Journal of Environmental Pathology, Toxicology and Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A Systems Biology Approach Unveils a Critical Role of DPP4 in Upper Gastrointestinal Cancer Patient Outcomes
This study was intended to elucidate the correlation of DPP4 expression and survival along with prognosis, followed by its associated enriched molecular pathways and immune cell marker levels in upper GI cancers. Results demonstrated a strong correlation between increased DPP4 expression and a worse prognosis in esophageal and gastric cancer and the co-expressed common genes with DPP4 were associated with crucial molecular pathways involved in tumorigenesis. Additionally, DPP4 was shown to be significantly linked to several immune infiltrating cell marker genes, including Macrophages (M1, M2 and Tumor Associated Macrophage...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Sudhir Kotnala Anupam Dhasmana Swati Dhasmana Shafiul Haque Murali M Yallapu Manish K Tripathi Meena Jaggi Subhash C Chauhan Source Type: research

Role of Alpha-Fetoprotein in the Pathogenesis of Cancer
J Environ Pathol Toxicol Oncol. 2024;43(2):57-76. doi: 10.1615/JEnvironPatholToxicolOncol.2023049145.ABSTRACTAlpha-fetoprotein (AFP) belongs to the albuminoid protein family and is considered as the fetal analog of serum albumin. This plasma protein is initially synthesized in the fetal liver and yolk sac and shows a maximum peak near the end of the first trimester. Later, concentrations begin to decline prenatally and drop precipitously after birth. This protein has three key ligand-binding pockets for interactions with various biomolecules. It contains multiple phosphorylation and acetylation sites for the regulation of ...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Alok Ghosh Chaudhuri Saptadip Samanta Monalisha Dey N S Raviraja Souvik Dey Source Type: research

Probing the Potential: Exploring Probiotics as a Novel Frontier in Cancer Prevention and Therapeutics
J Environ Pathol Toxicol Oncol. 2024;43(2):77-90. doi: 10.1615/JEnvironPatholToxicolOncol.2023049792.ABSTRACTCancer has emerged as one of the most prevalent diseases worldwide, with a consistent rise in the number of cases observed over the past few decades. The rising mortality rates associated with cancer have transformed it into a significant global challenge. Despite the presence of various anti-cancer drugs, the complete eradication of cancer remains an elusive goal. The numerous undesirable effects associated with cancer therapy further emphasize the importance of developing an alternative technique of cancer treatme...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Akhil Nair Kanchanlata Tungare Ameyota De Renitta Jobby Source Type: research

TFR1-Mediated Iron Metabolism Orchestrates Tumor Ferroptosis and Immunity in Non-Small Cell Lung Cancer
This study aimed to investigate the underlying molecular mechanisms of transferrin receptor (TFR1) in non-small cell lung cancer (NSCLC). Histological analysis was performed using hematoxylin-eosin (HE) staining. The number of CD8+ T cell were determined by flow cytometry and immunofluorescence assays. mRNA levels were analyzed by qRT-PCR. Protein expression was detected by western blot. Ferroptosis was detected by using propidium iodide (PI) staining. Xenograft experiment was applied for determining tumor growth. The results showed that interferon (IFN)-γ plus iron dextran (FeDx) induced iron overload and the ferroptosis...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Zunqiao Wang Xingkai Yao Keping Wang Bin Wang Source Type: research

Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure
In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor genomes by Whole-Genome Sequencing and High-Resolution SNP array. We also used various computational algorithms to detect both CNAs and complex chromosomal rearrangements. Genomic data obtained from each bioinformatics tool are interpreted comparatively to better understand CNAs and cancer-related Nucleotide variations in MPM tumors. In patients 1 and 2, we found pathogenic nucleotide variants of BAP1, RB1, and TP53. These two MPM genomes exhibit...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Tun ç Tuncel G üntülü Ak Hasan Veysi G üneş Muzaffer Metinta ş Source Type: research

Withaferin A-Encapsulated PEGylated Nanoliposomes Induce Apoptosis in B16F10 Melanoma Cells by Regulating Bcl2 and Bcl xl Genes and Mitigates Murine Solid Tumor Development
J Environ Pathol Toxicol Oncol. 2024;43(2):29-42. doi: 10.1615/JEnvironPatholToxicolOncol.2023046909.ABSTRACTWithaferin A (WA) is a natural steroidal lactone with promising pharmacological activities, but its poor solubility and bioavailability hinder its clinical application. The liposomal drug delivery system has attracted considerable attention to overcome the delivery limitations of pharmacological agents. The present study investigated the effect of WA-loaded pegylated nanoliposomes (LWA) on in vitro and in vivo B16F10 melanoma tumor models. In vitro results showed that LWA had significantly (P < 0.01) higher cytot...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Prathapan Abeesh Chandrasekharan Guruvayoorappan Source Type: research