Comparison Of Bicarbonate Values From Venous Blood Gas And Chemistry Panels Measured At The Time Of Diagnosis And Resolution Of Diabetes Ketoacidosis
ConclusionDiscordance between bicarbonate results from different analysis methods may lead to different determinations as to whether or not a patient meets the biochemical definition for diagnosis and resolution of DKA. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - August 17, 2019 Category: Endocrinology Source Type: research

Liquid and softgel capsules of l-thyroxine results lower serum thyrotropin levels than tablet formulations in hypothyroid patients
ConclusionsL-T4 ingested as liquid solution or softgel capsule is more bioavailable compared to L-T4 ingested as tablet, and it is slightly superior to capsule L-T4 only in the absence of co-ingestion of interfering medications. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - August 7, 2019 Category: Endocrinology Source Type: research

Glycaemic variability is associated with adverse cardiovascular outcomes in patients hospitalised with an acute myocardial infarction
Publication date: Available online 29 July 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Thora Y Chai, Mark McLean, Vincent W. Wong, N. Wah CheungAbstractUnlike admission hyperglycaemia, there is significant controversy surrounding whether acute glycaemic variability is associated with major adverse cardiovascular events (MACE) in patients immediately after an acute myocardial infarction (AMI). We conducted a retrospective post-hoc analysis in an AMI population and determined fluctuating glycaemia is associated with a higher risk of 3-month MACE. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 29, 2019 Category: Endocrinology Source Type: research

Assessment of serum thyroid hormone autoantibodies in the first trimester of gestation as predictors of postpartum thyroiditis
ConclusionsGestational positivity of THAb enhance enormously the predictivity for PPT of gestational positivity of TPOAb/TgAb. However, their low frequency (5.1%) and their sensitivity (17.5% [21/63]) go against their application in lieu of TPOAb/TgAb. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 24, 2019 Category: Endocrinology Source Type: research

Hypoglycemic symptoms in the absence of diabetes: Pilot evidence of clinical hypoglycemia in young women
ConclusionsIndividuals with hypoglycemic symptoms in the absence of diabetes experience clinical hypoglycemia, indicating the need to understand the etiology, behavioral responses, and other health risks that might be associated with this understudied condition. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - July 24, 2019 Category: Endocrinology Source Type: research

Publisher Note
Publication date: Available online 31 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - June 1, 2019 Category: Endocrinology Source Type: research

In Experimental Peripheral Arterial Disease, Type 2 Diabetes alters Post-Ischemic gene expression
Publication date: Available online 31 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Rahul Peravali, Lucas Gunnels, Karthik Dhanabalan, Folabi Ariganjoye, Ivan C. Gerling, Ayotunde O. DokunAbstractPeripheral arterial disease is characterized by impaired blood flow to tissues outside the heart due to atherosclerosis and it most frequently occurs in the lower extremities. Type 2 diabetes (T2D) is a well-known risk factor that accelerate the course and contributes to poor clinical outcomes of PAD. While there is some evidence that T2D is associated with altered expression of genes involved in regu...
Source: Journal of Clinical and Translational Endocrinology - June 1, 2019 Category: Endocrinology Source Type: research

Dobesity: relationship between vitamin d deficiency, obesity and sclerostin as a novel biomarker of bone metabolism
ConclusionThese results lead us to hypothesize that the relationship between sclerostin and Vitamin D levels has an important role in the link between obesity and bone metabolism. DObesity could be an active focus of research in the coming years. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 22, 2019 Category: Endocrinology Source Type: research

Chemokines in Hyperthyroidism
Publication date: Available online 17 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Valeria Mazzi, Alessandro Antonelli, Poupak FallahiAbstractThe term “hyperthyroidism” indicates a condition due to an exaggerate production of thyroid hormone; the most frequent cause is Graves' disease (GD).We review cytokines and chemokines in hyperthyroidism, with a special focus in GD.In GD, recruited Th1 lymphocytes are responsible for enhanced IFN-γ and TNF-α production, which in turn sti...
Source: Journal of Clinical and Translational Endocrinology - May 18, 2019 Category: Endocrinology Source Type: research

Bimodal distribution of fasting, one and two hour post load plasma glucose in Asian Indian pregnant women without pre-gestational diabetes: Gestational age related changes
Publication date: Available online 16 May 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): John Punnose, Rajeev Kumar Malhotra, Komal Sukhija, Anu Mathew, Aditi Chopra, Asha Sharma, Naimaa Choudhary (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 17, 2019 Category: Endocrinology Source Type: research

Urinary Metabolic Profiles after Vitamin D2 versus Vitamin D3 Supplementation in Prediabetes
ConclusionsAt comparable circulating 25(OH)D concentrations, vitamin D2 or D3 supplementation does not appear to result in different urinary metabolite profiles. Our finding does not support a biological difference between vitamin D2 and D3. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 9, 2019 Category: Endocrinology Source Type: research

The differences in the relationship between obstructive sleep apnea severity and trabecular bone score in men and women with type 2 diabetes
ConclusionsIn T2DM patients, there is a complex interrelationship among OSA severity, gender and TBS. More severe OSA predicted lower TBS in men, but predicted higher TBS in postmenopausal women. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - May 3, 2019 Category: Endocrinology Source Type: research

Metabolic Dysfunction in Emirati Subjects in Abu Dhabi: Relationship to Levels of Soluble RAGEs
Conclusion/DiscussionLevels of sRAGE, but not esRAGE, were associated with T2D status in Abu Dhabi, but not after correction for eGFR. Elevated levels of plasma insulin in both control and T2D subjects suggests the presence of metabolic dysfunction, even in subjects without diabetes. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Disparities in prediabetes and type 2 diabetes prevalence between indigenous and nonindigenous populations from Southeastern Mexico: The Comitan Study
ConclusionsThe prevalence of prediabetes and type 2 diabetes was significantly lower in indigenous than in nonindigenous participants. Also, prevalence of type 2 diabetes was lower those living in rural areas. Health benefits of a traditional lifestyle may partially account for these differences. (Source: Journal of Clinical and Translational Endocrinology)
Source: Journal of Clinical and Translational Endocrinology - April 21, 2019 Category: Endocrinology Source Type: research

Hyperthyroidism in the pregnant woman: maternal and fetal aspects
Publication date: Available online 12 April 2019Source: Journal of Clinical & Translational EndocrinologyAuthor(s): Mariacarla Moleti, Maria Di Mauro, Giacomo Sturniolo, Marco Russo, Francesco VermiglioAbstractHyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal complications. Also, fetal prognosis may be affected by the transplacental passage of maternal thyroid stimulating antibodies or thyrostatic agents, both of which may disr...
Source: Journal of Clinical and Translational Endocrinology - April 13, 2019 Category: Endocrinology Source Type: research