Indeterminate cell histiocytosis in a Chinese patient with florid and extensive nodular lesions and mixed intermediate cell and macrophage ‐monocyte bilineage
We report here a case of a healthy young Chinese woman who presented with disfiguring thick, infiltrated cutaneous nodules on the face, trunk and extremities which appeared progressively over a period of 4 years. No systemic involvement has been detected so far. Results of a skin biopsy showed diffuse dermal infiltration of histiocytoid cells with indented nuclei and positive staining for S100 and CD1a and negativity for CD207 (langerin). Admixed within were some CD68‐positive foamy histiocytes and multinucleated giant cells with focal positivity for CD163. Though the clinical presentation is more typical of progressive ...
Source: Journal of Cutaneous Pathology - February 22, 2018 Category: Pathology Authors: Qiping Chen, Joyce Siong ‐See Lee, Weiting Michelle Liang, Mei Fung Chan, Ramón M Pujol, Requena Luis, Suat Hoon Tan Tags: CASE REPORT Source Type: research
An unusual clinical presentation of myxoid dermatofibrosarcoma protuberans with a prominent vasculature: a potential pitfall in the diagnosis of myxoid soft tissue tumors
Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor that arises primarily on the trunk and extremities but seldom on the scalp. Several variants of DFSP have been described, including myxoid DFSP. Although typical DFSP may have focally myxoid areas, myxoid DFSP, in which most of the stroma is myxoid, is rare and can pose diagnostic challenges. Here, we report a case of myxoid DFSP with an unusual clinical presentation that could have been mistaken for a lipoma. Additionally, the myxoid DFSP displayed prominent vasculature in a myxoid stroma, which could have been mistaken for a myxoid liposarcoma. (Source: J...
Source: Journal of Cutaneous Pathology - February 22, 2018 Category: Pathology Authors: Patrick Tran, Gregory P Henderson, Michael McLemore Tags: CASE REPORT Source Type: research
Nerve alterations showing autophagy in two patients with lichen aureus
This report describes two patients with lichen aureus, a 20‐year‐old woman with a lesion on her right arm and a 51‐year‐old man with a lesion on the right side of his groin. Skin biopsy specimens revealed almost identical findings in both patients, including dense band‐like infiltrates containing lymphocytes, histiocytes with hemosiderin deposits scattered extravasated red blood cells and nerve alterations at the dermo‐epidermal interface. The nerves within the lesions were filled with granules, which stained positive with antibody to microtubule‐associated protein 1A/1B‐light chain 3, suggesting autophagy ...
Source: Journal of Cutaneous Pathology - February 22, 2018 Category: Pathology Authors: M. Yanagihara, T. Makino, T. Shimizu, T. Mochizuki Tags: CASE REPORT Source Type: research
Granulomatous and lichenoid Dermatitis after IgG4 anti ‐PD‐1 Monoclonal Antibody Therapy for Advanced Cancer
Nivolumab is a fully human IgG4 monoclonal antibody directed against programmed cell death protein 1 (PD‐1). PD‐1 inhibition allows T‐cell activation and recruitment to destroy cancer cells. Checkpoint inhibitors have shown significant survival advantage and relatively low side effects in comparison with conventional chemotherapy in several types of advanced cancer. Granulomatous cutaneous reactions have been reported showing sarcoidal and panniculitic morphology. Here we present a case of drug‐induced lichenoid and granulomatous dermatitis after checkpoint inhibitor therapy observed in a 63‐year‐old male treat...
