Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease
ConclusionsGTP protected against mitochondrial dysfunction and neurodegeneration by inducing UPRmt in the Dm PINK1B9 model of PD. Our results suggest that GTP is a promising candidate for PD, and reveal a new mechanism by which ginseng is neuroprotective.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 26, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory properties of the marine plant Posidonia oceanica (L.) Delile
ConclusionsOur results recognize an anti-inflammatory role of P. oceanica phytocomplex particularly emphasizing its cell safe mechanism of action. In conclusion, the marine plant P. oceanica may be of great interest for scientific research as a source of promising molecules for designing alternative strategies to the conventional treatment of inflammatory diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 26, 2019 Category: Drugs & Pharmacology Source Type: research

Bioguided identification of daucosterol, a compound that contributes to the cytotoxicity effects of Crateva adansonii DC (capparaceae) to prostate cancer cells
ConclusionThese results suggest that daucosterol is the major active principle responsible at least in part for the anticancer effect of the extract of Crateva adansonii.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 25, 2019 Category: Drugs & Pharmacology Source Type: research

Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities of harnessing the untapped medicinal plant from the Himalayas
ConclusionsAnalysis of various studies revealed a confusion about the botanical nomenclature of the plants and their geographical distributions. Absence of proper markers for identification of correct samples and improperly conducted studies on N. jatamansi were found to be the major hurdles to the use of ethnobotanical information and research findings into applications for human health. Development of markers using molecular, chemical and pharmacognosy based approaches for plant authentication and, in vitro propagation of authenticated material for easy availability of genuine plant material are the possible solutions to...
Source: Journal of Ethnopharmacology - September 25, 2019 Category: Drugs & Pharmacology Source Type: research

Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum ammi on gastrointestinal nematodes in donkey (Equus asinus): An in vivo study
Publication date: Available online 23 September 2019Source: Journal of EthnopharmacologyAuthor(s): Abbas Imani-Baran, Jalal Abdollahi, Hamid Akbari, Saeed Jafarirad, Sajjad MoharramnejadAbstractEthnopharmacological relevanceTrachyspermum ammi has been used traditionally as a popular ethnobotanical plant in human and animal parasitic infestations. Few scientific studies have been conducted on in vitro anthelmintic activity of T. ammi against various helminths and there is no study on its in vivo/in vitro anthelmintic properties against equine helminths.Aim of the studyThe present study aimed to evaluate in vivo anthelmintic...
Source: Journal of Ethnopharmacology - September 24, 2019 Category: Drugs & Pharmacology Source Type: research

Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control
ConclusionsAn increasing number of reports suggest that BGC can be regarded as an excellent source for exploring the potential antitumor constituents. However, the future antitumor research of BGC needs to follow the standard pharmacology guidelines, so as to provide comprehensive pharmacological information and aid the reproducibility of the data. Besides, to ensure the efficacy and safety of BGC-derived TCMs, it is vital to construct a comprehensive quality evaluation model on the basis of clarifying pharmacodynamic-related and toxicity-related compositions.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 24, 2019 Category: Drugs & Pharmacology Source Type: research

UPLC-HDMS-based on serum metabolomics reveals the toxicity of arecae semen
ConclusionsThis indicated that arecae semen possessed certain cardiotoxicity and inhibited the normal growth in Wistar male rats. In addition, the metabolomics approach is a useful tool to study the toxicity in TCM.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 23, 2019 Category: Drugs & Pharmacology Source Type: research

Central European ethnomedical and officinal uses of peat, with special emphasis on the Tołpa peat preparation (TPP): An historical review
ConclusionsTopical peat cure originated in Austria in about 1820. It evolved as a whole branch of Central European balneology which had been completely scientifically described by the 1950s. At that time an undefined peat extract was once successfully used in ear infections in paediatrics. Stanisław Tołpa's research project to find any internal application of peat ignored the achievements of ethnobiology, balneology, surgery and otorhinolaryngology known at that time. His strenuous and insistent efforts, carried out in isolation, crucially failed pre-clinical and clinical tests in any branch of his therapy. Three commerc...
Source: Journal of Ethnopharmacology - September 22, 2019 Category: Drugs & Pharmacology Source Type: research

