Neuroanatomical relationship between the cholinergic and tachykininergic systems in the adult human brainstem: an immunohistochemical study
Publication date: Available online 1 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): P. Marcos, R. CoveñasAbstractThe cholinergic system plays an important role in brain homeostasis and interacts with the neuropeptidergic systems, and the functional relationships between both systems are well known. However, in the brainstem the possible physiological interactions between neurokinins and acetylcholine are unknown, although both substances have been detected in the same brainstem nuclei and have been implicated in similar functions controlled from brainstem regions such as some cranial motor nuclei. The aim ...
Source: Journal of Chemical Neuroanatomy - October 2, 2019 Category: Neuroscience Source Type: research
Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine
Publication date: Available online 30 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Moulay Mustapha Bouyatas, Abdellatif Abbaoui, Halima GamraniAbstractLead (Pb) is a non physiological metal that has been implicated in toxic processes affecting several organs and biological systems, including the central nervous system. Several studies have focused on changes in lead-associated neurobehavioral and neurochemical alterations that occur due to Pb exposure. The present study evaluates the effects of acute and chronic Pb acetate exposure on serotoninergic and dopaminergic systems within the dorsal raphe nucle...
Source: Journal of Chemical Neuroanatomy - September 30, 2019 Category: Neuroscience Source Type: research
Neurotrophin Mediated HPA Axis Dysregulation in Stress Induced Genesis of Psychiatric Disorders: Orchestration by Epigenetic Modifications
Publication date: Available online 27 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Ashutosh Kumar, Pavan Kumar, Vikas Pareek, Muneeb A. Faiq, Ravi K. Narayan, Khursheed Raza, Pranav Prasoon, Vivek K. SharmaAbstractApart from their established role in embryonic development, neurotrophins (NTs) have diverse functions in the nervous system. Their role in the integration of physiological and biochemical aspects of the nervous system is currently attracting much attention. Based on a systematic analysis of the literature, we here propose a new paradigm that, by exploiting a novel role of NTs, may help explai...
Source: Journal of Chemical Neuroanatomy - September 29, 2019 Category: Neuroscience Source Type: research
Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice
Publication date: Available online 25 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Radouane El Fari, Abdellatif Abbaoui, Anas Bourziq, Mohamed Zroudi, Ahmed Draoui, Abdelaati El Khiat, Mounir Belkouch, Abdeljalil Elgot, Halima GamraniAbstractManganese (Mn) is an essential metallic trace element involved in several vital biological functions. Conversely, exposure to excessive levels of Mn induces manganism, causing neurodegeneration and symptoms similar to those seen in Parkinson's disease (PD). Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid exhibiting neuroprotective properties ag...
Source: Journal of Chemical Neuroanatomy - September 26, 2019 Category: Neuroscience Source Type: research
Geniposide attenuates neonatal mouse brain injury after hypoxic-ischemia involving the activation of PI3K/Akt signaling pathway
This study aims to investigate whether Geniposide has therapeutic potential to HI brain injury and the underlying mechanisms. C57/bl6 mice were subjected to HI insult on postnatal day 10. Geniposide (20 mg/kg b.w.) was administered intragastrically every day after HI insult for 7 successional days. Then mice at P18 were sacrificed and brain tissues were collected for further analysis. Geniposide treatment significantly inhibited cell apoptosis, reduced serum IgG leakage into brain tissue, attenuated astrogliosis and microgliosis, prevented loss of pericytes, loss of tight junction and adherens junction proteins. The PI3K...
Source: Journal of Chemical Neuroanatomy - September 26, 2019 Category: Neuroscience Source Type: research
Special Issue of the Journal of Chemical Neuroanatomy “New methods for studying brain connectivity using viral tracing”
Publication date: Available online 24 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Richard T. Born, Harry W.M. Steinbusch (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - September 25, 2019 Category: Neuroscience Source Type: research
Mobile phone induced cognitive and neurochemical consequences
This study was performed to find out the effect of mobile phone frequency on male Wistar rats. Animals were divided into two groups (n = 6 in each group). Group one was considered as control and group two (experimental group) was exposed to microwave radiation (2100 MHz) for 4 hours/day (5 days/week) for 3 months. Exposure of microwave radiation frequency showed significant alterations in cholinesterase activity, muscular strength, learning ability and anxiety. MWR exposure was also associated with significant alteration in the oxidative defense system and hippocampus degeneration. Histopathological observations cl...
