Topographic specializations of catecholaminergic cells and ganglion cells and distribution of calcium binding proteins in the crepuscular rock cavy (Kerodon rupestris) retina
Publication date: Available online 22 December 2017 Source:Journal of Chemical Neuroanatomy Author(s): Francisco Gilberto Oliveira, Expedito Silva do Nascimento-Júnior, Judney Cley Cavalcante, Fausto Pierdoná Guzen, Jeferson de Souza Cavalcante, Joacil Germano Soares, José Rodolfo Lopes de Paiva Cavalcanti, Leandro Moura de Freitas, Miriam Stela Maris de Oliveira Costa, Belmira Lara da Silveira Andrade-da-Costa The rock cavy (Kerodon rupestris) is a crepuscular Hystricomorpha rodent that has been used in comparative analysis of retinal targets, but its retinal organization remains to be investigated. ...
Source: Journal of Chemical Neuroanatomy - December 22, 2017 Category: Neuroscience Source Type: research

Cortical and spinal conditioned media modify the inward ion currents AND excitability and PROMOTE DIFFERENTIATION of human striatal primordium.
Publication date: Available online 20 December 2017 Source:Journal of Chemical Neuroanatomy Author(s): Eglantina Idrizaj, Erica Sarchielli, Annamaria Morelli, Rachele Garella, Maria Caterina Baccari, Pasquale Gallina, Gabriella Barbara Vannelli, Fabio Francini, Roberta Squecco Human striatal precursor cells (HSPs) isolated from ganglionic eminence may differentiate in electrophysiologically functional excitable neuron-like cells and a number of endogenous molecules such as hormones, neurotransmitters or growth factors can actually regulate neuronal growing and differentiation. The purpose of this research was to assess, b...
Source: Journal of Chemical Neuroanatomy - December 21, 2017 Category: Neuroscience Source Type: research

Reinforcing mitochondrial functions in aging brain: An insight into Parkinson's disease therapeutics
Publication date: Available online 18 December 2017 Source:Journal of Chemical Neuroanatomy Author(s): G. Chandra, R.A. Shenoi, R. Anand, U. Rajamma, K.P. Mohanakumar Mitochondria, the powerhouse of the neural cells in the brain, are also the seat of certain essential gene signaling pathways that control neuronal functions. Deterioration of mitochondrial functions has been widely reported in normal aging as well as in a spectrum of age-associated neurological diseases, including Parkinson’s disease (PD). Evidences accumulated in the recent past provide not only advanced information on the causes of mitochondrial bio...
Source: Journal of Chemical Neuroanatomy - December 19, 2017 Category: Neuroscience Source Type: research

Changes in the Element Concentration of the Dorsal Hippocampus CA1 Region during Memory Consolidation and Reconsolidation
Publication date: Available online 14 December 2017 Source:Journal of Chemical Neuroanatomy Author(s): Paulo Fernandes Costa Jobim, Carla Eliete Iochims dos Santos, Luka Jeromel, Primoz Pellicon, Livio Amaral, Johnny Ferraz Dias The concentration and distribution of Mg, P, Cl, K, Cu and Zn in the dorsal hippocampus CA1 region of rat brains were studied during memory consolidation and reconsolidation processes stimulated with inhibitory avoidance (IA) tests. Experimental rats were divided into four groups: i) group not submitted to inhibitory avoidance task (IA-N); ii) group submitted to inhibitory avoidance training sessi...
Source: Journal of Chemical Neuroanatomy - December 15, 2017 Category: Neuroscience Source Type: research

Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAP τ) induced neurotoxicity in Alzheimer’s disease Drosophila model
This study provides the first evidence that supplementation of C. pluricaulis along with the regular standard food ameliorate the neurotoxic effect of hMAPτ in AD Drosophila model and also reveals that it is a potent neuroprotective agent. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Non-steroidal anti-inflammatory drugs and nervous system development
Publication date: Available online 4 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Süleyman Kaplan (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

