Treatment of Lymph Node-Negative, Early-Stage HER2-Positive Breast Cancer [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Oguz, Keskin, Colak, Altundag, Akcali Tags: CORRESPONDENCE Source Type: research

Reply to S. Lehrer et al and J.C. Dowdy and R.M. Sayre [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Berwick Tags: CORRESPONDENCE Source Type: research

Melanoma Risk From Dietary Furocoumarins: How Much More Evidence Is Required? [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Dowdy, Sayre Tags: CORRESPONDENCE Source Type: research

Melanoma Risk and Citrus Consumption [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Lehrer, Green, Rosenzweig Tags: CORRESPONDENCE Source Type: research

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline [ASCO SPECIAL ARTICLE]
The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed and tasked with drafting the Breast Cancer Survivorship Care Guideline. A total of 1,073 articles met inclusion criteria; and, afte...
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Runowicz, Leach, Henry, Henry, Mackey, Cowens-Alvarado, Cannady, Pratt-Chapman, Edge, Jacobs, Hurria, Marks, LaMonte, Warner, Lyman, Ganz Tags: ASCO Guidelines, Quality of Life, Quality of Care, Pain Control, Supportive Care, Menopausal Symptoms, Breast Cancer ASCO SPECIAL ARTICLE Source Type: research

Lowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group [Pediatric Oncology]
Conclusion Reduction of therapy to two drugs did not compromise survival outcomes for patients in the IR-GR group, and escalation of therapy with PEI did not significantly improve OS and EFS in patients at HR. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Lopes, Macedo, Aguiar, Barreto, Martins, Sonaglio, Milone, Lima, Almeida, Lopes, Watanabe, D'Andrea, Pianovski, Melaragno, Vianna, Moreira, Bruniera, Zanardo de Oliveira Tags: Germ Cell Tumors Pediatric Oncology Source Type: research

Radiotherapy With 4 Gy x 5 Versus 3 Gy x 10 for Metastatic Epidural Spinal Cord Compression: Final Results of the SCORE-2 Trial (ARO 2009/01) [Radiation Oncology]
Conclusion Short-course RT with 4 Gy x 5 was not significantly inferior to 3 Gy x 10 in patients with MESCC and poor to intermediate expected survival. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Rades, Šegedin, Conde-Moreno, Garcia, Perpar, Metz, Badakhshi, Schreiber, Nitsche, Hipp, Schulze, Adamietz, Norkus, Rudat, Cacicedo, Schild Tags: Radiation Oncology Source Type: research

Prospective Study of 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography for Detecting Gastro-Entero-Pancreatic Neuroendocrine Tumors and Unknown Primary Sites [Gastrointestinal Cancer]
Purpose Gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) are increasing in incidence, and accurate staging is important for selecting the appropriate treatment. 68Ga-DOTATATE imaging is a promising approach for detecting GEPNETs and could help in selecting optimal therapeutic strategies. The aim of this study was to prospectively determine the clinical utility of 68Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) in detecting unknown primary and metastatic GEPNETs. Patients and Methods One hundred thirty-one patients were enrolled in a prospective study of patients undergoing 68Ga-DOTATATE P...
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Sadowski, Neychev, Millo, Shih, Nilubol, Herscovitch, Pacak, Marx, Kebebew Tags: Diagnosis & Staging, Diagnosis & Staging Gastrointestinal Cancer Source Type: research

Long-Term Cardiac Safety Analysis of NCCTG N9831 (Alliance) Adjuvant Trastuzumab Trial [Breast Cancer]
Conclusion The cumulative incidence of CE at 6 years was slightly higher with the addition of trastuzumab; however, the late development of CE is infrequent. Trastuzumab (in the context of anthracycline- and taxane-based therapy) continues to have a favorable benefit-risk ratio. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Advani, Ballman, Dockter, Colon-Otero, Perez Tags: Breast Cancer Source Type: research

Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study [Hematologic Malignancy]
Conclusion In adults with LL, an intensive pediatric-like ALL treatment protocol was associated with a good response rate and outcome. In patients with T-LL, the four-gene oncogenetic classifier and lactate dehydrogenase level were independent prognostic indicators. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Lepretre, Touzart, Vermeulin, Picquenot, Tanguy-Schmidt, Salles, Lamy, Bene, Raffoux, Huguet, Chevallier, Bologna, Bouabdallah, Benichou, Briere, Moreau, Tallon-Simon, Seris, Graux, Asnafi, Ifrah, Macintyre, Dombret Tags: Combined Therapy Hematologic Malignancy Source Type: research

