Expression of Three Adipokines (Adiponectin, Leptin and Resistin) in Normal Canine Skin: a Pilot Study
Publication date: Available online 28 November 2018Source: Journal of Comparative PathologyAuthor(s): T. Brément, C. Cossec, C. Roux, A.C. Knol, B. Dréno, A. Khammari, P. Bourdeau, V. BruetSummaryAdipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and sys...
Source: Journal of Comparative Pathology - November 29, 2018 Category: Pathology Source Type: research

Abstracts Title Page
Publication date: Available online 28 November 2018Source: Journal of Comparative PathologyAuthor(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - November 29, 2018 Category: Pathology Source Type: research

The Bicuspid Condition of the Aortic Valve Does Not Alter the Incidence of Accessory Coronary Artery Ostia in Syrian Hamsters (Mesocricetus auratus)
Publication date: January 2019Source: Journal of Comparative Pathology, Volume 166Author(s): M.C. Fernández, M.T. Soto-Navarrete, A.C. Durán, V. Sans-Coma, B. FernándezSummaryIn man and Syrian hamsters (Mesocricetus auratus), the prevalence of anomalies in the origin of the coronary arteries is significantly higher in individuals with bicuspid than with normal aortic valves. In hamsters, the incidence of accessory ostia is similar in individuals with normal and anomalous coronary arteries, all of them possessing a normal (tricuspid) aortic valve. In order to evaluate whether or not the presence of bicu...
Source: Journal of Comparative Pathology - November 29, 2018 Category: Pathology Source Type: research

Pancreatic Choristoma in a Canine Gallbladder
Publication date: January 2019Source: Journal of Comparative Pathology, Volume 166Author(s): Y. Abou Monsef, S. Atalay Vural, O. KutsalSummaryA 1.5-year-old male Siberian Husky dog was presented with a history of progressive twitching and tetraplegia. The dog was humanely destroyed and at necropsy examination an incidental intramural white lesion measuring 10 × 15 × 5 mm was observed in the gallbladder. Histologically, the mass consisted of pancreatic tissue located in the tunica adventitia of the gallbladder. Immunohistochemistry revealed that the islets of Langerhans were positive for...
Source: Journal of Comparative Pathology - November 29, 2018 Category: Pathology Source Type: research

Chronic Basophilic Leukaemia in a Dog
Publication date: January 2019Source: Journal of Comparative Pathology, Volume 166Author(s): D. Azakami, A. Saito, K. Ochiai, T. Ishiwata, K. Takahashi, N. Kaji, D. Kaji, N. Kaji, M. MichishitaSummaryA 13-year-old neutered female mixed-breed dog with a clinical history of emaciation, inappetence and vomiting for 2 months was presented. Blood tests showed marked leucocytosis with increased neutrophil and basophil count, mild thrombocytosis and anaemia. Seven days after the initial visit, the dog died and was submitted for necropsy examination. Grossly, the bone marrow was red in colour and hepatomegaly and splenomegaly with...
Source: Journal of Comparative Pathology - November 28, 2018 Category: Pathology Source Type: research

Primary Osteoma Cutis in the Interscapular Region of a Dog
Publication date: January 2019Source: Journal of Comparative Pathology, Volume 166Author(s): S.-H. Woo, D.-M. Go, S.-H. Lee, S.-S. Han, D.-Y. KimSummaryA 9-year-old neutered male Shih Tzu was presented with three contiguous firm nodules in the subcutaneous tissue of the interscapular region. Histopathological examination revealed that the nodules consisted of mature lamellar bone with a Haversian system, with no apparent lesion around the bone. Clinical examination revealed that the dog had no underlying disease and no history of trauma at the lesion site. Based on these findings and on the medical history, a diagnosis of ...
Source: Journal of Comparative Pathology - November 28, 2018 Category: Pathology Source Type: research

Evaluation of Histological, Immunohistochemical, Clinical and Genetic Prognostic Factors Associated with the Response of Canine Mast Cell Tumours to Glucocorticotherapy
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): R. dos Santos Horta, G. Eunice Lavalle, L. Narducci Monteiro, F.B.T.M. Alves dos Reis, M. de Pádua Costa, A. Giuliano, G. Dantas Cassali, J. DobsonSummaryMast cell tumours (MCTs) are one of the most frequent neoplasms in dogs. Glucocorticoids (GCs) are widely used in the management of this disease, although no guidelines for their use have been established. The aim of this study was to evaluate the correlation of MCT prognostic factors with measurable response to GCs. This retrospective study included 60 dogs treated with p...
Source: Journal of Comparative Pathology - November 21, 2018 Category: Pathology Source Type: research

