The role of HSP27 in the development of drug resistance of gastrointestinal malignancies: Current status and perspectives
Upregulation of heat ‐shock protein 27 (HSP27) is associated with decreased drug sensitivity as well as poorer survival in gastrointestinal (GI) malignancies. This review summarizes the potential role of HSP27 in chemotherapy drug resistance, and the therapeutic potential of HSP27 inhibitors as a novel strategy in the treatment of GI cancers. AbstractHeat ‐shock protein 27 (HSP27) is a chaperone molecule that plays a critical role in the refolding and activity of several proteins responsible for cancer cell drug toxicity. Upregulation of HSP27 is associated with decreased drug sensitivity as well as poorer survival in ...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Atena Soleimani, Mohammad Jalili ‐Nik, Amir Avan, Gordon A. Ferns, Majid Khazaei, Seyed Mahdi Hassanian Tags: REVIEW ARTICLE Source Type: research

Amino acids stimulate glycyl ‐tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells
Glycyl ‐tRNA synthetase (GlyRS) has a bipartite type of nuclear localization signals in its WHEP domain, and amino acids (Met, Leu, and Lys) trigger GlyRS phosphorylation at Thr544 and Ser704 in the cytoplasm and subsequent nuclear translocation. Nuclear p‐GlyRS physically interacts with and stimulates nuclear factor kappa B1 phosphorylation, thereby stimulating the expression of its downstream gene mammalian target of rapamycin and inhibiting autophagy. AbstractAmino acids are required for the activation of mammalian target of rapamycin (mTOR) to increase cell growth, protein and lipid synthesis, and inhibit autophagy...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Mengmeng Yu, Chaochao Luo, Xin Huang, Dongying Chen, Shanshan Li, Hao Qi, Xuejun Gao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Caspase ‐1‐dependent mechanism mediating the harmful impacts of the quorum‐sensing molecule N‐(3‐oxo‐dodecanoyl)‐l‐homoserine lactone on the intestinal cells
In this study, we emphasized on the caspases signal pathway and sterile inflammation to reveal the harmful effects of 3‐oxo‐C12‐HSL on LS174T goblet cells. Our data showed that 3‐oxo‐C12‐HSL is a major inducer of oxidative stress indicated by a high level of intracellular reactive oxygen species (ROS). However, TQ416, an inhibitor of paraoxonase 2, can effectively block oxidative stress. A higher ROS level is the trigger for activating the caspase‐1 and 3 cascade signal pathways. Blockade of ROS synthesis and caspase‐1 and 3 cascades can obviously rescue the viability of LS174T cells after 3‐oxo‐C12‐H...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Shiyu Tao, Qinwei Sun, Liuping Cai, Yali Geng, Canfeng Hua, Yingdong Ni, Ruqian Zhao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

LncRNA miR143HG suppresses bladder cancer development through inactivating Wnt/ β‐catenin pathway by modulating miR‐1275/AXIN2 axis
Our findings demonstrated that miR143HG/miR ‐1275/AXIN2 axis regulates bladder cancer tissue development by modulating Wnt/β‐catenin pathway. AbstractAlthough increasing long noncoding RNAs (lncRNAs) have been identified by high ‐throughput sequencing, their functions in human cancer remain largely unknown. The function of lncRNA miR143HG has not been explored before. In the present study, we found that miR143HG expression was significantly downregulated in bladder cancer tissues (BCa) compared with normal tissues. We sho wed that miR143HG high expression was associated with a high survival rate in BCa patients....
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Hui Xie, Hang Huang, Weiping Huang, Zhiyue Xie, Yu Yang, Feng Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods
This review summarizes, miRNAs biology, functions, role of miRNAs in epigenetics and intercellular communication; Alteration of miRNAs after exercise, their association with diseases, and their therapeutic potential; Bioinformatics tools for miRNA studies and their analysis methods. AbstractMicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA ‐mediated clinical tria...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Kioomars Saliminejad, Hamid Reza Khorram Khorshid, Shahrzad Soleymani Fard, Seyed Hamidollah Ghaffari Tags: MINI ‐REVIEW Source Type: research

