Issue Information ‐ PI
(Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Tags: Issue Information ‐ PI Source Type: research
Physiological study of the anorectal reflex in patients with functional anorectal and defecation disorders
CONCLUSIONSAnorectal motor, sensory and reflex abnormalities are seen in distinct patterns in patients with FI and constipation. This would suggest distinct physiological differences that may predict the potential for different neuromodulation treatment and behavioral modalities in these conditions. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Authors: Kumaran Thiruppathy, John Mason, Khalid Akbari, Amanda Raeburn, Anton Emmanuel Tags: Original Article Source Type: research
Nonvariceal upper gastrointestinal bleeding in elderly people: Clinical outcomes and prognostic factors
CONCLUSIONSClinical evolution and mortality do not differ between the elderly and younger patients with acute nonvariceal UGIB. Serum albumin level at admission is a prognostic marker for mortality in elder patients. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Authors: Jos é A González‐González, Roberto Monreal‐Robles, Diego García‐Compean, Jonathan Paz‐Delgadillo, Martín Wah‐Suárez, Héctor J. Maldonado‐Garza Tags: Original Article Source Type: research
Risk factors and clinical outcome of Clostridium difficile infection in patients with IBD: A single ‐center retrospective study of 260 cases in China
CONCLUSIONS
PCR‐based fecal test for CDI should be performed in these IBD patients. Hb <100 g/L may be an important risk factor for CDI in IBD. For patients with CDI, antibiotics should be administered promptly to prevent abdominal abscess. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Authors: Yu Bei Gu, Mao Chen Zhang, Jing Sun, Ke Zhi Lv, Jie Zhong Tags: Original Article Source Type: research
Use of neurotransmitter regulators in functional gastrointestinal disorders based on symptom analysis
It has been a great challenge for gastroenterologists to cope with functional gastrointestinal disorders (FGIDs) in clinical practice due to the contemporary increase in stressful events. A growing body of evidence has shown that neuroregulators such as anti‐anxiety agents and antidepressants function well on FGIDs, particularly in cases that are refractory to classical gastrointestinal (GI) medications. Among these central‐acting agents, small individualized doses of tricyclic antidepressants and selective serotonin reuptake inhibitors are usually recommended as a complement to routine GI management. When these drugs ...
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Authors: Qing Qing Luo, Sheng Liang Chen Tags: Review Article Source Type: research
Issue Information ‐ TOC
(Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 6, 2017 Category: Gastroenterology Tags: Issue Information ‐ TOC Source Type: research
Rise of PD ‐L1 expression during metastasis of colorectal cancer: implications for immunotherapy
In conclusion, PD‐L1 is prevalently expressed in metastatic CRCs, and increased PD‐L1 expression is frequently found in metastatic CRC as compared to primary tumor. These findings suggest that PD‐L1 expression in metastatic CRC should be considered as an independent factor while evaluating the suitability of patients for immunotherapy. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 1, 2017 Category: Gastroenterology Authors: Huanbin Wang, Han Yao, Chushu Li, Lunxi Liang, Yao Zhang, Yingxuan Chen, Jing ‐Yuan Fang, Jie Xu Tags: Original article Source Type: research
Successful eradication of Helicobacter pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), plus rabeprazole after failure of triplet therapy with vonoprazan: a report of three cases
ABSTRACT
Vonoprazan, a potassium‐competitive acid blocker, is used as a substitute drug for conventional proton pump inhibitors. Recently, vonoprazan has been applied for eradication of H. pylori (HP) infection, and the efficacies of vonoprazan‐based triple therapy against HP infection have already been reported. However, treatment sometimes fails in the primary and/or secondary triplet eradication therapy, including with the use of vonoprazan for HP infection. We experienced three cases of refractory HP infection. They were treated with eradication therapy for HP infection with chronic gastritis. After primary triplet...
Source: Journal of Digestive Diseases - June 1, 2017 Category: Gastroenterology Authors: Yutaka Nagata, Kazuhiko Nagasaka, Syunpei Koyama, Mai Murase, Minoru Saito, Toshinori Yazaki, Nobutoshi Komatsu, Takayuki Murase, Toshiki Uehara, Norihide Taniuchi Tags: Case report Source Type: research
Critical assessment of thioguanine treatment for Inflammatory Bowel Diseases: is it time to rehabilitate this treatment?