Zygomycosis due to Mucor racemosus Associated with a Circovirus Infection in a Blue Tit (Cyanistes caeruleus)
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): A. Schmitz, R. Korbel, M. RinderSummaryIn spring 2014, several wild passeriform garden birds were found severely ill or dead, all with severe periocular swellings. A blue tit (Cyanistes caeruleus) showing severe depression was humanely destroyed and sent for necropsy examination. In this bird, the lower eyelids were sagging, red and oedematous. Microscopical examination revealed marked infiltration of the eyelid tissue with fungal hyphae (stained by periodic acid–Schiff) without any inflammatory reaction. Polymerase chain re...
Source: Journal of Comparative Pathology - November 2, 2018 Category: Pathology Source Type: research

Tumour-to-Tumour Metastasis Phenomenon: Metastatic Prostatic Adenocarcinoma within an Anaplastic Oligodendroglioma in the Brain of a Dog
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): C. Ros, F. Fernández-Flores, C. de la Fuente, D. Pi, S. Añor, M. Planellas, M. PumarolaSummaryA 10-year-old entire male French bulldog was presented following clusters of generalized tonic–clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Computed tomog...
Source: Journal of Comparative Pathology - October 31, 2018 Category: Pathology Source Type: research

Epithelial-Myoepithelial Carcinoma in a Canine Salivary Gland
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): C.-H. Park, N. Shiwa, J. Sumimoto, K. KimitsukiSummaryA 7-year-old male cavalier King Charles spaniel was presented with a cervical subcutaneous mass. The mass had a multilobular growth pattern and each individual lobule contained ductal epithelial cells and myoepithelial cells surrounding the ductal cells. Immunohistochemically, the ductal epithelial cells were positive for cytokeratin (CK) 7 and CAM5.2 and the myoepithelial cells were positive for α-smooth muscle actin and p63. Both types of cells were positive for CK14, a...
Source: Journal of Comparative Pathology - October 26, 2018 Category: Pathology Source Type: research

Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): L.L. Hoon-Hanks, C.B. Frank, E.F. EdmondsonSummaryA 7-week-old male black Labrador retriever puppy was presented for post-mortem examination following progressive hindlimb paralysis and multiple masses within the skin. A highly compressive and infiltrative intradural mass was found within the T9–T11 spinal cord. Microscopical and immunohistochemical analysis revealed features compatible with spindle cell rhabdomyosarcoma (RMS). The adjacent spinal cord had numerous melanin-containing cells, arranged in small nodules, predomi...
Source: Journal of Comparative Pathology - October 26, 2018 Category: Pathology Source Type: research

Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): O.A. Santelices Iglesias, C. Wright, A.G. Duchene, M.A. Risso, P. Risso, C.N. Zanuzzi, F. Nishida, A. Lavid, F. Confente, M. Díaz, E.L. Portiansky, E.J. Gimeno, C.G. BarbeitoSummaryFeline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexp...
Source: Journal of Comparative Pathology - October 25, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - October 24, 2018 Category: Pathology Source Type: research

Histiocytic Ulcerative Colitis in an American Staffordshire Terrier
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): F.F. Argenta, S.O. de Souza, L.S. Meirelles, G.G.M. Snel, C. De Lorenzo, J. Ienes-Lima, F. Horn, D. Driemeier, S.P. PavariniSummaryA 9-year-old female American Staffordshire terrier was presented to a veterinary hospital with diarrhoea, severe prostration, hypothermia, dehydration and anaemia. The dog died 6 days after the first consultation. At necropsy examination the serosa of the large intestine showed a granular appearance and the mucosa was thickened, ulcerated and red, with prominent folding. Histological examination reveal...
Source: Journal of Comparative Pathology - October 22, 2018 Category: Pathology Source Type: research

A Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): M.P. Dagleish, J.J. Clark, C. Robson, M. Tucker, R.J. Orton, M.S. RocchiSummaryLouping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. N...
Source: Journal of Comparative Pathology - October 21, 2018 Category: Pathology Source Type: research

Pathological Characterization of Lymphoma with Pulmonary Involvement in Cats
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): R.V. Leite-Filho, W. Panziera, M.B. Bandinelli, S.P. PavariniSummaryStudies evaluating histological patterns of lung infiltration by lymphoma in cats are lacking. We evaluated retrospectively the histological patterns of 125 necropsy cases of feline lymphoma collected over a 12-year period. Of the 125 cases, 16 showed lung infiltration (12.8%). Nine cats were female, seven cats were male and all were of mixed breed. Gross lesions observed in the lungs consisted of masses (25%) and nodules (18.7%); however, the majority of cases (5...
Source: Journal of Comparative Pathology - October 21, 2018 Category: Pathology Source Type: research

Isocitrate Dehydrogenase 1 Expression in Canine Gliomas
The objective of this study was to investigate canine gliomas for the IDH1 R132H point mutation using immunohistochemistry. Thirty-one formalin-fixed and paraffin wax-embedded canine gliomas were examined for both IDH1 R132H expression and pan-IDH1 (IDH1 wild-type and point mutated IDH1). Glial tumour specimens were recorded to be either positive or negative for expression. Pan-IDH1 expression was identified in all 31 tumours (100%), while the IDH1 R132H point mutation was identified in none of the tumours (0%). Therefore, the IDH1 R132H point mutation was not identified in this population of canine gliomas and may not be ...
Source: Journal of Comparative Pathology - October 21, 2018 Category: Pathology Source Type: research

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): C.A. Bertram, K. Müller, R. KlopfleischSummaryDisorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 ful...
Source: Journal of Comparative Pathology - October 21, 2018 Category: Pathology Source Type: research

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): A.L. Stoll, A. Suárez-Bonnet, B.A. Summers, S.L. PriestnallSummaryDivergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only been reported once (in a dog). Incisional wedge biopsy of a locally extensive, ventral abdominal wall mass, which extended from the dermis to the subcutis, from a 12-year-old female domestic shorthaired cat, was p...
Source: Journal of Comparative Pathology - October 19, 2018 Category: Pathology Source Type: research

Polycystic Kidney-like Disease in a Red-ear Slider Turtle (Trachemys scripta elegans)
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): M. Tecilla, M. Bielli, F.C. OriggiSummaryA 14-year-old red-ear slider turtle (Trachemys scripta elegans) with no history of pre-existing clinical disease died and was referred for necropsy examination. Grossly, oesophageal prolapse, bilateral renal cysts and a paraduodenal cystic mass were detected. Tissues were processed routinely for histology and immunohistochemistry (IHC) with primary antibodies specific for Wilm's tumour suppressor gene-1 (WT-1), insulin, glucagon and pancytokeratins. Microscopically, renal medullary cysts and...
Source: Journal of Comparative Pathology - October 5, 2018 Category: Pathology Source Type: research

Corrigendum to ‘Evidence of Vasculogenic Mimicry in a Palpebral Melanocytoma in a Dog’, Volume 162, July 2018, Pages 43–46
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): L. Nordio, S. Fattori, M. Vascellari, C. Giudice (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - October 5, 2018 Category: Pathology Source Type: research

Retrospective Pathological Studies of Splenic Lesions in Domestic Hamsters (Phodopus spp.)
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): Y.C. Tuan, R.C. Wan, J.P. Kao, H.Y. Chiou, K. Takahashi, J.W. LiaoSummaryFifteen splenic biopsy specimens from a total of 212 biopsy specimens and necropsy cases of domestic hamsters (Phodopus spp.) from the Division of Wild (Exotic) Animal Medicine, Veterinary Medical Teaching Hospital, National Chung Hsing University, Taiwan, collected between 2010 and 2017, were studied retrospectively. The incidence of lesions in the spleen was 7.1% (15/212). The mean age of affected hamsters was 16.6 months and females were affected more than ...
Source: Journal of Comparative Pathology - September 20, 2018 Category: Pathology Source Type: research

