be further compiled, as it could have a beneficial impact on veterinary health care provided in elephant resorts and elephants’ well-being.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 12, 2019 Category: Drugs & Pharmacology Source Type: research

The role of gut microbiota for the activity of medicinal plants traditionally used in the European Union for gastrointestinal disorders
Publication date: Available online 10 August 2019Source: Journal of EthnopharmacologyAuthor(s): Timo A. Thumann, Eva-Maria Pferschy-Wenzig, Christine Moissl-Eichinger, Rudolf BauerAbstractEthnopharmacological relevance.Many medicinal plants have been traditionally used for the treatment of gastrointestinal disorders. According to the monographs published by the Committee on Herbal Medicinal Products (HMPC) at the European Medicines Agency, currently 44 medicinal plants are recommended in the European Union for the treatment of gastrointestinal disorders based on traditional use. The main indications are functional and chro...
Source: Journal of Ethnopharmacology - August 11, 2019 Category: Drugs & Pharmacology Source Type: research

Sagas of the Solanaceae: Speculative ethnobotanical perspectives on the Norse berserkers
ConclusionsWith its anticholinergic tropane alkaloids and symptom profile, H. niger is a much more likely cause of the berserker state than A muscaria. Though there is not enough archaeological and historical evidence to prove or disprove this theory, it provides a novel explanation that is at present the most viable means of understanding the berserkers' trance. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 11, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the toxicity potential of acute and sub-acute exposure to the aqueous root extract of Aristolochia ringens Vahl. (Aristolochiaceae)
ConclusionThese results show that AR contains detectible aristolochic acid I and has potential to induce toxic responses. Caution must therefore be exercised in its medicinal application especially when required for a prolonged use.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

Botany, traditional uses, phytochemistry, pharmacology and toxicology of Ilex pubescens Hook et Arn
ConclusionsThis review summarizes the results from current studies of I. pubescens, which is one of the valuable medicinal sources from traditional herbs. Some conventional uses have been evaluated by pharmacological investigation. In addition, unresolved issues include molecular mechanisms underlying bioactivities, pharmacokinetics, toxicology and efficacy, which are still being studied and explored before achieving integration into clinical medicines. (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

UPLC-ESI-IT-TOF-MS metabolomic study of the therapeutic effect of Xuefu Zhuyu decoction on rats with traumatic brain injury
This study revealed the holistic and dynamic metabolic changes caused by XFZYD in rats with TBI and provided important research methods and approaches for exploring the multiple metabolites and metabolic pathways involved in the therapeutic effect of XFZYD on TBI.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill
ConclusionOverall, our findings have preliminary confirmed that KYDS is closely related to metabolic and microbial dysbiosis, whereas YGP can improve the metabolic disorder of KYDS by acting on intestinal microbiota. Meanwhile, this will lay the foundation for the further KYDS's metagenomic research and the use of intestinal microbiotas as drug targets to treat KYDS.Graphical abstractIn our study, a comprehensive strategy integrating 1H NMR-based fecal metabonomics and 16S rRNA sequencing analysis was proposed to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect ...
Source: Journal of Ethnopharmacology - August 9, 2019 Category: Drugs & Pharmacology Source Type: research

Berberine restored nitrergic and adrenergic function in mesenteric and iliac arteries from streptozotocin-induced diabetic rats
ConclusionsIn the STZ-induced early diabetic rats, neural control of mesenteric and iliac vasomotor tone are altered differently. The diminished nitrergic nerve on superior mesenteric artery and enhanced adrenergic nerve on iliac artery both contributed to increased vasocontrictor responses. All these changes in diabetic rats were reversed by BBR, suggesting a novel mechanism of BBR in balance of neural regulation of vascular tone.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 8, 2019 Category: Drugs & Pharmacology Source Type: research

