A Case Report of Abnormal Fracture Healing as Detected With High-Resolution Peripheral Quantitative Computed Tomography
Fracture healing is a complex repair process with the primary objective of restoring the mechanical function of the fractured bone (1). Quantifying outcome in clinical fracture healing trials remains challenging (2,3). Using high-resolution peripheral quantitative computed tomography (HR-pQCT) in combination with micro finite element analysis ( µFEA), we previously described the typical healing of a distal radius fracture. This process consists of an increase in bone density of the trabecular compartment peaking at 6 wk post fracture, corresponding to the formation of a mineralized fracture callus (4,5). (Source: Journa...
Source: Journal of Clinical Densitometry - June 13, 2017 Category: Radiology Authors: Frans L. Heyer, Joost J.A. de Jong, Rob J.E.M. Smeets, Jacobus J. Arts, Martijn Poeze, Piet P. Geusens, Bert van Rietbergen, Joop P. van den Bergh, Paul C. Willems Tags: Case Report Source Type: research
Effect of Time of Administration of Teriparatide on Bone Mineral Density in Glucocorticoid-Induced Osteoporosis
Teriparatide (TPTD) (recombinant DNA origin human parathormone [1 –34]) is approved for the treatment of glucocorticoid-induced osteoporosis (GIO). There are reports of factors that affect the response to TPTD in GIO treatment. This work describes the case of a 71-yr-old woman diagnosed with lupus nephropathy treated with 40 mg/d of meprednisone, and who suffe red multiple vertebral fractures. Despite treatment with a single 5 mg dose of zoledronic acid, the patient continued to have vertebral fractures. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - June 1, 2017 Category: Radiology Authors: Silvina R. Mastaglia Tags: Case Report Source Type: research
Effect of Hand Positioning on DXA Total and Regional Bone and Body Composition Parameters, Precision Error, and Least Significant Change
Dual-energy X-ray absorptiometry (DXA) body composition measurements are performed in both clinical and research settings for estimations of total and regional fat mass, lean tissue mass, and bone mineral content. Subject positioning influences precision and positioning instructions vary between manufacturers. The aim of the study was to determine the effect of hand position and scan mode on regional and total body bone and body composition parameters and determine protocol-specific body composition precision errors. (Source: Journal of Clinical Densitometry)
Source: Journal of Clinical Densitometry - April 25, 2017 Category: Radiology Authors: Shane Thurlow, Brian Oldroyd, Karen Hind Tags: Original Article Source Type: research
Quantitative Ultrasound and Tibial Dysplasia in Neurofibromatosis Type 1
Neurofibromatosis type 1 (NF1) is a common autosomal dominant disorder associated with unilateral anterolateral bowing with subsequent fracture and nonunion. In infancy, physiologic bowing of the lower leg can be confused with pathologic tibial dysplasia in NF1. Little is known about the bone physiology of the tibiae prior to fracture or predictors of fracture. The aim of this study was to characterize bone quality of bowed tibiae prior to fracture in NF1 using quantitative ultrasound (QUS). Bone quality was assessed on both tibiae (the non-bowed and bowed tibiae) using QUS to measure speed of sound (SOS) at the mid-shaft ...
Source: Journal of Clinical Densitometry - April 21, 2017 Category: Radiology Authors: David A. Stevenson, Heather Hanson, Austin Stevens, John Carey, David Viskochil, Xiaoming Sheng, Karen Wheeler, Hillarie Slater Source Type: research