CONCLUSIONThe evidence to support thioguanine treatment is limited to observational studies. While encouraging, there is a need for prospective randomised controlled trials to determine the place of thioguanine in the management of inflammatory bowel disease. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 1, 2017 Category: Gastroenterology Authors: Ramya Movva, Alison Haywood, Sohil A Khan, Timothy H J Florin, Iulia Oancea Tags: Original article Source Type: research
Acute hemorrhagic rectal ulcer (AHRU) syndrome: comparison with non ‐AHRU lower gastrointestinal bleeding
ConclusionsAmong patients with massive hematochezia, 21.2% had AHRU. The majority of the AHRU patients (88%) were managed endoscopically. Low serum albumin level, poor ECOG performance status, and prior constipation could be used in distinguishing AHRU from non‐AHRU bleeding cases and could facilitate selection of the optimal bowel preparation method for massive hematochezia. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 1, 2017 Category: Gastroenterology Authors: Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam ‐Hoon Kim, Kyung‐Ah Kim, June Sung Lee Tags: Original article Source Type: research
Clinical pattern and prevalence of upper gastrointestinal toxicity in ketamine abusers
ConclusionAlthough epigastric symptoms are unusual in the young population, upper gastrointestinal toxicity was highly prevalent in over one‐quarter of ketamine abusers. Enquiry about ketamine abuse was recommended when assessing young patients with epigastric symptoms. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - June 1, 2017 Category: Gastroenterology Authors: Shirley Yuk Wah Liu, Stephen Ka Kei Ng, Yuk Him Tam, Samuel Chi Hang Yee, Franco Pui Tak Lai, Cindy Yuek Lam Hong, Philip Wai Yan Chiu, Enders Kwok Wai Ng, Chi Fai Ng Tags: Original article Source Type: research
Can clinical factors predict the need for intervention after positive intraoperative cholangiogram?
ConclusionsApproximately half of patients with abnormal IOC had normal ERCP. Elevated transaminases and sonographic biliary dilation have poor predictive value for choledocholithiasis. Thus, patients with a positive IOC may benefit from additional studies such as EUS or MRCP prior to ERCP. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - May 26, 2017 Category: Gastroenterology Authors: Mohammed Kaif, Deepak Agrawal, Jayaprakash Sreenarasimhaiah Tags: Original article Source Type: research
TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma
ConclusionTNFSF9 is a tumor suppressor in HCC. Based on its immune stimulatory aspect and the tumor inhibition property, TNFSF9 may be a promising therapeutic target for HCC. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - May 26, 2017 Category: Gastroenterology Authors: Yuling Shen, Yu Gan, Haifeng Gao, Yingchao Fan, Qing Wang, Hui Yuan, Yanfang Song, Jiadong Wang, Hong Tu Tags: Original article Source Type: research
Hypertriglyceridemic acute pancreatitis in an Emergency Department: the typical clinical features and genetic variants
CONCLUSIONSHTGAP had significantly remarkable severity and a higher trend of recurrence rate. Genetic information may be helpful for clinicians to investigate the pathogenesis of HTGAP and take interventions. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - May 26, 2017 Category: Gastroenterology Authors: Wan Jun Chen, Xiao Fan Sun, Rui Xue Zhang, Min Jie Xu, Tong Hai Dou, Xiao Bin Zhang, Min Zhong, Wei Qiang Yang, Li Liu, Xiao Ye Lu, Chang Qing Zhu Tags: Original article Source Type: research
A single disease entity for both chromosomal instable subtype gastric adenocarcinoma and esophageal adenocarcinoma
Abstract
According to the 2012 World Health Organization (WHO) statistic data,1 gastric carcinoma affects the Chinese population more than any other populations and over 42.5% (405 000/952 000) of gastric cancer (GC) patients published in that year were Chinese. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - May 16, 2017 Category: Gastroenterology Authors: Qin Huang Tags: Review Article Source Type: research
