Bartonella spp. as a Possible Cause or Cofactor of Feline Endomyocarditis–Left Ventricular Endocardial Fibrosis Complex
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): T.A. Donovan, N. Balakrishnan, I. Carvalho Barbosa, T. McCoy, E.B. Breitschwerdt, P.R. FoxSummaryEndomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp....
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Histocytic-like Atypical Mast Cell Tumours in Horses
This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1–2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferat...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Distribution of Connective Tissue in the Male and Female Porcine Liver: Histological Mapping and Recommendations for Sampling
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): P. Mik, Z. Tonar, A. Malečková, L. Eberlová, V. Liška, R. Pálek, J. Rosendorf, M. Jiřík, H. Mírka, M. Králíčková, K. WitterSummaryThe pig is a large animal model that is often used in experimental medicine. The aim of this study was to assess, in normal pig livers, sexual dimorphism in the normal fraction of hepatic interlobular and intralobular connective tissue (CT) in six hepatic lobes and in three macroscopical regions of interest (ROIs) with different positions rel...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Caseous Lymphadenitis Caused by Corynebacterium pseudotuberculosis in Alpine Chamois (Rupicapra r. rupicapra): a Review of 98 Cases
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): L. Domenis, R. Spedicato, E. Pepe, R. Orusa, S. RobettoSummaryCorynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) in domestic and wild ruminants. Here we describe CLA in alpine chamois (Rupicapra r. rupicapra) based on a series of 98 cases of C. pseudotuberculosis infection confirmed by bacteriology and gene sequence analysis. The population included 53 males and 45 females distributed within three age groups: up to 18 months (n = 14), 18 months to 4 years (n = 11) and over 4 yea...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Flow Cytometric Characterization of S-phase Fraction and Ploidy in Lymph Node Aspirates from Dogs with Lymphoma
We describe DNA-content analysis using LN aspirates from 112 dogs with lymphoma. S-phase fraction (SPF) accurately discriminated between low- and high-grade lymphomas, with 3.15% being the best discriminating cut-off value. SPF values strongly correlated with Ki67 expression as assessed by FC. Survival analyses were restricted to 33 dogs with high-grade B-cell lymphoma receiving standardized multi-agent chemotherapy, but no significant result was obtained for SPF. We also describe a subset of aneuploid cases and their respective follow-up. We conclude that DNA content analysis may be combined with morphological examination...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Pectoral Vessel Density and Early Ultrastructural Changes in Broiler Chicken Wooden Breast Myopathy
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): H.-K. Sihvo, N. Airas, J. Lindén, E. PuolanneSummaryIn wooden breast myopathy (WBM) of broiler chickens, the pectoralis major muscles show abnormally hard consistency and microscopical myodegeneration of unknown aetiology. To date, previous studies have focused primarily on chronic WBM and ultrastructural descriptions of early WBM are lacking. The aim of this study was to elucidate the pathogenesis of WBM by light microscopical morphometry of vessel density and the ultrastructural description of early WBM changes with transmissi...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

