Comparison of Plasma Pigment Epithelium-Derived Factor (PEDF), Retinol Binding Protein 4 (RBP-4), Chitinase-3-Like Protein 1 (YKL-40) and Brain-Derived Neurotrophic Factor (BDNF) for the Identification of Insulin Resistance
To evaluate and compare the association of four potential insulin resistance (IR) biomarkers (pigment-epithelium-derived factor [PEDF], retinol-binding-protein-4 [RBP-4], chitinase-3-like protein 1 [YKL-40] and brain-derived neurotrophic factor [BDNF]) with objective measures of IR. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 8, 2017 Category: Endocrinology Authors: FJK Toloza, MC P érez-Matos, ML Ricardo-Silgado, MC Morales-Álvarez, JO Mantilla-Rivas, JA Pinzón-Cortés, M Pérez-Mayorga, ML Arévalo-García, G Tolosa-González, CO Mendivil Source Type: research

Participation in a National Lifestyle Change Program is Associated with Improved Diabetes Control Outcomes
Clinical trials show lifestyle change programs are beneficial, yet large-scale, successful translation of these programs is scarce. We investigated the association between participation in the largest U.S. lifestyle change program, MOVE!, and diabetes control outcomes. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 6, 2017 Category: Endocrinology Authors: Sandra L Jackson, Lisa Staimez, Sandra Safo, Qi Long, Mary K Rhee, Solveig A Cunningham, Darin E Olson, Anne M Tomolo, Usha Ramakrishnan, KM Venkat Narayan, Lawrence S Phillips Source Type: research

Impaired balance is related to the progression of diabetic complications in both young and older adults
To investigate the balance ability in younger and older adults with diabetes and evaluate the associations between balance ability and microvascular complications. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 4, 2017 Category: Endocrinology Authors: Daisuke Kukidome, Takeshi Nishikawa, Miki Sato, Yoshiko Nishi, Risa Shimamura, Junji Kawashima, Seiya Shimoda, Hiroshi Mizuta, Eiichi Araki Source Type: research

H. pylori seroprevalence and risk of diabetes: an ancillary case –control study nested in the Diabetes Prevention Program
To determine the association between H. pylori infection and risk of incident diabetes in adults at high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 3, 2017 Category: Endocrinology Authors: Saud Alzahrani, Jason Nelson, Steven F. Moss, Jessica K. Paulus, William C. Knowler, Anastassios G. Pittas, Diabetes Prevention Program Research Group Source Type: research

Effect of Dipeptidyl Peptidase-4 Inhibitors on Circulating Tumor Necrosis Factor- α Concentrations: A Systematic Review and Meta-Analysis of Controlled Trials
Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes mellitus. There are also reports of an effect of these drugs in reducing inflammation through inhibition of tumor necrosis factor- α (TNF-α) that is an important mediator for several inflammatory processes. The present systematic review and meta-analysis was performed to evaluate the effect of DPP-4 inhibitors on circulating TNF-α levels in T2DM patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 3, 2017 Category: Endocrinology Authors: Stephen L. Atkin, Niki Katsiki, Maciej Banach, Dimitri P. Mikhailidis, Matteo Pirro, Amirhossein Sahebkar Source Type: research

GLP-1 receptor agonist, liraglutide, ameliorates hepatosteatosis induced by anti-CD3 antibody in female mice
Hepatosteatosis is mainly induced by obesity and metabolic disorders, but various medications also induce hepatosteatosis. The administration of anti-CD3 antibody was shown to induce hepatosteatosis, but changes in lipid and glucose metabolism remain unclear. We investigated the mechanism of hepatosteatosis induced by anti-CD3 antibody and the effects of glucagon-like peptide-1 (GLP-1) receptor agonist that was recently shown to affect immune function in metabolic disorders. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - June 1, 2017 Category: Endocrinology Authors: Arata Itoh, Junichiro Irie, Hirotsune Tagawa, Yukie Kusumoto, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Kikuchi, Masataka Fujita, Yuya Nakajima, Yuehong Wu, Satoru Yamada, Toshihide Kawai, William M Ridgway, Hiroshi Itoh Source Type: research

EDITORIAL: The Continuum of Dysglycemia: Predicting Progression from Prediabetes to Type 2 Diabetes
In the first Global Diabetes Report, released in 2016, the World Health Organization noted that the “prevalence of diabetes is steadily increasing everywhere…”1 Currently, there are more than 422 million adults with diabetes worldwide, and the global estimate is projected to increase to nearly 600 million adults by 2040.1–3 The country-specific estimates indicate that the top 10 nations wi th the highest diabetes burden are China (109.6 million), India (99.2 million), the United States of America (29.3 million), Brazil (14.3 million), Russian Federation (12.1 million), Mexico (11.5 million), Indonesia (10 million),...
Source: Journal of Diabetes and Its Complications - May 27, 2017 Category: Endocrinology Authors: Sam Dagogo-Jack Source Type: research