Androgen Deprivation Therapy and Future Alzheimers Disease Risk [Urologic Oncology]
Conclusion Our results support an association between the use of ADT in the treatment of prostate cancer and an increased risk of Alzheimer’s disease in a general population cohort. This study demonstrates the utility of novel methods to analyze electronic medical record data to generate practice-based evidence. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Nead, Gaskin, Chester, Swisher-McClure, Dudley, Leeper, Shah Tags: Bioinformatics, Systemic Therapy Urologic Oncology Source Type: research

Symptom Monitoring With Patient-Reported Outcomes During Routine Cancer Treatment: A Randomized Controlled Trial [Health Services and Outcomes]
Purpose There is growing interest to enhance symptom monitoring during routine cancer care using patient-reported outcomes, but evidence of impact on clinical outcomes is limited. Methods We randomly assigned patients receiving routine outpatient chemotherapy for advanced solid tumors at Memorial Sloan Kettering Cancer Center to report 12 common symptoms via tablet computers or to receive usual care consisting of symptom monitoring at the discretion of clinicians. Those with home computers received weekly e-mail prompts to report between visits. Treating physicians received symptom printouts at visits, and nurses received...
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Basch, Deal, Kris, Scher, Hudis, Sabbatini, Rogak, Bennett, Dueck, Atkinson, Chou, Dulko, Sit, Barz, Novotny, Fruscione, Sloan, Schrag Tags: Supportive Care, Outcomes Research, Quality of Life Health Services and Outcomes Source Type: research

Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain [Palliative and Supportive Care]
Conclusion Our findings do not support the role of pregabalin in patients with CIBP receiving radiotherapy. The role of pregabalin in CIBP with a clinical neuropathic pain component is unknown. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Fallon, Hoskin, Colvin, Fleetwood-Walker, Adamson, Byrne, Murray, Laird Tags: Palliative Care & Pain Management, Pain Control, Radiation Oncology, Other Palliative and Supportive Care Source Type: research

Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib [Rapid Communication]
Purpose Dual human epidermal growth factor receptor 2 (HER2) targeting can increase pathologic complete response rates (pCRs) to neoadjuvant therapy and improve progression-free survival in metastatic disease. CALGB 40601 examined the impact of dual HER2 blockade consisting of trastuzumab and lapatinib added to paclitaxel, considering tumor and microenvironment molecular features. Patients and Methods Patients with stage II to III HER2-positive breast cancer underwent tumor biopsy followed by random assignment to paclitaxel plus trastuzumab alone (TH) or with the addition of lapatinib (THL) for 16 weeks before surgery. An...
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Carey, Berry, Cirrincione, Barry, Pitcher, Harris, Ollila, Krop, Henry, Weckstein, Anders, Singh, Hoadley, Iglesia, Cheang, Perou, Winer, Hudis Tags: Combined Modality, Translational Oncology Rapid Communication Source Type: research

Cancer Survivorship Care: An Opportunity to Revisit Cancer Genetics [COMMENTS AND CONTROVERSIES]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Ruddy, Risendal, Garber, Partridge Tags: Cancer Etiology COMMENTS AND CONTROVERSIES Source Type: research

When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults [ONCOLOGY GRAND ROUNDS]
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 23-year-old man was urgently referred for evaluation of rapidly enlarging cervical lymphadenopathy, pro...
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: ODwyer, Advani Tags: Oncology Grand Rounds Source Type: research

Unlocking Electronic Medical Record Data to Identify Possible Connections Between Cancer and Cognitive Declines [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: McGinty Tags: Systemic Therapy, Systemic Therapy EDITORIALS Source Type: research

PRO-cision Medicine: Personalizing Patient Care Using Patient-Reported Outcomes [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Jensen, Snyder Tags: Outcomes Research, Quality of Life, Quality of Care EDITORIALS Source Type: research

Does Pregabalin Still Have a Role in Treating Cancer-Induced Bone Pain? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Raman, DeAngelis, Bruera, Chow, Lechner, Chow Tags: Pain Control, Pain Control, Palliative Care, Radiation Oncology EDITORIALS Source Type: research