Establishment of modified biopharmaceutics classification system absorption model for oral Traditional Chinese Medicine (Sanye Tablet)
ConclusionsThe five representative components (except for nuciferine) are all class III/IV, which correlates well with the absolute bioavailability results and demonstrates that they are poorly absorbed substances. The correlation between the classification results obtained using the “modified-BCS” and absorption in the body is better than the correlation obtained using the classic method, suggesting that the improved BCS is more suitable for the characterization of Sanye Tablet. These results indicate that the oral formulation of Sanye Tablet is a BCS III/IV drug.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 8, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trial
ConclusionsThe therapeutic effect of ShenYanXiaoBai high dose group was better than the two other treated groups from the 5th week to the 7th week, the comparison had a significant difference. The therapeutic effect of benazepril group was better than the ShenYanXiaoBai low dose group in the 7 weeks and the comparison had a significant difference.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L.
ConclusionsUntil now, significant progress has been witnessed in phytochemistry and pharmacology of E. prostrata. Thus, some traditional uses has been well supported and clarified by modern pharmacological studies. Moreover, E. prostrata also showed therapeutic potential in some refractory diseases such as cancer, dementia and diabetes. But, present findings are still insufficient that cannot satisfactorily explain some mechanisms of action. More well-designed studies in vitro especially in vivo are required to establish links between the traditional uses and bioactivities, discover new skeletons and activity molecules, as...
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Immunoregenerative effects of the bionically cultured Sanghuang mushrooms (Inonotus sanghuagn) on the immunodeficient mice
This study aims to establish a practical protocol for culture, particularly for a bunch of production of Sanghuang mushrooms possibly to commercialize the cultured Sanghuang based on deep comparison of quality and pharmacological activities between the cultured and the wild Sanghuang.Materials and methodsA phylogenetic tree containing five strains of the wild Sanghuang was constructed using rDNA markers. Different temperatures and medium compositions were surveyed to develop a practical protocol for culture of the Sanghuang mushrooms. 5-fluorouracil was used to induce the immunodeficient mice. Chemotherapeutic components a...
Source: Journal of Ethnopharmacology - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Phenolic constituents, pharmacological activities, quality control, and metabolism of Dracaena species: A review
ConclusionsDragon's blood is a valuable source of bioactive compounds, mainly flavonoids and their oligomers. Its potential therapeutic effects on different diseases are attractive, such as the notable effect on cardiovascular diseases. In future studies, there is an urgent need to test the effect of this extract on appropriate cell lines and animal models to analyze its ethnopharmacological applications; moreover, “composition−effect correlation” methods and omics technologies are demanded for identifying the effective material basis and therapeutic mechanisms before entering into clinical trials. Moreov...
Source: Journal of Ethnopharmacology - August 5, 2019 Category: Drugs & Pharmacology Source Type: research

Prediction of the mechanisms of action of shenkang in chronic kidney disease: A network pharmacology study and experimental validation
ConclusionsSK exerted a curative effect on CKD and CKD-related diseases by targeting different organs, regulating inflammation and proliferation processes, and inhibiting abnormal extracellular matrix accumulation. Thus, pharmacological network analysis with in vivo validation explained the potential effects and mechanisms of SK in the treatment of CKD. However, these findings need to be further confirmed with clinical studies.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Ginger essential oil and fractions against Mycobacterium spp.
ConclusionsIn general, GEO showed a mix of monoterpenes and sesquiterpenes and a better antimycobacterial activity than the semi-pure fractions. Cytotoxic effects of GEO and its fractions should be better investigated.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of traditional chinese medicine formula Le-Cao-Shi on hepatitis B: In vivo and in vitro studies
ConclusionLCS exerted potent anti-hepatitis effects against the infection of HBV. The above results demonstrated the first-hand experimental evidences for the anti-hepatitis B efficiency of LCS. Our study provides a basis for further exploration and development of this promising compound prescription to treat hepatitis B disease.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense
ConclusionsThe veratramine-type alkaloids from V. taliense may serve as new leads for the discovery of analgesic drugs.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 4, 2019 Category: Drugs & Pharmacology Source Type: research

Soluble yerba mate (Ilex Paraguariensis) extract enhances In vitro osteoblastic differentiation of bone marrow-derived mesenchymal stromal cells
ConclusionsTogether, these results help to explain the promoting effect on osteoblast differentiation produced by a low SYM concentration. However, a higher SYM concentration presented deleterious effects, including cytotoxicity, decreased ALP activity, increased cytokine production, decreased bone marker gene expression, increased MAPK signaling, and significant mineralization reduction. In conclusion, our results suggest a concentration-specific direct stimulatory effect of SYM on osteoblastic differentiation in vitro.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation
ConclusionsOur findings suggest that TGP improved OVA-induced allergic asthma in mice mainly by suppressing Ca2+ influx-dependent mast cell degranulation.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Nigella sativa seed extract applicability in preparations against methicillin-resistant Staphylococcus aureus and effects on human dermal fibroblasts viability
ConclusionsThe observed effectiveness of N. sativa seed extracts against bacteria was found to be dominantly dependent on concentration of thymoquinone. Its efficiency against S. aureus isolates as well as results of cytotoxicity examination against human dermal fibroblasts indicate on its applicability as an antibacterial agent for topical use and motivates further research in this area.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Cyberecoethnopharmacolomics
ConclusionsEthnopharmacology has a major role to play in global health care if the relevant sciences and cutting-edge technologies can coalesce synergistically as a responsive, evidence-based health care practice.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

A systems pharmacology approach to investigate the mechanism of Oryeong-san formula for the treatment of hypertension
ConclusionsThis study used the systems pharmacology approach to decipher the mechanisms of action of ORS for the treatment of hypertension. When hypertension drugs and ORS are used in combination for treatment, possible side effects should be considered because most hypertension drugs are related to the RAAS. The results of this study may provide clues to not only analyze the pharmacological activity of ORS for the treatment of hypertension but other diseases as well.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

