The role of electromagnetic fields in neurological disorders
Publication date: Available online 12 April 2016 Source:Journal of Chemical Neuroanatomy Author(s): Murat Terzi, Berra Ozberk, Omur Gulsum Deniz, Suleyman Kaplan In the modern world, people are exposed to electromagnetic fields (EMFs) as part of their daily lives; the important question is “What is the effect of EMFs on human health?” Most previous studies are epidemiological, and we still do not have concrete evidence of EMF pathophysiology. Several factors may lead to chemical, morphological, and electrical alterations in the nervous system in a direct or indirect way. It is reported that non-ionizing E...
Source: Journal of Chemical Neuroanatomy - April 24, 2016 Category: Neuroscience Source Type: research

Distribution of olfactory marker protein in the rat vomeronasal organ
Publication date: November 2016 Source:Journal of Chemical Neuroanatomy, Volume 77 Author(s): A. Rodewald, D. Gisder, V.M. Gebhart, H. Oehring, G.F Jirikowski Olfactory marker protein (OMP) may act as a modulator within the olfactory signal-transduction cascade. It has also been shown to have some importance in development of olfactory sensory organs. Here we used high resolution immunocytochemistry to localize OMP in the rat vomeronasal organ (VNO). Immunofluorescence for OMP was abundant in cilia and in apical dendrites of sensory cells, mostly associated with intraepithelial capillaries. Perikarya were stained to...
Source: Journal of Chemical Neuroanatomy - April 24, 2016 Category: Neuroscience Source Type: research

Expression of ecto-nucleoside triphosphate diphosphohydrolase3 (NTPDase3) in the female rat brain during postnatal development
Publication date: Available online 2 April 2016 Source:Journal of Chemical Neuroanatomy Author(s): Ivana Grković, Ivana Bjelobaba, Nataša Mitrović, Irena Lavrnja, Dunja Drakulić, Jelena Martinović, Miloš Stanojlović, Anica Horvat, Nadežda Nedeljković Nucleoside triphosphate diphosphohydrolase3 (NTPDase3) is membrane-bound ecto-enzyme which hydrolyzes extracellular ATP, thus modulating the function of purinergic receptors and the pattern of purinergic signaling. Here we analyzed the developmental expression of NTPDase3 in female hypothalamus, cerebral cortex and hippocampal formation at diffe...
Source: Journal of Chemical Neuroanatomy - April 2, 2016 Category: Neuroscience Source Type: research

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis
This study indicates that axonal and NMJ degeneration in the SOD1 model of ALS is a complex and evolving sequence of events. We provide evidence that YFP can detect morphological and plastic alterations in the SOD1G93A mouse, and that the pre- and post-synaptic integrity of the NMJ plays an important role in the pathogenic mechanisms of ALS. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - March 31, 2016 Category: Neuroscience Source Type: research

Glucose transporter 5 (GLUT5)-like immunoreactivity is localized in subsets of neurons and glia in the rat brain
This study aimed at examining the distribution of glucose transporter 5 (GLUT5), which preferentially transports fructose, in the rat brain by immunohistochemistry and Western blotting. Small immunoreactive puncta (less than 0.7μm) were sparsely distributed all over the brain, some of which appeared to be associated with microglial processes detected by an anti-ionized calcium-binding adapter molecule 1 (Iba-1) monoclonal antibody. In addition, some of these immunoreactive puncta seemed to be associated with tanycyte processes that were labeled with anti-glial fibrillary acidic protein (GFAP) monoclonal antibody. Ependy...
Source: Journal of Chemical Neuroanatomy - March 29, 2016 Category: Neuroscience Source Type: research

Neural regeneration dynamics of xenopus laevis olfactory epithelium after zinc sulfate-induced damage
Publication date: Available online 21 March 2016 Source:Journal of Chemical Neuroanatomy Author(s): J.L. Frontera, M. Raices, A.S. Cervino, A.G. Pozzi, D.A. Paz Neural stem cells (NSCs) of the olfactory epithelium (OE) are responsible for tissue maintenance and the neural regeneration after severe damage of the tissue. In the normal OE, NSCs are located in the basal layer, olfactory receptor neurons (ORNs) mainly in the middle layer, and sustentacular (SUS) cells in the most apical olfactory layer. In this work, we induced severe damage of the OE through treatment with a zinc sulfate (ZnSO4) solution directly in the...
Source: Journal of Chemical Neuroanatomy - March 22, 2016 Category: Neuroscience Source Type: research

