MicroRNAs expressed in depression and their associated pathways: a systematic review and a bioinformatics analysis
This study review systematically the literature to identify which microRNAs are currently being associated with depression and their related pathways. The electronic search was conducted in PubMed, Scopus, Scielo, ISI Web of Knowledge, and PsycINFO databases, using the search terms “Depressive Disorder” or “Depression” and “MicroRNAs”. After, microRNAs that were up and down-regulated in depression were analyzed by bioinformatics. We observed that among the 77 microRNAs cited by included studies, 54 had their levels altered in depressed individuals compared to controls, 30 being up-regula...
Source: Journal of Chemical Neuroanatomy - May 23, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: July 2019Source: Journal of Chemical Neuroanatomy, Volume 98Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 21, 2019 Category: Neuroscience Source Type: research

Elevated expression of miR-302 cluster improves traumatic brain injury by inhibiting phosphorylation of connexin43 via ERK signaling
We examined apoptosis and ERK1/2 and connexin43 phosphorylation in SH-SY5Y cells undergoing pulsatile shear stress treatment. We assessed expression of miR-302 cluster members and exogenously expressed miR-302 cluster in stressed cells to determine its effect on ERK1/2 and connexin43 phosphorylation. Finally, we investigated the effects of elevated miR-302 expression on cognitive function and brain damage in TBI rats generated by the controlled cortical impact method. Pulsatile shear stress leads to increased apoptosis and upregulation of ERK1/2 and connexin43 phosphorylation in vitro. Additionally, pulsatile shear stress ...
Source: Journal of Chemical Neuroanatomy - May 15, 2019 Category: Neuroscience Source Type: research

Hitchhiking on the neuronal highway: Mechanisms of transsynaptic specificity
This article will thus touch on three topics: First, how specific are the directional transmission patterns of these viruses? Second, what are the properties that confer synaptic specificity of viral transmission? Lastly, what can we learn from this specificity, and can we use it to devise better transsynaptic tracers? (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - May 8, 2019 Category: Neuroscience Source Type: research

Heterogeneous expression patterns of fibronectin in the mouse subiculum
Publication date: Available online 1 May 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Tetsuhiko Kashima, Asako Noguchi, Yuji Ikegaya, Nobuyoshi MatsumotoAbstractThe subiculum displays as much anatomical and physiological heterogeneity as the hippocampus. Recent studies suggest that the subiculum is also diverse in terms of gene expression. However, few studies have investigated the heterogeneity of the entire subiculum. To address this issue, we focused on fibronectin because its mRNA (FN1 mRNA) is expressed in the dorsal and ventral subiculum. We immunohistochemically characterized the intracellular expression o...
Source: Journal of Chemical Neuroanatomy - May 3, 2019 Category: Neuroscience Source Type: research

Harderian gland-derived stem cells as a cytotherapy in a guinea pig model of carboplatin-induced Hearing loss
ConclusionThe isolated HG-SCs were proved to restore structure and function of cochlea in guinea pig model of hearing loss.Graphical Abstract (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 30, 2019 Category: Neuroscience Source Type: research

PSD95 regulates morphological development of adult-born granule neurons in the mouse hippocampus
Publication date: Available online 30 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Muriel D Mardones, Patricia V Jorquera, Andrea Herrera Soto, Estibaliz Ampuero, Fernando J. Bustos, Brigitte van Zundert, Lorena Varela NallarAbstractIn the adult hippocampus new neurons are generated in the dentate gyrus from neural progenitor cells. Adult-born neurons integrate into the hippocampal circuitry and contribute to hippocampal function. PSD95 is a major postsynaptic scaffold protein that is crucial for morphological maturation and synaptic development of hippocampal neurons. Here we study the function of PSD95 in...
Source: Journal of Chemical Neuroanatomy - April 30, 2019 Category: Neuroscience Source Type: research