A strategic plan to identify key neurophysiological mechanisms and brain circuits in autism
Publication date: Available online 8 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Frédérique Bonnet-Brilhault, Laurice Tuller, Philippe Prévost, Joëlle Malvy, Rasha Zebib, Sandrine Ferré, Christophe dos Santos, Sylvie Roux, Emmanuelle Houy-Durand, Rémy Magné, Yassine Mofid, Marianne Latinus, Claire Wardak, Nadia Aguillon-Hernandez, Magali Batty, Marie Gomot Autism and Autism Spectrum Disorder (ASD) cover a large variety of clinical profiles which share two main dimensions: social and communication impairment and repetitive behaviors or restricted interests...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Cellular calcium signaling in the aging brain
Publication date: Available online 9 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Remya Chandran, Mantosh Kumar, Lakshmi Kesavan, Reena Sarah Jacob, Sowmya Gunasekaran, Sethu Lakshmi, C. Sadasivan, R.V. Omkumar Aging in the biological system is an irreversible process. In the initial stages of lifespan aging improves survival skills of an organism while in the later stages aging reduce the survival skills. Aging is associated with changes in several cellular and molecular functions among which calcium signaling is a prominent one. Calcium signaling is essential for many vital functions of the brain and...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Mitochondrial SIRT3 and neurodegenerative brain disorders
Publication date: Available online 9 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Anamika, Archita Khanna, Papia Acharjee, Arup Acharjee, Surendra Kumar Trigun Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require NAD+ for their activity, the cellular level of Sirtuins represents redox status of the cells and thereby serves as bona fide metabolic stress sensors. Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and a...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study
Publication date: Available online 24 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Elnaz Khordad, Fatemeh Alipour, Farimah Beheshti, Mahmoud Hosseini, Ali Akbar Rajabzadeh, Farimah Asiaei, Masoumeh Seghatoleslam Hypothyroidism causes an imbalance in antioxidant and pro-oxidants criteria in the brain and enhances the concentration of reactive oxygen species (ROS), and neuronal damage has been observed following an excessive ROS. The main purpose of this study was to examine the preventive effect of vitamin C on hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats. P...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Sequence and localization of kcnk10a in the brain of adult zebrafish (Danio rerio)
In this study, the full length sequence and localization of kcnk10a in the brain was investigated and gene expressions of the TREK channel family were examined to investigate association with reproduction. We initially identified the full length cDNA sequence of kcnk10a using Rapid Amplification of cDNA Ends and localization in the zebrafish brain using in situ hybridization. Furthermore, we examined the gene expression differences of kcnk2b, kcnk10a and kcnk10b mRNA between genders as well as developmental stages by real-time PCR. The deduced amino acid sequence of the identified kcnk10a mRNA contains highly conserved two...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Incomplete concordance of dopamine transporter Cre (DATIREScre)-mediated recombination and tyrosine hydroxylase immunoreactivity in the mouse forebrain
This study extends earlier literature focusing primarily on DAT expression in midbrain structures to demonstrate a heterogeneity of DAT and TH co-localization in forebrain neurons, particularly those in the hypothalamus. It also highlights the importance of carefully selecting and validating transgenic mouse lines when studying dopaminergic neurons. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Spinal cord self-repair during tail regeneration in Polypedates maculatus and putative role of FGF1 as a neurotrophic factor
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Jutshina Hota, Sushri Sangita Pati, Pravati Kumari Mahapatra Spinal cord injury could be fatal in man and often results in irreversible medical conditions affecting mobility. However, anuran amphibians win over such pathological condition by the virtue of regeneration abilities. The tail of anuran tadpoles therefore allures researchers to study spinal cord injury and self- repair process. In the present study, we inflicted injury to the spinal cord by means of surgical transection of the tail and investigated the self-repair activit...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Chitosan-film associated with mesenchymal stem cells enhanced regeneration of peripheral nerves: A rat sciatic nerve model