Urocystitis and Ureteritis in Holstein Calves with Septicaemia Caused by Salmonella enterica Serotype Dublin
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): R.A. Costa, M.L. Casaux, R.D. Caffarena, M. Macías-Rioseco, C.O. Schild, M. Fraga, F. Riet-Correa, F. GiannittiSummarySalmonellosis is an enteric or multisystemic disease of global distribution that affects numerous animal species. Although Salmonella enterica has been associated with urinary tract lesions in man, information on urocystitis/ureteritis in cattle caused by salmonellae is lacking. This communication describes lesions of the inferior urinary tract in four Holstein calves with septicaemia caused by S.enterica sub...
Source: Journal of Comparative Pathology - September 12, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - September 12, 2018 Category: Pathology Source Type: research

Systemic Yersinia pseudotuberculosis as a Cause of Osteomyelitis in a Captive Ring-tailed Lemur (Lemur catta)
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): D. Walker, J. Gibbons, J.D. Harris, C.S. Taylor, C. Scott, G.K. Paterson, L.R. MorrisonSummaryYersinia pseudotuberculosis and Yersiniaenterocolitica are ubiquitous pathogens with wildlife and domestic animal reservoirs. Outbreaks of ‘non-plague’ yersiniosis in man and non-human primates are reported frequently (including zoological specimens and research breeding colonies) and are usually characterized by enteritis, mesenteric lymphadenitis and occasionally organ abscessation. In people, non-septic reactive arthrit...
Source: Journal of Comparative Pathology - September 12, 2018 Category: Pathology Source Type: research

Genital Tract Pathology in Female Pet Rabbits (Oryctolagus cuniculus): a Retrospective Study of 854 Necropsy Examinations and 152 Biopsy Samples
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): C.A. Bertram, K. Müller, R. KlopfleischSummaryGenital tract disorders, especially uterine disorders, are the most common conditions of the female pet rabbit (Oryctolagus cuniculus); however, there have been few large studies of diseases of the female genital tract of this species. The present study examined diseases of the ovaries, Fallopian tubes, uterus and vagina, retrospectively over a period of 22 years, and included 854 full post-mortem examinations of female pet rabbits and 152 female genital tract biopsy samples. The a...
Source: Journal of Comparative Pathology - September 7, 2018 Category: Pathology Source Type: research

Putative Rodlet Cell Neoplasms in the Livers of Two White Suckers (Catostomus commersonii)
Publication date: October 2018Source: Journal of Comparative Pathology, Volume 164Author(s): J.C. Wolf, S.A. Smith, B.S. Jortner, M.E. McMasterSummaryAlthough discovered more than a century ago, piscine rodlet cells (RCs) remain somewhat of a mystery to scientists in terms of their origin and function. Initially described as parasites, and later as potential secretory cells, the prevailing theory is that RCs are leucocyte-like cells that possess pathogen defence capabilities. The current case report involves a novel type of neoplasm discovered in the livers of two adult female white suckers (Catostomus commersonii) th...
Source: Journal of Comparative Pathology - September 7, 2018 Category: Pathology Source Type: research

The Journal of Comparative Pathology Educational Trust and Petplan Charitable Trust Joint Research Award in Veterinary Pathology
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): M.J. Day (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - August 28, 2018 Category: Pathology Source Type: research

Metaphyeal and Diaphyseal Dysplasia of the Third Cervical Vertebra Secondary to Physeal Necrosis in a Quarter Horse Foal
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): C. Yang, S. Weisbrode, J. Yardley, E. Schroeder, C. PremanandanSummaryIschaemia-induced physeal injury has not been described previously in the horse. A 1-month-old Quarter horse foal was submitted for necropsy examination due to an acute onset of ataxia followed by a 4-week history of progressive decline. Focal narrowing of the spinal canal due to ventral compression by the rotation of the cranial aspect of the third cervical vertebra (C3) was observed. The metaphysis and diaphysis of C3 were markedly shortened and white–tan ...
Source: Journal of Comparative Pathology - August 24, 2018 Category: Pathology Source Type: research