The effects of Jilin sika Deer's (Cervus dybowski) tendon liquid supplementation on endurance drop jumps performance, biochemistry profile of free boxing players
ConclusionsTD supplementation leads to better physiological adaptation in free boxing players and has the potential for use as a nutrient supplement toward a variety of benefits for endurance athletes.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs?
ConclusionsPre-clinical in vitro and in vivo animal experiments failed to yield any promising drug leads. However, if the recent randomised controlled trials can be independently replicated in well-designed and executed clinical trials it might indicate that A. afra contain powerful ‘prodrugs’. Future research on A. afra should therefore focus on reproducing the randomised controlled trials and on artificially metabolising A. afra extracts/compounds in order to identify the presence of any ‘prodrugs’.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacology of the club moss subfamily Huperzioideae (Lycopodiaceae, Lycopodiophyta): A phylogenetic and chemosystematic perspective
ConclusionHuperzioideae club mosses have interesting pharmaceutical potential supported by ethnopharmacological investigations. Bioprospecting of these plants should be preceded by careful plant identification to produce consistent and reproducible data. We expect that DNA barcoding and LC-MS-based chemical fingerprinting could facilitate and improve ethnopharmaceutical studies in selection of club moss taxa.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity
ConclusionsTogether, the results herein obtained show that EuL presented anti-inflammatory activity by decreasing the influx of PMN to the inflamed tissue, as well as the cytokine IL-1β level. This anti-inflammatory activity was also accompanied by significant anti-hypersensitive effect. The effects presented by EuL seem not to be correlated with an antioxidant activity. However other extract chemical compounds could be responsible for its important anti-inflammatory effects.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

The protection of indolealkylamines from LPS-induced inflammation in zebrafish
ConclusionsOverall, the mechanism underlying the anti-inflammatory activity of IAAs probably attributed to their capability to suppress NF-κB and MAPKs inflammatory pathway. Meanwhile, IAAs could also interfere the metabolism of SM, Cer and PC probably by regulating LBP, PLA2, CERK, SMPD and SGMS.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Antidiabetic property of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell) leaf extracts in fructose-fed streptozotocin-injected rats via anti-inflammatory activity and inhibition of carbohydrate metabolizing enzymes
Publication date: Available online 30 July 2019Source: Journal of EthnopharmacologyAuthor(s): T. Olabisi Obafemi, M. Tolulope Olaleye, Afolabi C. AkinmoladunAbstractEthnopharmacological relevanceMiracle fruit plant (Synsepalum dulcificum) has many applications in folk medicine. The leaves are used traditionally to treat diabetes and other diseases. The antidiabetic potential of Synsepalum dulcificum leaves in rats has been studied but the mechanisms involved are yet to be elucidated.AimThe present study aimed to provide insight into the antidiabetic mechanisms of methanol and flavonoid-rich leaf extracts of Synsepalum dulc...
Source: Journal of Ethnopharmacology - August 1, 2019 Category: Drugs & Pharmacology Source Type: research

Hyphenated chromatography detection and compound-target-disease investigation on herb-pair Chuanxiong Rhizoma - Xiangfu Rhizoma
ConclusionsOur work successfully explained the compatible mechanism of CR-XR Yaodui, which exert ‘multi-components, multi targets’ in treating Qizhi and Xueyu Zheng.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

The freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb possess hypoglycemic, hypolipidemic and hypoinsulinemic on type 2 diabetes rat model
This study investigated the antihyperglycaemic, antidyslipidemic and antihyperinsulinemic activity of the freeze-dried extracts of Rotheca myricoides (Hochst.) Steane & Mabb (RME) in an animal model of type 2 diabetes mellitus.MethodsType 2 diabetes was induced by dietary manipulation for 56 days via (high fat- high fructose diet) and intraperitoneal administration of streptozocin (30 mg/kg). Forty freshly-weaned Sprague Dawley rats were randomly assigned into the negative control (high fat/high fructose diet), low dose test (50mg/kg RME, high dose test (100mg/kg RME and positive control (Pioglitazone, 20mg/kg) group...
Source: Journal of Ethnopharmacology - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

Plants utilized as medicines by residents of Quilombo da Fazenda, Núcleo Picinguaba, Ubatuba, São Paulo, Brazil: A participatory survey
ConclusionsThe participatory method identified a large number of factors that influence medicinal plant use: the patient's blood type; the condition of the plant and the disease (hot-cold system); the route of administration and dosage; the preventive uses of the plants; and the influence of other factors, such as the sun, the moon and dew. The participatory approach is useful for gaining insight on the decision processes of medicinal plant use in traditional societies, and also for those communities wanting to document their knowledge with or without the participation of the academy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 27, 2019 Category: Drugs & Pharmacology Source Type: research