Conclusion Taken together, mesenchymal stem cells associated with Cs could improve functional and histomorphological properties of the sciatic nerve after injury which may have some clinical outcomes as well. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Suleyman Kaplan, M. Emin Onger, B. Zuhal Altunkaynak, Ebru Elibol, Omur G. Deniz, M. Önder Karayiğit, Murat Yarım, Cafer Marangoz, Murat Çetin Ragbetli The aim of this study is to investigate the effects of spermine and the passive avoidance learning on hippocampus following transient cerebral ischemia in the chicks. The study is composed of the pure control (CG), sham (SG) and experimental groups (n=20). Experimental groups (ischemia group, IG and ischemia-spermine group, ISG) were exposed to ischemia for 20min wherea...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Diffusion tensor and volumetric magnetic resonance imaging findings in the brains of professional musicians
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Niyazi Acer, Serap Bastepe-Gray, Ayse Sagiroglu, Kazim Z. Gumus, Levent Degirmencioglu, Gokmen Zararsiz, Muhammet Usame Ozic Professional musicians represent an ideal model to study the training-induced brain plasticity. The current study aimed to investigate the brain volume and diffusion characteristics of musicians using structural magnetic resonance and diffusion tensor imaging (DTI). The combined use of volumetric and diffusion methods in studying musician brain has not been done in literature. Our study group consisted of seve...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Numerical and length densities of microvessels in the human brain: Correlation with preferential orientation of microvessels in the cerebral cortex, subcortical grey matter and white matter, pons and cerebellum
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Tereza Kubíková, Petra Kochová, Petr Tomášek, Kirsti Witter, Zbyněk Tonar To provide basic data on the local differences in density of microvessels between various parts of the human brain, including representative grey and white matter structures of the cerebral hemispheres, the brain stem and the cerebellum, we quantified the numerical density NV and the length density LV of microvessels in two human brains. We aimed to correlate the density of microvessels with previously published data on thei...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Changes in the expression and localization of signaling molecules in mouse facial motor neurons during regeneration of facial nerves
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Jeongtae Kim, Shiori Kobayashi, Chigusa Shimizu-Okabe, Akihito Okabe, Changjong Moon, Taekyun Shin, Chitoshi Takayama After injury, peripheral axons usually re-extend toward their target, and neuronal functions recover. Previous studies have reported that expression of various molecules are transiently altered in motor neurons after nerve injury, but the time course of these changes and their relationship with functional recovery have not been clearly demonstrated. We used the mouse facial nerve transection and suturing model, and e...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat
Publication date: March 2018 Source:Journal of Chemical Neuroanatomy, Volume 88 Author(s): Przemysław Kowiański, Grażyna Lietzau, Aleksandra Steliga, Ewelina Czuba, Beata Ludkiewicz, Monika Waśkow, Jan H. Spodnik, Janusz Moryś Coffee and nicotine consumption are frequently combined, indicating possible intensifying effect of caffeine on smoking behavior, although neurobiological background of this phenomenon remains unknown. We aimed at determining the effect of caffeine and nicotine, applied separately or simultaneously, on activation of six structures of the brain reward system: nucleus accumbens (NAc), ventral teg...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Distribution of Smad mRNA and proteins in the rat brain
In this study, we examined the expression of Smad1, -2, -3, -4, -5, and -8 mRNA in the rat brain by means of RT-PCR and in situ hybridization (ISH). In addition, we examined the nuclear accumulation of Smad1, -2, -3, -5, and -8 proteins after intracerebroventricular injection of TGF-β1, activin A, or BMP6 with immunohistochemistry to investigate whether TGF-β, activin, and/or BMP activate Smads in the rat brain. RT-PCR analysis revealed that Smad1, -2, -3, -4, -5, and -8 mRNA was expressed in the brain and that the Smad3 and Smad8 mRNA differed in the expression level between brain regions. For example, there wer...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Distribution of NADPH-diaphorase reactivity in the central nervous system of the common toad (Bufo bufo)
We examined the distribution of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-reactive elements in the central nervous system (CNS) of the common toad, Bufo bufo. The investigation involved adult male and female toads collected during the breeding season. Labeled neurons of different morphological appearances (weakly or darkly stained, unipolar, bipolar, and multipolar) and fibers were observed across all subdivisions of the amphibian brain. Overall, a similar distribution of NADPH-d-labeled neurons was observed in the brain of male and female toads. In the secondary prosencephalon NADPH-d-labeled neuron...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research