Metabolomics coupled with SystemsDock reveal the protective effect and the potential active components of Naozhenning granule against traumatic brain injury
Conclusion1H-NMR based metabolomics and molecular docking provided the insights for the synergistic mechanisms and the potential active compounds of NZN in treating cerebral trauma. However, the bioactive compounds and their synergistic effect need to be further validated.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

Ginkgo biloba extract improves brain uptake of ginsenosides by increasing blood-brain barrier permeability via activating A1 adenosine receptor signaling pathway
ConclusionsEGb might induce ERM/MLC phosphorylation and increase the cell-cell junction gaps to cause a reversible increase of the BBB permeability via A1R signaling pathway. Our results may contribute to better use of EGb in the treatment of brain diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton] – A critical review
ConclusionThe widespread availability and recommendation of synthetic compounds for addressing human health have several side effects besides higher costs. Hence, examining natural bioactive compounds is imperative. This review investigates and presents the pertinent information on cardamom and its traditional uses, as well as potential pharmacological properties of CEO and extracts. Additional research studies are needed to understand the mechanism of action of bioactive constituents.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

The genus Tamarix: Traditional uses, phytochemistry, and pharmacology
ConclusionsTamarix spp. are plants rich in polyphenolic compounds with valuable medicinal properties; though, there are several methodological problems such as lack of a mechanistic approach and taxonomic ambiguities in the current available data. High-quality preclinical studies, as well as well-designed clinical trials are necessary to confirm the safety and efficacy of these plants in humans.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 20, 2019 Category: Drugs & Pharmacology Source Type: research

Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation
ConclusionsOur data show that KLHTT has anti-neutrophilic inflammatory effects in inhibiting ROS generation and cell adhesion. KLHTT also mitigated NET formation, mainly via an ROS-dependent pathway. In addition, KLHTT reduced neutrophil infiltration and improved the severity of IMQ-induced psoriasis-like skin inflammation in mice. Therefore, KLHTT may prove to be a safe and effective psoriasis therapy in the future.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 19, 2019 Category: Drugs & Pharmacology Source Type: research

Musa acuminata and its bioactive metabolite 5-Hydroxymethylfurfural mitigates quorum sensing (las and rhl) mediated biofilm and virulence production of nosocomial pathogen Pseudomonas aeruginosa in vitro
ConclusionThis study investigated the ideal antibiofilm and antivirulence potential of MAM and its bioactive compound 5HMF, and confirms the ethnopharmacological value of these peels against P. aeruginosa infections.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 17, 2019 Category: Drugs & Pharmacology Source Type: research

Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities for harnessing the untapped medicinal plant from the Himalayas
ConclusionsAnalysis of various studies revealed a confusion about the botanical nomenclature of the plants and their geographical distributions. Absence of proper markers for identification of correct samples and improperly conducted studies on N. jatamansi were found to be the major hurdles to the use of ethnobotanical information and research findings into applications for human health. Development of markers using molecular, chemical and pharmacognosy based approaches for plant authentication and, in vitro propagation of authenticated material for easy availability of genuine plant material are the possible solutions to...
Source: Journal of Ethnopharmacology - September 17, 2019 Category: Drugs & Pharmacology Source Type: research

Best practice in research – Overcoming common challenges in phytopharmacological research
ConclusionWe call for an approach which incorporates a careful design, meticulous execution and a detailed reporting of studies focusing on the pharmacology/bioactivity of bioactive preparations. Clearly testable research questions must be developed and investigated experimentally. As the founder of pharmacology Claude Bernard put it already in 1865: ‘…. either the experimenter's hypothesis will be disproved or it will be proved by experiment. When experiment disproves its preconceived ideas, the experimenter must discard or modify it.‘Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2019 Category: Drugs & Pharmacology Source Type: research

