21-Gene Recurrence Score Assay As a Predictor of Adjuvant Chemotherapy Administration for Early-Stage Breast Cancer: An Analysis of Use, Therapeutic Implications, and Disparity Profile [Breast Cancer]
Conclusion The RS assay significantly influences clinicians’ recommendations for chemotherapy in patients with EBC. Black patients tended to have higher assay scores, which may reflect use patterns or less favorable tumor biology for estrogen receptor–positive disease. There are significant differences in use and clinical implications of the test on the basis of race, insurance, and type of facility. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Jasem, Amini, Rabinovitch, Borges, Elias, Fisher, Kabos Tags: Chemotherapy, Population and observational studies (SEER, WHI observational, etc.) Breast Cancer Source Type: research

Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in Patients With Estrogen Receptor-Positive Breast Cancer [Breast Cancer]
Conclusion Adding pictilisib to anastrozole significantly increases suppression of tumor cell proliferation in luminal B primary breast cancer. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Schmid, Pinder, Wheatley, Macaskill, Zammit, Hu, Price, Bundred, Hadad, Shia, Sarker, Lim, Gazinska, Woodman, Korbie, Trau, Mainwaring, Gendreau, Lackner, Derynck, Wilson, Butler, Earl, Parker, Purushotham, Thompson Tags: Combined Modality, Hormonal Therapy, Translational Oncology, Breast Cancer Source Type: research

Distinctive Cancer Associations in Patients With Neurofibromatosis Type 1 [Rapid Communication]
Purpose The current study was designed to determine the risk of cancer in patients with neurofibromatosis type 1 (NF1) by cancer type, age, and sex with unprecedented accuracy to be achieved by combining two total population–based registers. Patients and Methods A population-based series of patients with NF1 (N = 1,404; 19,076 person-years) was linked to incident cancers recorded in the Finnish Cancer Registry and deaths recorded in the national Population Register Centre between 1987 and 2012. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were calculated for selected cancer types. Su...
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Uusitalo, Rantanen, Kallionpaa, Poyhonen, Leppavirta, Yla-Outinen, Riccardi, Pukkala, Pitkaniemi, Peltonen, Peltonen Tags: Epidemiology, Cancer Etiology, Brain Tumors, Rare tumor types, Rhabdomyosarcoma & Soft Tissue Sarcoma, Epidemiology, Hereditary Cancers & Genetic Predisposition, CNS Tumors, Outcomes Research, Rapid Communications, Epidemiology, Rhabdo & Other Soft Tissue Source Type: research

Balancing the Risk-Benefit Ratio in the Treatment of Patients With Advanced-Stage Hodgkin Lymphoma [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Borchmann, Engert Tags: Chemotherapy EDITORIALS Source Type: research

Progress in the Earlier Detection of Pancreatic Cancer [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Brentnall Tags: Risk factors, Diagnosis & Staging, MRI, Ultrasound EDITORIALS Source Type: research

Window-of-Opportunity Trials in the Preoperative Setting: Insights Into Drug Development for Estrogen Receptor-Positive Breast Cancer [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Goetz, Suman Tags: EDITORIALS Source Type: research

What Is the Malignancy Risk in Neurofibromatosis Type 1? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Authors: Evans Tags: Epidemiology, Statistical Genetics, Cancer Etiology, CNS Tumors EDITORIALS Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 31, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Erratum [erratum]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Tags: ERRATUM Source Type: research

Reply to A. Fiorentino et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Curley Tags: CORRESPONDENCE Source Type: research

A Plethora of Therapeutic Opportunities for Elderly Patients With Cancer: A Nontrivial Choice [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Fiorentino, Mazzola, Giaj Levra, Ricchetti, Fersino, Alongi Tags: CORRESPONDENCE Source Type: research

Reply to J. Jurgens et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Cai, Zhou Tags: CORRESPONDENCE Source Type: research

The (Con-) Fusion in ALK Diagnostics: When Food and Drug Administration-Approved Algorithms Fail [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Jurgens, Engel-Riedel, Stoelben, Schildgen, Schildgen, Brockmann Tags: CORRESPONDENCE Source Type: research