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms
Publication date: Available online 27 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Gabriela Pandini Silote, Ariandra Sartim, Amanda Sales, Amanda Eskelund, FS Guimarães, Gregers Wegener, Samia JocaAbstractSignificant limitations with the currently available antidepressant treatment strategies have inspired research on finding new and more efficient drugs to treat depression. Cannabidiol (CBD) is a non-psychotomimetic component of Cannabis sativa, and emerges in this regard as a promising compound. In 2010, we were the first laboratory to demonstrate that CBD is effective in animal models of predictiv...
Source: Journal of Chemical Neuroanatomy - April 28, 2019 Category: Neuroscience Source Type: research

Distribution of D1 and D2 receptor- immunoreactive neurons in the paraventricular nucleus of the hypothalamus in the rat
Publication date: Available online 21 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Xuerui Ran, Yanli Yang, Yamei Meng, Yong Li, Li Zhou, Zhiyong Wang, Jinxia ZhuAbstractThe paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating the functions of internal organs, and it is the key nucleus for coordinating endocrine, behavior and autonomic stress responses. Dopamine receptors are widely expressed in the hypothalamus and participate in the regulation of many vital activities, such as blood pressure and glycolipid metabolism, but the details of the cellular localization of dopamin...
Source: Journal of Chemical Neuroanatomy - April 22, 2019 Category: Neuroscience Source Type: research

Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats
In conclusion, G-CSF had beneficial effects after cerebral ischemia on the neurological behavioral outcome, infarct volume and preserved the regular spatial distribution of CA1 hippocampal neurons. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 19, 2019 Category: Neuroscience Source Type: research

Evaluation of intracerebral ventricles volume of patients with Parkinson's disease using the atlas-based method: a methodological study
Publication date: Available online 13 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Hikmet Kocaman (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 13, 2019 Category: Neuroscience Source Type: research

Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson’s disease by promoting Wnt/β-catenin signaling pathway
This study was to investigate the functions and mechanisms of mulberrin in PD. PD models were established by administering 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to Sprague Dawley rats in vivo and Lipopolysaccharide (LPS) treatment on microglial BV2 cells in vitro. Rota-rod test was applied to investigate the roles of mulberrin on MPTP-induced behavioral impairment. The effects of mulberrin on neuronal number and microglia activation were assessed by tyrosine hydroxylase (TH) immunohistochemistry and ionized calcium binding adaptor molecule-1 (Iba-1) immunofluorescence. Inflammatory cytokines and oxidative mar...
Source: Journal of Chemical Neuroanatomy - April 10, 2019 Category: Neuroscience Source Type: research

Localization of AMPA, kainate, and NMDA receptor mRNAs in the pigeon cerebellum
Publication date: Available online 9 April 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Atoji Yasuro, Sarkar SonjoyAbstractIn the present study, we investigated the location of mRNA for three types of ionotropic glutamate receptors (iGluRs) in the pigeon cerebellum and then compared the results with those of mammals. The following nine iGluRs subunits were analyzed by in situ hybridization: AMPA receptors (GluA1, GluA2, GluA3, and GluA4), kainate receptors (GluK1, GluK2, and GluK4), and NMDA receptors (GluN1 and GluN2 A). Subunit hybridization revealed expression in different cell types of the cerebellar c...
Source: Journal of Chemical Neuroanatomy - April 10, 2019 Category: Neuroscience Source Type: research

BACE1-AS prevents BACE1 mRNA degradation through the sequestration of BACE1-targeting miRNAs
In this study, we reveal that BACE1-AS shares many miRNA-response elements with BACE1. The overexpression of BACE1-AS results in the repression of miRNAs that target BACE1, thus preventing BACE1 mRNA from being degraded. The knockdown of BACE1-AS increases the levels of these miRNAs, thereby reducing the expression of BACE1. Thus, BACE1-AS functions as a competing endogenous RNA (ceRNA). Our results also deepen the understanding of the regulation of BACE1 by BACE1-AS. In addition to increasing the stability of BACE1 mRNA through the formation of RNA duplexes, BACE1-AS can regulate BACE1 indirectly by acting as a ceRNA. The...
Source: Journal of Chemical Neuroanatomy - April 7, 2019 Category: Neuroscience Source Type: research

Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 7, 2019 Category: Neuroscience Source Type: research

Improvement in neurogenesis and memory function by administration of Passiflora incarnate L. extract applied to sleep disorder in rodent models
In conclusion, our results suggest that PF lead high hippocampal neurogenesis in the animals even in inherited sleep-disturbed animals. The increased hippocampal neurogenesis functionally enhanced memory and learning functions by repeated PF oral administration. These results identify PF as a potential therapy for enhancing memory functions and prevention of Alzheimer's disease through actions on the hippocampus. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - April 4, 2019 Category: Neuroscience Source Type: research

Melanin-concentrating hormone receptor-1 is located in primary cilia of the dorsal raphe neurons
Publication date: Available online 31 March 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Sofía Niño-Rivero, Pablo Torterolo, Patricia LagosAbstractThe melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the posterior hypothalamus and incerto-hypothalamic area. These neurons project throughout the central nervous system, including the dorsal raphe nucleus (DRN). In rodents, MCH exerts its biological functions through the MCHR-1 receptor. We previously demonstrated that intra-DRN MCH administration increases REM sleep time and induces a pro-depressive behavior...
Source: Journal of Chemical Neuroanatomy - April 1, 2019 Category: Neuroscience Source Type: research

BMP6 expression in the adult rat central nervous system
Publication date: Available online 27 March 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yutaro Hayashi, Sumiko Mikawa, Chikara Ogawa, Kazuma Masumoto, Fuminori Katou, Kohji SatoAbstractBMP6, a member of the TGF-β superfamily, is known to be involved in many diseases, such as Alzheimer’s disease, suggesting that BMP6 plays pivotal roles in the central nervous system (CNS), however, there’s no information about the distribution of BMP6 in the adult CNS. Therefore, we investigated BMP6 expression in the CNS using immunohistochemistry. BMP6 was intensely expressed in most neurons and their axons. Fu...
Source: Journal of Chemical Neuroanatomy - March 28, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - March 20, 2019 Category: Neuroscience Source Type: research

The effects of epothilone D on microtubule degradation and delayed neuronal death in the hippocampus following transient global ischemia
This study examined the effects of pre- and postischemic treatment with different doses of EpoD on the microtubule damage and the delayed neuronal death in the hippocampal CA1 subfield on day 2 following reperfusion after 13-min global cerebral ischemia. Our results showed that systemic treatment with 0.5 mg/kg EpoD only slightly alleviated the microtubule disruption and the CA1 neuronal death, while treatment with 3.0 mg/kg EpoD was not only ineffective against the CA1 neuronal death, but also produced additional damage in the dentate gyrus in some ischemic rats. Since the pyramidal cells in the CA1 subfield...
Source: Journal of Chemical Neuroanatomy - March 12, 2019 Category: Neuroscience Source Type: research

Human Placental Extract Ameliorates Cytokine and Cytokine Receptor Signaling in the Rat Hippocampus upon Benzo[α]Pyrene Exposure
Publication date: Available online 9 March 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Rajeshwari Parida, Sanjay Das, Trichur R. Raju, Talakad N. SathyaprabhaAbstractBenzo[alpha]Pyrene (B[a]P) causes toxicity via Cytochrome P450 1A1 (CYP1A1) metabolic activity in the brain. Studies have shown that neuronal IL-2 and TNF-α are associated with the hippocampus development and regulation, but their association with the CYP1A1 activity remains unidentified. Limited action of human placental extract (HPE) in the activation of tissue repair and wound healing is known, but their role in B[a]P clearance in the hippo...
Source: Journal of Chemical Neuroanatomy - March 10, 2019 Category: Neuroscience Source Type: research

