α‐2‐Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts
α‐2‐Macroglobulin positively regulates microvesicle shedding through the activation of low‐density lipoprotein receptor‐related protein‐1 on myofibroblasts. AbstractMicrovesicles (MVs) are recognized as an important class of cell ‐to‐cell messengers. Although the properties of MVs are increasingly documented, the mechanisms regulating MV biogenesis remain debated. Myofibroblasts are a key cellular component of wound healing and have been shown to produce MVs upon stimulation with serum. However, the mediator(s) responsib le for the observed effect of serum on MV release have yet to be identified. To isolate ...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Alexandra Laberge,
Akram Ayoub,
Syrine Arif,
S ébastien Larochelle,
Alain Garnier,
Véronique J. Moulin Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Central adiponectin induces trabecular bone mass partly through epigenetic downregulation of cannabinoid receptor CB1
1.Globular adiponectin (gAPN) enhanced expression levels of various histone deacetylases (HDACs), especially HDAC5.
2.Chromatin immunoprecipitation assays revealed HDAC5 bound to the transcriptional start site 2 (TSS2) region of the CB1 promoter.
3.Our study identified a possible novel central APN‐HDAC5‐ CB1 signaling mechanism that promotes peripheral bone formation through epigenetic regulation of hypothalamic CB1 expression. AbstractCentral adiponectin (APN) in either the globular (gAPN) or full ‐length forms decreases sympathetic tone and increases trabecular bone mass in mice through the hypothalamus. It is kn...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Hua Jiang,
Yuwei Wu,
Paloma Valverde,
Dana Murray,
Jin Tang,
Qi Yao,
Qianqian Han,
Jin Zhang,
Lan Zhang,
Lei Sui,
Yin Tang,
Qisheng Tu,
Jake Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
A novel infram deletion in MSH6 gene in glioma: Conversation on MSH6 mutations in brain tumors
ConclusionPatients should be evaluated for MMR mutation before chemo and radiotherapy, and it is valuable to follow ‐up these mutations during the treatment too. In temozolomide (TMZ)‐resitance cases, it is suggested to use complementary strategies such as using HDACis and a combination of a STAT3 Inhibitor and an mTOR inhibitor, BER inhibition mechanism, and PARP‐1 inhibitor. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Zeinab Deris Zayeri,
Maryam Tahmasebi Birgani,
Javad Mohammadi Asl,
Davood Kashipazha,
Mohammadreza Hajjari Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Identification of functional lncRNAs in atrial fibrillation by integrative analysis of the lncRNA ‐mRNA network based on competing endogenous RNAs hypothesis
In this study, we identified eight functional long noncoding RNAs (lncRNAs) for atrial fibrillation based on competing endogenous RNA (ceRNA) hypothesis. These eight lncRNAs showed a good diagnostic power for atrial fibrillation (AF) and could be used as potential biomarkers AbstractA mounting body of evidence has suggested that long noncoding RNAs (lncRNAs) play critical roles in human diseases by acting as competing endogenous RNAs (ceRNAs). However, the functions and ceRNA mechanisms of lncRNAs in atrial fibrillation (AF) remain to date unclear. In this study, we constructed an AF ‐related lncRNA‐mRNA network (AFLMN...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Cheng Qian,
Hang Li,
Danqi Chang,
Baozhu Wei,
Yanggan Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Cardiovascular complications and related risk factors underlying opium consumption
Opium might have deleterious influences on cardiovascular events. As a result, people need to be trained with regard to the adverse effects of opium on cardiovascular events. It may cause hypertension, dyslipidemia, and hormonal abnormalities. AbstractOpium is considered as the second most abused addictive compound in worldwide. It seems that one of the causes for common consumption of opium in many countries is a traditional belief, even among medical personnel, through which opium might have advantageous influences on cardiovascular events and be beneficial in controlling hypertension, dyslipidemia, and diabetes. Accordi...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Reyhaneh T. Ebdali,
Seyyedeh Samaneh Tabaee,
Samira Tabaei Tags: REVIEW ARTICLE Source Type: research