You-Gui-Yin improved the reproductive dysfunction of male rats with chronic kidney disease via regulating the HIF1α-STAT5 pathway
ConclusionsYGY has obvious reversal effects on the abnormal symptoms of adenine-induced CKD and the abnormal symptoms of rats with hypothyroidism and male reproductive hypotension. Its mechanism is related to its ability to regulate the HIF1α-STAT5 pathway.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2019 Category: Drugs & Pharmacology Source Type: research

Bioactive components of ethnomedicine Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia
ConclusionCollectively our data suggest that the bioactive chemical pool which is responsible for the therapeutic effects of EW can be extracted in petroleum ether, and fractionated to a relatively small multiple components. Such components include known anti-inflammatory chemicals, which may contribute to the possible microglia polarization in brain lesion during the recovery of ischemic stroke.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: 5 December 2019Source: Journal of Ethnopharmacology, Volume 245Author(s): (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 14, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnobotanical study of medicinal plants in the Adrar Province, Mauritania
Publication date: Available online 11 September 2019Source: Journal of EthnopharmacologyAuthor(s): Cheikh Yebouk, Fatima Zahrae Redouan, Guillermo Benítez, Mohamed Bouhbal, Mohamed Kadiri, Ahmed Ismail Boumediana, Joaquín Molero-Mesa, Abderrahmane MerzoukiGraphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 12, 2019 Category: Drugs & Pharmacology Source Type: research

Differential mRNA expression combined with network pharmacology reveals network effects of Liangxue Tongyu Prescription for acute intracerebral hemorrhagic rats
ConclusionOur study confirmed the exact efficacy of the LTP in the treatment of AICH and revealed the potential pharmacodynamic components and mode of action of the LTP on AICH. Using differential transcriptome of mRNA combined with network pharmacology, we screened out 29 chemical compounds as the potential effective ingredients of LTP which acted on 7 targets of AICH involving 5 pathological pathways, mainly including repairing the brain function defect, improving neural function, protecting blood-brain barrier from damage, reducing inflammatory factors, and inhibiting apoptosis. The present study not only provides a new...
Source: Journal of Ethnopharmacology - September 12, 2019 Category: Drugs & Pharmacology Source Type: research

The effects of Elaeagnus angustifolia L. whole fruit on the sex hormone profile in menopausal women: A double-blind, randomized, placebo-controlled study
ConclusionsThe improvement of the sex hormone profile was not in a full accordance with Iranian folklore after E. angustifolia consumption in the present menopausal participants. However, considering a strong belief on the beneficial effects of E. angustifolia in Iranian folklore, a long-term studies of larger group participants are needed to evaluate the efficacy.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 11, 2019 Category: Drugs & Pharmacology Source Type: research

Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice
ConclusionsThe triterpene derivatives of the dichloromethane extract are likely to be responsible for its anti-psoriatic activity. The abundant polyphenolic load of the decoction contributes to its high antioxidant activity and the most effective results against psoriasis. The anti-psoriatic activity of the decoction confirmed the traditional use of this plant as antioxidant, wound healing and skin barrier repair agent.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 11, 2019 Category: Drugs & Pharmacology Source Type: research

A network pharmacology approach to discover action mechanisms of Yangxinshi Tablet for improving energy metabolism in chronic ischemic heart failure
ConclusionYXS treated chronic ischemic heart failure through activating its targets which play pivotal roles in oxygen delivery, glucose utilization and mitochondrial biogenesis to improve energy metabolism through a multi-component, multi-level, multi-target, multi-pathway and multi-mechanism approaches.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 9, 2019 Category: Drugs & Pharmacology Source Type: research

Improvement on metabolic syndrome in high fat diet-induced obese mice through modulation of gut microbiota by Sangguayin decoction
ConclusionData indicated that SGY reshaped gut microbial structure and improved PUFA metabolism. These functions of SGY may alter hepatic lipid metabolism, conferring preventative effects against high-fat diet induced metabolic syndrome.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 9, 2019 Category: Drugs & Pharmacology Source Type: research

Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models
ConclusionsCOLE therefore, may be a good tocolytic, anti-diarrheal and anti-inflammatory agent and offers hope of new drug discovery for such uses.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 9, 2019 Category: Drugs & Pharmacology Source Type: research

Identification and quantification of the quality markers and anti-migraine active components in Chuanxiong Rhizoma and Cyperi Rhizoma herbal pair based on chemometric analysis between chemical constituents and pharmacological effects
ConclusionsOur study illustrated the underlying correlations between chemical constituents and pharmacological effects, explored the anti-migraine material basis, and could lay a foundation for the improvement of quality control of CRCR in practice.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 9, 2019 Category: Drugs & Pharmacology Source Type: research

Paeonia lactiflora root extract suppresses cancer cachexia by down-regulating muscular NF-κB signalling and muscle-specific E3 ubiquitin ligases in cancer-bearing mice
ConclusionRP restored skeletal muscle function and mass in cancer-bearing mice by down-regulating the muscular NF-κB signalling pathway and muscle-specific E3 ubiquitin ligases. Our study indicates that RP is a potential candidate for development as a therapeutic agent against cancer cachexia.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 8, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of genetic variation and environmental factors on bergenin in Rodgersia sambucifolia Hemsl.
Publication date: Available online 6 September 2019Source: Journal of EthnopharmacologyAuthor(s): Mei-Fang Song, Li-xia Zhang Yue-Zhang, Yan-Hong Guan, Hai-Tao Li, Zhong-Lian ZhangAbstractEthnopharmacological relevanceBergenin is a well-known active compound that exhibits antioxidant, antiarrhythmic, hepatoprotective, and anti-inflammatory activities. However, the resource reserve of Rodgersia sambucifolia, one of the main raw materials for extracting bergenin, have sharply declined, and the bergenin content in different germplasms differs vastly, resulting in a serious shortage of the market supply of bergenin.Aim of the ...
Source: Journal of Ethnopharmacology - September 8, 2019 Category: Drugs & Pharmacology Source Type: research

Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay
ConclusionsIn this work, we identified four natural cannabinoids from two fungi: Ganoderma cochlear (Blume & T. Nees) Bres., Hedwigia and Ganoderma hainanense J.D. Zhao, L.W. Hsu & X.Q. Zhang. They exhibited structural and functional diversities. Our work confirms the presence of active ingredients in the Ganoderma species to CB1 and CB2, and this finding establishes connections between the fungi and the cannabinoid receptors, which will serve as a starting point to connect their beneficial effects to the endocannabinoid system. This research will also enrich the inventory of cannabinoids and phytocannabinoids from...
Source: Journal of Ethnopharmacology - September 6, 2019 Category: Drugs & Pharmacology Source Type: research

Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes
In this study, the gastrointestinal digested donkey milk was simulated in vitro and its products of protein digestion were analyzed by SDS-PAGE. We then performed cell viability assay, insulin secretion assay, animal experiments and ELISA assays to study the anti-diabetic effect of donkey milk in vitro and in vivo. Donkey milk’s anti-diabetic molecular mechanism and specific targets were detected by using quantitative real time PCR.ResultsLysozyme (LZ) and α-lactalbumin (α-La ) exhibited significantly lower digestibility and higher retention than the other components of donkey milk. In vitro, 500 μg/mL...
Source: Journal of Ethnopharmacology - September 6, 2019 Category: Drugs & Pharmacology Source Type: research

Non-random medicinal plants selection in the Kichwa community of the Ecuadorian Amazon
In this study, we used the negative binomial model and an examination of studentized residuals to demonstrate that a Kichwa community in the Ecuadorian Amazon over-utilized different sets of medicinal plant families depending on the gender of the informants or the experience of the community. We showed that utilizing local data instead of nationwide data reveals new over-utilized families. Seven of the nine most over-utilized medicinal plant families we found were previously reported in different biogeographical regions. The other two families are novel reports. Overall, our study proposes a novel method to uncover the int...
Source: Journal of Ethnopharmacology - September 6, 2019 Category: Drugs & Pharmacology Source Type: research

