Using generalized additive models to decompose time series and waveforms, and dissect heart –lung interaction physiology
AbstractCommon physiological time series and waveforms are composed of repeating cardiac and respiratory cycles. Often, the cardiac effect is the primary interest, but for, e.g., fluid responsiveness prediction, the respiratory effect on arterial blood pressure also convey important information. In either case, it is relevant to disentangle the two effects. Generalized additive models (GAMs) allow estimating the effect of predictors as nonlinear, smooth functions. These smooth functions can represent the cardiac and respiratory cycles ’ effects on a physiological signal. We demonstrate how GAMs allow a decomposition of p...
Source: Journal of Clinical Monitoring and Computing - June 13, 2022 Category: Information Technology Source Type: research

Evaluation of machine learning models as decision aids for anesthesiologists
The objective of this study was to determine if ML models can serve as decision aids to improve anesthesiologists ’ prediction of peak intraoperative glucose values and postoperative opioid requirements. A web-based tool was used to present actual surgical case and patient information to 10 practicing anesthesiologists. They were asked to predict peak glucose levels and post-operative opioid requirements for 100 surgical patients with and without presenting ML model estimations of peak glucose and opioid requirements. The accuracies of the anesthesiologists’ estimates with and without ML estimates as reference were com...
Source: Journal of Clinical Monitoring and Computing - June 9, 2022 Category: Information Technology Source Type: research

Validation of a non-invasive pressure –time index of the inspiratory muscles in spontaneously breathing newborn infants
AbstractTo validate the pressure –time index of the inspiratory muscles as a non-invasive index of inspiratory muscle function in spontaneously breathing infants by comparing it against the gold-standard pressure–time index of the diaphragm. Prospective observational cohort study of consecutive infants breathing unsupported in room air in a tertiary neonatal intensive care unit, studied prior to discharge from neonatal care. The invasive pressure–time index of the diaphragm was calculated using a transdiaphragmatic dual-pressure catheter that measured transdiaphragmatic pressure by subtraction of the oesophageal from...
Source: Journal of Clinical Monitoring and Computing - June 8, 2022 Category: Information Technology Source Type: research

Validation of the patient State Index for monitoring sedation state in critically ill patients: a prospective observational study
ConclusionsThe PSI correlated positively with RASS scores, which represented a widely used tool for assessing sedation levels, and the values were significantly different among RASS scores. Additionally, the PSI had a high sensitivity and specificity for distinguishing light from deep sedation. The PSI could be useful for assessing sedation levels in ICU patients.University Hospital Medical Information Network (UMIN000035199, December 10, 2018). (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - June 4, 2022 Category: Information Technology Source Type: research

Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis
AbstractIn vitro studies have thoroughly documented age-dependent impact of storage lesions in packed red blood cells (pRBC) on erythrocyte oxygen carrying capacity. While studies have examined the effect of pRBC age on patient outcome only few data exist on the microcirculation as their primary site of action. In this secondary analysis we examined the relationship between age of pRBC and changes of microcirculatory flow (MCF) in 54 patients based on data from the Basel Bedside assessment Microcirculation Transfusion Limit study (Ba2MiTraL) on effects of pRBC on sublingual MCF. Mean change from pre- to post-transfusion pr...
Source: Journal of Clinical Monitoring and Computing - June 3, 2022 Category: Information Technology Source Type: research

Real-world outcomes of the hypotension prediction index in the management of intraoperative hypotension during non-cardiac surgery: a retrospective clinical study
AbstractThe Hypotension Prediction Index (HPI) is a validated algorithm developed by applying machine learning for predicting intraoperative arterial hypotension (IOH). We evaluated whether the HPI, combined with a personalized treatment protocol, helps to reduce IOH (depth and duration) and perioperative events in real practice. This was a single-center retrospective study including 104 consecutive adults undergoing urgent or elective non-cardiac surgery with moderate-to-high risk of bleeding, requiring invasive blood pressure and continuous cardiac output monitoring. Depending on the sensor, two comparable groups were id...
Source: Journal of Clinical Monitoring and Computing - June 2, 2022 Category: Information Technology Source Type: research