Source: Journal of Cutaneous Pathology - February 22, 2018 Category: Pathology Authors: Julio A. Diaz ‐Perez, Mara G. Beveridge, Victor A. Thomas, Thomas L. Cibull Tags: CASE REPORT Source Type: research
Multiple perineuriomatous melanocytic nevi
We present a possibly unique case of a patient with multiple such perineuriomatous nevi. This presentation raises the possibility of a germline mutation may be responsible for the pathogenesis of these unusual lesions. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 22, 2018 Category: Pathology Authors: Emily NC Ryder, Nicolas Turnball, Patrick O Emanuel Tags: CASE REPORT Source Type: research
Sox10 positive breast carcinoma metastatic to the skin
Journal of Cutaneous Pathology, EarlyView. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 19, 2018 Category: Pathology Source Type: research
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Journal of Cutaneous Pathology, Ahead of Print. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 19, 2018 Category: Pathology Source Type: research
Superficial acral fibromyxoma in the heel with new vascular features on dermoscopy
We report a case of SAFM in a rare localization in the heel with a new entity on dermoscopy. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 15, 2018 Category: Pathology Authors: Asude Kara Polat, Muge Gore Karaali, Asli Vefa Turgut Erdemir, Ayse Esra Koku Aksu, Cem Leblebici, Mehmet Salih Gurel Tags: CASE REPORT Source Type: research
Histological Immune Response Patterns in Sentinel Lymph Nodes Involved by Metastatic Melanoma and Prognostic Significance
ConclusionsNodal micromorphometric features (i.e. FCC) are likely related to host immune response to metastasis. Quantitative evaluation of lymphoid follicular centers could provide valuable prognostic information to help to stratify patients. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 15, 2018 Category: Pathology Authors: James Abbott, Meghan Buckley, Laura A. Taylor, George Xu, Giorgos Karakousis, Brian J. Czerniecki, Phyllis A. Gimotty, Paul J. Zhang Tags: ORIGINAL ARTICLE Source Type: research
Molecular Testing Practices and Perceptions among Dermatopathologists
ConclusionsWider adoption of molecular testing in dermatopathology may be limited by factors such as physician training, test costs/insurance coverage, logistical issues, and lack of evidence‐based clinical practice guidelines. Dermatopathologists have concerns regarding clinical validity/utility and inappropriate/overuse of some molecular tests. The importance of longitudinal education in molecular technologies and their applications for trainee and practicing physicians is highlighted. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 13, 2018 Category: Pathology Authors: Kristin Torre, Preeti Jhorar, Rong Wu, John Pfeifer, Zendee Elaba, Michael Murphy Tags: ORIGINAL ARTICLE Source Type: research
GATA ‐3 staining in primary cutaneous apocrine cribriform carcinoma: usefulness To differentiate it from breast cancer metastasis
CONCLUSIONEven when GATA3 expression has been reported in many benign and malignant adnexal tumors, mostly the sebaceous, follicular and apocrine ones, as well as in many other neoplasms, GATA3 staining to differentiate PCACC from skin breast cancer metastasis has a high negative predictive value. A positive GATA3 staining in this context should led to rule out PCACC with a high level of confidence. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 12, 2018 Category: Pathology Authors: M. Llamas ‐Velasco, Y. C. Pérez‐Gónzalez, E. Daudén, A. Rütten Tags: ORIGINAL ARTICLE Source Type: research
Cutaneous Refractile Foreign Body Microemboli with Intravascular Injection of Oral Medication
We present a case of a 35‐year‐old male with a complex medical history of Von Willebrand disease, Behcet's disease and diverticular disease. Following a sigmoidectomy/colostomy for diverticular perforation, he presented with fever and an indurated right arm displaying livedoid purpura. The right distal fingertips showed purpura with focal ulceration. A punch biopsy of the right wrist did not show evidence of inflammatory vasculitis or pyogenic infection, but instead demonstrated a focus of polarizing, refractile material occluding a dilated arterial lumen within the mid‐dermis. The patient admitted to injecting a sus...
Source: Journal of Cutaneous Pathology - February 12, 2018 Category: Pathology Authors: Nicholas Bercovici, Kristen Russomanno, Frank Santoro, Christopher Scola, Michael Murphy, Zendee Elaba Tags: CASE REPORT Source Type: research
Issue Information
(Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 9, 2018 Category: Pathology Tags: ISSUE INFORMATION Source Type: research
Histopathological findings in pregnancy associated cutaneous hyperpigmentation
Hyperpigmentation in pregnancy is a common phenomenon, experienced to some degree by up to 90% of pregnant women. It mainly involves sun‐exposed areas, but it can extend to non‐exposed zones. Cases with extensive hyperpigmentation are rarely reported. In this paper, we describe the case of a 30‐year‐old phototype V woman in her 37th week of pregnancy, who presented with brownish hyperpigmentation of the skin in extensive areas, including both axillae, the abdomen and the lowest part of the back. In the abdomen, there was a reinforcement of the hyperpigmentation through the linea nigra and the umbilicus. The hyperpi...
Source: Journal of Cutaneous Pathology - February 9, 2018 Category: Pathology Authors: Angel Fernandez ‐Flores, Juan M. Barja, Alejandro Vilas‐Sueiro, Antonio Alija Tags: CASE REPORT Source Type: research