Reply to T. Reinert et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Ellis, Robertson Tags: CORRESPONDENCE Source Type: research

Definition of First-Line Endocrine Therapy for Hormone Receptor-Positive Advanced Breast Cancer [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Reinert, Barrios Tags: CORRESPONDENCE Source Type: research

Rising [ART OF ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Loren Tags: Emotions of the oncologist, All Art of Oncology Articles Source Type: research

Statistical Challenges in the Analysis of Health-Related Quality of Life in Cancer Clinical Trials [STATISTICS IN BRIEF]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Bonnetain, Fiteni, Efficace, Anota Tags: Clinical Trials, Statistics in Oncology STATISTICS IN BRIEF Source Type: research

Guideline on Muscle-Invasive and Metastatic Bladder Cancer (European Association of Urology Guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement [ASCO SPECIAL ARTICLE]
Purpose To endorse the European Association of Urology guideline on muscle-invasive (MIBC) and metastatic bladder cancer. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The guideline on MIBC and metastatic bladder cancer was reviewed for developmental rigor by methodologists. The ASCO Endorsement Panel then reviewed the content and recommendations. Results The ASCO Endorsement Panel determined that the recommendations from the European Association of Urology guideline on MI...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Milowsky, Rumble, Booth, Gilligan, Eapen, Hauke, Boumansour, Lee Tags: ASCO Guidelines, Non-ASCO Guidelines, Surgery, Chemotherapy ASCO SPECIAL ARTICLE Source Type: research

Definitions, End Points, and Clinical Trial Designs for Non-Muscle-Invasive Bladder Cancer: Recommendations From the International Bladder Cancer Group [REVIEW ARTICLE]
Conclusion The International Bladder Cancer Group has developed formal recommendations regarding definitions, end points, and clinical trial designs for NMIBC to encourage uniformity among studies in this disease. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Kamat, Sylvester, Bohle, Palou, Lamm, Brausi, Soloway, Persad, Buckley, Colombel, Witjes Tags: Clinical Trials, Chemotherapy, Combined Modality Therapy REVIEW ARTICLE Source Type: research

Patient-Reported Outcomes Labeling for Products Approved by the Office of Hematology and Oncology Products of the US Food and Drug Administration (2010-2014) [Health Services and Outcomes]
Conclusion Although symptoms and functional decrements are common among patients with cancer, PRO labeling is rare in the United States, likely because of logistical hurdles and oncology study design. Recent developments within the FDA OHOP to capture PROs in oncology studies for the purpose of product labeling are encouraging. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Gnanasakthy, DeMuro, Clark, Haydysch, Ma, Bonthapally Tags: Outcomes Research Health Services and Outcomes Source Type: research

Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement [Palliative and Supportive Care]
Purpose Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Patients and Methods Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratifi...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Kissane, Zaider, Li, Hichenberg, Schuler, Lederberg, Lavelle, Loeb, Del Gaudio Tags: Supportive Care, Palliative Care Palliative and Supportive Care Source Type: research

A Randomized Phase II Trial of Short-Course Androgen Deprivation Therapy With or Without Bevacizumab for Patients With Recurrent Prostate Cancer After Definitive Local Therapy [Urologic Oncology]
Purpose Patients with recurrent prostate cancer after local treatment make up a heterogeneous population for whom androgen deprivation therapy (ADT) is the usual treatment. The purpose of this randomized phase II trial was to investigate the efficacy and toxicity of short-course ADT with or without bevacizumab in men with hormone-sensitive prostate cancer. Patients and Methods Eligible patients had an increasing prostate-specific antigen (PSA) of ≤ 50 ng/mL and PSA doubling time of less than 18 months. Patients had either no metastases or low burden, asymptomatic metastases (lymph nodes
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: McKay, Zurita, Werner, Bruce, Carducci, Stein, Heath, Hussain, Tran, Sweeney, Ross, Kantoff, Slovin, Taplin Tags: Combined Modality Therapy Urologic Oncology Source Type: research