The Temporomandibular Joint of the Domestic Dog (Canis lupus familiaris) in Health and Disease
This study aimed to characterize the histological, biomechanical and biochemical properties of the temporomandibular joint (TMJ) of the domestic dog in health and disease. In addition, we sought to identify structure–function relationships and to characterize TMJ degenerative lesions that may be found naturally in this species. TMJs (n = 20) from fresh cadaver heads (n = 10) of domestic dogs were examined macroscopically and microscopically and by cone-beam computed tomography. The TMJ discs were evaluated for their mechanical and biochemical properties. If TMJ arthritic changes were found, p...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Role of Angiopoietin-like 4 on Bone Vascularization in Chickens Exposed to High-altitude Hypoxia
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): S. Huang, M. Wang, M.U. Rehman, L. Zhang, X. Tong, Y. Shen, J. LiSummaryThe aim of this study was to investigate the role and expression of a novel angiogenic factor (angiopoietin-like 4, ANGPTL4) in tibial growth plates of broiler chickens exposed to high-altitude hypoxia. One-day-old healthy broiler chickens (n = 120) were transported from lowland to a high-altitude hypoxic region (nearly 3,000 m above sea level) and were reared under hypoxic- (natural lower oxygen content) and normoxic conditions (nearly 21% oxygen co...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Comparative Pathogenicity of Malaysian QX-like and Variant Infectious Bronchitis Virus Strains in Chickens at Different Age of Exposure to the Viruses
In this study, the pathogenicity of IBS130/2015 (QX-like) and IBS037A/2014 (variant) IBVs in 1-day-old and 30-day-old specific pathogen free (SPF) chickens was characterized. Both strains caused respiratory and kidney infections based on immunohistochemistry (IHC), real-time quantitative polymerase chain reaction (qPCR) and a ciliostasis study; however, the results showed that the QX-like strain was more pathogenic, caused higher mortality and showed higher tissue tropism for the kidney than the variant strain. In contrast, despite causing low or no mortality depending on the age of the infected chickens, the Malaysian var...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Comparative Neuropathology of Major Indian Bluetongue Virus Serotypes in a Neonatal BALB/c Mouse Model
This study of the relative neurovirulence of BTV serotypes is likely to help design suitable vaccination and control strategies for the disease. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Bartonella spp. as a Possible Cause or Cofactor of Feline Endomyocarditis–Left Ventricular Endocardial Fibrosis Complex
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): T.A. Donovan, N. Balakrishnan, I. Carvalho Barbosa, T. McCoy, E.B. Breitschwerdt, P.R. FoxSummaryEndomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp....
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Histocytic-like Atypical Mast Cell Tumours in Horses
This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1–2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferat...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Distribution of Connective Tissue in the Male and Female Porcine Liver: Histological Mapping and Recommendations for Sampling
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): P. Mik, Z. Tonar, A. Malečková, L. Eberlová, V. Liška, R. Pálek, J. Rosendorf, M. Jiřík, H. Mírka, M. Králíčková, K. WitterSummaryThe pig is a large animal model that is often used in experimental medicine. The aim of this study was to assess, in normal pig livers, sexual dimorphism in the normal fraction of hepatic interlobular and intralobular connective tissue (CT) in six hepatic lobes and in three macroscopical regions of interest (ROIs) with different positions rel...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Bartonella spp. as a Possible Cause or Cofactor of Feline Endomyocarditis –Left Ventricular Endocardial Fibrosis Complex
Publication date: July 2018 Source:Journal of Comparative Pathology, Volume 162 Author(s): T.A. Donovan, N. Balakrishnan, I. Carvalho Barbosa, T. McCoy, E.B. Breitschwerdt, P.R. Fox Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp. DNA...
Source: Journal of Comparative Pathology - July 5, 2018 Category: Pathology Source Type: research

Comparative Neuropathology of Major Indian Bluetongue Virus Serotypes in a Neonatal BALB/c Mouse Model
This study of the relative neurovirulence of BTV serotypes is likely to help design suitable vaccination and control strategies for the disease. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 4, 2018 Category: Pathology Source Type: research

Histocytic-like Atypical Mast Cell Tumours in Horses
This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1–2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferat...
Source: Journal of Comparative Pathology - June 30, 2018 Category: Pathology Source Type: research

Distribution of Connective Tissue in the Male and Female Porcine Liver: Histological Mapping and Recommendations for Sampling
Publication date: July 2018 Source:Journal of Comparative Pathology, Volume 162 Author(s): P. Mik, Z. Tonar, A. Malečková, L. Eberlová, V. Liška, R. Pálek, J. Rosendorf, M. Jiřík, H. Mírka, M. Králíčková, K. Witter The pig is a large animal model that is often used in experimental medicine. The aim of this study was to assess, in normal pig livers, sexual dimorphism in the normal fraction of hepatic interlobular and intralobular connective tissue (CT) in six hepatic lobes and in three macroscopical regions of interest (ROIs) with different positions relativ...
Source: Journal of Comparative Pathology - June 28, 2018 Category: Pathology Source Type: research