Midcingulate Cortex: Structure, Connections, Homologies, Functions and Diseases
Publication date: Available online 15 March 2016 Source:Journal of Chemical Neuroanatomy Author(s): A. Brent Midcingulate cortex (MCC) has risen in prominence as human imaging identifies unique structural and functional activity therein and this is the first review of its structure, connections, functions and disease vulnerabilities. The MCC has two divisions (anterior, aMCC and posterior, pMCC) that represent functional units and the cytoarchitecture, connections and neurocytology of each is shown with immunohistochemistry and receptor binding. The MCC is not a division of anterior cingulate cortex (ACC) and the &ldquo...
Source: Journal of Chemical Neuroanatomy - March 16, 2016 Category: Neuroscience Source Type: research

Axonal activity-dependent myelination in development: insights for myelin repair
Publication date: Available online 8 March 2016 Source:Journal of Chemical Neuroanatomy Author(s): Stanislaw Mitew, Yao Lulu Xing, Tobias D. Merson Recent advances in transgenic tools have allowed us to peek into the earliest stages of vertebrate development to study axon-glial communication in the control of peri-natal myelination. The emerging role of neuronal activity in regulating oligodendrocyte progenitor cell behavior during developmental myelination has opened up an exciting possibility– a role for neuronal activity in the early stages of remyelination. Recent work from our laboratory and others has also...
Source: Journal of Chemical Neuroanatomy - March 10, 2016 Category: Neuroscience Source Type: research

Sodium and water intake are not affected by gabac receptor activation in the lateral parabrachial nucleus of sodium-depleted rats
Publication date: Available online 9 March 2016 Source:Journal of Chemical Neuroanatomy Author(s): Gean Domingos-Souza, Cesar Arruda Meschiari, Samyra Lopes Buzelle, João Carlos Callera, José Antunes-Rodrigues The activation of GABAergic receptors, GABAA and GABAB, in the lateral parabrachial nucleus (LPBN) increases water and sodium intake in satiated and fluid-depleted rats. The present study investigated the presence of the GABAC receptor in the LPBN, its involvement in water and sodium intake, and its effects on cardiovascular parameters during the acute fluid depletion induced by furosemide combin...
Source: Journal of Chemical Neuroanatomy - March 10, 2016 Category: Neuroscience Source Type: research

Stereological Analyses of Reward System Nuclei in Maternally Deprived/Separated Alcohol Drinking Rats
In this study we use operant conditioning of rats to show that the maternal separation stress (MS) model of ELS consumes up to 3-fold greater quantities of 10% vol/vol EtOH in 1-hour, consistently over a 3-week period. This was correlated with a significant 22% reduction in the number of neurons in the VTA of naïve MS rats, similar to genetically alcohol-preferring (P) rats which show a 35% reduction in tyrosine hydroxylase (TH)-positive dopaminergic neurons in the VTA. MS rats had a significantly higher 2-fold immobility time in the forced swim test (FST) and reduced sucrose drinking compared to controls, indicative ...
Source: Journal of Chemical Neuroanatomy - March 4, 2016 Category: Neuroscience Source Type: research

An applicable method of drawing cerebrospinal fluid in rats
Conclusions CSF collection by CC puncture using a negative pressure collection apparatus is fast to operate, safe to the rats, and maximum amount of CSF can be collected. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - February 24, 2016 Category: Neuroscience Source Type: research

An applicable method of drawing cerebrospinal fluid in rat
Conclusions CSF collection by CC puncture using a negative pressure collection apparatus is fast to operate, safe to the rats, and maximum amount of CSF can be collected. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - February 23, 2016 Category: Neuroscience Source Type: research

Immunohistochemical distribution of the cannabinoid receptor 1 and fatty acid amide hydrolase in the dog claustrum
Publication date: Available online 22 February 2016 Source:Journal of Chemical Neuroanatomy Author(s): Andrea Pirone, Carlo Cantile, Vincenzo Miragliotta, Carla Lenzi, Elisabetta Giannessi, Bruno Cozzi Cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) are part of the endocannabinoid system (ECB) which exerts a neuromodulatory activity on different brain functions and plays a key role in neurogenesis. Although many studies have reported FAAH and CB1R expression in the brain of different animal species, to the best of our knowledge they have never been described in the canine claustrum. Claustrum sa...
Source: Journal of Chemical Neuroanatomy - February 23, 2016 Category: Neuroscience Source Type: research

