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Molecular Mechanisms of Nonalcoholic Fatty Liver Disease: Potential Role for 12-Lipoxygenase
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane —mainly arachidonic acid and linoleic acid—to prod...
Source: Journal of Diabetes and Its Complications - July 31, 2017 Category: Endocrinology Authors: Niharika Samala, Sarah A. Tersey, Naga Chalasani, Ryan M. Anderson, Raghavendra G. Mirmira Tags: Review article Source Type: research

Red cell distribution width is associated with hemoglobin A1C elevation, but not glucose elevation
To investigate the association between red cell distribution width (RDW) and elevation of glucose/glycated hemoglobin (HbA1c). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 29, 2017 Category: Endocrinology Authors: Xue Bao, Min Wan, Yeqing Gu, Yanqi Song, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, HongBin Shi, Qian Su, Liyun Fang, Huijun Yang, Fei Yu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Guolin Wang, Ming Yu, Kaijun Niu Source Type: research

Healthcare Resource Use and Associated Costs of Hypoglycemia in Patients with Type 2 Diabetes Prescribed Sulfonylureas
The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 28, 2017 Category: Endocrinology Authors: Berhanu Alemayehu, Jinan Liu, Swapnil Rajpathak, Samuel S. Engel Source Type: research

The association between pulse wave velocity and peripheral neuropathy in patients with type 2 diabetes mellitus
Diabetic peripheral neuropathy (DPN) is the most common diabetic complication, affecting up to half of the patients with type 2 diabetes mellitus (T2DM). Increased aortic stiffness, measured with the carotid-femoral pulse wave velocity (PWV), has been associated with incidence of cardiovascular disease independently of traditional risk factors. Previous data showed associations between risk factors for macroangiopathy and DPN in diabetes. However, the association between PWV and DPN is not well known. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 26, 2017 Category: Endocrinology Authors: Anastasios Tentolouris, Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Gerasimos Siasos, Ioannis Ntanasis-Stathopoulos, Nikolaos Tentolouris Source Type: research

Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice
Calcium Dobesilate (CaD) is beneficial in early stages of diabetic retinopathy (DR), but its mechanisms of action remains to be elucidated. The aim was to investigate the effect of CaD on proinflammatory cytokines and oxidative stress. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 26, 2017 Category: Endocrinology Authors: Patricia Bogdanov, Cristina Sol à-Adell, Cristina Hernández, Marta García-Ramírez, Joel Sampedro, Olga Simó-Servat, Marta Valeri, Christian Pasquali, Rafael Simó Source Type: research

Nutrition therapy for diabetes: Implications for decreasing cardiovascular complications
The diabetic state confers an increased risk for premature cardiovascular diseases (CVD) including myocardial infarction and ischemic stroke. Furthermore CVD is the leading cause of mortality. Potential mechanisms mediating the increased risk include dyslipidemia, hypertension, advanced glycation, a pro-coagulant diathesis, increased oxidative stress anda pro- inflammatory state.1,2 (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 26, 2017 Category: Endocrinology Authors: Ishwarlal Jialal, Naval Vikram Source Type: research

Myo-inositol lowers the risk of developing gestational diabetic mellitus in pregnancies: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
to explore the potential benefit of myo-inositol on pregnant women with high risk of developing gestational diabetes mellitus (GDM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 20, 2017 Category: Endocrinology Authors: Xianshan Guo, Shizhe Guo, Zhiyi Miao, Zhen Li, Hongya Zhang Tags: Review article Source Type: research

The Readmission Rates in Patients with versus those without Diabetes Mellitus at an Urban Teaching Hospital
We examined the 30-day hospital readmission rates and their association with the admission diagnosis and the length of stay (LOS) in patients with diabetes versus those without diabetes mellitus (DM) in an urban teaching hospital. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 18, 2017 Category: Endocrinology Authors: Halis Sonmez, Varinder Kambo, Dimiter Avtanski, Larry Lutsky, Leonid Poretsky Source Type: research

Serum amyloid A enrichment impairs the anti-inflammatory ability of HDL from diabetic nephropathy patients
This study compared the anti-inflammatory capacities of HDL from healthy controls, T2DM patients with normal renal function, and T2DM patients with DN. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 13, 2017 Category: Endocrinology Authors: Jing Yan Mao, Jia Teng Sun, Ke Yang, Wei Feng Shen, Lin Lu, Rui Yan Zhang, Xue Mei Tong, Yan Liu Source Type: research

Relative changes in earned income five years after diagnosis with diabetes: A register based study 1996-2012
With previous studies indicating that diabetes affects employment status and lifetime earnings, the aim of this study was to determine the impact on earnings in the immediate period after diagnosis. Recognising that earnings and employment status are dynamic over the life course, we matched people with diabetes to counterparts in the general population and compared nominal growth in earned income five calendar years after diagnosis. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 9, 2017 Category: Endocrinology Authors: Bryan Cleal, Ulrik Haagen Panton, Ingrid Willaing, Richard I.G. Holt Source Type: research

Association of angiotensin-II levels with albuminuria in subjects with normal glucose metabolism, prediabetes, and type 2 diabetes mellitus
The relationship between the renin –angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 6, 2017 Category: Endocrinology Authors: Se Hee Min, Sung Hye Kong, Jie-Eun Lee, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Kyong Soo Park, Hak Chul Jang, Soo Lim Source Type: research

Left Ventricular Mass, Geometry and Function in Diabetic Patients Affected by Coronary Artery Disease
Coronary artery disease(CAD) is quite common among diabetic patients, our study goal is to detect the prevalence of left ventricular(LV) adverse changes in geometry, mass and diastolic function on diabetic, but not hypertensive patients, with coronary artery disease(CAD) and LV ejection fraction(LVEF)> 45%, actually unknown, because of current guidelines that do not include echocardiographic assessment for follow up of diabetic patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 6, 2017 Category: Endocrinology Authors: Maria Maiello, Annapaola Zito, Santa Carbonara, Marco Matteo Ciccone, Pasquale Palmiero Source Type: research

Comparison of MDRD, CKD-EPI, and Cockcroft-Gault equation in relation to measured glomerular filtration rate among a large cohort with diabetes
To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 5, 2017 Category: Endocrinology Authors: Anke Schwandt, Michael Denkinger, Peter Fasching, Martin Pfeifer, Christian Wagner, J örg Weiland, Andrej Zeyfang, Reinhard W. Holl Source Type: research

Sex-Dependent Effects of Diabetes Mellitus on the Revascularization Rate in Mid-Term Follow Up of Young Patients with Coronary Artery Disease
We investigated the association between Type-2 diabetes mellitus (DM) and the need for revascularization at a 5-year follow-up of young coronary artery disease patients and the role of sex in this regard. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 4, 2017 Category: Endocrinology Authors: Masoumeh Lotfi-Tokaldany, Seyed Hesameddinn Abbasi, Abbasali Karimi, Seyed Ebrahim Kassaian, Tahereh Davarpasand, Arash Jalali, Saeed Sadeghian Source Type: research

No evidence for progressive deterioration in stimulated insulin secretion in renal transplant recipients after 12 years Tacrolimus exposure
Tacrolimus (Tac) inhibits insulin secretion in a Tac-trough blood level dependent way early post-transplant in renal transplant recipients (Rtx). It is unknown whether long-term exposure results into a progressive beta cells dysfunction. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - July 4, 2017 Category: Endocrinology Authors: Mari ëlle A.C.J. Gelens, Johannes P. van Hooff, Len Usvyat, Maarten H. Christiaans Source Type: research