Signs of subclinical atherosclerosis in asymptomatic patients at increased risk of type 2 diabetes mellitus
We aimed to study carotid intima media thickness (CIMT) in asymptomatic patients with an increased risk of type 2 diabetes mellitus (T2DM) and in a pre-diabetic state. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2017 Category: Endocrinology Authors: Loretta Zsuzsa Kiss, Zsolt Bagyura, R éka Vadas, Lívia Polgár, Árpád Lux, Eszter Édes, Orsolya Szenci, Pál Soós, Zsolt Szelid, Dávid Becker, György Jermendy, Béla Merkely Source Type: research

Atherosclerosis associated with dynamic inflammation changes after multifactorial intervention in short-duration type 2 diabetes: A randomized, controlled, 10-year follow-up trial
To analyze the impact of dynamic changes in inflammation on atherosclerosis in short-duration type 2 diabetes after multifactorial intervention. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2017 Category: Endocrinology Authors: Chunhong Shi, Lili Men, Cuiping Yu, Junjie Yao, Ran Bai, Yu Yang, Lipeng Sun, Guohua Sun, Guirong Song, Yuhong Zhang, Qian Xing, Jianling Du Source Type: research

Type 2 Diabetes Specialty Clinic Model for the Accountable Care Organization Era
A third of the patients with Type 2 diabetes have an advance disease that requires complex pharmacotherapies and advanced expertise, dependent on multiple clinical interactions. Unfortunately, limited providers availability enables only sporadic interactions. Additionally, the expanding Accountable Care Organization (ACO) concept enhances providers' compensation when clinical performance is improving while limiting face-to-face clinic visits. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2017 Category: Endocrinology Authors: Heather Klingeman, Martha Funnell, Amolak Jhand, Sangeeta Lathkar-Pradhan, Israel Hodish Source Type: research

Validation of a quick screening instrument for measuring fear of hypoglycaemia in persons with diabetes
Fear of hypoglycaemia (FoH) presents in 10 –25% of persons with diabetes [1] and has a negative impact on well-being, diabetes self-management and metabolic control [2,3]. Despite improvements in diabetes treatment [4,5], FoH remains a major barrier in achieving glycaemic control and good quality of life. In medical practice, the extensive FoH lists are insufficiently used outside research settings and hypoglycaemias are both underreported and not asked for [6]. This could be bypassed by a quick and practical screening procedure in busy clinics [7]. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 25, 2017 Category: Endocrinology Authors: C.B. Schmidt, B.J. Potter van Loon, E. Kili ç, F.J. Snoek, A. Honig Tags: Letter to the Editor Source Type: research

Once weekly glucagon-like peptide-1 receptor agonist albiglutide vs. prandial insulin added to basal insulin in patients with type 2 diabetes mellitus: Results over 52 weeks
We have previously reported that once-weekly albiglutide was noninferior to thrice-daily lispro for glycemic lowering, with decreased weight and risk of hypoglycemia, in patients inadequately controlled on basal insulin over 26 weeks. Findings after 52 weeks reveal similar responses to albiglutide as an add-on to insulin glargine. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 24, 2017 Category: Endocrinology Authors: Lawrence A. Leiter, Jorge Luiz Gross, Francis Chow, Diane Miller, Susan Johnson, Bo Ahr én, for the HARMONY 6 Study Group Source Type: research

Once weekly glucagon-like peptide-1 receptor agonist albiglutide vs prandial insulin added to basal insulin in patients with type 2 diabetes mellitus: results over 52weeks
We have previously reported that once-weekly albiglutide was noninferior to thrice-daily lispro for glycemic lowering, with decreased weight and risk of hypoglycemia, in patients inadequately controlled on basal insulin over 26 weeks. Findings after 52 weeks reveal similar responses to albiglutide as an add-on to insulin glargine. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 24, 2017 Category: Endocrinology Authors: Lawrence A. Leiter, Jorge Luiz Gross, Francis Chow, Diane Miller, Susan Johnson, Bo Ahr én, for the HARMONY 6 Study Group Source Type: research

Table of Contents
(Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 18, 2017 Category: Endocrinology Source Type: research

Intensive Glycemic Control in Younger and Older U.S. Adults with Type 2 Diabetes
To determine the extent to which older vs. younger adults with diabetes intensively control glycemia. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - May 18, 2017 Category: Endocrinology Authors: Sarah Casagrande, Catherine C. Cowie, Judith E. Fradkin Source Type: research