Looking Deep Into the Heterogeneity of Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Can We Understand It Better? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Loi, Savas Tags: Translational Oncology, Gene Expression and Profiling, Immunology/Immunobiology EDITORIALS Source Type: research

Advertising [Oncology Career Center]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Tags: Oncology Career Center Source Type: research

A Right Atrial Mass: "More Than Meets the Eye" [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Arora, Schwartz, Tilson, Netto, Mandal Tags: Diagnosis & Staging, Surgery, CT, Breast Cancer, Thoracic DIAGNOSIS IN ONCOLOGY Source Type: research

Dasatinib-Related Pulmonary Toxicity Mimicking an Atypical Infection [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Jasielec, Larson Tags: Leukemia, Supportive Care, Diagnosis & Staging DIAGNOSIS IN ONCOLOGY Source Type: research

Adult Langerhans Cell Histiocytosis As a Diagnostic Pitfall [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 9, 2016 Category: Cancer & Oncology Authors: Pierro, Vaiselbuh Tags: Rare tumor types DIAGNOSIS IN ONCOLOGY Source Type: research

ERRATA [Errata]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Tags: Errata Source Type: research

Reply to M.G. McNamara et al and T.H. Oo [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Lyman, Kuderer Tags: CORRESPONDENCE Source Type: research

Comment on "Efficacy of Prophylactic Low-Molecular Weight Heparin for Ambulatory Patients With Advanced Pancreatic Cancer: Outcomes From the CONKO-004 Trial" [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Oo Tags: CORRESPONDENCE Source Type: research

"If You Prick Us, Do We Not Bleed?" Whom Should We Choose? [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: McNamara, Lamarca, Hubner, Valle Tags: CORRESPONDENCE Source Type: research

Reply to E. Giovannetti et al [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Ahn Tags: CORRESPONDENCE Source Type: research

Prognostic and Predictive Roles of Thymidylate Synthase Expression in Lung Cancer: The Debate Is Still Open [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Giovannetti, Zucali, Rolfo, Assaraf, Peters Tags: CORRESPONDENCE Source Type: research

When Patients Leave [ART OF ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Geynisman Tags: Emotions of the oncologist, Patient communication, All Art of Oncology Articles Source Type: research

Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting [SPECIAL ARTICLE]
Conclusion This consensus summary equips health care professionals with novel diagnostic and treatment methodologies that aim for optimal treatment of the mother, while protecting fetal and pediatric health. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Lishner, Avivi, Apperley, Dierickx, Evens, Fumagalli, Nulman, Oduncu, Peccatori, Robinson, Van Calsteren, Vandenbroucke, Van den Heuvel, Amant Tags: Non-ASCO Guidelines, Diagnosis & Staging, Radiation, Chemotherapy, Biologic Therapy, Diagnosis & Staging, Radiation, Chemotherapy, Diagnosis & Staging, Chemotherapy, Combined Therapy, Biological Therapy, Supportive Care SPECIAL ARTICLE Source Type: research

Rituximab Maintenance for a Maximum of 5 Years After Single-Agent Rituximab Induction in Follicular Lymphoma: Results of the Randomized Controlled Phase III Trial SAKK 35/03 [Hematologic Malignancy]
Purpose Rituximab maintenance therapy has been shown to improve progression-free survival in patients with follicular lymphoma; however, the optimal duration of maintenance treatment remains unknown. Patients and Methods Two hundred seventy patients with untreated, relapsed, stable, or chemotherapy-resistant follicular lymphoma were treated with four doses of rituximab monotherapy in weekly intervals (375 mg/m2). Patients achieving at least a partial response were randomly assigned to receive maintenance therapy with one infusion of rituximab every 2 months, either on a short-term schedule (four administrations) or a long...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Taverna, Martinelli, Hitz, Mingrone, Pabst, Cevreska, del Giglio, Vanazzi, Laszlo, Raats, Rauch, Vorobiof, Lohri, Biaggi Rudolf, Rondeau, Rusterholz, Heijnen, Zucca, Ghielmini Tags: Biologic Therapy Hematologic Malignancy Source Type: research