Effects of FOSL1 silencing on osteosarcoma cell proliferation, invasion and migration through the ERK/AP ‐1 signaling pathway
Our findings revealed a novel mechanism by which Fos ‐like antigen‐1 (FOS1) depletion played a significantly negative role in the osteosarcoma (OS) progression through the regulation of the extracellular‐signal‐regulated kinase/activator protein‐1 signaling pathway. Functional suppression of FOSL1 might be a future therapeutic strategy regar ding OS. Osteosarcoma (OS), as the most frequent primary malignancy of bone, is characterized by the presence of malignant mesenchymal cells. In the current study, our aim was to explore the possible effects Fos ‐like antigen‐1 (FOSL1) had on the silencing regarding OS ce...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Yu Han, Xingyu Zhao, Yifu Sun, Yutong Sui, Jianguo Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Cancer stem cells as a therapeutic target in bladder cancer
In this study, we briefly discuss the biology of bladder cancer and then address the possible relationship between molecular biology of bladder cancer and  cancer stem cells. Subsequently, the mechanisms of resistance applied by cancer stem cells against the conventional therapeutic tools, especially chemotherapy, are discussed. Moreover, by emphasizing the biomarkers described for cancer stem cells in bladder cancer, we have provided, described, and proposed targets on cancer stem cells for therapeutic interventions and, finally, reviewed some immunotargeting strategies against bladder cancer stem cells. (Source: Jou...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Nazi Aghaalikhani, Nadereh Rashtchizadeh, Pejman Shadpour, Abdolamir Allameh, Marzieh Mahmoodi Tags: MINI REVIEW Source Type: research

Roles of miRNA ‐1 and miRNA‐133 in the proliferation and differentiation of myoblasts in duck skeletal muscle
MicroRNA (miRNA) ‐1 targets histone deacetylase 4 to promote the differentiation of duck myoblasts and miRNA‐133 may affect serum response factor and transforming growth factor β receptor 1 expression to promote proliferation, which indicates that miRNA‐1 and miRNA‐133 play different important roles in skel etal muscle development. AbstractMicroRNA (miRNA) ‐1 and miRNA‐133 are derived from the same bicistronic pairs with roles in skeletal muscle development. Many investigations have focused on the role of miRNA‐1 and miRNA‐133 in the regulation of skeletal muscle development in mammals and fish. Howeve...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Ningzhao Wu, Tiantian Gu, Lu Lu, Zhengfeng Cao, Qianqian Song, Zhixiu Wang, Yang Zhang, Guobin Chang, Qi Xu, Guohong Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Roles of phosphatase and tensin homolog in skeletal muscle
In this review, we mainly discuss the role of phosphatase and tensin homolog in regulating the development, glucose metabolism, stem cell fate decision, and regeneration of skeletal muscle. AbstractThe phosphatase and tensin homolog (PTEN), originally identified as a tumor suppressor, is an important regulator of the PI3K –Akt pathway. PTEN plays crucial roles in various cellular processes, including cell survival, cell growth, cell proliferation, cell differentiation, and cell metabolism. In metabolic tissues, PTEN expression affects insulin sensitivity and glucose homeostasis. In skeletal muscle, the deletion of PT...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Tizhong Shan, Jiaqi Liu, Ziye Xu, Yizhen Wang Tags: MINI REVIEW Source Type: research

KCNQ1OT1 facilitates progression of non ‐small‐cell lung carcinoma via modulating miRNA‐27b‐3p/HSP90AA1 axis
Long noncoding RNA  KCNQ1OT1 promotes non‐small‐cell lung cancer progression. KCNQ1OT1 modulates HSP90AA1 expression by sponging miR‐27b‐3p. AbstractLong noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes within the kcnq1 domain. But its roles in carcinogenesis and metastasis remain largely elusive. Herein, we evaluated its potential in non ‐small‐cell lung cancer (NSCLC) progression. We demonstrated that the KCNQ1OT1 level was upregulated in NSCLC tissues and cell lines. High KCNQ1OT1 level correlated with poor overall and progression‐free survival in NSCLC patients. KCNQ1OT1 facil...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Zhiwu Dong, Ping Yang, Xiaojian Qiu, Shuang Liang, Bing Guan, Haisheng Yang, Feifei Li, Li Sun, Huiling Liu, Guanghui Zou, Kewen Zhao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Microtia patients: Auricular chondrocyte ECM is promoted by CGF through IGF ‐1 activation of the IGF‐1R/PI3K/AKT pathway
ConclusionCGF ‐released IGF‐1 stimulates the synthesis of the auricular chondrocyte ECM via the IGF‐1R/PI3K/AKT signaling pathway. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Xia Chen, Ruhong Zhang, Qun Zhang, Zhicheng Xu, Feng Xu, Datao Li, Yiyuan Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Garcinol suppresses RANKL ‐induced osteoclastogenesis and its underlying mechanism
In conclusion, our data demonstrated that garcinol inhibited the RANKL‐induced osteoclastogenesis by suppressing the MAPK, NF‐κB, and PI3K‐AKT signaling pa thways and thus has potential as a novel therapeutic option for osteolytic bone diseases. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Yewei Jia, Jiawei Jiang, Xuanyuan Lu, Tan Zhang, Kangxian Zhao, Weiqi Han, Wanlei Yang, Yu Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Circulating visfatin levels and cancers risk: A systematic review and meta ‐analysis
Visfatin levels is abnormal in many types of cancers. There is a significant association between high circulating visfatin levels and increased risk of various cancers. Visfatin may represent a potential biomarker for early detection of cancers. AbstractVisfatin levels have been reported to be abnormal in many types of cancers. However, epidemiological studies yielded inconsistent results. Therefore, a meta ‐analysis was performed to assess the association between circulating visfatin levels and cancer risk. A systematic search was conducted for relevant studies in health‐related electronic databases up to March 2018. ...
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Masoumeh Mohammadi, Faezeh Mianabadi, Hassan Mehrad ‐Majd Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