The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration
Publication date: Available online 6 February 2016 Source:Journal of Chemical Neuroanatomy Author(s): YuHong Fu, George Paxinos, Charles Watson, Glenda M. Halliday The pathology of Parkinson’s disease (PD) is characterised by the loss of neurons in the substantia nigra parcompacta (A9), which results in the insufficient release of dopamine, and the appearance of motor symptoms. Not all neurons in the A9 subregions degenerate in PD, and the dopaminergic (DA) neurons located in the neighbouring ventral tegmental area (A10) are relatively resistant to PD pathogenesis. An increasing number of quantitative studies u...
Source: Journal of Chemical Neuroanatomy - February 7, 2016 Category: Neuroscience Source Type: research

Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure
The objective of the this study was to evaluate the effects of cellular phone radiation on oxidative stress paremeters and oxide levels in mouse brain during pentylenetetrazole (PTZ) induced epileptic seizure. Eight weeks old mice were used in the study. Animals were distributed in the following groups: Group I: Control group treated with PTZ, Group II: 15min cellular phone radiation+PTZ treatment+30min cellular phone radiation, Group III: 30min cellular phone radiation+PTZ treatment+30min cellular phone radiation. The RF radiation was produced by a 900MHz cellular phone. Lipid peroxidation, which is the indicator of oxida...
Source: Journal of Chemical Neuroanatomy - February 2, 2016 Category: Neuroscience Source Type: research

Expression of c-Fos protein in medial septum/diagonal band of Broca and CA3 region, associated with the temporary inactivation of the supramammillary area.
Publication date: Available online 21 January 2016 Source:Journal of Chemical Neuroanatomy Author(s): Lourdes Aranda The supramammillary (SuM) area is part of the diencephalic nuclei comprising the mammillary bodies, and is a key structure in the memory and spatial learning processes. It is a critical region in the modulation/generation of hippocampal theta rhythm. In addition, many papers have recently shown a clear involvement of this structure in the processes of spatial learning and memory in animal models, although it is still not known how it modulates spatial navigation and response emotional. The aim of the pres...
Source: Journal of Chemical Neuroanatomy - January 24, 2016 Category: Neuroscience Source Type: research

LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity
This study suggests a likely interaction between genetic and environmental risk factors in the PD pathogenesis and that the G2019S mutation in LRRK2 increases the susceptibility of dopamine neurons to PD-causing toxins. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 24, 2016 Category: Neuroscience Source Type: research

The protective role of ascorbic acid on hippocampal CA1 pyramidal neurons in a rat model of maternal lead exposure
This study was designed to examine if ascorbic acid also protects neuronal morphology during developmental lead exposure. Timed pregnant rats were divided into four treatment groups: (1) control, (2) 100mg/kg ascorbic acid once a day via gavage, (3) 0.05% lead acetate in drinking water, and (4) 0.05% lead+100mg/kg oral ascorbic acid. Brains of eight male pups (P25) per treatment group were processed for Golgi staining. Changes in hippocampal CA1 pyramidal neurons' somal size were estimated by cross-sectional area and changes in dendritic arborization by Sholl's analysis. One-way ANOVA was used to compare results among trea...
Source: Journal of Chemical Neuroanatomy - January 18, 2016 Category: Neuroscience Source Type: research

Stereological approaches to dementia research using human brain tissue
Publication date: Available online 14 January 2016 Source:Journal of Chemical Neuroanatomy Author(s): D. Erskine, A.A. Khundakar The relationship between the clinical features of dementia disorders and the underlying neuropathological changes that occur to the brain has long been of interest to researchers working in the field of neurodegenerative disorders. The majority of neuropathological research in dementia has utilised semi-quantitative analysis of protein inclusions, which are the defining histological feature of these conditions. However, the advent of three-dimensional stereological techniques has enabled unbi...
Source: Journal of Chemical Neuroanatomy - January 15, 2016 Category: Neuroscience Source Type: research