Association of Androgen Deprivation Therapy With Depression in Localized Prostate Cancer [Urologic Oncology]
Purpose Androgen deprivation therapy (ADT) may contribute to depression, yet several studies have not demonstrated a link. We aimed to determine whether receipt of any ADT or longer duration of ADT for prostate cancer (PCa) is associated with an increased risk of depression. Methods We identified 78,552 men older than age 65 years with stage I to III PCa using the SEER-Medicare–linked database from 1992 to 2006, excluding patients with psychiatric diagnoses within the prior year. Our primary analysis was the association between pharmacologic ADT and the diagnosis of depression or receipt of inpatient or outpatient p...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Dinh, Reznor, Muralidhar, Mahal, Nezolosky, Choueiri, Hoffman, Hu, Sweeney, Trinh, Nguyen Tags: Systemic Therapy Urologic Oncology Source Type: research

Metformin Use and Survival of Patients With Pancreatic Cancer: A Cautionary Lesson [Gastrointestinal Cancer]
Conclusion Our findings did not suggest the benefit of metformin use after patients are diagnosed with PDAC. We highlight the importance of patient selection and appropriate statistical analytical methods when studying medication exposure and cancer survival. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Chaiteerakij, Petersen, Bamlet, Chaffee, Zhen, Burch, Leof, Roberts, Oberg Tags: Prognostic Studies, Epidemiology, Statistics in Oncology Gastrointestinal Cancer Source Type: research

[18F]Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET)/Computed Tomography (CT) in Suspected Recurrent Breast Cancer: A Prospective Comparative Study of Dual-Time-Point FDG-PET/CT, Contrast-Enhanced CT, and Bone Scintigraphy [Breast Cancer]
Conclusion FDG-PET/CT was accurate in diagnosing recurrence in breast cancer patients. It allowed for distant recurrence to be correctly ruled out and resulted in only a small number of false-positive cases. Exploratory findings suggest that FDG-PET/CT has greater accuracy than conventional imaging technologies in this patient group. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Hildebrandt, Gerke, Baun, Falch, Hansen, Farahani, Petersen, Larsen, Duvnjak, Buskevica, Bektas, Soe, Jylling, Ewertz, Alavi, Hoilund-Carlsen Tags: Diagnosis & Staging, Nuclear Medicine, CT Breast Cancer Source Type: research

Adjunct Screening With Tomosynthesis or Ultrasound in Women With Mammography-Negative Dense Breasts: Interim Report of a Prospective Comparative Trial [Breast Cancer]
Conclusion The Adjunct Screening With Tomosynthesis or Ultrasound in Women With Mammography-Negative Dense Breasts’ interim analysis shows that ultrasound has better incremental BC detection than tomosynthesis in mammography-negative dense breasts at a similar FP-recall rate. However, future application of adjunct screening should consider that tomosynthesis detected more than 50% of the additional BCs in these women and could potentially be the primary screening modality. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Tagliafico, Calabrese, Mariscotti, Durando, Tosto, Monetti, Airaldi, Bignotti, Nori, Bagni, Signori, Sormani, Houssami Tags: Diagnosis & Staging Breast Cancer Source Type: research

Genomic Characterization of Primary Invasive Lobular Breast Cancer [Breast Cancer]
Conclusion This study demonstrates that we can now begin to individualize the treatment of ILBC, with HER2, HER3, and AKT1 mutations representing high-prevalence therapeutic targets and FOXA1 mutations and ESR1 gains deserving urgent dedicated clinical investigation, especially in the context of endocrine treatment. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Desmedt, Zoppoli, Gundem, Pruneri, Larsimont, Fornili, Fumagalli, Brown, Rothe, Vincent, Kheddoumi, Rouas, Majjaj, Brohee, Van Loo, Maisonneuve, Salgado, Van Brussel, Lambrechts, Bose, Metzger, Galant, Bertucci, Piccart-Gebhart, Viale, Biganzoli, Campbell Tags: Translational Oncology, Breast Cancer, Cancer Biomarkers, Oncogenes Source Type: research