TNF ‐α–TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis
Conclusion: TNF ‐α–TNFR signal pathway was involved in the occurrence and development of CWP by activating FAS–caspase‐8 and thus inhibiting autophagy while promoting apoptosis of AM. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 23, 2018 Category: Cytology Authors: Qingzeng Qian, Xiangke Cao, Bin Wang, Yi Qu, Qingqiang Qian, Zhiqian Sun, Fumin Feng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Leukemia inhibitory factor inhibits the proliferation of gastric cancer by inducing G1 ‐phase arrest
Unlike LIF promotes tumor progression, we found LIF serves as a negative regulator of gastric cancer, inhibits metastasis and the proliferation. AbstractLeukemia inhibitory factor (LIF), a member of the interleukin ‐6 cytokine family, plays a complex role in cancer. LIF inhibits the proliferation and survival of several myeloid leukemia cells but promotes tumor progression and metastasis in many solid tumors. However, the relationship between LIF and gastric cancer has not been well understood. LIF was downr egulated in gastric cancer as detected by western blot analysis and immunohistochemistry (IHC). Notably, LIF was d...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Guoxing Xu, Haibin Wang, Weizheng Li, Zengfu Xue, Qi Luo Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA
AbstractMetabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction and loss have central roles in the initiation and progression of the disease, the understanding of cellular and molecular pathways associated with pancreatic β‐cell dysfunction can provide more information about the underlying pathways involved in T2D. Multiple lines evidenc e indicated that oxidative stress, microRNA, and long noncoding RNA play significant roles in various steps of diseases. Oxidative stress is one of th...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mohammad Javad Saeedi Borujeni, Ebrahim Esfandiary, Azar Baradaran, Ali Valiani, Mustafa Ghanadian, Pilar Codo ñer‐Franch, Reyhane Basirat, Eulalia Alonso‐Iglesias, Hamed Mirzaei, Amid Yazdani Tags: REVIEW ARTICLE Source Type: research

MicroRNA ‐1271 functions as a potential tumor suppressor in hepatitis B virus–associated hepatocellular carcinoma through the AMPK signaling pathway by binding to CCNA1
This study indicated a potential therapeutic approach of downregulation of miR ‐1271 in HBV‐associated hepatocellular carcinoma treatment. AbstractHepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA ‐1271 (miR‐1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR‐1271 to influence cell proliferation, migration, invasion, and apoptosis in HBV‐associated HCC through the Adenosine monophosphate–activated protein kinase (AMPK) signaling ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yang Chen, Zhen ‐Xian Zhao, Fei Huang, Xiao‐Wei Yuan, Liang Deng, Di Tang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Clusterin enhances AKT2 ‐mediated motility of normal and cancer prostate cells through a PTEN and PHLPP1 circuit
In human prostate cells, clusterin (CLU) overexpression was found to enhance the phosphorylation of AKT restricted to isoform 2. Mechanistically, this was explained by the finding that the phosphatase PHLPP1, known to dephosphorylate AKT2 at S474, is markedly downregulated by CLU, whereas miR ‐190, a negative regulator of PHLPP1, is upregulated. Moreover, we found that PTEN was heavily phosphorylated at the inhibitory site S380, contributing to the hyperactivation of AKT signaling. Remarkably, we also demonstrated that by keeping AKT2 phosphorylation high, CLU dramatically enhances the migratory behavior of prostate epit...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Jessika Bertacchini, Laura Mediani, Francesca Beretti, Marianna Guida, Aram Ghalali, Federica Brugnoli, Valeria Bertagnolo, Emanuel Petricoin, Francesco Poti, Jessica Arioli, Laura Anselmi, Alessia Bari, James McCubrey, Alberto M. Martelli, Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis
MicroRNAs (miRNAs) regulate several biological and physiological processes in mammalian cells, including cellular proliferation, differentiation, apoptosis, and metabolism. Recent studies have confirmed the alteration of them during the cancer development. Matrix metalloproteinases (MMPs), belonging to the large family of proteases, have also been demonstrated to play crucial roles in tissue remodeling, and to support cancer progression and metastasis. There are several known miRNAs which regulate the MMP family and their expression. The expression profiles of miRNAs involved in MMP regulation, change during cancer progres...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mahsa Javadian, Tohid Gharibi, Najibeh Shekari, Meghdad Abdollahpour ‐Alitappeh, Ali Mohammadi, Arezoo Hossieni, Hamed Mohammadi, Tohid Kazemi Tags: MINI ‐REVIEW Source Type: research

Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of β‐catenin and matrix metallopeptidase 9
Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have been made to treat the disease in recent decades, effective drugs against metastatic melanoma are lack. We found that lycorine significantly suppressed melanoma cell migration and invasion in vitro, and decreased the metastasis of melanoma cells to lung tissues in mice by reducing intracellular levels of β‐catenin protein through degradation of the protein via the ubiquitin–proteasome pathway. Our findings support the notion that targeting the oncogenic β‐catenin signaling by lycorine is a new option to inhibit me...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Pan Zhang, Mengli Zhang, Di Yu, Wenming Liu, Lin Hu, Bin Zhang, Quansheng Zhou, Zhifei Cao Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Long noncoding RNA –antisense noncoding RNA in the INK4 locus accelerates wound healing in diabetes by promoting lymphangiogenesis via regulating miR‐181a/Prox1 axis
ConclusionANRIL could promote lymphangiogenesis during the diabetic wound healing process via sponging miR ‐181a to enhance Prox1 expression, which might help design new therapy to improve the wound healing efficacy for diabetes. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Zhi ‐You He, Tian‐Hong Wei, Pi‐Hong Zhang, Jie Zhou, Xiao‐Yuan Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Biomaterial aided differentiation and maturation of induced pluripotent stem cells
Recent technological advancements in biomaterial scaffolds aids to improve the differentiation of induced pluripotent stem cells (iPSCs) with desired properties. Here, we discuss in detail with examples that different fabrication techniques incorporates physical and topographical or biochemical cues in the biomaterial scaffold which guides in the differentiation of iPSCs to a specific functional cell phenotype. AbstractEngineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bharath Kumar Velmurugan, Lohanathan Bharathi Priya, Paramasivan Poornima, Li ‐Jen Lee, Rathinasamy Baskaran Tags: REVIEW ARTICLE Source Type: research

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
Tumors have specific mechanisms to break T cell responses. CD8+ T cells are the key immune cells for killing cancer cells presenting major histocompatibility complex (MHC) class I molecules. For pursuing this purpose, the cells must first be primed by their cardinal interactions with dendritic cells (DCs),  natural killer (NK) cells, and CD4+ T cells, among them play essential roles for this priming. Then, the primed cells are activated to form effector  cytotoxic T lymphocytes (CTLs) for killing cancer cells via release of granules or induction of FasL‐mediated apoptosis. In the established tumors, however, th...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bagher Farhood, Masoud Najafi, Keywan Mortezaee Tags: REVIEW ARTICLE Source Type: research