Cross-modal plasticity in sensory deprived animal models: From the thalamocortical development point of view
Publication date: Available online 13 October 2015 Source:Journal of Chemical Neuroanatomy Author(s): Cecilia Mezzera, Guillermina López-Bendito Over recent decades, our understanding of the plasticity of the central nervous system has expanded enormously. Accordingly, it is now widely accepted that the brain can adapt to changes by reorganizing its circuitry, both in response to external stimuli and experience, as well as through intrinsic mechanisms. A clear example of this is the activation of a deprived sensory area and the expansion of spared sensory cortical regions in individuals who suffered peripheral s...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

The MCH neuron population as a model for the development and evolution of the lateral and dorsal hypothalamus
Publication date: Available online 13 October 2015 Source:Journal of Chemical Neuroanatomy Author(s): Chometton Sandrine, Croizier Sophie, Fellmann Dominique, Risold Pierre-Yves The LHA contains neurons producing melanin-concentrating hormone (MCH) or hypocretin (Hcrt) that have emerged as being more conspicuous and representative of the posterior LHA. In this review, we focus on MCH neurons and show that they have unique qualities. Their distribution is conserved in the posterior hypothalamus of all vertebrates and their ontogenetic differentiation is very precocious in the rodent embryo. In mammals, interspecific d...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Developing a census of brain cells for the corticoendogram of human consciousness
Publication date: Available online 27 October 2015 Source:Journal of Chemical Neuroanatomy Author(s): Peter R. Mouton, Christina Sobin (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Neurodegenerative changes and apoptosis induced by intrauterine and extrauterine exposure of radiofrequency radiation
This study was performed to identify the effects of global system for mobile communications (GSM) modulated mobile phone like RFR in 1800MHz frequency on oxidative DNA damage and lipid peroxidation beside the apoptotic cell formation, using histopathological and immunohistochemical methods in the brain tissue of 1-month-old male and female New Zealand White rabbits that were exposed to these fields at their mother's womb and after the birth. Oxidative DNA damage and lipid peroxidation levels were investigated by measuring the 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels, respectively. Histopa...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Oxidative stress of brain and liver is increased by Wi-Fi (2.45GHz) exposure of rats during pregnancy and the development of newborns
In conclusion, Wi-Fi-induced oxidative stress in the brain and liver of developing rats was the result of reduced GSH-Px, GSH and antioxidant vitamin concentrations. Moreover, the brain seemed to be more sensitive to oxidative injury compared to the liver in the development of newborns. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