Randomized Phase III Trial of Standard Therapy Plus Low Molecular Weight Heparin in Patients With Lung Cancer: FRAGMATIC Trial [Thoracic Oncology]
Conclusion LMWH did not improve overall survival in the patients with lung cancer in this trial. A significant reduction in VTE is associated with an increase in clinically relevant nonmajor bleeding. Strategies to target those at greatest risk of VTE are warranted. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Macbeth, Noble, Evans, Ahmed, Cohen, Hood, Knoyle, Linnane, Longo, Moore, Woll, Appel, Dickson, Ferry, Brammer, Griffiths Tags: Supportive Care, Supportive Care, Combined Modality Thoracic Oncology Source Type: research

Financial Concerns About Participation in Clinical Trials Among Patients With Cancer [Health Services and Outcomes]
Purpose The decision to enroll in a clinical trial is complex given the uncertain risks and benefits of new approaches. Many patients also have financial concerns. We sought to characterize the association between financial concerns and the quality of decision making about clinical trials. Methods We conducted a secondary data analysis of a randomized trial of a Web-based educational tool (Preparatory Education About Clinical Trials) designed to improve the preparation of patients with cancer for making decisions about clinical trial enrollment. Patients completed a baseline questionnaire that included three questions rel...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Wong, Schluchter, Albrecht, Benson, Buzaglo, Collins, Flamm, Fleisher, Katz, Kinzy, Liu, Manne, Margevicius, Miller, Miller, Poole, Raivitch, Roach, Ross, Meropol Tags: Cost of Cancer Care Health Services and Outcomes Source Type: research

Randomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials [Clinical Trials]
Purpose Lack of knowledge and negative attitudes have been identified as barriers to participation in clinical trials by patients with cancer. We developed Preparatory Education About Clinical Trials (PRE-ACT), a theory-guided, Web-based, interactive computer program, to deliver tailored video educational content to patients in an effort to overcome barriers to considering clinical trials as a treatment option. Patients and Methods A prospective, randomized clinical trial compared PRE-ACT with a control condition that provided general clinical trials information produced by the National Cancer Institute (NCI) in text form...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Meropol, Wong, Albrecht, Manne, Miller, Flamm, Benson, Buzaglo, Collins, Egleston, Fleisher, Katz, Kinzy, Liu, Margevicius, Miller, Poole, Roach, Ross, Schluchter Tags: Outcomes Research Clinical Trials Source Type: research

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma [Gastrointestinal Cancer]
Conclusion High-dose hypofractionated proton therapy demonstrated high LC rates for HCC and ICC safely, supporting ongoing phase III trials of radiation in HCC and ICC. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Hong, Wo, Yeap, Ben-Josef, McDonnell, Blaszkowsky, Kwak, Allen, Clark, Goyal, Murphy, Javle, Wolfgang, Drapek, Arellano, Mamon, Mullen, Yoon, Tanabe, Ferrone, Ryan, DeLaney, Crane, Zhu Tags: Radiation, Radiation Oncology Gastrointestinal Cancer Source Type: research

Outcomes After Stereotactic Body Radiotherapy or Radiofrequency Ablation for Hepatocellular Carcinoma [Gastrointestinal Cancer]
Purpose Data guiding selection of nonsurgical treatment of hepatocellular carcinoma (HCC) are lacking. We therefore compared outcomes between stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) for HCC. Patients and Methods From 2004 to 2012, 224 patients with inoperable, nonmetastatic HCC underwent RFA (n = 161) to 249 tumors or image-guided SBRT (n = 63) to 83 tumors. We applied inverse probability of treatment weighting to adjust for imbalances in treatment assignment. Freedom from local progression (FFLP) and toxicity were retrospectively analyzed. Results RFA and SBRT groups were similar with res...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Wahl, Stenmark, Tao, Pollom, Caoili, Lawrence, Schipper, Feng Tags: Surgery, Radiation, Combined Modality, Radiation Oncology Gastrointestinal Cancer Source Type: research

Lapatinib in Combination With Capecitabine Plus Oxaliplatin in Human Epidermal Growth Factor Receptor 2-Positive Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma: TRIO-013/LOGiC--A Randomized Phase III Trial [Gastrointestinal Cancer]
Conclusion Addition of lapatinib to CapeOx did not increase OS in patients with HER2-amplified gastroesophageal adenocarcinoma. There were clear differences in the effect of lapatinib depending on region and age. Future studies could examine this correlation. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Hecht, Bang, Qin, Chung, Xu, Park, Jeziorski, Shparyk, Hoff, Sobrero, Salman, Li, Protsenko, Wainberg, Buyse, Afenjar, Houe, Garcia, Kaneko, Huang, Khan-Wasti, Santillana, Press, Slamon Tags: Clinical Trials, Chemotherapy Gastrointestinal Cancer Source Type: research