Ultrasonic cardiac output monitor provides effective non-invasive bedside measurements of neonatal cardiac output
This study determined the accuracy and validity for the haemodynamic parameters of haemodynamically stable neonates after postnatal circulatory adaptation using the ultrasonic cardiac output monitor (USCOM) in comparison with echocardiography. We conducted a prospective, observational study of neonates born at 23 –41 weeks of gestation. They all underwent both echocardiography and USCOM assessments for comparison purposes. The 127 neonates were examined at the median of postmenstrual age of 35 weeks and there was a very high correlation between the cardiac output measurements provided by both methods. Th e mean differe...
Source: Journal of Clinical Monitoring and Computing - June 1, 2022 Category: Information Technology Source Type: research

Description of the validity of the Analgesia Nociception Index (ANI) and Nociception Level Index (NOL) for nociception assessment in anesthetized patients undergoing surgery: a systematized review
The objectives were to describe and a nalyze the validation strategies and results. A systematized review was conducted using a comprehensive search with keywords under three concepts (nociception/pain, ANI/NOL, and validity) in four databases. A quality assessment using an adapted GRADE approach for measurement tools, and a risk of bia s assessment using QUADAS-2 tool were performed by two reviewers. Out of 525 results, 15 validation studies were included. Strategies included hypothesis testing, discriminative, and criterion validation. Significant changes in ANI/NOL values were found in response to nociceptive stimuli at...
Source: Journal of Clinical Monitoring and Computing - June 1, 2022 Category: Information Technology Source Type: research

The impact of urine flow on urine oxygen partial pressure monitoring during cardiac surgery
ConclusionsPuO2 measurements were acquired with enough temporal resolution to demonstrate real-time PuO2 monitoring during CPB and the post-CPB period.ClinicalTrials.gov Identifier:NCT03335865, First Posted Date: Nov. 8th, 2017. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - June 1, 2022 Category: Information Technology Source Type: research

Is endotracheal tube displacement during head and neck extension due to ascending movement or tracheal lengthening? An observational ultrasonographic study
In conclusion, the ETT cuff displaced toward the larynx in a less degree than the tip did from the carina due to the tracheal lengthening during head and neck extension. Nevertheless, we suggest that ultrasonographic assessment of cuff position may avoid ETT misplacement.Trial registrationhttps://cris.nih.go.kr/ (approval no. KCT0005319); registered on May 14, 2019. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - May 26, 2022 Category: Information Technology Source Type: research

Blind vs. video-laryngoscope-guided laryngeal mask insertion: A prospective randomized comparison of oropharyngeal leak pressure and fiberoptic grading
ConclusionsThe findings of our study suggest that the video-laryngoscope-guided LMA-Classic insertion with a standard blade technique may be a helpful alternative to blind insertion. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - May 26, 2022 Category: Information Technology Source Type: research

Costs, benefits and the prevention of patient deterioration
(Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - May 26, 2022 Category: Information Technology Source Type: research

A simple technique to assess postoperative epidural functionality
We describe a method of successfully measuring EWA while reducing wastefulness. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - May 26, 2022 Category: Information Technology Source Type: research

Besdata Video Laryngeal Mask (BD-VLM)- a New Vision-Incorporated 3rd Generation Video Laryngeal Mask Airway
AbstractSince the recent editorial 2, we were approached to evaluate another video laryngeal mask airway - the Besdata Video Laryngeal Mask (BD-VLM) TM, which has a different design concept, specifications and characteristics (Figure 1) compared to the other two. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - May 26, 2022 Category: Information Technology Source Type: research

Evaluation of indigenously developed closed-loop automated blood pressure control system (claps): a preliminary study
AbstractClosed-loop systems have been designed to assist anesthetists in controlling anesthetic drugs and also maintaining the stability of various physiological variables in the normal range. In the present study, we describe and clinically evaluated a novel closed-loop automated blood pressure control system (CLAPS) in patients undergoing cardiac surgery under cardiopulmonary bypass. Forty ASA II –IV adult patients undergoing elective cardiac surgery were randomly allocated to receive adrenaline, noradrenaline, phenylephrine and nitroglycerine (NTG) adjusted either through CLAPS (CLAPS group) or manually (Manual group)...
Source: Journal of Clinical Monitoring and Computing - May 19, 2022 Category: Information Technology Source Type: research