The Temporomandibular Joint of the Domestic Dog (Canis lupus familiaris) in Health and Disease
This study aimed to characterize the histological, biomechanical and biochemical properties of the temporomandibular joint (TMJ) of the domestic dog in health and disease. In addition, we sought to identify structure–function relationships and to characterize TMJ degenerative lesions that may be found naturally in this species. TMJs (n = 20) from fresh cadaver heads (n = 10) of domestic dogs were examined macroscopically and microscopically and by cone-beam computed tomography. The TMJ discs were evaluated for their mechanical and biochemical properties. If TMJ arthritic changes were found, p...
Source: Journal of Comparative Pathology - June 15, 2018 Category: Pathology Source Type: research

Comparative Pathogenicity of Malaysian QX-like and Variant Infectious Bronchitis Virus Strains in Chickens at Different Age of Exposure to the Viruses
In this study, the pathogenicity of IBS130/2015 (QX-like) and IBS037A/2014 (variant) IBVs in 1-day-old and 30-day-old specific pathogen free (SPF) chickens was characterized. Both strains caused respiratory and kidney infections based on immunohistochemistry (IHC), real-time quantitative polymerase chain reaction (qPCR) and a ciliostasis study; however, the results showed that the QX-like strain was more pathogenic, caused higher mortality and showed higher tissue tropism for the kidney than the variant strain. In contrast, despite causing low or no mortality depending on the age of the infected chickens, the Malaysian var...
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Role of Angiopoietin-like 4 on Bone Vascularization in Chickens Exposed to High-altitude Hypoxia
Publication date: May 2018 Source:Journal of Comparative Pathology, Volume 161 Author(s): S. Huang, M. Wang, M.U. Rehman, L. Zhang, X. Tong, Y. Shen, J. Li The aim of this study was to investigate the role and expression of a novel angiogenic factor (angiopoietin-like 4, ANGPTL4) in tibial growth plates of broiler chickens exposed to high-altitude hypoxia. One-day-old healthy broiler chickens (n = 120) were transported from lowland to a high-altitude hypoxic region (nearly 3,000 m above sea level) and were reared under hypoxic- (natural lower oxygen content) and normoxic conditions (nearly 21% oxygen conten...
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent M üllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Pectoral Vessel Density and Early Ultrastructural Changes in Broiler Chicken Wooden Breast Myopathy
Publication date: May 2018 Source:Journal of Comparative Pathology, Volume 161 Author(s): H.-K. Sihvo, N. Airas, J. Lindén, E. Puolanne In wooden breast myopathy (WBM) of broiler chickens, the pectoralis major muscles show abnormally hard consistency and microscopical myodegeneration of unknown aetiology. To date, previous studies have focused primarily on chronic WBM and ultrastructural descriptions of early WBM are lacking. The aim of this study was to elucidate the pathogenesis of WBM by light microscopical morphometry of vessel density and the ultrastructural description of early WBM changes with transmission e...
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Flow Cytometric Characterization of S-phase Fraction and Ploidy in Lymph Node Aspirates from Dogs with Lymphoma
We describe DNA-content analysis using LN aspirates from 112 dogs with lymphoma. S-phase fraction (SPF) accurately discriminated between low- and high-grade lymphomas, with 3.15% being the best discriminating cut-off value. SPF values strongly correlated with Ki67 expression as assessed by FC. Survival analyses were restricted to 33 dogs with high-grade B-cell lymphoma receiving standardized multi-agent chemotherapy, but no significant result was obtained for SPF. We also describe a subset of aneuploid cases and their respective follow-up. We conclude that DNA content analysis may be combined with morphological examination...
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Caseous Lymphadenitis Caused by Corynebacterium pseudotuberculosis in Alpine Chamois (Rupicapra r. rupicapra): a Review of 98 Cases
Publication date: May 2018 Source:Journal of Comparative Pathology, Volume 161 Author(s): L. Domenis, R. Spedicato, E. Pepe, R. Orusa, S. Robetto Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) in domestic and wild ruminants. Here we describe CLA in alpine chamois (Rupicapra r. rupicapra) based on a series of 98 cases of C. pseudotuberculosis infection confirmed by bacteriology and gene sequence analysis. The population included 53 males and 45 females distributed within three age groups: up to 18 months (n = 14), 18 months to 4 years (n = 11) and over 4 years (...
Source: Journal of Comparative Pathology - June 1, 2018 Category: Pathology Source Type: research