The ever-changing brain: Clinical implications
Publication date: Available online 1 November 2015 Source:Journal of Chemical Neuroanatomy Author(s): Davide Dulcis (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Neurobiology of Brain Disorders, 1st edition, M.J. Zigmond, J.T. Coyle, L.P. Rowland (Eds.). Imprint: Academic Press (3 December 2014)
Publication date: November 2015 Source:Journal of Chemical Neuroanatomy, Volume 69 Author(s): Dibbanti Harikrishnareddy, Bikash Medhi (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Organization of cholinergic, catecholaminergic, serotonergic and orexinergic nuclei in three strepsirrhine primates: Galago demidoff, Perodicticus potto and Lemur catta
Publication date: December 2015 Source:Journal of Chemical Neuroanatomy, Volume 70 Author(s): Tanya Calvey, Nina Patzke, Consolate Kaswera-Kyamakya, Emmanuel Gilissen, Mads F. Bertelsen, John D. Pettigrew, Paul R. Manger The nuclear organization of the cholinergic, catecholaminergic, serotonergic and orexinergic systems in the brains of three species of strepsirrhine primates is presented. We aimed to investigate the nuclear complement of these neural systems in comparison to those of simian primates, megachiropterans and other mammalian species. The brains were coronally sectioned and immunohistochemically staine...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease
In this study, we aimed to investigate how TH is regulated in the brain, gut and adrenal gland as well as changes in mature brain-derived neurotrophic factor (mBDNF) and proBDNF levels in a low-dose (2mg/kg, 5 days/week for 4 weeks) rotenone model of Parkinson's disease (PD). Rearing behaviour decreased by week 3 in the rotenone group (p <0.01), with further decreases in rearing by week 4 (p <0.001); however, TH remained unchanged in the substantia nigra (SN) and striatum; TH levels were also unaltered in other catecholaminergic cell groups of the brainstem such as A1C1 neurons or locus coeruleus. In the olfa...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish
In this study, we identified two MT homologous genes (mt2 and smtb) in the zebrafish. Digoxigenin-in situ hybridization showed the expression of mt2 and smtb genes in the ventricular layers in the telencephalon, diencephalon, mesencephalon and rhombencephalon, most of which are cell proliferating regions in the brain of zebrafish. Cellular characteristics of MT genes expressing cells were examined by double-labelling with markers for neurons (HuC/D) and astrocytes (glial fibrillary acidic protein, GFAP and S100 protein) and cell proliferation marker (PCNA). mt2 and smtb mRNAs are expressed in neurons and not in astrocytes,...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Nuclear organization of some immunohistochemically identifiable neural systems in two species of the Euarchontoglires: A Lagomorph, Lepus capensis, and a Scandentia, Tupaia belangeri
Publication date: December 2015 Source:Journal of Chemical Neuroanatomy, Volume 70 Author(s): Tanya Calvey, Abdulaziz N. Alagaili, Mads F. Bertelsen, Adhil Bhagwandin, John D. Pettigrew, Paul R. Manger The present study describes the organization of the nuclei of the cholinergic, catecholaminergic, serotonergic and orexinergic systems in the brains of two members of Euarchontoglires, Lepus capensis and Tupaia belangeri. The aim of the present study was to investigate the nuclear complement of these neural systems in comparison to previous studies on Euarchontoglires and generally with other mammalian species. Brain...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): John F. Smiley, Troy A. Hackett, Cynthia Bleiwas, Eva Petkova, Aleksandar Stankov, J. John Mann, Gorazd Rosoklija, Andrew J. Dwork Although major depressive disorder (MDD) and schizophrenia (SZ) are closely associated with disrupted functions in frontal and limbic areas of cerebral cortex, cellular pathology has also been found in other brain areas, including primary sensory cortex. Auditory cortex is of particular interest, given the prominence of auditory hallucinations in SZ, and sensory deficits in MDD. We u...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Different methods for evaluating the effects of microwave radiation exposure on the nervous system
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Berrin Zuhal Altunkaynak, Gamze Altun, Ahmed Yahyazadeh, Arife Ahsen Kaplan, Omur Gulsum Deniz, Aysın Pinar Türkmen, Mehmet Emin Önger, Suleyman Kaplan Microwave radiation (MWR) leads to hazardous effects on he central nervous system (CNS) for both human and animals. The widespread use of mobile phones has increased the risks of health problems in the CNS caused by radiofrequency (RF) electromagnetic fields. To determine these effects various methodological approaches related to neuroscience such as s...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Aging affects new cell production in the adult hippocampus: A quantitative anatomic review
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Shozo Jinno In the last century, cognitive impairment in elderly people was considered as the consequence of neuronal death. However, later analyses indicated that age-related reduction in neuron number was limited to specific regions of the central nervous system, and was irrelevant to brain dysfunction in both humans and non-human animals. Recent studies have indicated that progressive diminution of neural plasticity across an individual's life span may underlie age-related brain dysfunction. To date, various factors...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Laura N. Borodinsky, Yesser H. Belgacem Morphogenetic proteins are responsible for patterning the embryonic nervous system by enabling cell proliferation that will populate all the neural structures and by specifying neural progenitors that imprint different identities in differentiating neurons. The adoption of specific neurotransmitter phenotypes is crucial for the progression of neuronal differentiation, enabling neurons to connect with each other and with target tissues. Preliminary neurotransmitter specification ...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Electromagnetic field and brain development
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Suleyman Kaplan, Omur Gulsum Deniz, Mehmet Emin Önger, Aysın Pınar Türkmen, Kıymet Kübra Yurt, Işınsu Aydın, Berrin Zuhal Altunkaynak, Devra Davis Rapid advances in technology involve increased exposures to radio-frequency/microwave radiation from mobile phones and other wireless transmitting devices. As cell phones are held close to the head during talking and often stored next to the reproductive organs, studies are mostly focused on the brain. In fact, more research is especially needed t...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Differential developmental strategies by Sonic hedgehog in thalamus and hypothalamus
Publication date: Available online 12 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Yuanfeng Zhang, Gonzalo Alvarez-Bolado The traditional concept of diencephalon (thalamus plus hypothalamus) and with it the entire traditional subdivision of the developing neural tube are being challenged by novel insights obtained by mapping the expression of key developmental genes. A model in which the hypothalamus is placed in the most rostral portion of the neural tube, followed caudally by a diencephalon formed by prethalamus, thalamus and pretectum has been proposed. The adult thalamus and hypothalamus are qui...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Long live the axon. Parallels between ageing and pathology from a presynaptic point of view
Publication date: Available online 14 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Federico W. Grillo All animals have to find the right balance between investing resources into their reproductive cycle and protecting their tissues from age-related damage. In higher order organisms the brain is particularly vulnerable to ageing, as the great majority of post-mitotic neurons are there to stay for an entire life. While ageing is unavoidable, it may progress at different rates in different individuals of the same species depending on a variety of genetic and environmental factors. Inevitably though, age...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