Automatic Ground Truth for Deep Learning Stereology of Immunostained Neurons and Microglia in Mouse Neocortex
We report that the throughput efficiency of using ASA to automatically annotate images of Iba1 microglia is more than 5 times greater than that of manual stereology counts of the same sections. Moreover, we show that ASA is significantly more accurate in counting microglia cells than a moderately experienced data collector (about 10% higher overall accuracy) when both were compared to counts by an expert neurohistologist. Thus, the ASA method applied to EDF images from disector stacks can be extremely useful to automate and increase the accuracy of cell counts, which could be especially helpful and cost-effective when expe...
Source: Journal of Chemical Neuroanatomy - March 4, 2019 Category: Neuroscience Source Type: research

Variable Colocalisation of GABAA receptor subunits and Glycine Receptors on Neurons in the Human Hypoglossal Nucleus
Publication date: Available online 27 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): H.J. Waldvogel, F.M. Biggins, A. Singh, C.J. Arasaratnam, R.L.M. FaullAbstractThe hypoglossal nucleus, the nucleus of the twelfth cranial nerve, is located dorsally in the midline of the medulla oblongata. The hypoglossal nucleus contains lower motor neurons which innervate the tongue muscles that control tongue movements involved in speech production, swallowing, mastication and associated respiratory movements. GABAA and glycine receptors are heteropentameric ionotropic receptors that facilitate fast-response, inhibitory...
Source: Journal of Chemical Neuroanatomy - February 28, 2019 Category: Neuroscience Source Type: research

Subcommissural organ–Reissner’s fiber complex plasticity in two animal models of copper intoxication and modulatory effect of curcumin: Involvement of serotonin
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): Abdellatif Abbaoui, Lahcen Tamegart, Radouane El Fari, Halima GamraniAbstractMetal neurotoxicity is a universal health preoccupation. Previous data revealed an obvious neurochemical impairment induced by metal elements as copper. This investigation was conducted to study the subcommissural organ (SCO) response to acute and subchronic Cu exposure as well as its serotoninergic innervation in Wistar rats, and the probable protective potential of curcumin in these toxicological circumstances. By mean of immunohistochemistry using antibodi...
Source: Journal of Chemical Neuroanatomy - February 23, 2019 Category: Neuroscience Source Type: research

Conditioned medium obtained from mesenchymal stem cells attenuates focal cerebral ischemia reperfusion injury through activation of ERK1/ERK2-BDNF signaling pathway
This study was conducted to investigate if CM obtained from MSCs gives rise to neuroprotection by targeting neurogenesis. To induce focal cerebral ischemia in rats, middle cerebral artery (MCA) was occluded for 1 h and the amniotic mesenchymal stem cells-conditioned medium (AMSC-CM) at the dose of 0.5 μl was administered 30 min after reperfusion by stereotactic intracerebral infusion. The animals were randomly divided into three groups: sham operated animals received all procedures except occlusion of MCA (sham, n = 12), I/R group only received occlusion of MCA (MCAO, n =&thinsp...
Source: Journal of Chemical Neuroanatomy - February 19, 2019 Category: Neuroscience Source Type: research

Up-regulation of TREM2 Accelerates the Reduction of Amyloid Deposits and Promotes Neuronal Regeneration in the Hippocampus of Amyloid Beta1-42 Injected Mice
Publication date: Available online 18 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin TianAbstractAlzheimer’s disease (AD) is characterized by a robust inflammatory response elicited by the accumulation and subsequently deposition of amyloid beta (Aβ) within the brain. The immune cells of brain migrate to and invest their processes within Aβ plaques and clear plaques from the brain. Previous studies have shown that treatment of myeloid cell with nuclear factor inhibitor increases expression of phagocytesis-rela...
Source: Journal of Chemical Neuroanatomy - February 19, 2019 Category: Neuroscience Source Type: research

Subcommissural organ–Reissner’s fiber complex plasticity in tow animal models of copper intoxication and modulatory effect of curcumin: Involvement of serotonin
Publication date: Available online 19 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Abdellatif Abbaoui, Lahcen Tamegart, Radouane El Fari, Halima GamraniAbstractMetal neurotoxicity is a universal health preoccupation. Previous data revealed an obvious neurochemical impairment induced by metal elements as copper. This investigation was conducted to study the subcommissural organ (SCO) response to acute and subchronic Cu exposure as well as its serotoninergic innervation in Wistar rats, and the probable protective potential of curcumin in these toxicological circumstances. By mean of immunohistochemistry us...
Source: Journal of Chemical Neuroanatomy - February 19, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2019Source: Journal of Chemical Neuroanatomy, Volume 96Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - February 14, 2019 Category: Neuroscience Source Type: research