Changes in Renal Peritubular Capillaries in Canine and Feline Chronic Kidney Disease
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): R. Nakamura, A. Yabuki, O. Ichii, H. Mizukawa, N. Yokoyama, O. Yamato Renal capillary rarefaction is a crucial event that leads to tubulointerstitial damage during the progression of chronic kidney disease (CKD). In the present study, changes in CD34-positive renal capillaries were investigated in dogs and cats with CKD. A significant decrease in CD34-positive capillaries was observed in canine diseased kidneys, even at the early stage of disease. In cats, CD34-positive capillaries were well preserved in the diseased kidneys, with ...
Source: Journal of Comparative Pathology - May 3, 2018 Category: Pathology Source Type: research

Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): J.N. Silva, L.H.M. Miranda, R.C. Menezes, I.D.F. Gremião, R.V.C. Oliveira, S.M.M. Vieira, F. Conceição-Silva, L. Ferreiro, S.A. Pereira Sporotrichosis is caused by species of fungi within the Sporothrix schenckii complex that infect man and animals. In Rio de Janeiro, Brazil, an epidemic has been observed since 1998, with most of the cases being related to transmission from infected cats. Although the definitive diagnosis of feline sporotrichosis is made by fungal culture, cytopathological and histopathological...
Source: Journal of Comparative Pathology - April 13, 2018 Category: Pathology Source Type: research

The Journal of Comparative Pathology Educational Trust and Petplan Charitable Trust Award in Veterinary Pathology
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - April 12, 2018 Category: Pathology Source Type: research

Pleomorphic Malignant Mesothelioma in a Broiler Breeder Infected with Avian Leucosis Virus Subgroup J
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): T. Murakami, Y. Sassa Avian leucosis virus (ALV) is an oncogenic retrovirus that induces tumours including lymphoid leucosis and myeloid leucosis. Pleomorphic malignant mesothelioma and myelocytoma, which were thought to be induced by ALV subgroup J (ALV-J) infection, were identified in a 432-day-old broiler breeder. The bird showed no clinical signs; however, at necropsy examination there were multiple nodules in the alimentary tract. Microscopical analysis showed that these consisted of pleomorphic cells and myelocyte-like cells....
Source: Journal of Comparative Pathology - April 12, 2018 Category: Pathology Source Type: research

Dental and Temporomandibular Joint Pathology of the Grey Wolf (Canis lupus)
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): S. Döring, B. Arzi, J.N. Winer, P.H. Kass, F.J.M. Verstraete Skulls from 392 grey wolves (Canis lupus) were examined macroscopically according to predefined criteria. Two hundred and seven skulls were included in this study, comprised of 124 young adults (59.9%) and 83 adults (40.1%); of these, 65 (31.4%) specimens were from male wolves and 104 (50.3%) were from females, with 38 (18.4%) of unknown sex. Out of 8,694 possible teeth, 8,339 (95.9%) were present for evaluation. Fifty-five teeth (15.5%) were absent congenitally, 30 ...
Source: Journal of Comparative Pathology - April 10, 2018 Category: Pathology Source Type: research

