Effect of positioning of the roi on bmd of the forearm and its subregions
Inconsistent positioning of patients and region of interest (ROI) is known to influence the precision of bone mineral density (BMD) measurements in the spine and hip. However it is unknown whether minor shifts in the positioning of the ROI along the shaft of the radius affect the measurement of forearm BMD and its subregions. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Elizabeth O. Rosen, Elizabeth A. McNamara, LaTarsha G. Whittaker, Alan O. Malabanan, Harold N. Rosen Source Type: research
Effect of Vertebral Body Exclusion on TBS and FRAX Calculations
Spinal degenerative changes are common and elevate DXA-measured BMD. However, existing data suggest trabecular bone score (TBS) is relatively unaffected by degenerative changes. Clinically, we observed patients in whom spinal degenerative changes appeared to substantially elevate not only BMD, but also TBS. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: R. White, N. Binkley, D. Krueger Source Type: research
Effect of 3 year Denosumab Treatment on Hip Structure in Japanese Postmenopausal Women and Men with Osteoporosis
Denosumab inhibits bone resorption by binding to and inactivating RANK ligand (RANKL), a key mediator of osteoclast formation, maturation and activation. As in the pivotal phase 3 study, FREEDOM, in predominantly postmenopausal Caucasian women with osteoporosis the efficacy of denosumab was evaluated by the phase 3 study, DIRECT, in Japanese osteoporosis patients. The study showed that 2-year treatment of denosumab significantly reduced risk of new vertebral fracture by 74.0% compared to placebo. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Teruki Sone, Naohiro Kon, Naoki Okubo, Masao Fukunaga, Masako Ito, Toshitaka Nakamura Source Type: research
Epidemiology Of Hip Fractures In Ukraine: Results Of STOP-Study
Hip fracture is one of the most serious complications of osteoporosis, which has important medical, social and economic complications. It is well known that incidence of hip fractures gradually increases with age and depends on the sex, but similar epidemiological studies in Ukraine are limited. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: V.V. Povoroznyuk, N.V. Grygorieva, M.O. Korzh, S.S. Strafun, V.M. Vaida, F.V. Klymovytsky, R.O. Vlasenko, J.A. Kanis, H. Johansson, E.V. McCloskey Source Type: research
Estimates of the precision of total and regional soft tissue body composition by dual-energy X-ray absorptiometry in persons with chronic spinal cord injury
In both the clinical and research setting, the total body dual energy X-ray absorptiometry (DXA) scan is widely employed to measure longitudinal changes in fat tissue mass and lean tissue mass of the total body and regional areas in persons with spinal cord injury (SCI). Knowledge of the precision error is essential due to less than optimal limb positioning (i.e., joint contracture and spasticity) that could confound the reliability of body composition measurements. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Christopher M. Cirnigliaro, Ashraf S. Gorgey, William A. Bauman, Robert A. Adler Source Type: research
Feasibility and Safety of Establishing a Bisphosphonate Infusion Program in a Pediatric Orthopedic Department: A Ten-Year Experience,
Bisphosphonates have been shown to increase bone mineral density (BMD) in adult osteoporosis patients and are potentially useful in pediatric patients with significantly reduced BMD due to chronic illness and musculoskeletal disorders. While the long term efficacy of this therapy is still being elucidated, safety remains underreported. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Marianne Floor, Mirini Kim, Lindsey Weigley, Christina Dollar, Austin Gillies, Laura Lowe Tosi Source Type: research
Forearm studies on Norland Dual Energy X-ray Absorptiometry with seated, prone or supine positioning are equivalent
Densitometry relies on patient positioning to insure that regions of interest are comparable and reflective of standard studies. Traditional forearm scanning has, in the past, been carried out with a subject seated in front of a scanner with the forearm secured in place on the scanner. Unfortunately, given the enclosed arm design the Norland Elite Scanner will not allow the subject to sit in front of the scanner to have forearm studies performed. The current study documents equivalence between forearm studies performed with the subject positioned in a seated or laying in a prone or supine position. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Chad A. Dudzek, Patrick C. Cunniff, Tom V. Sanchez Source Type: research
Fracture Liaison Service at a University Hospital with Level 1 Trauma Center 1 year later
The Fracture Liaison Service (FLS) model improves osteoporosis care following fragility fractures in adults (1). Our institution has implemented the FLS model housed within our Department of Orthopedics utilizing the American Orthopedic Association Own the Bone (OTB) program. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Kristyn J. Hare, Neil Binkley, Paul Anderson Source Type: research
Interactive Case-based Postgraduate Medical Education with Bone Health TeleECHO
Bone Health TeleECHO is a non-profit collaborative medical educational project developed at ECHO Institute at the University of New Mexico Health Sciences Center in association with the Osteoporosis Foundation of New Mexico. It uses videoconferencing technology to link healthcare professionals interested in achieving an advanced level of knowledge about the evaluation and treatment of osteoporosis and metabolic bone diseases. Weekly online sessions have been held since October 2015. Participants use videoconferencing technology with a computer or smartphone for discussion of real de-identified patient cases, with brief did...