Scoring System Prognostic of Outcome in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndrome [Hematologic Malignancy]
We examined 2,133 patients with MDS undergoing HLA-matched (n = 1,728) or -mismatched (n = 405) allo HCT from 2000 to 2012. We used a Cox multivariable model to identify factors prognostic of mortality in a training subset (n = 1,151) of the HLA-matched cohort. A weighted score using these factors was assigned to the remaining patients undergoing HLA-matched allo HCT (validation cohort; n = 577) as well as to patients undergoing HLA-mismatched allo HCT. Results Blood blasts greater than 3% (hazard ratio [HR], 1.41; 95% CI, 1.08 to 1.85), platelets 50 x 109/L or less at transplantation (HR, 1.37; 95% CI, 1.18 to 1.61), Kar...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Shaffer, Ahn, Hu, Nishihori, Malone, Valcarcel, Grunwald, Bacher, Hamilton, Kharfan-Dabaja, Saad, Cutler, Warlick, Reshef, Wirk, Sabloff, Fasan, Gerds, Marks, Olsson, Wood, Costa, Miller, Cortes, Daly, Kindwall-Keller, Kamble, Rizzieri, Cahn, Gale, Willia Tags: Leukemia Hematologic Malignancy Source Type: research

Controlled, Randomized, Open-Label Trial of Risk-Stratified Corticosteroid Prevention of Acute Graft-Versus-Host Disease After Haploidentical Transplantation [Hematologic Malignancy]
This study evaluated whether a prophylaxis strategy directed by the graft-versus-host disease (GVHD) biomarker might reduce the 100-day incidence of acute GVHD grades II to IV. Patients and Methods This controlled, open-label, randomized trial included 228 patients who underwent haploidentical transplantation. On the basis of bone marrow allogeneic graft CD4:CD8 ratios, patients were categorized as low risk (n = 83; group A) or high risk (n = 145). Patients at high risk were randomly assigned to either receive (n = 72; group B) or not receive (n = 73; group C) low-dose corticosteroid prophylaxis. Results The incidence in...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Chang, Xu, Wang, Zhang, Chen, Chen, Wang, Han, Sun, Yan, Tang, Mo, Liu, Huang Tags: Leukemia Hematologic Malignancy Source Type: research

Proposed Staging System for Patients With HPV-Related Oropharyngeal Cancer Based on Nasopharyngeal Cancer N Categories [Rapid Communication]
Purpose Patients with human papillomavirus (HPV)–related oropharyngeal cancer (OPC) generally present with more advanced disease but have better survival than patients with HPV-unrelated OPC. The current American Joint Commission on Cancer (AJCC)/Union for International Cancer Control (UICC) TNM staging system for OPC was developed for HPV-unrelated OPC. A new staging system is needed to adequately predict outcomes of patients with HPV-related OPC. Patients and Methods Patients with newly diagnosed HPV-positive OPC (by p16 immunohistochemistry or in situ hybridization) treated at our institution from January 2003 th...
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Dahlstrom, Garden, William, Lim, Sturgis Tags: Epidemiology, Diagnosis & Staging, Rapid Communications Source Type: research

Default Options: Opportunities to Improve Quality and Value in Oncology [COMMENTS AND CONTROVERSIES]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Ojerholm, Halpern, Bekelman Tags: Cost Effectiveness, Quality of Care COMMENTS AND CONTROVERSIES Source Type: research

Current Status of Supplemental Screening in Dense Breasts [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Berg Tags: Diagnosis & Staging, Risk factors, Non-ASCO Guidelines, MRI, Ultrasound, Breast Imaging EDITORIALS Source Type: research

Another Breast Cancer Entity Confirmed: Genomics of Invasive Lobular Breast Cancer [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Gatza, Carey Tags: Translational Oncology EDITORIALS Source Type: research

Graft-Versus-Host Disease Prevention: Corticosteroids Revisited [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Alyea Tags: Combined Therapy EDITORIALS Source Type: research

Human Papillomavirus and Oropharyngeal Cancer Stage [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Gillison Tags: Diagnosis & Staging EDITORIALS Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

Intrathecal Trastuzumab Halts Progression of CNS Metastases in Breast Cancer [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Bousquet, Darrouzain, de Bazelaire, Ternant, Barranger, Winterman, Madelaine-Chambin, Thiebaut, Polivka, Paintaud, Culine, Janin Tags: Chemotherapy DIAGNOSIS IN ONCOLOGY Source Type: research