The plastic neurotransmitter phenotype of the hippocampal granule cells and of the moss in their messy fibers
Publication date: Available online 15 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Rafael Gutiérrez The granule cells (GCs) and their axons, the mossy fibers (MFs), make synapses with interneurons in the hilus and CA3 area of the hippocampus and with pyramidal cells of CA3, each with distinct anatomical and functional characteristics. Many features of synaptic communication observed at the MF synapses are not usually observed in most cortical synapses, and thus have drawn the attention of many groups studying different aspects of the transmission of information. One particular aspect of the GC...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Morphological and antioxidant impairments in the spinal cord of male offspring rats following exposure to a continuous 900MHz electromagnetic field during early and mid-adolescence
Publication date: Available online 17 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Ayşe İkinci, Tolga Mercantepe, Deniz Unal, Hüseyin Serkan Erol, Arzu Şahin, Ali Aslan, Orhan Baş, Havva Erdem, Osman Fikret Sönmez, Haydar Kaya, Ersan Odacı The effects of devices emitting electromagnetic field (EMF) on human health have become the subject of intense research among scientists due to the rapid increase in their use. Children and adolescents are particularly attracted to the use of devices emitting EMF, such as mobile phones. The aim of this study was therefore to investigate cha...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Environment- and activity-dependent dopamine neurotransmitter plasticity in the adult substantia nigra
Publication date: Available online 21 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Tim D. Aumann The ability of neurons to change the amount or type of neurotransmitter they use, or ‘neurotransmitter plasticity’, is an emerging new form of adult brain plasticity. For example, it has recently been shown that neurons in the adult rat hypothalamus up- or down-regulate dopamine (DA) neurotransmission in response to the amount of light the animal receives (photoperiod), and that this in turn affects anxiety- and depressive-like behaviors (Dulcis et al., 2013). In this Chapter I consolidate rec...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Controversies related to electromagnetic field exposure on peripheral nerves
Publication date: Available online 21 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Ferhat Say, Berrin Zuhal Altunkaynak, Sina Coşkun, Ömür Gülsüm Deniz, Çağrı Yıldız, Gamze Altun, Arife Ahsen Kaplan, Sefa Ersan Kaya, Ahmet Pişkin Electromagnetic field (EMF) is a pervasive environmental presence in modern society. In recent years, mobile phone usage has increased rapidly throughout the world. As mobile phones are generally held close to the head while talking, studies have mostly focused on the central and peripheral nervous system. There is a need for further ...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Effects of GSM modulated radio-frequency electromagnetic radiation on permeability of blood–brain barrier in male & female rats
This study was designed to investigate the possible effects of pulse modulated 900MHz and 1800MHz radio-frequency radiation on the permeability of blood–brain barrier of rats. Study was performed with 6 groups of young adult male and female wistar albino rats. The permeability of blood-brain barrier to intravenously injected evans blue dye was quantitatively examined for both control and radio-frequency radiarion exposed groups. For male groups; Evans blue content in the whole brain was found to be 0.08±0.01mg% in the control, 0.13±0.03mg% in 900MHz exposed and 0.26±0.05mg% in 1800MHz exposed ani...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Mitochondrial regulation of reactive oxygen species (ROS) production—Unexpected observations in early postnatal cerebral vasculature
Publication date: Available online 24 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): S. Wolf, A. Mattheis, U. Laufs, C. Meier, T. Tschernig Nicotinamide-nucleotide-transhydrogenase (Nnt) is a mitochondrial protein. It is altered and functionally lacking in the C57BL/6J sub-strain. This leads to the generation of more radical oxygen species than in the C57BL/6N sub-strain. During studies on the effect of Nnt in perinatal hypoxia the cerebral vasculature was investigated in postnatal day 9 mice using post mortem arterial filling with silicone rubber compounds. Surprisingly, the tiny vessels were no l...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Combination of grafted Schwann cells and lentiviral-mediated prevention of glial scar formation improve recovery of spinal cord injured rats
Publication date: Available online 30 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Anh Do Thi, Florence E. Perrin, Mathieu Desclaux, Paulette Saillour, Lahouari Amar, Alain Privat, Jacques Mallet The present study was intended to combine three therapeutic approaches in a well-defined rat model of spinal cord injury, a lateral hemisection at thoracic level. A guidance channel was implanted at the lesion site. This channel was seeded with native Schwann cells or Schwann cells that had been previously transduced with a lentiviral vector carrying the GDNF gene. Thereafter, these experiences were re...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters
Publication date: Available online 31 December 2015 Source:Journal of Chemical Neuroanatomy Author(s): Luis Puelles, Loreta Medina, Ugo Borello, Isabel Legaz, Anne Teissier, Alessandra Pierani, John L.R. Rubenstein The progeny of Dbx1-expressing progenitors was studied in the developing mouse pallium, using two transgenic mouse lines: (1) Dbx1nlslacZ mice, in which the gene of the β-galactosidase reporter (LacZ) is inserted directly under the control of the Dbx1 promoter, allowing short-term lineage tracing of Dbx1-derived cells; and (2) Dbx1CRE mice crossed with a Cre-dependent reporter strain (ROSA26loxP&mi...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