Aging mildly affects Dendritic Arborisation and Synaptic Protein Expression in Human Substantia Nigra Pars Compacta
Publication date: Available online 8 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Aditi Naskar, Anita Mahadevan, Mariamma Philip, Phalguni Anand AlladiAbstractThe protein α-synuclein, a major component of Lewy bodies in nigral neurons of aged and Parkinson's disease (PD) patients, normally co-localizes with synaptophysin and regulates the pool of synaptic vesicles. Our earlier study on substantia nigra pars compacta (SNpc) in an Asian-Indian population, demonstrated an age-associated linear but non-logarithmic increase in soluble α-synuclein without any loss of nigral neurons. Another distinc...
Source: Journal of Chemical Neuroanatomy - February 8, 2019 Category: Neuroscience Source Type: research

Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): Zahra Hassannejad, Mahmoud Yousefifard, Yaser Azizi, Shayan Abdollah Zadegan, Kiavash Sajadi, Mahdi Sharif-Alhoseini, Aida Shakouri-Motlagh, Mona Mokhatab, Motahareh Rezvan, Farhad Shokraneh, Mostafa Hosseini, Alexander R. Vaccaro, James S. Harrop, Vafa Rahimi-MovagharAbstractThe pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies regarding the...
Source: Journal of Chemical Neuroanatomy - February 8, 2019 Category: Neuroscience Source Type: research

Axonal Degeneration and Demyelination Following Traumatic Spinal Cord Injury; A Systematic Review and Meta-analysis
Publication date: Available online 3 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Zahra Hassannejad, Mahmoud Yousefifard, Yaser Azizi, Shayan Abdollah Zadegan, Kiavash Sajadi, Mahdi Sharif-Alhoseini, Aida Shakouri-Motlagh, Mona Mokhatab, Motahareh Rezvan, Farhad Shokraneh, Mostafa Hosseini, Alexander R. Vaccaro, James S. Harrop, Vafa Rahimi-MovagharAbstractThe pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative results of animal studies re...
Source: Journal of Chemical Neuroanatomy - February 4, 2019 Category: Neuroscience Source Type: research

Visual impairment in neuromyelitis optica spectrum disorders (NMOSD)
Publication date: Available online 1 February 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yan Wu, Lianmei Zhong, Jia GengAbstractNeuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) have garnered attention due to their high pathogenicity, high risk of relapse, and poor prognosis as an inflammatory central nervous system (CNS) syndrome. There is a consensus that the anti-aquaporin-4 antibody (AQP4-IgG) is the main pathogen detectable in majority of NMOSD patients, including traditional NMO and AQP4-IgG-positive optic neuritis. In serum-negative NMOSD patients, myelin oligodendrocyte glycoprotein (MOG) an...
Source: Journal of Chemical Neuroanatomy - February 2, 2019 Category: Neuroscience Source Type: research

Intrathecal transplantation of Wharton’s jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury
Publication date: April 2019Source: Journal of Chemical Neuroanatomy, Volume 97Author(s): Yousef Mohamadi, Seyed Mohammad Hossein Noori Moghahi, Mahboubeh Mousavi, Maryam Borhani-Haghighi, Farid Abolhassani, Iraj Ragerdi Kashani, Gholamreza HassanzadehAbstractAfter spinal cord injury (SCI) local inflammation is induced following secretion of interleukin-1beta (IL-1β) and IL-18. It has been described that the secretion of IL-1β and IL-18 is mediated by a cytoplasmic multiprotein complex, termed inflammasome. Mesenchymal stem cells (MSCs) have been extensively used for treating inflammatory diseases in which they s...
Source: Journal of Chemical Neuroanatomy - February 1, 2019 Category: Neuroscience Source Type: research