Beneficial effects of dietary restriction in aging brain
Publication date: Available online 12 October 2017 Source:Journal of Chemical Neuroanatomy Author(s): Ibanylla Kynjai Hynniewta Hadem, Teikur Majaw, Babiangshisha Kharbuli, Ramesh Sharma Aging is a multifactorial complex process that leads to the deterioration of biological functions wherein its underlying mechanism is not fully elucidated. It affects the organism at the molecular and cellular level that contributes to the deterioration of structural integrity of the organs. The central nervous system is the most vulnerable organ affected by aging and its effect is highly heterogeneous. Aging causes alteration in the stru...
Source: Journal of Chemical Neuroanatomy - October 12, 2017 Category: Neuroscience Source Type: research

Peripheral nerve and diclofenac sodium: Molecular and clinical approaches
Publication date: Available online 14 September 2017 Source:Journal of Chemical Neuroanatomy Author(s): Arife Ahsen Kaplan, Kıymet Kübra Yurt, Ömür Gülsüm Deniz, Gamze Altun Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed medications worldwide. Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes. This drug can be used to relieve neuropathic pain. In this review, we examine the relevant researches, including in vivo, animal, and clinical human studies, with the aim of understanding the ef...
Source: Journal of Chemical Neuroanatomy - September 15, 2017 Category: Neuroscience Source Type: research

Nuclear organisation of cholinergic, catecholaminergic, serotonergic and orexinergic neurons in two relatively large-brained rodent species —The springhare (Pedetes capensis) and Beecroft’s scaly-tailed Squirrel (Anomalurus beecrofti)
Publication date: Available online 13 September 2017 Source:Journal of Chemical Neuroanatomy Author(s): Jordan Sweigers, Adhil Bhagwandin, Muhammad A. Spocter, Consolate Kaswera-Kyamakya, Emmanuel Gilissen, Paul R. Manger, Busisiwe C. Maseko The present study describes the nuclear organization of the cholinergic, catecholaminergic, serotonergic and orexinergic systems in the brains of the springhare and Beecroft’s scaly-tailed squirrel following immunohistochemical labelling. We aimed to investigate any differences in the nuclear organization of these neural systems when compared to previous data on other species of...
Source: Journal of Chemical Neuroanatomy - September 13, 2017 Category: Neuroscience Source Type: research

Methyl aspartylphenylalanine, the pons and cerebellum in mice: An evaluation of motor, morphological, biochemical, immunohistochemical and apoptotic effects
In this study, adult mice were assigned to five groups, and administered vehicle (distilled water), or aspartame (20, 40, 80 and 160mg/kg body weight) for 28days. Behavioural tests to assess motor-balance and gait were conducted on day 28, following which animals were sacrificed. Sections of the cerebellar cortex and pons were processed, for general histology and Bielschwosky’s silver staining protocol. Glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) immunoreactivity were assessed. Antioxidant status and aspartic acid/cysteine-aspartic acid protease (caspase)-3 levels were also assessed using...
Source: Journal of Chemical Neuroanatomy - September 8, 2017 Category: Neuroscience Source Type: research