Protective role of microRNA ‐374 against myocardial ischemia‐reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha‐mediated Notch1 axis
By inhibiting the activity of dystrobrevin ‐alph‐mediated Notch1 axis, miR‐374 could protect against myocardial Ischemia‐reperfusion injury in mice after thoracic epidural anesthesia. AbstractIschemia ‐reperfusion (I/R) injury often leads to myocardial apoptosis and necrosis. Studies have demonstrated the role microRNAs (miRs) played in myocardial I/R injury. Thus, we established a myocardial I/R injury model and a thoracic epidural anesthesia (TEA) model in mice to explore whether microRNA‐3 74 (miR‐374) affects myocardial I/R injury. We collected myocardial tissues to evaluate whether TEA exerts a protectio...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Zheng Zhao, Yun Zhao, Li Ying ‐Chun, Lei Zhao, Wei Zhang, Jian‐Guo Yang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Roles of Nrf2/HO ‐1 and HIF‐1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury
CIRI can lead to remote organ injury in the lungs. The Nrf2/HO ‐1 antioxidative stress pathway minimizes pulmonary free radical injury, and HIF‐1α/VEGF advances angiogenesis and repair of the alveolar–capillary barrier. These findings provide a theoretical basis for clinical treatment. AbstractCerebral ischemia/reperfusion injury (CIRI) leads to injury in distant organs, most commonly the lungs, although limited studies have examined self ‐protective mechanisms during CIRI‐induced lung injury. Here, we investigated self‐protective mechanisms that attenuate stress‐related injury and promote the angio...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Jianhua Fan, Hui Lv, Jie Li, Yuqin Che, Baoning Xu, Zuo Tao, Wenjun Jiang Tags: RAPID COMMUNICATION Source Type: research

Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats
Flavonoid genistein may have a potency to protect bone marrow sinusoids during methotrexate therapy, which is associated, at least partially, with its indirect effect of promoting angiogenic factor vascular endothelial growth factor expression in osteoblasts and its direct effect of enhancing nitric oxide production in sinusoidal endothelial cells. AbstractCancer chemotherapy can cause significant damage to the bone marrow (BM) microvascular (sinusoidal) system. Investigations must now address whether and how BM sinusoidal endothelial cells (SECs) can be protected during chemotherapy. Herein we examined the potential prote...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Mohammadhossein Hassanshahi, Yu ‐Wen Su, Samira Khabbazi, Chia‐Ming Fan, Ke‐Ming Chen, Ju‐Fang Wang, Airong Qian, Peter R. Howe, De‐Wen Yan, Hou‐De Zhou, Cory J. Xian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non ‐small cell lung cancer by regulating Galectin‐1‐AKT/ERK1/2 signaling
The dysregulation of the circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). Together, these data provide mechanistic insights into circRNA FGFR3 (circFGFR3)‐mediated regulation of both the AKT and ERK1/2 signaling pathways by sponging miR‐22‐3p and increasing Gal‐1 expression. AbstractThe dysregulation of circular RNA (circRNA) expression is involved in the progression of several cancers, including non ‐small cell lung cancer (NSCLC). However, the role and underlying molecular mechanisms of circRNA FGFR3 (circFGFR3) in NSCLC p...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Bai ‐Quan Qiu, Peng‐Fei Zhang, Dian Xiong, Jian‐Jun Xu, Xiang Long, Shu‐Qiang Zhu, Xu‐Dong Ye, Yin Wu, Xu Pei, Xue‐Mei Zhang, Yong‐Bing Wu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

c ‐Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70‐dependent turnover manner
1. c ‐Src triggers proliferative and survival signals in response to a circuit of differential tensional forces; 2. Extracellular matrix remodeling‐related scenario is rigorously modulated: possible role of c‐Src on delivering signals; 3. Heat shock proteins (HSPs) were identified in response to hy pertensive stress in vitro; 4. 20S proteasome‐related genes were overexpressed and suggested protein turnover. AbstractShear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress ‐related tensional forces might be associated with pathophysiological susceptibi...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Tha ís Silva Pinto, Célio Junior da Costa Fernandes, Rodrigo Augusto da Silva, Anderson Moreira Gomes, José Cavalcante Souza Vieira, Pedro de M. Padilha, Willian F. Zambuzzi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MiR ‐145‐modulated SOX9‐mediated hypospadias through acting on mitogen‐activated protein kinase signaling pathway
This study primarily explored how miR ‐145, mitogen‐activated protein kinase (MAPK) signaling and a downstream transcription factor (i.e., SOX9) mediated development of hypospadias. The hypospadias tissues and preputial tissues were isolated from pediatric inpatients postoperatively. Simultaneously, the rat models of hypospadias wer e established, and spermatogonial stem cells were separated. The expressions of proteins that symbolized cell apoptosis and oxidative stress were quantified via western blot analysis. Furthermore, the apoptosis, proliferation, and viability of cells were evaluated by means of flow cytometry...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yafeng Shang, Yanjie Kang, Jiantao Sun, Pengtao Wei, Jinhui Yang, Han Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