The role of HSP27 in the development of drug resistance of gastrointestinal malignancies: Current status and perspectives
Upregulation of heat ‐shock protein 27 (HSP27) is associated with decreased drug sensitivity as well as poorer survival in gastrointestinal (GI) malignancies. This review summarizes the potential role of HSP27 in chemotherapy drug resistance, and the therapeutic potential of HSP27 inhibitors as a novel strategy in the treatment of GI cancers. AbstractHeat ‐shock protein 27 (HSP27) is a chaperone molecule that plays a critical role in the refolding and activity of several proteins responsible for cancer cell drug toxicity. Upregulation of HSP27 is associated with decreased drug sensitivity as well as poorer survival in ...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Atena Soleimani,
Mohammad Jalili ‐Nik,
Amir Avan,
Gordon A. Ferns,
Majid Khazaei,
Seyed Mahdi Hassanian Tags: REVIEW ARTICLE Source Type: research
Amino acids stimulate glycyl ‐tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells
Glycyl ‐tRNA synthetase (GlyRS) has a bipartite type of nuclear localization signals in its WHEP domain, and amino acids (Met, Leu, and Lys) trigger GlyRS phosphorylation at Thr544 and Ser704 in the cytoplasm and subsequent nuclear translocation. Nuclear p‐GlyRS physically interacts with and stimulates nuclear factor kappa B1 phosphorylation, thereby stimulating the expression of its downstream gene mammalian target of rapamycin and inhibiting autophagy. AbstractAmino acids are required for the activation of mammalian target of rapamycin (mTOR) to increase cell growth, protein and lipid synthesis, and inhibit autophagy...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Mengmeng Yu,
Chaochao Luo,
Xin Huang,
Dongying Chen,
Shanshan Li,
Hao Qi,
Xuejun Gao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Caspase ‐1‐dependent mechanism mediating the harmful impacts of the quorum‐sensing molecule N‐(3‐oxo‐dodecanoyl)‐l‐homoserine lactone on the intestinal cells
In this study, we emphasized on the caspases signal pathway and sterile inflammation to reveal the harmful effects of 3‐oxo‐C12‐HSL on LS174T goblet cells. Our data showed that 3‐oxo‐C12‐HSL is a major inducer of oxidative stress indicated by a high level of intracellular reactive oxygen species (ROS). However, TQ416, an inhibitor of paraoxonase 2, can effectively block oxidative stress. A higher ROS level is the trigger for activating the caspase‐1 and 3 cascade signal pathways. Blockade of ROS synthesis and caspase‐1 and 3 cascades can obviously rescue the viability of LS174T cells after 3‐oxo‐C12‐H...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Shiyu Tao,
Qinwei Sun,
Liuping Cai,
Yali Geng,
Canfeng Hua,
Yingdong Ni,
Ruqian Zhao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
LncRNA miR143HG suppresses bladder cancer development through inactivating Wnt/ β‐catenin pathway by modulating miR‐1275/AXIN2 axis
Our findings demonstrated that miR143HG/miR ‐1275/AXIN2 axis regulates bladder cancer tissue development by modulating Wnt/β‐catenin pathway. AbstractAlthough increasing long noncoding RNAs (lncRNAs) have been identified by high ‐throughput sequencing, their functions in human cancer remain largely unknown. The function of lncRNA miR143HG has not been explored before. In the present study, we found that miR143HG expression was significantly downregulated in bladder cancer tissues (BCa) compared with normal tissues. We sho wed that miR143HG high expression was associated with a high survival rate in BCa patients. Gai...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Hui Xie,
Hang Huang,
Weiping Huang,
Zhiyue Xie,
Yu Yang,
Feng Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
An overview of microRNAs: Biology, functions, therapeutics, and analysis methods
This review summarizes, miRNAs biology, functions, role of miRNAs in epigenetics and intercellular communication; Alteration of miRNAs after exercise, their association with diseases, and their therapeutic potential; Bioinformatics tools for miRNA studies and their analysis methods. AbstractMicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA ‐mediated clinical tria...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Kioomars Saliminejad,
Hamid Reza Khorram Khorshid,
Shahrzad Soleymani Fard,
Seyed Hamidollah Ghaffari Tags: MINI ‐REVIEW Source Type: research
Effects of FOSL1 silencing on osteosarcoma cell proliferation, invasion and migration through the ERK/AP ‐1 signaling pathway