Randomized Trial of Low-Dose Morphine Versus Weak Opioids in Moderate Cancer Pain [Palliative and Supportive Care]
Purpose The WHO guidelines on cancer pain management recommend a sequential three-step analgesic ladder. However, conclusive data are lacking as to whether moderate pain should be treated with either step II weak opioids or low-dose step III strong opioids. Patients and Methods In a multicenter, 28-day, open-label randomized controlled study, adults with moderate cancer pain were assigned to receive either a weak opioid or low-dose morphine. The primary outcome was the number of responder patients, defined as patients with a 20% reduction in pain intensity on the numerical rating scale. Results A total of 240 patients wi...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Bandieri, Romero, Ripamonti, Artioli, Sichetti, Fanizza, Santini, Cavanna, Melotti, Conte, Roila, Cascinu, Bruera, Tognoni, Luppi Tags: Pain Control Palliative and Supportive Care Source Type: research

Cetuximab and Radiotherapy Versus Cisplatin and Radiotherapy for Locally Advanced Head and Neck Cancer: A Randomized Phase II Trial [Head and Neck Cancer]
Conclusion CTX concomitant to RT lowered compliance and increased acute toxicity rates. Efficacy outcomes were similar in both arms. These results raise the issue of appropriately selecting patients with head and neck cancer who can benefit from CTX in combination with RT. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Magrini, Buglione, Corvo, Pirtoli, Paiar, Ponticelli, Petrucci, Bacigalupo, Crociani, Lastrucci, Vecchio, Bonomo, Pasinetti, Triggiani, Cavagnini, Costa, Tonoli, Maddalo, Grisanti Tags: Radiation, Chemotherapy, Combined Modality Head and Neck Cancer Source Type: research

Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2 [Breast Cancer]
Conclusion The data from this exploratory analysis suggest that the efficacy of everolimus was largely independent of the most commonly altered genes or pathways in hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer. The potential impact of chromosomal instabilities and low-frequency genetic alterations on everolimus efficacy warrants further investigation. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Hortobagyi, Chen, Piccart, Rugo, Burris, Pritchard, Campone, Noguchi, Perez, Deleu, Shtivelband, Masuda, Dakhil, Anderson, Robinson, He, Garg, McDonald, Bitter, Huang, Taran, Bachelot, Lebrun, Lebwohl, Baselga Tags: Combined Modality, Hormonal Therapy Breast Cancer Source Type: research

Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers [Rapid Communication]
We report absolute risks and hazard ratios within the cohort from competing risk analyses. Results After a median follow-up of 12.5 years, 578 CBCs were observed in our study population. CBC risk for BRCA1 and BRCA2 mutation carriers was two to three times higher than for noncarriers (hazard ratios, 3.31 [95% CI, 2.41 to 4.55; P
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: van den Broek, van t Veer, Hooning, Cornelissen, Broeks, Rutgers, Smit, Cornelisse, van Beek, Janssen-Heijnen, Seynaeve, Westenend, Jobsen, Siesling, Tollenaar, van Leeuwen, Schmidt Tags: Epidemiology, Translational Oncology, Prognostic Studies, Genetic epidemiology Rapid Communication Source Type: research

Can Stereotactic Body Radiotherapy Effectively Treat Hepatocellular Carcinoma? [ONCOLOGY GRAND ROUNDS]
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 78-year-old woman with a past medical history of hepatitis C virus (HCV) presented on routine examinati...
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Barry, Knox, Wei, Dawson Tags: Oncology Grand Rounds Source Type: research

Lapatinib in Gastric Cancer: What Is the LOGiCal Next Step? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Janjigian Tags: Chemotherapy, Translational Oncology, Chemotherapy, Translational Oncology EDITORIALS Source Type: research

Is Cancer Pain Control Improved by a Simple WHO Pain Analgesic Ladder Approach Combined With Tumor-Directed Treatment? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Kaasa Tags: Pain Control, Pain Control EDITORIALS Source Type: research

Cisplatin Versus Cetuximab With Radiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - February 2, 2016 Category: Cancer & Oncology Authors: Husain, Burtness, Decker Tags: Radiation, Chemotherapy, Combined Modality, Radiation Oncology EDITORIALS Source Type: research