Sympathetic Innervation and Adrenergic Receptors in Equine Deep Digital Flexor Tendinopathy: Preliminary Results
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): F. Beccati, M. Pepe, L. Antinori, L. Pascucci, E. Chiaradia, M.T. MandaraSummaryThe aim of this study was to delineate the pattern of sympathetic innervation in the suprasesamoidean region of the deep digital flexor tendon (DDFT) in horses with tendinopathy by immunohistochemical labelling for tyrosine hydroxylase (TH) and α-1 adrenergic receptor (α1-AR). Twelve forelimbs were obtained from 10 horses with DDFT tendinopathy and six feet obtained from six horses were used as healthy controls. Post-mortem radiographic, ultr...
Source: Journal of Comparative Pathology - August 18, 2018 Category: Pathology Source Type: research

Ganglioneuromatosis of the Gallbladder in a Dog with Cholecystitis and Cholestasis
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): G.A. Ramírez, J. Altimira, M. VilafrancaSummaryA 2-year-old entire female mixed-breed dog was presented with signs of cholestasis. Abdominal ultrasonography revealed a gallbladder with a thickened and hyperechoic wall and luminal calculi. Exploratory laparotomy with cholecystectomy was performed and histopathological examination of the specimens from the cholecystectomy demonstrated extensive proliferation of large, prominent nerves containing ganglion cells with no atypia mainly located in the gallbladder mucosa. The neural ...
Source: Journal of Comparative Pathology - August 18, 2018 Category: Pathology Source Type: research

Complex Gill Disease: an Emerging Syndrome in Farmed Atlantic Salmon (Salmo salar L.)
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): A. Herrero, K.D. Thompson, A. Ashby, H.D. Rodger, M.P. DagleishSummaryGill disorders have become a significant problem during the marine phase of farming Atlantic salmon (Salmo salar L.). The term complex gill disease (CGD) includes a wide range of clinical gill disease presentations generally occurring from the end of summer to early winter on marine Atlantic salmon farms. The gross and histological lesions observed are the resultant culmination of exposure to a mixture of environmental insults, pathogenic organisms and farm manage...
Source: Journal of Comparative Pathology - August 17, 2018 Category: Pathology Source Type: research

Computerized Cytomorphometric and Cytomorphological Analysis of Canine Transmissible Venereal Tumours
This study compared the nuclear and cellular morphometric parameters (i.e. radius, diameter, perimeter and area) in different types of CTVT with other canine round cell tumours including lymphoma, mast cell tumour (MCT) and histiocytic tumour (HCT). We also evaluated the relationship between clinical information and the different CTVT cytomorphologic types. CTVT cells from 44 dogs revealed that the measured parameters were significantly different between different round cell tumours and among the CTVT cytomorphological types. CTVT had the largest cells, followed by HCTs, MCTs and lymphomas. The mixed type of CTVT had the l...
Source: Journal of Comparative Pathology - August 16, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 28, 2018 Category: Pathology Source Type: research

Oral and Dental Examination Findings in Beech Martens (Martes foina)
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): K. Slabá, B. Kryštufek, A. NemecSummaryDetailed clinical and radiographical descriptions of oral/dental pathology in the beech marten (Martes foina) are lacking. In the present study, skulls of M. foina from a museum collection (n = 109) were examined macroscopically according to predefined criteria and full-mouth dental radiographs were obtained. Occlusion was diagnosed as ‘scissor bite’ in 22.5% of evaluated skulls, 77% of evaluated skulls showed ‘level bite’ of incisors and 9.2% of ...
Source: Journal of Comparative Pathology - July 24, 2018 Category: Pathology Source Type: research

Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma
In this study we investigate the significance of BAP1 in canine melanoma. Nuclear BAP1 protein was detected in five canine oral melanoma cell lines using an antibody commonly used for analysis of human tissues. BAP1 loss of function mutations often lead to loss of nuclear BAP1 (nBAP1) expression in humans; this is associated with a poorer prognosis in uveal and mucosal melanoma. Therefore, as a prelude to a study evaluating the prognostic significance of nBAP1 expression in dogs, immunohistochemistry (IHC) was used to assess cases of canine melanoma for nBAP1 expression. In 89 cases where tumour cells were identified by me...
Source: Journal of Comparative Pathology - July 19, 2018 Category: Pathology Source Type: research