Neurons Expressing Estrogen Receptor α Differentially Innervate the Periaqueductal Gray Matter of Female Rats
Publication date: Available online 28 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Silvana da Silva Pacheco, Tatiane Araujo Rondini, Jackson Cioni Bittencourt, Carol Fuzeti EliasAbstractThe periaqueductal gray matter (PAG) is a brainstem site involved in distinct autonomic and behavioral responses. Among them, the motor control of female sexual behavior, including lordosis, is well described. Lordosis reflex is highly dependent on increasing levels of estradiol that occur in the afternoon of the proestrus day in normally cycling females. This effect is thought to be mediated primarily via actions in the v...
Source: Journal of Chemical Neuroanatomy - January 29, 2019 Category: Neuroscience Source Type: research

Intrathecal transplantation of Wharton's jelly mesenchymal stem cells suppresses the NLRP1 inflammasome in the rat model of spinal cord injury
Publication date: Available online 28 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Yousef Mohamadi, Seyed Mohammad Hossein Noori Moghahi, Mahboubeh Mousavi, Maryam Borhani-Haghighi, Farid Abolhassani, Iraj Ragerdi Kashani, Gholamreza HassanzadehAbstractAfter spinal cord injury (SCI) local inflammation is induced following secretion of interleukin-1beta (IL-1β) and IL-18. It has been described that the secretion of IL-1β and IL-18 is mediated by a cytoplasmic multiprotein complex, termed inflammasome. Mesenchymal stem cells (MSCs) have been extensively used for treating inflammatory diseases in w...
Source: Journal of Chemical Neuroanatomy - January 29, 2019 Category: Neuroscience Source Type: research

The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson’s disease
Publication date: Available online 25 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Michaela E Johnson, Xin-Fu Zhou, Larisa BobrovskayaABSTRACTLoss of dopaminergic neurons in the substantia nigra (SN) is one of the pathological hallmarks in Parkinson’s disease (PD). This neuron loss is accompanied by reduced protein and activity levels of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine synthesis. Reduced nigral brain-derived neurotrophic factor (BDNF) has been postulated to contribute to the loss of nigral dopaminergic neurons in PD by causing a lack of trophic support. Prior to ...
Source: Journal of Chemical Neuroanatomy - January 26, 2019 Category: Neuroscience Source Type: research

Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer’s disease
This study aimed at investigating the protective effect of NAD-299 (the selective 5-HT1A receptor antagonist) and TCB-2 (the potent5-HT2A receptor agonist) on the hippocampal oxidative stress biomarkers and the number of intact neurons in streptozotocin (STZ)-induced Alzheimer's disease in rats.Fifty adult male Wistar rats weighing 250-300 g were divided into five groups: sham, STZ-treated, STZ + NAD-299 (5 μg/1 μl icv), STZ + TCB-2 (5 μg/1 μl icv) and STZ + NAD-299 (5 μg/0.5 μl icv) +TCB-2 (5 μg/0.5&thins...
Source: Journal of Chemical Neuroanatomy - January 24, 2019 Category: Neuroscience Source Type: research

Chemical neuroanatomy of the substantia nigra in the ovine brain
Publication date: Available online 18 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Samantha J. Murray, Brittney L. Black, Suzanne J. Reid, Skye R. Rudiger, C. Simon Bawden, Russell G. Snell, Henry J. Waldvogel, Richard L.M. FaullAbstractThe substantia nigra is an integral component of the basal ganglia circuitry for limbic and motor functions. Dysfunction and degeneration of the basal ganglia are fundamental aspects of neurodegenerative diseases such as Parkinson’s disease and Huntington’s disease. With the increasing use of sheep to model neurological diseases, it is crucial to understand the...
Source: Journal of Chemical Neuroanatomy - January 20, 2019 Category: Neuroscience Source Type: research

