Post-occlusive reactive hyperaemia of skin microvasculature and foot complications in type 2 diabetes
Diabetes-related microvascular disease has been implicated in the development of foot ulceration and amputation. Assessment of microvascular function may be effective in identifying those at risk of diabetic foot complications. We investigated the relationship between active or previous foot complication and post-occlusive reactive hyperaemia (PORH) measured by laser-Doppler fluxmetry (LDF) in people with type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 14, 2017 Category: Endocrinology Authors: S.M. Lanting, A.L. Barwick, S.M. Twigg, N.A. Johnson, M.K. Baker, S.K. Chiu, I.D. Caterson, V.H. Chuter Source Type: research

Dissociation of Local and Global Skeletal Muscle Oxygen Transport Metrics in Type 2 Diabetes
Exercise capacity is impaired in type 2 diabetes, and this impairment predicts excess morbidity and mortality. This defect appears to involve excess skeletal muscle deoxygenation, but the underlying mechanisms remain unclear. We hypothesized that reduced blood flow, reduced local recruitment of blood volume/hematocrit, or both contribute to excess skeletal muscle deoxygenation in type 2 diabetes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 14, 2017 Category: Endocrinology Authors: P. Mason McClatchey, Timothy A. Bauer, Judith G. Regensteiner, Irene E. Schauer, Amy G. Huebschmann, Jane E.B. Reusch Source Type: research

Frailty and Sarcopenia - newly emerging and high impact complications of diabetes
Diabetes increases the risk of physical dysfunction and disability. Diabetes-related complications and coexisting morbidities partially explain the deterioration in physical function. The decline in muscle mass, strength and function associated with diabetes leads to sarcopenia, frailty and eventually disability. Frailty acts as a mediator in the pathogenesis of disability in older people with diabetes and its measurement in routine daily practice is recommended. Frailty is a dynamic process which progresses from a robust condition to a pre-frail stage then frailty and eventually disability. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 12, 2017 Category: Endocrinology Authors: AJ Sinclair, AH Abdelhafiz, L Rodr íguez-Mañas Source Type: research

Prevalence of Overactive Bladder and its Impact on Quality of Life in 1025 Patients with Type 2 Diabetes in Mainland China
This study examined the prevalence of overactive bladder (OAB) and investigated the impact of OAB on quality of life (QOL) in patients with type 2 diabetes in Mainland China. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 10, 2017 Category: Endocrinology Authors: Dongjuan Xu, Jie Gao, Xiaojuan Wang, Liqun Huang, Kefang Wang Source Type: research

Neuropathy and Presence of Emotional Distress and Depression in Longstanding Diabetes: Results From the Canadian Study of Longevity in Type 1 Diabetes
To determine the association of neuropathy and other complications with emotional distress and depression among patients with longstanding type 1 diabetes (T1DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 10, 2017 Category: Endocrinology Authors: Johnny-Wei Bai, Leif E. Lovblom, Marina Cardinez, Alanna Weisman, Mohammed A. Farooqi, Elise M. Halpern, Genevieve Boulet, Devrim Eldelekli, Julie A. Lovshin, Yuliya Lytvyn, Hillary A. Keenan, Michael H. Brent, Narinder Paul, Vera Bril, David Z.I. Cherney Source Type: research

Urinary lysophopholipids are increased in diabetic patients with nephropathy
Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assessed whether LPA and LPC were associated to the development of nephropathy in diabetic human patients. Several molecular species of LPA and LPC were quantified by LC/MS –MS in urine and plasma from type 2 diabetic patients with (cases; n=41) or without (controls, n=41) nephropath...
Source: Journal of Diabetes and Its Complications - May 10, 2017 Category: Endocrinology Authors: Jean-S ébastien Saulnier-Blache, Eva Feigerlova, Jean Michel Halimi, Pierre Gourdy, Ronan Roussel, Bruno Guerci, Aude Dupuy, Justine Bertrand-Michel, Jean-Loup Bascands, Samy Hadjadj, Joost P. Schanstra Source Type: research

Corneal confocal microscopy best identifies the development and progression of neuropathy in patients with Type 1 Diabetes
A sub-set of 38 individuals with type 1 diabetes that fulfilled a strict criterion of “normal” classification for all 7 measures of neuropathy at baseline, were identified and followed. Corneal nerve morphology, as captured with corneal confocal microscopy demonstrated the greatest, and most sustained degeneration over a 4 year period. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 5, 2017 Category: Endocrinology Authors: Katie Edwards, Nicola Pritchard, Cirous Dehghani, Dimitrios Vagenas, Anthony Russell, Rayaz A Malik, Nathan Efron Source Type: research