Expression of Oestrogen Receptor, Progesterone Receptor and Akt in Canine Circumanal Gland Tumours
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): S.-H. Kim, B.-J. Seung, S.-H. Cho, H.-Y. Lim, J.-H. Hwang, J.-H. SurSummaryWe investigated the expression of oestrogen receptor alpha (OR-α), progesterone receptor (PR) and Akt in canine circumanal gland tumours. Immunohistochemistry was conducted on seven normal circumanal glands, 30 circumanal gland adenomas and 40 circumanal gland carcinomas. The expression of OR-α and PR was significantly lower in circumanal gland carcinomas than in circumanal gland adenomas. In contrast, the expression of Akt was markedly higher in ci...
Source: Journal of Comparative Pathology - July 19, 2018 Category: Pathology Source Type: research

Feline Injection Site Sarcomas: Data from Switzerland 2009–2014
Publication date: August 2018Source: Journal of Comparative Pathology, Volume 163Author(s): R. Graf, F. Guscetti, M. Welle, D. Meier, A. PospischilSummaryFeline injection site sarcomas (FISS) were first described in the early 1990s. Despite extensive research, the pathogenesis of these tumours has not been elucidated conclusively. Their appearance and the marked increase in their incidence has been mainly connected to the injection of vaccines, and it is assumed that a chronic inflammatory reaction at the injection site triggers subsequent malignant transformation. The role of alum-based adjuvants has been discussed, ...
Source: Journal of Comparative Pathology - July 19, 2018 Category: Pathology Source Type: research

Expression of Stem Cell Factor in Feline Mast Cell Tumour
In this study, we examined SCF expression in 23 samples of feline MCTs. SCF expression was detected in 10 cutaneous MCTs and a case of splenic mastocytosis. In the cutaneous MCTs, SCF-positive tumour cells were located at the margins. Kit was expressed in eight of the 10 cutaneous cases of SCF-expressing MCTs. In these cases, Kit-positive cells were located near to SCF-positive cells, and SCF/Kit double-positive tumour cells were found. Ki67-positive tumour cells were not found near to SCF-positive cells. These results suggest that SCF autocrine/paracrine mechanisms are involved in the expansion of cutaneous MCTs, but not ...
Source: Journal of Comparative Pathology - July 19, 2018 Category: Pathology Source Type: research

Evidence of Vasculogenic Mimicry in a Palpebral Melanocytoma in a Dog
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): L. Nordio, S. Fattori, M. Vascellari, C. GiudiceSummaryA 7-year-old neutered female Doberman pinscher was presented with a palpebral nodule on the haired eyelid of the left eye. The nodule was removed surgically. Microscopically, the nodule was consistent with eyelid melanocytoma. The tumour was characterized by the presence of numerous lacunar and slit-like spaces filled by erythrocytes and interspersed throughout the neoplastic melanocytes. Immunohistochemically, these spaces were lined by cells expressing PNL2 and factor VIII, but ...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Diffuse Infiltrative Colonic Lipomatosis in a Vietnamese Pot-bellied Pig
Publication date: July 2018Source: Journal of Comparative Pathology, Volume 162Author(s): A. Kokosinska, D.R. RissiSummaryDiffuse infiltrative gastrointestinal lipomatosis (DIGIL) is characterized by widespread proliferation of adipose tissue within the submucosal and subserosal layers of the gastrointestinal tract. Here we describe a case of diffuse infiltrative colonic lipomatosis in a 3-year-old male Vietnamese pot-bellied pig. Gross anatomical changes included obesity with sparse small intestinal contents and no colonic contents. The colonic lumen was narrowed and the colonic wall was diffusely thickened (∼5 m...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Editorial Board
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Caseous Lymphadenitis Caused by Corynebacterium pseudotuberculosis in Alpine Chamois (Rupicapra r. rupicapra): a Review of 98 Cases
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): L. Domenis, R. Spedicato, E. Pepe, R. Orusa, S. RobettoSummaryCorynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis (CLA) in domestic and wild ruminants. Here we describe CLA in alpine chamois (Rupicapra r. rupicapra) based on a series of 98 cases of C. pseudotuberculosis infection confirmed by bacteriology and gene sequence analysis. The population included 53 males and 45 females distributed within three age groups: up to 18 months (n = 14), 18 months to 4 years (n = 11) and over 4 yea...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Flow Cytometric Characterization of S-phase Fraction and Ploidy in Lymph Node Aspirates from Dogs with Lymphoma
We describe DNA-content analysis using LN aspirates from 112 dogs with lymphoma. S-phase fraction (SPF) accurately discriminated between low- and high-grade lymphomas, with 3.15% being the best discriminating cut-off value. SPF values strongly correlated with Ki67 expression as assessed by FC. Survival analyses were restricted to 33 dogs with high-grade B-cell lymphoma receiving standardized multi-agent chemotherapy, but no significant result was obtained for SPF. We also describe a subset of aneuploid cases and their respective follow-up. We conclude that DNA content analysis may be combined with morphological examination...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Pectoral Vessel Density and Early Ultrastructural Changes in Broiler Chicken Wooden Breast Myopathy
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): H.-K. Sihvo, N. Airas, J. Lindén, E. PuolanneSummaryIn wooden breast myopathy (WBM) of broiler chickens, the pectoralis major muscles show abnormally hard consistency and microscopical myodegeneration of unknown aetiology. To date, previous studies have focused primarily on chronic WBM and ultrastructural descriptions of early WBM are lacking. The aim of this study was to elucidate the pathogenesis of WBM by light microscopical morphometry of vessel density and the ultrastructural description of early WBM changes with transmissi...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