Small Intestinal Lymphatic Hypoplasia in Three Dogs with Clinical Signs of Protein-losing Enteropathy
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): J.M. Malatos, N.A. Kurpios, G.E. Duhamel Intestinal lymphatic hypoplasia (ILH) is a rare but well-documented cause of protein-losing enteropathy (PLE) in human infants. To our knowledge, this condition has not been reported previously in veterinary medicine. Here we report the clinical and histopathological findings in three dogs that presented with clinical signs of PLE. The onset of PLE was early in an 18-month-old Great Pyrenees, while the other two dogs, a pug and a Tibetan terrier, had a later onset at 4 and 12 years of age, r...
Source: Journal of Comparative Pathology - April 5, 2018 Category: Pathology Source Type: research

Diffuse Pulmonary Adenocarcinoma with Micropapillary Growth Pattern in a Cat
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): M. Romanucci, M. Massimini, G. Aste, S.V.P. Defourny, P.E. Crisi, A. Boari, L. Della Salda A 12-year-old female European shorthair cat was presented with severe dyspnoea. Echocardiography revealed hypertrophic cardiomyopathy and pleural effusion. The cat died from acute decompensated left heart failure. At necropsy examination, the lungs were diffusely congested and firm, with multifocal grey areas and sparse haemorrhages. No solid masses were detected. Histopathology revealed a diffuse neoplastic proliferation characterized by irr...
Source: Journal of Comparative Pathology - April 5, 2018 Category: Pathology Source Type: research

Development and Evaluation of a Tissue-Engineered Fibrin-based Canine Mitral Valve Three-dimensional Cell Culture System
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): M.-M. Liu, T.C. Flanagan, S. Jockenhovel, A. Black, C.-C. Lu, A.T. French, D.J. Argyle, B.M. Corcoran Myxomatous mitral valve disease is the most common cardiac disease of the dog, but examination of the associated cellular and molecular events has relied on the use of cadaveric valve tissue, in which functional studies cannot be undertaken. The aim of this study was to develop a three-dimensional (3D) cell co-culture model as an experimental platform to examine disease pathogenesis. Mitral valve interstitial (VIC) and endothelial ...
Source: Journal of Comparative Pathology - March 31, 2018 Category: Pathology Source Type: research

Immunohistochemical Characterization of Immune Cell Infiltration in Feline Glioma
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): D.R. Rissi, B.F. Porter, C.E. Boudreau, P.M. Krimer, A.D. Miller The relationship between inflammatory cells and tumour biology has been defined in many human intracranial neoplasms, but it is relatively poorly characterized in veterinary medicine. The aim of this study was to define the immune cell infiltration in cases of feline glioma and its possible association with tumour morphology and type. A retrospective search identified 18 gliomas that met inclusion criteria. Tumours were subjected to immunohistochemistry (IHC) for CD3,...
Source: Journal of Comparative Pathology - March 31, 2018 Category: Pathology Source Type: research

Non-tuberculous Mycobacteria can Cause Disseminated Mycobacteriosis in Cats
We describe three cases of disseminated mycobacteriosis in cats, caused by M ycobacterium malmoense, M ycobacterium branderi/shimoidei and M. avium, with no identified underlying immunosuppression. In all cases, extracellular mycobacteria were seen in the pulmonary epithelium, intestinal lumen and glomerular tufts, which could affect the shedding of the organism. The present study highlights the importance of mycobacteriosis as a differential even in immunocompetent animals. Considering the close relationship of owners and pets and the potential presence of free mycobacteria in secretions, cats should be considered as...
Source: Journal of Comparative Pathology - March 28, 2018 Category: Pathology Source Type: research

Diffuse-type Gastric Mucinous and Signet Ring Cell Adenocarcinoma in a Captive California King Snake (Lampropeltis getula californiae)
Publication date: April 2018 Source:Journal of Comparative Pathology, Volume 160 Author(s): C.-S. Hsueh, W.-T. Li, C.-R. Jeng, V.F. Pang, H.-W. Chang An adult female California king snake (Lampropeltis getula californiae) housed in Taipei Zoo was presented with a 2-week history of anorexia, fatigue and abdominal swelling. Exploratory laparotomy revealed a gastric mass with two circular perforations and multiple mottled white to beige protuberances along the mucosal surface. Histologically, the gastric mass showed an invasive, transmural growth of epithelial cells arranged in nests, lobules, acini and sheets in the mucosa ...
Source: Journal of Comparative Pathology - March 27, 2018 Category: Pathology Source Type: research

