Cognitive, Behavioural, Speech, Language and Developmental Outcomes Associated with Pathogenic Variants in the ERF Gene
This study investigates cognitive, behavioural, speech, language, and developmental outcomes in the first 5 children identified at the Oxford Craniofacial Unit as having ERF-related craniosynostosis, together with three of their carrier parents. There were no consistent findings related to overall intelligence. However, a pattern of cognitive difficulties is described, which includes poor attention, impulsivity and difficulties with functional fine motor skills, such as handwriting. A high frequency of speech, language and communication difficulties was evident, which was most often related to early language difficultie...
Source: Journal of Craniofacial Surgery - September 1, 2022 Category: Surgery Tags: Clinical Studies Source Type: research

Application of Deep Learning Techniques for Automated Diagnosis of Non–Syndromic Craniosynostosis Using Skull
Non–syndromic craniosynostosis (NSCS) is a disease, in which a single cranial bone suture is prematurely fused. The early intervention of the disease is associated with a favorable outcome at a later age, so appropriate screening of NSCS is essential for its clinical management. The present study aims to develop a classification and detection system of NSCS using skull X-ray images and a convolutional neural network (CNN) deep learning framework. A total of 56 NSCS cases (scaphocephaly [n = 17], trigonocephaly [n = 28], anterior plagiocephaly [n = 8], and posterior plagiocephaly [n = 3]) and 25 healthy control infants we...
Source: Journal of Craniofacial Surgery - September 1, 2022 Category: Surgery Tags: Clinical Studies Source Type: research

Facial Flap Necrosis From COVID-19 Face Mask Precautions
Abstract: Use of facial mask coverings has been a strong Centers for Disease Control and Prevention recommendation as an essential mitigation measure in the spread of the SARS-CoV-2 novel coronavirus (COVID)-19 virus. Face mask utilization has been shown to induce changes in the skin microclimate, especially around the perioral and perinasal regions. This results in increased mask adjustments and development of friction between masks and the underlying skin. The authors report novel findings of 2 individuals with skin cancer who underwent facial reconstruction during the COVID-19 pandemic. They encountered untoward seq...
Source: Journal of Craniofacial Surgery - September 1, 2022 Category: Surgery Tags: Clinical Studies Source Type: research

Computed Tomography Assessment of Maxillary Sinus and Inferior Nasal Airway After Le Fort I Osteotomy
This study aimed to evaluate and predict the factors that affect the postoperative maxillary sinus and inferior nasal cavity conditions after Le Fort I osteotomy. Subjects and Methods: The rate of aerated (healthy) sinus area and the inferior nasal airway area were calculated by preoperative computed tomography measurements and at 1 week and 1 year postoperatively. Factors predicting the rate of aerated sinus area and the ratio of the inferior nasal cavity area after 1-week were examined using these variables. Results: The subjects consisted of 112 patients (224 sides) who underwent Le Fort I osteotomy with s...
Source: Journal of Craniofacial Surgery - September 1, 2022 Category: Surgery Tags: Clinical Studies Source Type: research

Resection of Tumors Located in the Anterior Skull Base and Sellar Region Through the Supraorbital Keyhole Approach via a Forehead Wrinkle Incision: Modifications and Deficiencies
Conclusions: The SKA via forehead wrinkle incision is a flexible and feasible method for tumors near the midline of the anterior skull base and sellar region. However, this approach requires strict preoperative planning, which includes choosing appropriate tumors and applicable forehead wrinkles. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - September 1, 2022 Category: Surgery Tags: Clinical Studies Source Type: research