How motor, cognitive and musical expertise shapes the brain: Focus on fMRI and EEG resting-state functional connectivity
Publication date: Available online 30 August 2017 Source:Journal of Chemical Neuroanatomy Author(s): Pauline Cantou, Hervé Platel, Béatrice Desgranges, Mathilde Groussard Brain activity and structure are shaped by life experiences. This plasticity has often been demonstrated with different types of expertise by using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Experts showed domain-specific functional neural changes during completion of a task when compared to non-experts. However, all of these results are task-dependent and even though they have proven useful for understan...
Source: Journal of Chemical Neuroanatomy - September 6, 2017 Category: Neuroscience Source Type: research

Myths and truths about the cellular composition of the human brain: A review of influential concepts
Publication date: Available online 2 September 2017 Source:Journal of Chemical Neuroanatomy Author(s): Christopher S. Bvon Bartheld Over the last 50 years, quantitative methodology has made important contributions to our understanding of the cellular composition of the human brain. Not all of the concepts that emerged from quantitative studies have turned out to be true. Here, I examine the history and current status of some of the most influential notions. This includes claims of how many cells compose the human brain, and how different cell types contribute and in what ratios. Additional concepts entail whether we lose ...
Source: Journal of Chemical Neuroanatomy - September 3, 2017 Category: Neuroscience Source Type: research

The in situ morphology of microglia is highly sensitive to the mode of tissue fixation
Publication date: Available online 1 September 2017 Source:Journal of Chemical Neuroanatomy Author(s): Bogdan Cătălin, Laura Stopper, Tudor-Adrian Bălşeanu, Anja Scheller Microglia are known as the most motile cells in the central nervous system (CNS). It was shown in vivo that they permanently scan their direct microenvironment and react to pathological conditions within minutes. Many studies of brain pathologies use fixed brain tissue to investigate cellular changes. Unfortunately, due to technical reasons, the time span between the induction of the fixation procedure (start of the perfusion) and the finally-fixed t...
Source: Journal of Chemical Neuroanatomy - September 2, 2017 Category: Neuroscience Source Type: research

How Motor, Cognitive and Musical Expertise Shapes the Brain: Focus on the fMRI and EEG Resting-State Functional Connectivity
Publication date: Available online 30 August 2017 Source:Journal of Chemical Neuroanatomy Author(s): Pauline Cantou, Hervé Platel, Béatrice Desgranges, Mathilde Groussard Brain activity and structure are shaped by life experiences. This plasticity has often been demonstrated with different types of expertise by using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Experts showed domain-specific functional neural changes during completion of a task when compared to non-experts. However, all of these results are task-dependent and even though they have proven useful for understan...
Source: Journal of Chemical Neuroanatomy - August 31, 2017 Category: Neuroscience Source Type: research

Protective Effect of α-Lipoic Acid against α-Cypermethrin-Induced Changes in Rat Cerebellum
This study was planned to evaluate the possible role of α-lipoic acid in α −cypermethrin induced toxicity in brain of male albino rats. Rats were divided into four groups. The control, α-cypermethrin, α-lipoic acid and α −cypermethrin plus α-lipoic acid treated groups. The duration of the experiment was four weeks. Our results showed that the administration of α-cypermethrin caused a significant decreased in γ- aminobutyric acid level, acetylcholinesterase, catalase, superoxide dismutase activities and increase in lipid peroxidation in cerebellum. Furthermore, the...
Source: Journal of Chemical Neuroanatomy - August 26, 2017 Category: Neuroscience Source Type: research

Parvalbumin, but not calretinin, neurons express high levels of α1-containing GABAA receptors, α7-containing nicotinic acetylcholine receptors and D2-dopamine receptors in the basolateral amygdala of the rat
In conclusion, the present results indicate that not only principal neurons but also GABAergic interneurons have specific receptors, which allow these cells to respond to the GABAergic, cholinergic and dopaminergic inputs coming to the basolateral amygdala of the rat. Since these cells receive intrinsic GABAergic inputs, they are strongly interconnected. Since they also receive extrinsic cholinergic and dopaminergic inputs, such stimulation may result in stimulus-driven feed-forward control of the principal neurons. The effects of such control may be either feed-forward inhibition of the principal neurons via α7 nico...
Source: Journal of Chemical Neuroanatomy - August 20, 2017 Category: Neuroscience Source Type: research