Transient receptor potential melastatin-3 in the rat sensory ganglia of the trigeminal, glossopharyngeal and vagus nerves
In this study, immunohistochemistry for TRPM3 was conducted in the rat trigeminal, glossopharyngeal and vagal sensory ganglia. TRPM3-immunoreactivity was expressed by half of sensory neurons in the trigeminal (TG), petrosal (PG) and jugular ganglia (JG), and by about 80% of sensory neurons in the nodose ganglion (NG). They mostly had small to medium-sized cell bodies. A trichrome immunofluorescence method showed co-existence of TRPM3 with TRP vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP). Approximately 70% of TRPM3-immunoreactive (-IR) neurons contained TRPV1-immunoreactivity in all the examined ganglia. M...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research

UMSC-derived exosomes promote retinal ganglion cells survival in a rat model of optic nerve crush
Publication date: Available online 10 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Dongyan Pan, Xin Chang, Mengqiao Xu, Mingke Zhang, Shoumei Zhang, Yue Wang, Xueting Luo, Jiajun Xu, Xiangqun Yang, Xiaodong SunAbstractTraumatic optic neuropathy or glaucoma lead to retinal ganglion cells loss and cause blindness, and there is no effective therapy strategy by far. Mesenchymal cells from the Wharton’s jelly of the umbilical cord (umbilical cord mesenchymal stem cells, UMSCs) and UMSC-derived exosomes (UMSC-Exos) are promising candidates for allogeneic therapy in regenerative medicine, but their effort ...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research

Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton’s Jelly and olfactory mucosa as sources of MSCs
Publication date: Available online 10 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Rafieh Alizadeh, Zohreh Bagher, Seyed Kamran Kamrava, Masoumeh Falah, Hatef Ghasemi Hamidabadi, Mahdi Eskandarian Boroujeni, Fatemeh Mohammadi, Sepideh Khodaverdi, Arash Zare-Sadeghi, Arta Olya, Ali KomeiliAbstractThe generation of dopaminergic neurons from stem cells is a potential therapeutic approach to treat neurodegenerative disorders, such as Parkinson’s disease. The current study aims to investigate the potential of two different types of mesenchymal stem cells derived from human Wharton’s jelly and nasal...
Source: Journal of Chemical Neuroanatomy - January 11, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2019Source: Journal of Chemical Neuroanatomy, Volume 95Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - January 10, 2019 Category: Neuroscience Source Type: research

Neural functions of the aging brain: Daily living, developmental and geriatric disabilities
Publication date: January 2019Source: Journal of Chemical Neuroanatomy, Volume 95Author(s): TR. Raju, KP. MohanakumarAbstractNeuronal, microglial, astrocytic and oligodendrocytic functions of the brain are significantly affected during normal aging, and more so if inflicted with neurological diseases. Aging is a consistent risk factor for many neurodegenerative diseases that are sporadic in nature, whereas developmental neurological disabilities stem from errors in brain development. The neuronal functions are affected in both developmental disabilities and geriatric diseases. This special issue, is based on the two-days m...
Source: Journal of Chemical Neuroanatomy - January 10, 2019 Category: Neuroscience Source Type: research

Automatic Stereology of Mean Nuclear Size of Neurons using an Active Contour Framework
Publication date: Available online 7 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Hady Ahmady Phoulady, Dmitry Goldgof, Lawrence O. Hall, Kevin R. Nash, Peter R. MoutonAbstractThe use of unbiased stereology to quantify structural parameters such as mean cell and nuclear size (area and volume) can be useful for a wide variety of biological studies. Here we propose a novel segmentation framework using an Active Contour Model to automate the collection of stereology from stained cells and other objects in tissue sections. This approach is demonstrated for stained brain sections from young adult Fischer 344 r...
Source: Journal of Chemical Neuroanatomy - January 8, 2019 Category: Neuroscience Source Type: research

Distinct regional patterns in noradrenergic innervation of the rat prefrontal cortex
Publication date: Available online 7 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Juan-Carlos Cerpa, Alain R. Marchand, Etienne CoutureauAbstractThe anatomy and functions of the rodent prefrontal cortex (PFC) have been extensively studied. It is now clear that the PFC is at the core of various executive functions and that these functions depend on monoaminergic neuromodulation. The PFC receives extensive projections from monoaminergic nuclei and, in particular, from the locus cœruleus (LC) which is the major source of noradrenaline (NA) in the cortex. Projections of this nucleus have long been consi...
Source: Journal of Chemical Neuroanatomy - January 8, 2019 Category: Neuroscience Source Type: research