Source: Journal of Chemical Neuroanatomy - September 23, 2019 Category: Neuroscience Source Type: research
The temporal and spatial changes of microtubule cytoskeleton in the CA1 stratum radiatum following global transient ischemia
Publication date: Available online 5 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Tian-Qing Xiong, Chun-Yan Guo, Bai-hong Tan, Yue Gui, Yan-Chao LiAbstractThe down-regulation of microtubule proteins has been widely documented in the ischemic brain, but the temporal or spatial alteration of microtubules has not been systematically investigated in the vulnerable areas after ischemia. By examining the stability and distribution of microtubules following transient global ischemia, we found that the biomarkers of stable microtubules, MAP2 and acetylated α-tubulin, became significantly down-regulated in the ...
Source: Journal of Chemical Neuroanatomy - September 6, 2019 Category: Neuroscience Source Type: research
Postischemic fish oil treatment restores dendritic integrity and synaptic proteins levels after transient, global cerebral ischemia in rats
Publication date: Available online 6 September 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Daniela Velasquez de Oliveira, Tuany Caroline Bernardi, Silvana Regina de Melo, Jacqueline Godinho, Rúbia Maria Weffort de Oliveira, Humberto MilaniAbstractWe previously found that fish oil (FO) facilitated memory recovery in the absence of pyramidal neuron rescue after transient, global cerebral ischemia (TGCI). Fish oil preserved the expression of microtubule-associated protein 2 (MAP-2), suggesting a relationship between dendritic plasticity and memory recovery that is mediated by FO after TGCI. The present study exami...
Source: Journal of Chemical Neuroanatomy - September 6, 2019 Category: Neuroscience Source Type: research
Volumetric investigation of the hippocampus in rat offspring due to diabetes in pregnancy–A stereological study
ConclusionThese data indicate that diabetes during pregnancy has a negative impact on the development of the hippocampus in the rats. These changes in the volume of hippocampal CA1, DG, and subiculum areas might be at the core of underlying neurocognitive and neurobehavioral impairments observed in the children of diabetic mothers. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 31, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: October 2019Source: Journal of Chemical Neuroanatomy, Volume 100Author(s): (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 28, 2019 Category: Neuroscience Source Type: research
Changes in pyramidal and granular neuron numbers in the rat hippocampus 7 days after exposure to a continuous 900-MHz electromagnetic field during early and mid-adolescence
In conclusion, higher numbers of both pyramidal and granule neurons were found in the male rat hippocampus after continuous 900-MHz EMF treatment. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 27, 2019 Category: Neuroscience Source Type: research
Volumetric Investigation of the Hippocampus in Rat Offspring Due to Diabetes in Pregnancy- A Stereological Study
ConclusionThese data indicate that diabetes during pregnancy has a negative impact on the development of the hippocampus in the rats. These changes in the volume of hippocampal CA1, DG, and subiculum areas might be at the core of underlying neurocognitive and neurobehavioral impairments observed in the children of diabetic mothers. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 21, 2019 Category: Neuroscience Source Type: research
Long noncoding RNA NORAD regulates MPP+-induced Parkinson’s disease model cells
ConclusionWe presented a novel functional role of lncRNA NORAD in regulating human Parkinson’s disease. (Source: Journal of Chemical Neuroanatomy)
Source: Journal of Chemical Neuroanatomy - August 15, 2019 Category: Neuroscience Source Type: research
Regulation of adult hippocampal neurogenesis exerted by sexual, cognitive and physical activity: An update
Publication date: Available online 14 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): P. Leal-Galicia, H. Romo-Parra, L.M. Rodríguez-Serrano, M. Buenrostro-JáureguiAbstractIn 1962, Joseph Altman described that the brain generates neurons after the postnatal period, and this continues throughout your life (Altman, 1962). This was a breakthrough in the neuroscience field because before this the accepted paradigm was that the brain only generated neurons during the embryonal development. This discovery has been controversial ever since, especially since one of the areas of the brain with neurogenic properties ...
Source: Journal of Chemical Neuroanatomy - August 14, 2019 Category: Neuroscience Source Type: research