Tamoxifen and amphetamine abuse: Are there therapeutic possibilities?
Publication date: October 2017 Source:Journal of Chemical Neuroanatomy, Volumes 83–84 Author(s): Sarah Mikelman, Natalie Mardirossian, Margaret E. Gnegy Although best known as a selective estrogen receptor modulator (SERM), tamoxifen is a drug with a wide range of activities. Tamoxifen has demonstrated some efficacy has a therapeutic for bipolar mania and is believed to exert these effects through inhibition of protein kinase C (PKC). As the symptoms of amphetamine treatment in rodents are believed to mimic the symptoms of a manic episode, many of the preclinical studies for this indication have demonstrated that ta...
Source: Journal of Chemical Neuroanatomy - August 18, 2017 Category: Neuroscience Source Type: research

Acute spinal cord injury: a review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention
Publication date: Available online 10 August 2017 Source:Journal of Chemical Neuroanatomy Author(s): Emrullah Hayta, Hasan Elden Acute spinal cord injury (SCI) is one of the serious central nervous system injuries, which can lead to significant neurological impairments and a reduction in quality of life with loss in sensory and motor functions. Although recent advancements contribute to the understanding of the underlying pathophysiological processes developed after SCI, currently, there is limited innovative and effective treatment options besides conventional rehabilitation and management of SCI to alleviate the conditi...
Source: Journal of Chemical Neuroanatomy - August 10, 2017 Category: Neuroscience Source Type: research

Extending the family: Roles for uptake2 transporters in regulation of monoaminergic signaling
Publication date: Available online 28 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): Paul J. Gasser, Lynette C. Daws (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 28, 2017 Category: Neuroscience Source Type: research

Editorial for the special issue: Monoamine transporters in health and disease
Publication date: Available online 27 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): Paul J. Gasser, Lynette C. Daws (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 27, 2017 Category: Neuroscience Source Type: research

Receptor visualization and the atomic bomb. A historical account of the development of the chemical neuroanatomy of receptors for neurotransmitters and drugs during the Cold War
Publication date: Available online 27 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): J.M. Palacios, G. Mengod This is a historical account of how receptors for neurotransmitters and drugs got to be seen at the regional, cellular, and subcellular levels in brain, in the years going from the end of the World War II until the collapse of the Soviet Union, the Cold War (1945-1991). The realization in the US of the problem of mental health care, as a consequence of the results of medical evaluation for military service during the war, let the US Government to act creating among other things the National Institute...
Source: Journal of Chemical Neuroanatomy - July 27, 2017 Category: Neuroscience Source Type: research

Differentiation Potential of Human CD133 Positive Hematopoietic Stem Cells into Motor Neuron- like Cells, in vitro
Conclusion Human UCB- CD133+ HSCs are remarkably potent cell candidates to transdifferentiate into motor neuron-like cells, in vitro. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 25, 2017 Category: Neuroscience Source Type: research

Advances and perspectives in tissue clearing using CLARITY
Publication date: Available online 17 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): Kristian H. Reveles Jensen, Rune W. Berg CLARITY is a tissue clearing method, which enables immunostaining and imaging of large volumes for 3D-reconstruction. The method was initially time-consuming, expensive and relied on electrophoresis to remove lipids to make the tissue transparent. Since then several improvements and simplifications have emerged, such as passive clearing (PACT) and methods to improve tissue staining. Here, we review advances and compare current applications with the aim of highlighting needed improveme...
Source: Journal of Chemical Neuroanatomy - July 17, 2017 Category: Neuroscience Source Type: research

