MiRNA ‐548c‐5p downregulates inflammatory response in preeclampsia via targeting PTPRO
In this study, we first elucidate the role of miR‐548c‐5p and its underlying molecular mechanism in preeclampsia. Compared with healthy controls, miR‐548c‐5p was obviously downregulated in serum exosomes and placental mononuclear cells in patients with preeclampsia. Nonetheless, PTPRO was significantly upregulated and negatively associated with miR‐548c‐5p in placental mononuclear cells in patients with preeclampsia. PTPRO was a target of miR‐548c‐5p. PTPRO was downregulated in the miR‐548c‐5p‐overexpressed macropha ges. In addition, miR‐548c‐5p could inhibit the proliferation and activation of LP...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Zengfang Wang,
Pingping Wang,
Zengyan Wang,
Zhihao Qin,
Xia Xiu,
Donghua Xu,
Xiaozhen Zhang,
Yingliang Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA ‐342‐3p target sequence
AbstractLong noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development and progression. However, the role and molecular mechanism of lncRNAs in resistance to chemotherapy of colorectal cancer (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body ‐specific RNA 2 (SCARNA2) is expressed higher in CRC tissues than in adjacent normal tissues, and a robust expression of SCARNA2 is correlated with a bad prognosis of CRC patients after surgery. SCARNA2 overexpression significantly promoted chemoresistance in CRC cells, and downregulation of SCAR...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Peng ‐Fei Zhang,
Jing Wu,
Yin Wu,
Wei Huang,
Min Liu,
Zhao‐Ru Dong,
Bai‐Ying Xu,
Yong Jin,
Fei Wang,
Xue‐Mei Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Potential of bacterial culture media in biofabrication of metal nanoparticles and the therapeutic potential of the as ‐synthesized nanoparticles in conjunction with artemisinin against MDA‐MB‐231 breast cancer cells
The present research endeavor explores the potential of bacterial culture media (CM) in the biofabrication of metal nanoparticles (NPs) and, thereafter, ascertains their therapeutic potential against MDA‐MB‐231 breast cancer cells together with artemisinin. AbstractIn the recent past, various groups have proposed diverse biocompatible methods for the synthesis of metal nanoparticles (NPs). Besides culture biomass, culture supernatants (CS) are increasingly being explored for the synthesis of NPs; however, with the ever ‐increasing exploration of various CS in the biofabrication of NPs, it is equally important to ex...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Badrealam Farheen Khan,
Hamidullah,
Sonam Dwivedi,
Riyuraj Konwar,
Swaleha Zubair,
Mohammad Owais Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Sodium –glucose cotransporter inhibitors and oxidative stress: An update
In this report we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free radical generation or potentiation of cellular anti‐oxidative capacity, and its importance in preven tion of cardiovascular and diabetes complications. AbstractSodium –glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have antioxi dan...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Habib Yaribeygi,
Stephen L. Atkin,
Alexandra E. Butler,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
Benzo(a)pyrene inhibits endometrial cell apoptosis in early pregnant mice via the WNT5A pathway
In this study, we focused on the effect of BaP on endometrial cell apoptosis and the role of WNT signaling during this process. Pregnant mice were gavaged with corn o il (control group) or 0.2 mg·kg−1·day−1 BaP (treatment group) from Days 1 to 6 of pregnancy. BaP impaired endometrial function by decreasing the expression of HOXA10 and BMP2, two markers of receptivity and decidualization. WNT5A and β‐catenin were activated in the BaP group. BaP affected the expression of apoptosis‐related proteins and inhibited the apoptosis of endometrial stromal cells. In vitro, human endometrial stromal cells (HESCs) were tr...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Ting Yi,
Min Liu,
Xueyan Li,
Xueqing Liu,
Yubin Ding,
Junlin He,
Hanting Xu,
Rufei Gao,
Xinyi Mu,
Yanqing Geng,
Yingxiong Wang,
Xuemei Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L ‐arginine
In conclusion, either hemin or L‐arginine had protective effects against PCOS with better pa thophysiological changes with hemin. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Merhan M. Ragy,
Heba A. Abdel ‐Hamid,
Nisreen D.M. Toni Tags: REVIEW ARTICLE Source Type: research
Ethyl acetate and n ‐butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre‐osteoblast cell line MC3T3‐E1 (sub‐clone 4)
The present study reports the osteoblast differentiation and mineralization potential of ethyl acetate (CQ ‐EA) and butanol (CQ‐B) extracts ofCissus quadrangularis (CQ) on mouse pre ‐osteoblast cell line MC3T3‐E1 (sub‐clone 4) with an objective to isolate an antiosteoporotic compound. We have concluded in this part of the study that the CQ‐EA treatment resulted in early differentiation and mineralization as compared with the CQ‐B treatment. These findings suggest that low concentrations of CQ‐EA and CQ‐B have proliferative and osteogenic properties. CQ‐EA, however, is more potent osteogenic than CQ‐B....
