Cost-Utility of Empagliflozin in Patients with Type 2 Diabetes at High Cardiovascular Risk
In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for the prevention of cardiovascular morbidity and mortality in patients with T2D. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - October 13, 2017 Category: Endocrinology Authors: Elaine Nguyen, Craig I. Coleman, Suresh Nair, Erin R. Weeda Source Type: research

Epidemiological characteristics of lower extremity arterial disease in Chinese diabetes patients at high risk: a prospective, multicenter, cross-sectional study
To determine the epidemiological characteristics of lower extremity arterial disease (LEAD) in high-risk patients and identify practical gaps in LEAD management. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - October 13, 2017 Category: Endocrinology Authors: Xiaomei Zhang, Xingwu Ran, Zhangrong Xu, Zhifeng Cheng, Feixia Shen, Yanmei Yu, Lin Gao, Sanbo Chai, Changjiang Wang, Jianying Liu, Jing Liu, Zilin Sun, Jiajun Zhao, Linong Ji, China DIA-LEAD Study Investigators Source Type: research

Cardiovascular Benefits of Combined Interval Training and Post-Exercise Nutrition in Type 2 Diabetes
The purpose of this study was to examine whether the combination of high-intensity interval training (HIIT) and post-exercise protein supplementation would improve cardiovascular outcomes in individuals with T2D. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - October 13, 2017 Category: Endocrinology Authors: Monique E. Francois, Kevin J. Pistawka, Frank A. Halperin, Jonathan P. Little Source Type: research

Serum lipids and mortality in an American Indian population: a longitudinal study
This study examines the relationship between serum lipids and mortality in American Indians. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - October 3, 2017 Category: Endocrinology Authors: Stephanie K. Tanamas, Pierre-Jean Saulnier, Robert L. Hanson, Robert G. Nelson, Wen-Chi Hsueh, Maurice L. Sievers, Peter H. Bennett, William C. Knowler Source Type: research

Longitudinal trends and predictors of statin use among patients with diabetes
Statins reduce morbidity and mortality among patients with diabetes, but their use remains suboptimal. Understanding trends in statin use may inform strategies for improvement. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 25, 2017 Category: Endocrinology Authors: Meghan B. Brennan, Elbert S. Huang, Jennifer M. Lobo, Hyojung Kang, Marylou Guihan, Anirban Basu, Min-Woong Sohn Source Type: research

AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages
Advanced glycation end products (AGEs) are non-enzymatically glycated protein, lipid, or nucleic acid by Maillard reaction,1 found in extracellular fluid including blood plasma and tissues. AGEs are often increased in aging, but mainly in poorly controlled diabetes mellitus and chronic kidney disease2 and independently relate to total and cardiovascular mortality.3 By interacting with the receptor for AGE (RAGE), AGEs induce oxidative stress and NF-KB-mediated transactivation of inflammatory genes and Rage, leading to vascular damage. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 22, 2017 Category: Endocrinology Authors: Rodrigo Tallada Iborra, Adriana Machado-Lima, Ligia Shimabukuro Okuda, Paula Ramos Pinto, Edna R. Nakandakare, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella, Russell Pickford, Tom Woods, Margaret A. Brimble, Kerry-Anne Rye, Rui Lu, Shinji Yokoyama Source Type: research

Self-rated health among American adolescents with type 1 diabetes in the T1D Exchange Clinic Registry
The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 22, 2017 Category: Endocrinology Authors: Nada A. Abualula, Margaret F. Rodan, Renee A. Milligan, Kathryn H. Jacobsen Source Type: research

Severe Hypoglycemia is a Risk Factor for Atrial Fibrillation in Type 2 Diabetes Mellitus: Nationwide Population-Based Cohort Study
This study investigated the association between severe hypoglycemia (SH) and new onset atrial fibrillation (AF) and all-cause mortality in adult patients with type 2 diabetes mellitus (T2DM). (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 19, 2017 Category: Endocrinology Authors: Seung-Hyun Ko, Yong-Moon Park, Jae-Seung Yun, Seon-Ah Cha, Eue-Keun Choi, Kyungdo Han, Eugene Han, Yong-Ho Lee, Yu-Bae Ahn Source Type: research

Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort
To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 19, 2017 Category: Endocrinology Authors: Anne Gedebjerg, Thomas Peter Almdal, Klara Berencsi, J ørgen Rungby, Jens Steen Nielsen, Daniel R. Witte, Søren Friborg, Ivan Brandslund, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen Source Type: research

Relation of Elevated Serum Uric Acid Levels to First-degree Heart Block and Other Cardiac Conduction Defects in Hospitalized Patients with Type 2 Diabetes
Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 19, 2017 Category: Endocrinology Authors: Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher Source Type: research

The importance of subclinical left ventricular dysfunction and blood pressure pattern in asymptomatic type-2 diabetic patients: the diagnostic and prognostic significance of Tissue Doppler parameters, left ventricular global longitudinal strain, and nighttime blood pressure during sleep
The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 15, 2017 Category: Endocrinology Authors: Angelina Stevanovic, Milica Dekleva Source Type: research

Brain gray matter changes in type 2 diabetes mellitus: A meta-analysis of whole-brain voxel-based morphometry study
We aimed to identify alterations in global gray matter volumes (GMV) and consistent regional abnormalities in T2DM patients via meta-analysis. Methods: A systematic search for relevant studies indexed in the PubMed and Embase databases was conducted. A quantitative meta-analysis of volumetric and whole-brain VBM data was conducted using STATA v.12.0 and AES-SDM software packages, respectively. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 15, 2017 Category: Endocrinology Authors: Guangyao Wu, Lin Lin, Qing Zhang, Jianlin Wu Source Type: research

The relation between HbA1c and hypoglycemia revisited; a secondary analysis from an intervention trial in patients with type 1 diabetes and impaired awareness of hypoglycemia
We aimed to re-assess the previously shown but recently disputed association between HbA1c and severe hypoglycemia. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 15, 2017 Category: Endocrinology Authors: Cornelis A.J. van Beers, Martine G. Caris, J. Hans DeVries, Erik H. Sern é Source Type: research

Validating the Association between Plasma Tumour Necrosis Factor Receptor 1 Levels and the Presence of Renal Injury and Functional Decline in Patients with Type 2 Diabetes
Elevated plasma soluble tumour necrosis factor receptor 1(TNFR1) predicts long-term progression of chronic kidney disease. We investigated the association between elevated TNFR1 and the presence of renal disease in patients with Type 2 diabetes mellitus registering a haemoglobin A1c (HbA1c)>48mmol/mol despite medical therapy. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 15, 2017 Category: Endocrinology Authors: Alison Doody, Sabrina Jackson, Jessie A. Elliott, Ronan J. Canavan, C. Godson, David Slattery, Patrick J. Twomey, Malachi J. McKenna, Carel W. le Roux, Neil G. Docherty Source Type: research

Blood glucose and pressure controls in diabetic kidney disease: narrative review of adherence, barriers and evidence of achievement
This article reviews the epidemiology and the clinical evidence regarding achieving blood pressure (BP) and blood glucose control in patients with CKD and DM, with emphasis on adherence and barriers within the context of Australian clinical guidelines. (Source: Journal of Diabetes and Its Complications)
Source: Journal of Diabetes and Its Complications - September 15, 2017 Category: Endocrinology Authors: Fergus William Gardiner, Ezekiel Uba Nwose, Phillip Taderera Bwititi, Judith Crockett, Lexin Wang Tags: Review article Source Type: research