Obvious anxiogenic-like effects of subchronic copper intoxication in rats, outcomes on spatial learning and memory and neuromodulatory potential of curcumin
Publication date: Available online 3 January 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Abdellatif Abbaoui, Halima GamraniAbstractCopper (Cu) is a transition metal and an essential trace element, but excessive levels of Cu might disturb vital functions and systems including the Central Nervous System (CNS). Curcumin has numerous beneficial effects including protective potential on the CNS toxicity. Previous studies have revealed solid evidence showing metal elements implication in the physiopathology of psychiatric disorders, principally anxiety, as well as association between stressful conditions and the incep...
Source: Journal of Chemical Neuroanatomy - January 3, 2019 Category: Neuroscience Source Type: research

Serotonergic dysfunction in a model of parkinsonism induced by reserpine
Publication date: Available online 28 December 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Pollyana C. Leal, José Marcos M. Bispo, Rovena C.G.J. Engelberth, Kayo Diogenes de A. Silva, Ywlliane R. Meurer, Alessandra M. Ribeiro, Regina H. Silva, Murilo Marchioro, José R. SantosAbstractParkinson’s disease (PD) is mainly characterized by a dopamine deficiency accompanied by structural and functional changes in striatal neuronal projections. However, studies have considered PD as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the ...
Source: Journal of Chemical Neuroanatomy - December 29, 2018 Category: Neuroscience Source Type: research

Automated Cell Counts on Tissue Sections by Deep Learning and Unbiased Stereology
Publication date: Available online 27 December 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Saeed S. Alahmari, Dmitry Goldgof, Lawrence Hall, Hady Ahmady Phoulady, Raj H. Patel, Peter R. MoutonAbstractIn recent decades stereology-based studies have played a significant role in understanding brain aging and developing novel drug discovery strategies for treatment of neurological disease and mental illness. A major obstacle to further progress in a wide range of neuroscience sub-disciplines remains the lack of high-throughput technology for stereology analyses. Though founded on methodologically unbiased principles...
Source: Journal of Chemical Neuroanatomy - December 28, 2018 Category: Neuroscience Source Type: research

A novel image segmentation method for the evaluation of inflammation-induced cortical and hippocampal white matter injury in neonatal mice
Publication date: Available online 23 December 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Amin Mottahedin, Xiaoli Zhang, Aura Zelco, Maryam Ardalan, Jacqueline C.Y. Lai, Carina Mallard, Xiaoyang Wang, Hady Ahmady PhouladyAbstractThe developing brain is very susceptible to environmental insults, and very immature infants often suffer from long-term neurological syndromes associated with white matter injuries such as periventricular leukomalacia. Infection and inflammation are important risk factors for neonatal brain white matter injuries, but the evaluation of white matter injury in animal models, especially th...
Source: Journal of Chemical Neuroanatomy - December 24, 2018 Category: Neuroscience Source Type: research

Osmotic stress induces corticosteroid-binding globulin expression in the rat hypothalamo-hypophyseal system
Publication date: Available online 21 December 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Elena V. Sivukhina, Gustav F. JirikowskiAbstractCorticosteroid-binding globulin CBG is expressed in magnocellular hypothalamic nuclei, in part colocalized with vasopressin (VP) and oxytocin (OT). Here we subjected intact adult male rats to chronic osmotic stress to determine effects on distribution of CBG in VP and OT neurons and in neurons expressing corticotropin- releasing hormone (CRH). Drinking 2% NaCl solution for seven days resulted in increased CBG-immunoreactivity in magnocellular neurons. Triple immunofluorescenc...
Source: Journal of Chemical Neuroanatomy - December 22, 2018 Category: Neuroscience Source Type: research