Mechanical properties of the human spinal cord under the compressive loading
This study was aimed at experimentally measuring the mechanical properties of the human cervical spinal cord of 24 isolated fresh samples under the unconfined compressive loading at a relatively low strain rate. The stress-strain data revealed the elastic modulus and maximum/failure stress of 40.12±6.90 and 62.26±5.02kPa, respectively. Owing to the nonlinear response of the spinal cord, the Yeoh, Ogden, and Mooney-Rivlin hyperelastic material models have also been employed. The results may have implications not only for understanding the linear elastic and nonlinear hyperelastic mechanical properties of the c...
Source: Journal of Chemical Neuroanatomy - July 15, 2017 Category: Neuroscience Source Type: research

Comparative investigation of neuronal nitric oxide synthase immunoreactivity in rat and human claustrum
Publication date: Available online 15 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): Boycho Landzhov, Dimka Hinova-Palova, Lawrence Edelstein, Elena Dzhambazova, Ilina Brainova, Georgi P. Georgiev, Vesela Ivanova, Adrian Paloff, Wladimir Ovtscharoff We compared the distribution, density and morphological characteristics of nitric oxide synthase-immunoreactive (NOS-ir) neurons in the rat and human claustrum. These neurons were categorized by diameter into three main types: large, medium and small. In the human claustrum, large neurons ranged from 26 to 40μm in diameter, medium neurons from 20 to 25μm an...
Source: Journal of Chemical Neuroanatomy - July 15, 2017 Category: Neuroscience Source Type: research

Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A Comparative Study
In this study, the neuroprotective effects of estrogen was evaluated in the 1-methyl-4-phe-nyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD with cognitive deficit and compared to Levodopa (LD), a well reported neuroprotective agent used for treating PD. Twenty-four Swiss albino mice were randomly divided into four groups: Control, MPTP, MPTP+LD and MPTP+estrogen. The behavioral recovery in both LD and estrogen treated mice were investigated using the rotarod, foot printing, narrow beam walking test and hanging tests. Non-motor behavioral recovery in both LD and estrogen treated were investigated using the Y-maze and Morri...
Source: Journal of Chemical Neuroanatomy - July 13, 2017 Category: Neuroscience Source Type: research

Development of the cerebellum in turbot (Psetta maxima): Analysis of cell proliferation and distribution of calcium binding proteins
Publication date: Available online 13 July 2017 Source:Journal of Chemical Neuroanatomy Author(s): Encarnación De Miguel, Rosa Álvarez-Otero (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - July 13, 2017 Category: Neuroscience Source Type: research

Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer ’s disease: A potential therapeutic target?
Publication date: Available online 30 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): Parmi Patel, Jigna Shah Amyloid beta (Aβ) deposition is considered to be one of the primary reason to trigger Alzheimer’s disease (AD). Literature clearly suggests decline in Aβ clearance to be accountable for progression of late onset AD as compared to augmented Aβ production. There may be several pathways for Aβ clearance out of which one of the major pathway is the vascular-mediated removal of Aβ from the brain across the blood-brain barrier (BBB) via efflux pumps or receptors. Among Aβ...
Source: Journal of Chemical Neuroanatomy - June 30, 2017 Category: Neuroscience Source Type: research

Computer-assisted three-dimensional tracking of sensory innervation in the murine bladder mucosa with two-photon microscopy
Publication date: Available online 28 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): Anna Schueth, Bart Spronck, Marc A.M.J. van Zandvoort, Gommert A. van Koeveringe A strong association between functional bladder disorders and bladder sensation is well-known, with a relationship between malfunctioning detrusor muscle and abnormal sensation arising from the sub-urothelium and the lamina propria (LP), has been suggested. However, the exact underlying pathophysiology of these bladder disorders is not completely understood. Therefore, it is important to gain knowledge on sensory innervation of the urinary bladd...
Source: Journal of Chemical Neuroanatomy - June 29, 2017 Category: Neuroscience Source Type: research