RETRACTED: The synergistic effect between β-amyloid1–42 and α-synuclein on the synapses dysfunction in hippocampal neurons
This article has been retracted at the request of the Editor and the Publisher. After a thorough investigation, the Publisher has concluded that the acceptance of this article was based upon the positive advice of at least one faked reviewer report. The report was submitted from a fictitious email account which was provided to the journal as a suggested reviewer by the corresponding author during the submission of the paper. This manipulation of the peer-review process represents a clear violation of the fundamentals of peer review, our publishing policies, and publishing ethics standards. Apologies are offered to the revi...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model
Publication date: January 2016 Source:Journal of Chemical Neuroanatomy, Volume 71 Author(s): Sachchida Nand Rai, Satyndra Kumar Yadav, Divakar Singh, Surya Pratap Singh Parkinson's disease (PD) is characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc) region of brain. Oxidative stress and inflammation plays important role in the neurodegeneration and development of PD. Ursolic Acid (UA: 3β-hydroxy-urs-12-en-28-oic acid) is a natural pentacyclic triterpenoid found in various medicinal plants. Its anti-inflammatory and antioxidant activity is a well-e...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Ontogeny and innervation of taste buds in mouse palatal gustatory epithelium
This study reveals that the nerve fibers preceded the development of taste buds in the palate of mice, and therefore the nerve fibers have roles in the initial induction of taste buds in the soft palate. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

Three-dimensional visualization of the distribution of melanin-concentrating hormone producing neurons in the mouse hypothalamus
We present here a new procedure to represent the 3D distribution of neuronal cell bodies within the brain, using exclusively softwares free for research purposes. Our technique is based on digitalized photos of brain slices processed by immunohistochemical technique, and the 3D Slicer software. The technique presented enables transposition of immunohistochemical or in situ hybridization data to the stereotaxic mouse brain atlas (e.g. Paxinos, G., Franklin, K.B.J., 2001. The Mouse Brain in Stereotaxic Coordinates. second ed. Academic Press, San Diego). By exporting the finalized models into a popular 3D design software (3DS...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research

New learning and memory related pathways among the hippocampus, the amygdala and the ventromedial region of the striatum in rats
Conclusion The results implicated potential new functional and structural pathways through these brain areas during the process of learning and memory. The pathways ran from ventromedial portion (the marginal division) of the striatum to the central amygdaloid nucleus and then to the hippocampus before going back to the marginal division of the striatum. Two smaller circuits were between the marginal division and the central amygdaloid nucleus, and between the central amygdaloid nucleus and the hippocampus. These connections have added new dimensions of neural networks of learning and memory, and might be involved in the p...
Source: Journal of Chemical Neuroanatomy - January 12, 2016 Category: Neuroscience Source Type: research