Our findings revealed a novel mechanism by which Fos ‐like antigen‐1 (FOS1) depletion played a significantly negative role in the osteosarcoma (OS) progression through the regulation of the extracellular‐signal‐regulated kinase/activator protein‐1 signaling pathway. Functional suppression of FOSL1 might be a future therapeutic strategy regar ding OS. Osteosarcoma (OS), as the most frequent primary malignancy of bone, is characterized by the presence of malignant mesenchymal cells. In the current study, our aim was to explore the possible effects Fos ‐like antigen‐1 (FOSL1) had on the silencing regarding OS ce...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Yu Han,
Xingyu Zhao,
Yifu Sun,
Yutong Sui,
Jianguo Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Cancer stem cells as a therapeutic target in bladder cancer
In this study, we briefly discuss the biology of bladder cancer and then address the possible relationship between molecular biology of bladder cancer and cancer stem cells. Subsequently, the mechanisms of resistance applied by cancer stem cells against the conventional therapeutic tools, especially chemotherapy, are discussed. Moreover, by emphasizing the biomarkers described for cancer stem cells in bladder cancer, we have provided, described, and proposed targets on cancer stem cells for therapeutic interventions and, finally, reviewed some immunotargeting strategies against bladder cancer stem cells. (Source: Journal...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Nazi Aghaalikhani,
Nadereh Rashtchizadeh,
Pejman Shadpour,
Abdolamir Allameh,
Marzieh Mahmoodi Tags: MINI REVIEW Source Type: research
Roles of miRNA ‐1 and miRNA‐133 in the proliferation and differentiation of myoblasts in duck skeletal muscle
MicroRNA (miRNA) ‐1 targets histone deacetylase 4 to promote the differentiation of duck myoblasts and miRNA‐133 may affect serum response factor and transforming growth factor β receptor 1 expression to promote proliferation, which indicates that miRNA‐1 and miRNA‐133 play different important roles in skel etal muscle development. AbstractMicroRNA (miRNA) ‐1 and miRNA‐133 are derived from the same bicistronic pairs with roles in skeletal muscle development. Many investigations have focused on the role of miRNA‐1 and miRNA‐133 in the regulation of skeletal muscle development in mammals and fish. However, t...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Ningzhao Wu,
Tiantian Gu,
Lu Lu,
Zhengfeng Cao,
Qianqian Song,
Zhixiu Wang,
Yang Zhang,
Guobin Chang,
Qi Xu,
Guohong Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Roles of phosphatase and tensin homolog in skeletal muscle
In this review, we mainly discuss the role of phosphatase and tensin homolog in regulating the development, glucose metabolism, stem cell fate decision, and regeneration of skeletal muscle. AbstractThe phosphatase and tensin homolog (PTEN), originally identified as a tumor suppressor, is an important regulator of the PI3K –Akt pathway. PTEN plays crucial roles in various cellular processes, including cell survival, cell growth, cell proliferation, cell differentiation, and cell metabolism. In metabolic tissues, PTEN expression affects insulin sensitivity and glucose homeostasis. In skeletal muscle, the deletion of PTEN r...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Tizhong Shan,
Jiaqi Liu,
Ziye Xu,
Yizhen Wang Tags: MINI REVIEW Source Type: research
KCNQ1OT1 facilitates progression of non ‐small‐cell lung carcinoma via modulating miRNA‐27b‐3p/HSP90AA1 axis
Long noncoding RNA KCNQ1OT1 promotes non‐small‐cell lung cancer progression. KCNQ1OT1 modulates HSP90AA1 expression by sponging miR‐27b‐3p. AbstractLong noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes within the kcnq1 domain. But its roles in carcinogenesis and metastasis remain largely elusive. Herein, we evaluated its potential in non ‐small‐cell lung cancer (NSCLC) progression. We demonstrated that the KCNQ1OT1 level was upregulated in NSCLC tissues and cell lines. High KCNQ1OT1 level correlated with poor overall and progression‐free survival in NSCLC patients. KCNQ1OT1 facilitat...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Zhiwu Dong,
Ping Yang,
Xiaojian Qiu,
Shuang Liang,
Bing Guan,
Haisheng Yang,
Feifei Li,
Li Sun,
Huiling Liu,
Guanghui Zou,
Kewen Zhao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