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Authors: Rabail Hassan Toor,
Raazia Tasadduq,
Achyut Adhikari,
Muhammad Iqbal Chaudhary,
Jane B. Lian,
Janet L. Stein,
Gary S. Stein,
Abdul Rauf Shakoori Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Retraction: “Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics With Functional Pathways Analysis” by Zhang, X., Tong, P., Chen, J., Pei, Z., Zhang, X., Chen, W., Xu, J., and Wang, J.
The above article from theJournal of Cellular Physiology, published online on 10 March 2016 in Wiley Online Library as Early View (http://onlinelibrary.wiley.com/enhanced/doi/10.1002/jcp.25353/), has been retracted by agreement between Gary Stein, the journal's Editor ‐in‐Chief, and Wiley Periodicals, Inc. The retraction has been agreed following an investigation at the University of Texas, MD Anderson Cancer Center, which confirmed that the article was submitted and approved for publication by Dr. Jin Wang without acknowledgement of NIH funding received or t he consent and authorship of Dr. Ann Killary and Dr. Subrata...
Source: Journal of Cellular Physiology - November 15, 2018 Category: Cytology Tags: Retraction Source Type: research
Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches
ConclusionCML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient –Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Ali Amin Asnafi,
Zeinab Deris Zayeri,
Saeid Shahrabi,
Kazem Zibara,
Tina Vosughi Tags: REVIEW ARTICLE Source Type: research
DANCR contributed to hepatocellular carcinoma malignancy via sponging miR ‐216a‐5p and modulating KLF12
In conclusion, our study indicated that DANCR might provide a new perspective for HCC treatment. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 14, 2018 Category: Cytology Authors: Jianchu Wang,
Jian Pu,
Ying Zhang,
Tianwei Yao,
Zongjiang Luo,
Wenchuan Li,
Guidan Xu,
Juan Liu,
Wujun Wei,
Yibin Deng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
TGF β mediates collagen production in human CRSsNP nasal mucosa‐derived fibroblasts through Smad2/3‐dependent pathway and CTGF induction and secretion
Transforming growth factor β1 (TGF‐β1) mediates collagen expression–production through a canonical Smad2/3‐dependent pathway and connective tissue growth factor (CTGF) induction and secretion in human nasal fibroblasts. Moreover, TGF‐β1, CTGF, and collagen are highly expressed in human chronic rhinosinusitis withou t nasal polyp (CRSsNP) nasal mucosa specimens, suggesting their roles in tissue remodeling during CRSsNP progression. AbstractChronic rhinosinusitis without nasal polyp (CRSsNP) is characterized by tissue remodeling and fibrosis. Transforming growth factor ‐β (TGF‐β) is considered a master switc...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Jiunn ‐Min Shieh,
Yih‐Jeng Tsai,
Jessie Chao‐Yun Chi,
Wen‐Bin Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pre ‐eclampsia onset and SPARC: A possible involvement in placenta development
In conclusion, SPARC can play a pivot al role in PE and PE–IUGR onset and it should be considered as a key molecule for future investigations in such pathologies. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Giovanni Tossetta,
Sonia Fantone,
Stefano R. Giannubilo,
Elena Marinelli Busilacchi,
Andrea Ciavattini,
Mario Castellucci,
Nicoletta Di Simone,
Monica Mattioli ‐Belmonte,
Daniela Marzioni Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction
Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR ‐induced insulin sensitivity and improved insulin resistance. AbstractLifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is di...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Habib Yaribeygi,
Stephen L. Atkin,
Majid Ramezani,
Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research
A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population
AbstractGenome ‐wide association studies (GWASs) showed that three single nucleotide polymorphisms (SNPs; rs10968576, rs1412239, and rs824248) in the leucine‐rich repeat and Ig domain containing 2 (LINGO2) were associated with obesity or type 2 diabetes (T2D). We aimed to determine the influence of the LINGO2 variants on the gestational diabetes mellitus (GDM) risk. Thus, we performed a case–control study including 964 GDM cases and 1,021 controls to test the associations between the three LINGO2 variants (rs10968576, rs1412239, and rs824248) and susceptibility to GDM. Logistic regression analyses show ed no signific...
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Tong Su,
Qingxia Ren,
Yingying Lu,
Wen Tai,
Yuan Zhu,
Zhengying Li,
Juan Wen,
Lingmin Hu,
Le Zhang,
Jiehua Ma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO ‐1 pathway
In conclusion, our study showed that LL202 exerts an anti‐inflammatory effect by enhancing the antioxidant capacity of the Nrf2/HO‐1 pathway to macrophages. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 13, 2018 Category: Cytology Authors: Yuan Gao,
Dongsheng Bai,
Yue Zhao,
Qin Zhu,
Yihui Zhou,
Zhiyu Li,
Na Lu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