Inflammatory Lesion Patterns in Target Organs of Visna/Maedi in Sheep and their Significance in the Pathogenesis and Diagnosis of the Infection
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): E. Gayo, L. Polledo, A. Balseiro, C.Pérez Martínez, M.J. García Iglesias, S. Preziuso, G. Rossi, J.F. García Marín Ovine visna/maedi (VM) infection is characterized by the development of chronic inflammatory lesions in different organs, mainly in the lung, mammary gland and central nervous system (CNS), with either histiocytic or lymphocytic pattern predominance being described in the CNS. To help to understand the role of host immune response in the development of these patterns, 50 naturally-...
Source: Journal of Comparative Pathology - March 4, 2018 Category: Pathology Source Type: research

Ovarian Teratocarcinoma in an Emu (Dromaius novaehollandiae): Histopathological and Immunohistochemical Characterization
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): J. Leal de Araujo, A. Perry, J. Wild, L. Kleinschmdit, S. Hoppes, R.R. Rech A 17-year-old female emu (Dromaius novaehollandiae) was presented for clinical evaluation due to a 3-week history of anorexia and progressive weight loss. The emu died after sedation. At necropsy examination, the ovary and the majority of the oviduct were effaced by a multinodular cystic mass and accompanied by 6 l of coelomic effusion. Histopathology revealed a neoplasm composed of well-differentiated, poorly organized tissues derived from ectoderm...
Source: Journal of Comparative Pathology - March 3, 2018 Category: Pathology Source Type: research

Pathology and Distribution of Velogenic Viscerotropic Newcastle Disease Virus in the Reproductive System of Vaccinated and Unvaccinated Laying Hens (Gallus gallus domesticus) by Immunohistochemical Labelling
This study investigated the pathological changes in the reproductive system of laying hens that lead to the poor egg production and quality in Newcastle disease (ND) and the distribution of the virus in the system. Two hundred and forty Isa-Brown pullets were divided randomly into vaccinated and unvaccinated groups (n = 120 each). The vaccinated group was given Hitchner B1 vaccine at 1 day of age, La Sota vaccine at 4 weeks of age and Komarov vaccine at 9 and 16 weeks of age. At the peak of egg production, the laying hens (32 weeks old) were assigned randomly into four groups (n = 60): VC, vaccinated wi...
Source: Journal of Comparative Pathology - March 3, 2018 Category: Pathology Source Type: research

Amyloid-producing Odontoameloblastoma in a Black-tailed Prairie Dog (Cynomys ludovicianus)
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): M.K. Kok, J.K. Chambers, N. Ushio, Y. Miwa, H. Nakayama, K. Uchida A 6-year-old female black-tailed prairie dog (Cynomys ludovicianus) was presented with a space-occupying lesion in the left submandibular region. On computed tomography, a low attenuating, poorly circumscribed mass infiltrated the left mandibular bone, with osteolytic change. Microscopically, the lesion was composed of odontogenic epithelium proliferating in nests and embedded in abundant dental papilla-like ectomesenchyme, including dentine and enamel. Multifoca...
Source: Journal of Comparative Pathology - February 7, 2018 Category: Pathology Source Type: research

Neoplasia in Three Aye-Ayes (Daubentonia madagascariensis)
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): A. Rodriguez Barbon, R. Cowen, C. Knott, K. Hughes, K. Allinson, C.V. Williams, A. Routh Tumours diagnosed in three aged captive aye-ayes (Daubentonia madagascariensis), held in two different institutions, are described. A cerebral glioblastoma was diagnosed based on histological and immunohistochemical findings in one of the animals following initial presentation with bilateral mydriasis, absent pupillary reflex, head tilt and ataxia. A second animal was humanely destroyed due to impaired locomotion associated with spondylosis ...
Source: Journal of Comparative Pathology - February 5, 2018 Category: Pathology Source Type: research