Improvement in mitochondrial function underlies the effects of ANNAO tablets on attenuating cerebral ischemia-reperfusion injuries
ConclusionsThe obtained data demonstrated that ANNAO tablets exhibited an obvious anti-cerebral ischemia-reperfusion effect, which could be attributed to the improvement of mitochondrial quality control.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 6, 2019 Category: Drugs & Pharmacology Source Type: research

Ethnopharmacology, phytochemistry, biological activities, and therapeutic applications of Cedrela serrata Royle: A mini review
ConclusionThere were convincing evidence in in vitro studies supporting C. serrata antioxidant, anti-infective, anti-diabetic, anti-glycating, and cytotoxic activities. Nevertheless, all reported pharmacological activities were carried out in vitro and a gap in research i.e. preclinical and clinical investigation still exists. The authors emphasize the need for future in-depth research and clinical trials to investigate C. serrata pharmacological activity, clinical efficacy and safety. The potential chemical compounds with suggestive classes may need to be isolated and pharmacological activities must be established for the...
Source: Journal of Ethnopharmacology - September 6, 2019 Category: Drugs & Pharmacology Source Type: research

Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique
ConclusionsThis study highlights the clinical application of metabolomics in disease diagnose and therapy evaluation, which will help in improving our understanding of depression and will lay solid foundation for the clinic application of TCMs. In addition, it suggests that the combination of the two potential biomarkers had also achieved a high diagnostic value, which consequently could be used a diagnose biomarkers.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

What do we need to know about drone brood homogenate and what is known
ConclusionsThis paper presents the most important information on the use of drone brood in folk medicine. The studies carried out with the use of animals and humans have shown that the drone brood has an adjuvant effect that improves the efficiency of the organism. Due to its high content of amino acids and proteins, it is used as a tonic and adaptogenic agent. The presence of sex hormones in the homogenate allows its use as a potency raising agent and equalizing the hormonal system in people of both sexes. Based on the facts quoted above, it can be concluded that DBH is a promising nutritional product, an unjustly neglect...
Source: Journal of Ethnopharmacology - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

Anticancer properties of Prunus mume extracts (Chinese plum, Japanese apricot)
ConclusionThe pool of in vitro data and signs of anticancer activities in mice models and in Human, although very limited, support the use of this extract to treat cancer, notably gastro-intestinal tumors. However, more robust evidence of anticancer activity in Human are awaited. Beyond cancer treatment, the use of P. mume extracts to prevent or to treat mucositis and other gastro-intestinal damages induced by anticancer drugs is underlined.The woody plant Prunus mume, a member of the Rosaceae family, has a long plantation history in China, and has widely been planted in Asia due to its high ornamental value (colorful coro...
Source: Journal of Ethnopharmacology - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

In vitro differentiation induction of embryonal carcinoma stem cells into insulin-producing cells by Cichorium intybus L. leaf extract
ConclusionsIn conclusion, LE as a natural herbal extract was efficiently able to induce the differentiation of P19 EC cells into the clusters similar to pancreatic islets with the molecular, cellular and functional characteristics of mature β cells.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

HPLC-ESI-QqQ based standardization, mutagenic and genotoxic potential of methanol extract of Ziziphus mauritiana Lam leaves
ConclusionThe findings of the present study confirm that MEZ is not-mutagenic and non-genotoxic in the presence or absence of the exogenous metabolizing system.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

Transcriptomics and metabolomics reveal the cardioprotective effect of Compound Danshen tablet on isoproterenol-induced myocardial injury in high-fat-diet fed mice
ConclusionThese genes and metabolites might provide clues for further molecular mechanistic study of Compound Danshen tablet.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 2, 2019 Category: Drugs & Pharmacology Source Type: research