Hemophagocytic Lymphohistiocytosis With Cerebral Involvement in Richter's Syndrome [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 22, 2016 Category: Cancer & Oncology Authors: Joris, Guiheneuf, Rumebe, Claisse, Gruson, Royer Tags: Diagnosis & Staging DIAGNOSIS IN ONCOLOGY Source Type: research

Reply to A. Korfel et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Schmitz, Nickelsen Tags: CORRESPONDENCE Source Type: research

Therapy for Secondary CNS Involvement in Malignant Lymphomas: No Standard Yet! [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Korfel, Chamberlain, Neuwelt, Thiel, Doolittle, Schlegel, Dreyling, Rubenstein, Fischer, Bjorkholm, Martus, Weller, Glantz Tags: CORRESPONDENCE Source Type: research

Reply to M.C. Chamberlain and T.J. Kruser [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Verschraegen, Thomas, Vinh-Hung Tags: CORRESPONDENCE Source Type: research

Systemic Therapy in Unresectable Meningioma Before Radiotherapy [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Kruser Tags: CORRESPONDENCE Source Type: research

What Lessons Are Imparted From SWOG S9005 for Recurrent Meningioma? [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Chamberlain Tags: CORRESPONDENCE Source Type: research

Reply to C. Shah et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Solin, Gray, Hughes, Wood, Lowen, Badve, Baehner, Ingle, Perez, Recht, Sparano, Davidson Tags: CORRESPONDENCE Source Type: research

Radiation Therapy and the Evolving Definition of Low Risk in Ductal Carcinoma in Situ [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Shah, Vicini, Khan, Arthur, Wazer Tags: CORRESPONDENCE Source Type: research

Can Arts and Communication Programs Improve Physician Wellness and Mitigate Physician Suicide? [ART OF ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Genovese, Berek Tags: Emotions of the oncologist, Patient communication, All Art of Oncology Articles Source Type: research

Comparison of Treatment Effects Measured by the Hazard Ratio and by the Ratio of Restricted Mean Survival Times in Oncology Randomized Controlled Trials [STATISTICS IN ONCOLOGY]
Conclusion On average, the HR provided significantly larger treatment effect estimates than the ratio of RMST. The HR may seem large when the absolute effect is small. RMST-based measures should be routinely reported in randomized trials with time-to-event outcomes. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Trinquart, Jacot, Conner, Porcher Tags: Clinical Trials, Statistics in Oncology Source Type: research

American Society of Clinical Oncology Statement: Human Papillomavirus Vaccination for Cancer Prevention [ASCO SPECIAL ARTICLE]
American Society of Clinical Oncology (ASCO), the leading medical professional oncology society, is committed to lessening the burden of cancer and as such will promote underused interventions that have the potential to save millions of lives through cancer prevention. As the main providers of cancer care worldwide, our patients, their families, and our communities look to us for guidance regarding all things cancer related, including cancer prevention. Through this statement and accompanying recommendations, ASCO hopes to increase awareness of the tremendous global impact of human papillomavirus (HPV) –caused cancer...
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Bailey, Chuang, duPont, Eng, Foxhall, Merrill, Wollins, Blanke Tags: Behavioral and Lifestyle Risk Factors ASCO SPECIAL ARTICLE Source Type: research

Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT) [Palliative and Supportive Care]
Purpose To determine the effectiveness of acupuncture for the management of hot flashes in women with breast cancer. Patients and Methods We conducted a pragmatic, randomized controlled trial comparing acupuncture plus enhanced self-care versus enhanced self-care alone. A total of 190 women with breast cancer were randomly assigned. Random assignment was performed with stratification for hormonal therapy; the allocation ratio was 1:1. Both groups received a booklet with information about climacteric syndrome and its management to be followed for at least 12 weeks. In addition, the acupuncture group received 10 traditional...
Source: Journal of Clinical Oncology - May 10, 2016 Category: Cancer & Oncology Authors: Lesi, Razzini, Musti, Stivanello, Petrucci, Benedetti, Rondini, Ligabue, Scaltriti, Botti, Artioli, Mancuso, Cardini, Pandolfi Tags: Combined Modality, Complementary & Alternative Medicine Palliative and Supportive Care Source Type: research