Parotid Salivary Gland Basal Cell Adenocarcinoma in a Big-eared Opossum (Didelphis aurita)
We describe the gross, microscopical and immunohistochemical features of a parotid salivary gland basal cell adenocarcinoma in a free-living big-eared opossum. This case represents the first report of salivary gland neoplasia in opossums. Graphical abstract (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 5, 2018 Category: Pathology Source Type: research

Pulmonary Basaloid Squamous Cell Carcinoma in a Dog
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): A. Morey-Matamalas, A. de Stefani, D. Corbetta, L. Grau-Roma, S. de Brot A 9-year-old neutered male crossbred dog with a 4-week history of progressive vestibulocerebellar signs was presented for necropsy examination. Gross examination revealed neoplastic growth in the lungs, thoracic lymph nodes, left kidney and cerebellum. Microscopically, the tumour consisted of an infiltrative, densely cellular, basaloid epithelial neoplastic growth with extensive areas of abrupt keratinization. Immunohistochemically, neoplastic cells express...
Source: Journal of Comparative Pathology - February 3, 2018 Category: Pathology Source Type: research

World Health Organisation Classification of Lymphoid Tumours in Veterinary and Human Medicine: a Comparative Evaluation of Gastrointestinal Lymphomas in 61 Cats
Publication date: February 2018 Source:Journal of Comparative Pathology, Volume 159 Author(s): B. Wolfesberger, A. Fuchs-Baumgartinger, V. Greß, S.E. Hammer, G. Gradner, K. Knödl, A. Tichy, B.C. Rütgen, C. Beham-Schmid To diagnose and classify the various entities of lymphomas, the World Health Organisation (WHO) classification is applied in human as well as in veterinary medicine. We validated the concordance of these classification systems by having a veterinary and human pathologist evaluate gastrointestinal lymphoma tissue from 61 cats. In 59% of all cases, there was a match between their respective di...
Source: Journal of Comparative Pathology - February 3, 2018 Category: Pathology Source Type: research

PathoPig – Strengthening Post-mortem Diagnostics and Early Detection of Pig Diseases
Publication date: January 2018 Source:Journal of Comparative Pathology, Volume 158 Author(s): M. Schediwy, S. Balmer, G. Rosato, T. Sydler, D. Hadorn, H. Posthaus, P.J. Bless, M. Harisberger, C. Gurtner (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 2, 2018 Category: Pathology Source Type: research

Mycoplasmal and Viral Co-infections in Bovine Respiratory Disease Complex in Swiss Cattle
Publication date: January 2018 Source:Journal of Comparative Pathology, Volume 158 Author(s): K. Mehinagic, P. Pilo, N. Stokar-Regenscheit (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 2, 2018 Category: Pathology Source Type: research

Inhibition of the Immune Response in Sheep Infected with Bovine Leukaemia Virus
Publication date: January 2018 Source:Journal of Comparative Pathology, Volume 158 Author(s): M. Wasiak, A. Kycko, M. Reichert (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 2, 2018 Category: Pathology Source Type: research

Forensic Relevance of Agonal Wounds in Slaughter Pigs
Publication date: January 2018 Source:Journal of Comparative Pathology, Volume 158 Author(s): K. Barington, H.E. Jensen (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 2, 2018 Category: Pathology Source Type: research

Bacillus anthracis as a Cause of Bovine Abortion – A Challenging Case Regarding Diagnosis and Biosafety
Publication date: January 2018 Source:Journal of Comparative Pathology, Volume 158 Author(s): M. Dettwiler, K. Mehinagic, S.Gobeli Brawand, S. Rottenberg, H. Posthaus (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - February 2, 2018 Category: Pathology Source Type: research