The Temporomandibular Joint of the Domestic Dog (Canis lupus familiaris) in Health and Disease
This study aimed to characterize the histological, biomechanical and biochemical properties of the temporomandibular joint (TMJ) of the domestic dog in health and disease. In addition, we sought to identify structure–function relationships and to characterize TMJ degenerative lesions that may be found naturally in this species. TMJs (n = 20) from fresh cadaver heads (n = 10) of domestic dogs were examined macroscopically and microscopically and by cone-beam computed tomography. The TMJ discs were evaluated for their mechanical and biochemical properties. If TMJ arthritic changes were found, p...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Sertoli Cell Tumour and Uterine Leiomyoma in Miniature Schnauzer Dogs with Persistent Müllerian Duct Syndrome Caused by Mutation in the AMHR2 Gene
This report describes two miniature schnauzer dogs with PMDS caused by a known nonsense mutation in the AMHR2 gene, with concurrent development of genital neoplasia. The first case (78,XY and SRY-positive) had unilateral cryptorchidism and a Sertoli cell tumour in the abdominal testicle. The second case (mosaic karyotype 77,XY,rob/78,XY and SRY-positive) had both gonads descended in the scrotum and developed an abdominal mass derived from the uterine wall, which showed histological features typical of leiomyoma. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Role of Angiopoietin-like 4 on Bone Vascularization in Chickens Exposed to High-altitude Hypoxia
Publication date: May 2018Source: Journal of Comparative Pathology, Volume 161Author(s): S. Huang, M. Wang, M.U. Rehman, L. Zhang, X. Tong, Y. Shen, J. LiSummaryThe aim of this study was to investigate the role and expression of a novel angiogenic factor (angiopoietin-like 4, ANGPTL4) in tibial growth plates of broiler chickens exposed to high-altitude hypoxia. One-day-old healthy broiler chickens (n = 120) were transported from lowland to a high-altitude hypoxic region (nearly 3,000 m above sea level) and were reared under hypoxic- (natural lower oxygen content) and normoxic conditions (nearly 21% oxygen co...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Comparative Pathogenicity of Malaysian QX-like and Variant Infectious Bronchitis Virus Strains in Chickens at Different Age of Exposure to the Viruses
In this study, the pathogenicity of IBS130/2015 (QX-like) and IBS037A/2014 (variant) IBVs in 1-day-old and 30-day-old specific pathogen free (SPF) chickens was characterized. Both strains caused respiratory and kidney infections based on immunohistochemistry (IHC), real-time quantitative polymerase chain reaction (qPCR) and a ciliostasis study; however, the results showed that the QX-like strain was more pathogenic, caused higher mortality and showed higher tissue tropism for the kidney than the variant strain. In contrast, despite causing low or no mortality depending on the age of the infected chickens, the Malaysian var...
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research

Comparative Neuropathology of Major Indian Bluetongue Virus Serotypes in a Neonatal BALB/c Mouse Model
This study of the relative neurovirulence of BTV serotypes is likely to help design suitable vaccination and control strategies for the disease. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - July 11, 2018 Category: Pathology Source Type: research