Predicting Readmission Risk of Patients with Diabetes Hospitalized for Cardiovascular Disease: A Retrospective Cohort Study
To develop and validate a tool that predicts 30d readmission risk of patients with diabetes hospitalized for cardiovascular disease (CVD), the Diabetes Early Readmission Risk Indicator-CVD (DERRI-CVD ™). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 5, 2017 Category: Endocrinology Authors: Daniel J. Rubin, Sherita Hill Golden, Marie E. McDonnell, Huaqing Zhao Source Type: research

Lower cognitive performance among long-term type 1 diabetes survivors
We examined if long-standing T1D without complications is associated with lower cognitive performance. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 4, 2017 Category: Endocrinology Authors: Anna Awad, Robert Lundqvist, Olov Rolandsson, Anna Sundstr öm, Mats Eliasson Source Type: research

Retraction notice to "Acarbose on insulin resistance after an oral fat load: a double-blind, placebo controlled study"
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 3, 2017 Category: Endocrinology Authors: Giuseppe Derosa, Pamela Maffioli, Angela D'Angelo, Elena Fogari, Lucio Bianchi, Arrigo F.G Cicero Source Type: research

Erratum to “Prevalence and risk factors for diabetic retinopathy at diagnosis (DRAD) in patients recently diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA)” [J Diabetes Complications 30(8): 1456–1461]
In the article above, there is an incorrect description of regression models (p. 1459, and in the table footer of Table 3 (p. 1460) and supplementary table). All results in the original tables are of the correct regression models, described below: (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 3, 2017 Category: Endocrinology Authors: Mats Martinell, Mozhgan Dorkhan, Jan St ålhammar, Petter Storm, Leif Groop, Carin Gustavsson Source Type: research

Structured Lifestyle Intervention in Patients with the Metabolic Syndrome Mitigates Oxidative Stress but Fails to Improve Measures of Cardiovascular Autonomic Neuropathy
To assess the role of oxidative stress in mediating adverse outcomes in metabolic syndrome (MetS) and resultant cardiovascular autonomic neuropathy (CAN), and to evaluate the effects of lifestyle interventions on measures of oxidative stress and CAN in subjects with MetS. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 2, 2017 Category: Endocrinology Authors: Subramaniam Pennathur, Mamta Jaiswal, Elizabeth A. White, Lynn Ang, David M. Raffel, Melvyn Rubenfire, Rodica Pop-Busui Source Type: research

The clinical characteristics of patients with mitochondrial tRNA Leu(UUR)m.3243A > G mutation: Compared with type 1 diabetes and early onset type 2 diabetes
This study presents nine patients with mitochondrial tRNA Leu (UUR) m.3243A>G mutation and compares the clinical characteristics and diabetes complications with type 1 diabetes (T1DM) or early onset type 2 diabetes (T2DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 28, 2017 Category: Endocrinology Authors: Jie Zhu, Peng Yang, Xiang Liu, Li Yan, Sharvan Rampersad, Feng Li, Hong Li, Chunjun Sheng, Xiaoyun Cheng, Manna Zhang, Shen Qu Source Type: research

Multi-center feasibility study of microwave radiometry thermometry for non-invasive differential diagnosis of arterial disease in diabetic patients with suspected critical limb ischemia
Diagnosis of vascular involvement in diabetic foot ulceration (DFU) remains challenging. We conducted a proof of concept study to investigate the feasibility of microwave radiometry (MWR) thermometry for non-invasive differential diagnosis of critical limb ischemia (CLI) in subjects with DFU. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 28, 2017 Category: Endocrinology Authors: Stavros Spiliopoulos, Vasiliki Theodosiadou, Nikolaos Barampoutis, Konstantinos Katsanos, Periklis Davlouros, Lazaros Reppas, Panagiotis Kitrou, Konstantinos Palialexis, Chrysostomos Konstantos, Elias Siores, Dimitrios Alexopoulos, Dimitris Karnabatidis, Source Type: research

The Clinical Characteristics of patients with Mitochondrial tRNA Leu(UUR)m.3243A > G mutation: Compared with Type 1 diabetes and Early onset type 2 diabetes
This study presents nine patients with mitochondrial tRNA Leu (UUR) m.3243A>G mutation and compares the clinical characteristics and diabetes complications with type 1 diabetes (T1DM) or early onset type 2 diabetes (T2DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - April 28, 2017 Category: Endocrinology Authors: Jie Zhu, Peng Yang, Xiang Liu, Li Yan, Sharvan Rampersad, Feng Li, Hong Li, Chunjun Sheng, Xiaoyun Cheng, Manna Zhang, Shen Qu Source Type: research