Forest fevers: traditional treatment of malaria in the southern lowlands of Laos
ConclusionTraditional healers are important actors in the treatment of malaria in southern Laos, and herbal remedies should be evaluated further by the use of reverse treatment outcome trials, especially those which may be of use as complementary remedies in treating P. vivax. Initiatives on knowledge transmission, medicinal plant conservation and healthcare integration are also urgently needed.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

Indigenous traditional knowledge of medicinal plants used by herbalists in treating opportunistic infections among people living with HIV/AIDS in Uganda
ConclusionThere is wide spread use of a rich diversity medicinal plants species and practices by TMP to manage OI in HIV/AIDS patients in Uganda.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin
ConclusionsLWDH could inhibit the phenotypic conversion of VSMCs in vitro and in vivo by increasing the activity of myocardin through up-regulating the expression of ERα and promoting the interaction between ERα and SRC3. Our research reveals the under mechanism of how LWDH inhibits the phenotypic conversion of VSMCs.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

Synergistic nourishing ‘Yin’ effect of iridoid and phenylpropanoid glycosides from Radix Scrophulariae in vivo and in vitro
ConclusionsThe nourishing ‘Yin’ benefits were clearly produced when IG and PG were used in combination, which provided the scientific evidence of multiple-components and multiple-approach synergistic effect of Chinese traditional herbal medicine to control and management of diseases.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

Melissa officinalis ssp. altissima extracts: A therapeutic approach targeting psoriasis in mice.
ConclusionsThe triterpene derivatives of the dichloromethane extract are likely to be responsible for its anti-psoriatic activity. The abundant polyphenolic load of the decoction contributes to its high antioxidant activity and the most effective results against psoriasis. The anti-psoriatic activity of the decoction confirmed the traditional use of this plant as antioxidant, wound healing and skin barrier repair agent.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 30, 2019 Category: Drugs & Pharmacology Source Type: research

Hypericum olympicum L. recovers DNA damage and prevents MMP–9 activation induced by UVB in human dermal fibroblasts
ConclusionExperimental studies have proven the traditional use of Hypericum olympicum in inflamed skin problems acting by inhibition of the inflammatory pathway and recovery of DNA damage induced experimentally.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 30, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory activity of the sesquiterpene lactone diacethylpiptocarphol in dextransulfate sodium-induced colitis in mice
ConclusionsSesquiterpene lactone DPC, isolated from Vernonia scorpioides showed anti-inflammatory activity, in this experimental model of colitis the sesquiterpene lactones DPC and PTH exhibit equal anti-inflammatory activity.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 30, 2019 Category: Drugs & Pharmacology Source Type: research

Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv
ConclusionThis paper reports for the first time antiplasmodial principles from C. racemosum and thereby gives reason to the traditional use of the plant.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 30, 2019 Category: Drugs & Pharmacology Source Type: research

Antihypertensive and antidiabetic activities of Erythrina senegalensis DC (Fabaceae) stem bark aqueous extract on diabetic hypertensive rats
ConclusionThese results suggest that the aqueous extract of E. senegalensis possess antihypertensive, hypoglycemic, hypolipidemic, cardiomodulator and antioxidant properties involved in the improvement of the metabolic disorders found in HDR. This may be due at least in part to the presence of Erysenegalensein (D, O, N, E), Warangalone, senegalensin and 6,8-diprenylgenistein identified in the extract.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 30, 2019 Category: Drugs & Pharmacology Source Type: research

Antifungal and biofilm inhibitory effect of Cymbopogon citratus (lemongrass) essential oil on biofilm forming by Candida tropicalis isolates; an in vitro study
ConclusionCymbopogon citratus oil has good potential to be used as an antifungal and antibiofilm agent on silicone rubber prostheses and medical devices on which C. tropicalis biofilms form a serious risk for skin infections and may cause a shorter lifespan of the prosthesis.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - August 28, 2019 Category: Drugs & Pharmacology Source Type: research