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: E. Michael Lewiecki, Rachelle Rochelle, Matthew F. Bouchonville, David H. Chafey, Thomas P. Olenginski, Sanjeev Arora Source Type: research
Low-Trauma Non-Vertebral Fractures In Ukrainian Postmenopausal Women With Obesity And Metabolic Syndrome
Osteoporosis and obesity are two of the worldwide problems, which increase morbidity, disability and mortality among people. Abdominal obesity leads to the metabolic syndrome (MS) development. It was researched that components of MS have influence on bone mineral density (BMD), but data are contradictory.The aim of this study was to determine freaquency of non-vertebral fractures in women with obesity and MS. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Vladyslav Povoroznyuk, Larysa Martynyuk, Nataliia Dzerovych, Liliya Martynyuk Source Type: research
Natural Phenotypes of Fat, Lean, and Bone and Their Association to Metabolic Markers
Our group have developed a method to deconvolute whole body DXA scans into three images, each consisting uniquely of fat, lean, and bone masses. These images are being explored as more sensitive markers of risk for a variety of diseases. We asked if images of fat, lean, and bone distribution can be used to define natural phenotypical groupings and if these groupings are related to common risk factors for metabolic disease and bone fragility. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: John A. Shepherd, Michaela K. Piel, Markus Sommer, Bennett K. Ng, Briana Bourgeois, Steven B. Heymsfield Source Type: research
Obesity, bone density for weight and prevalent vertebral fracture at age 62 years: the Newcastle Thousand Families Study
Obesity is a global epidemic and there remains uncertainty concerning the effect of obesity on skeletal health, particularly in the context of osteoporosis and fracture. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Karen Hind, Harry Rudman, Mark Pearce, Laura Treadgold, Fraser Birrell Source Type: research
Osteoporosis-Related Fracture Events in the US
Osteoporosis is an important public health problem. Even patients who are hospitalized for fracture remain subsequently untreated. Current evidence on fracture occurrence is required to help payers and policymakers prioritize access to therapies and programs that can reduce the burden and cost of osteoporosis. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: D. Leader, S.A. Williams, J.R. Curtis, R. Weiss Source Type: research
Persistent Fracture Reduction with Abaloparatide-SC (TYMLOS ™) Followed by 24 Months of Alendronate
In the ACTIVE phase III trial, 2463 postmenopausal women with osteoporosis were randomized 1:1:1 to abaloparatide (ABL; n=824), blinded placebo (PBO; n=821), or open-label teriparatide (n=818). During ACTIVE, ABL increased BMD and reduced vertebral, nonvertebral, clinical, and major osteoporotic fractures compared to PBO. Women who completed ABL or PBO treatment in ACTIVE were eligible to enroll in an extension study (ACTIVExtend) to receive up to 24 months of open-label alendronate (ALN). (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: K.G. Saag, P.D. Miller, F. Cosman, LA Fitzpatrick, G Hattersley, B Mitlak, JP Bilezikian, RK Dore Source Type: research
Radiotranslucent foam isolation blocks improve regional tissue accuracy in whole body DXA scans
DXA regional body composition accuracy and precision are critically important in many clinical applications including monitoring lymphedema, performance training, and injury recovery. While total body composition measurements are highly precise, regional measurements exhibit lower precision partly due to inconsistencies in subject positioning. In particular, tissue overlap between body regions (such as breast tissue from the trunk overlying the arms, or hands overlapping the hip) limits the ability to follow regional changes in fat and lean masses, as well as symmetry measures. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - October 1, 2018 Category: Radiology Authors: Bennett K. Ng, Yong E. Liu, Thomas L. Kelly, Kevin E. Wilson, John A. Shepherd Source Type: research