Comparison of unbiased stereological estimation of total number of cresyl violet stained neurons and parvalbumin positive neurons in the adult human spiral ganglion
Publication date: Available online 23 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): C. Kaur, I. Pal, S. Saini, T.G. Jacob, T.C. Nag, A. Thakar, D.N. Bhardwaj, T.S. Roy Estimation of total number of neurons in the Spiral Ganglion (SG) at various ages and their functional status is important as these neurons are constantly exposed to noise and other environmental factors that may lead to neuronal loss with aging due to excitotoxic damage. Parvalbumin (PV) is a calcium-binding protein (CBP), found in highly metabolically active neurons. It helps in buffering cytosolic calcium, which is essential for neurotrans...
Source: Journal of Chemical Neuroanatomy - June 24, 2017 Category: Neuroscience Source Type: research

Immunomodulation of Parkinson ’s disease using Mucuna pruriens (Mp)
Publication date: Available online 19 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): Sachchida Nand Rai, Hareram Birla, Walia Zahra, Saumitra Sen Singh, Surya Pratap Singh Immune control is associated with nigrostriatal neuroprotection for Parkinson’s disease (PD); though its direct cause and effect relationships have not yet been realized and modulating the immune system for therapeutic gain has been openly discussed. While the pathobiology of PD remains in study, neuroinflammation is thought to speed nigrostriatal degeneration. The neuroinflammatory cascade associated with PD begins with aggregation ...
Source: Journal of Chemical Neuroanatomy - June 21, 2017 Category: Neuroscience Source Type: research

Nitroglycerin increases serotonin transporter expression in rat spinal cord but anandamide modulated this effect
Publication date: Available online 15 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): Gábor Nagy-Grócz, Zsuzsanna Bohár, Annamária Fejes-Szabó, Klaudia Flóra Laborc, Eleonóra Spekker, Lilla Tar, László Vécsei, Árpád Párdutz Migraine is one of the most prevalent neurological diseases, which affects 16% of the total population. The exact pathomechanism of this disorder is still not well understood, but it seems that serotonin and its transporter has a crucial role in the pathogenesis. One of the animal models of migraine ...
Source: Journal of Chemical Neuroanatomy - June 16, 2017 Category: Neuroscience Source Type: research

Probenecid-treatment reduces demyelination induced by cuprizone feeding
In conclusion, early demyelination in the optic nerve was moderately reduced by 10days treatment with a low dose probenecid. This is a hint for the involvement of pannexin-1 modulated inflammation in cuprizone feeding induced toxic demyelination. Thus, probenecid is a candidate for the treatment of neuro-inflammation and multiple sclerosis. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - June 16, 2017 Category: Neuroscience Source Type: research

Cocaine adulteration
Publication date: Available online 12 June 2017 Source:Journal of Chemical Neuroanatomy Author(s): Oliver Kudlacek, Tina Hofmaier, Anton Luf, Felix P. Mayer, Thomas Stockner, Constanze Nagy, Marion Holy, Michael Freissmuth, Rainer Schmid, Harald H. Sitte Cocaine is a naturally occurring and illicitly used psychostimulant drug, which exerts its activity at monoaminergic neurotransmitter transporters. These transporters mediate the reuptake of the monoamines dopamine, serotonin and norepinephrine and are blocked by cocaine. The increase of monoamines in the extracellular space is the phenomenon underlying the drug effects t...
Source: Journal of Chemical Neuroanatomy - June 12, 2017 Category: Neuroscience Source Type: research

Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter
Publication date: Available online 30 May 2017 Source:Journal of Chemical Neuroanatomy Author(s): Caline S. Karam, Namita Sen, Jonathan A. Javitch The dopamine transporter (DAT), which mediates the inactivation of released dopamine through its reuptake, is the primary molecular target for the actions of psychostimulants. An increasing number of studies support an essential role for phosphorylation of serines (Ser) in the distal amino (N) terminus of DAT in regulating its function. Still, the molecular details of the regulation of phosphorylation and its impact on function are not fully understood. To address this, we have...
Source: Journal of Chemical Neuroanatomy - May 30, 2017 Category: Neuroscience Source Type: research