MRS1754 inhibits proliferation and migration of bladder urothelial carcinoma by regulating mitogen ‐activated protein kinase pathway
MRS1754 inhibits proliferation and migration of bladder urothelial carcinoma (BUC) cells. Bay60 ‐6583 could reverse the inhibitory effect of MRS1754 on BUC cells proliferation and migration. MRS1754 inhibits progression of BUC by suppressing the phosphorylation of the mitogen‐activated protein kinase (MAPK) pathway. AbstractBladder urothelial carcinoma (BUC) is one of the most common urological malignancies. Our previous study found that adenosine A2b receptor (A2bR) was upregulated in BUC tissues and cells. In the present study, we investigated the effect of MRS1754 (a selective A2bR antagonist) on cell proliferation ...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Yihong Zhou, Xi Chu, Ye Yi, Zheng Hao, Xiaoping Zheng, Tang Yuxin, Yingbo Dai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases
Endoplasmic reticulum (ER) stress and an exaggerated unfolded protein response (UPR) were observed in the vastus lateralis (VL) muscle of patients with respiratory sarcopenia and cachexia, particularly in those with lung cancer (LC). The three branches of UPR were similarly upregulated in muscles of cancer cachectic patients, whereas in the sarcopenic chronic obstructive pulmonary disease (COPD) patients, inositol ‐requiring enzyme (IRE) 1 arm was mostly upregulated in their VL. The differential expression profile of ER stress and UPR markers observed in chronic and acute respiratory diseases offers a niche for the desig...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Esther Barreiro, Anna Salazar ‐Degracia, Antonio Sancho‐Muñoz, Joaquim Gea Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

IL ‐17 and IL‐22 elicited by a DNA vaccine encoding ROP13 associated with protection against Toxoplasma gondii in BALB/c mice
AbstractToxoplasma gondii, an intracellular parasitic protozoan, is capable of infecting man and all warm ‐blooded animals. Cell‐mediated immunity is vital in mounting protective responses againstT. gondii infection. Recent studies have shown that T ‐helper (Th) 17 responses may play a key role in parasite control. In this current study, we constructed a DNA vaccine encodingT. gondii ROP13 in a pcDNA vector. Groups of BALB/c mice were immunized intramuscularly with pcROP13 or controls and challenged with the RH strain ofT. gondii. The results showed that immunization with pcROP13 could elicit an antibody response aga...
Source: Journal of Cellular Physiology - November 22, 2018 Category: Cytology Authors: Paria Alizadeh, Ehsan Ahmadpour, Ahmad Daryani, Tohid Kazemi, Adel Spotin, Mahmoud Mahami ‐Oskouei, Robin J Flynn, Yaghob Azadi, Saba Rajabi, Siamak Sandoghchian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all ‐trans‐retinoic acid in erlotinib‐treated renal tubular epithelial cells
Rosiglitazone and all ‐trans‐retinoic acid (ATRA) increased transient receptor potential melastatin 6 (TRPM6) expression in renal tubular epithelial cells. Rosiglitazone and ATRA increased Mg2+ influx. Rosiglitazone and ATRA may reverse the reduction in Mg2+ reabsorption caused by antiepidermal growth factor receptor (anti ‐EGFR) drugs. AbstractAnti ‐epidermal growth factor receptor (EGFR) drugs including erlotinib cause a side effect of hypomagnesemia. In lung adenocarcinoma A549 cells, anticancer agents such as cisplatin and doxorubicin dose‐dependently increased toxicity, but the effects were significantly sup...
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Aya Manabe, Chisa Furukawa, Hajime Hasegawa, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action
ConclusionSt. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy ofH. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Nahid Zirak, Mojtaba Shafiee, Ghasem Soltani, Mohammad Mirzaei, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Specific knockdown of WNT8b expression protects against phosphate ‐induced calcification in vascular smooth muscle cells by inhibiting the Wnt–β‐catenin signaling pathway
WNT8b knockdown terminates phosphate ‐induced vascular calcification in vascular smooth muscle cells by inhibiting the Wnt–β‐catenin signaling pathway. In the last 10 years, the prevalence, significance, and regulatory mechanisms of vascular calcification (VC) have gained increasing recognition. The aim of this study is to explore the action ofWNT8b in the development of phosphate ‐induced VC through its effect on vascular smooth muscle cells (VSMCs) in vitro by inactivating the Wnt–β‐catenin signaling pathway. To explore the effect ofWNT8b on the Wnt –β‐catenin signaling pathway ...
Source: Journal of Cellular Physiology - November 21, 2018 Category: Cytology Authors: Bin ‐Yao Tian, Li Yao, Zi‐Tong Sheng, Peng‐Zhi Wan, Xiao‐Bo Qiu, Jian Wang, Tian‐Hua Xu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets
Vitamin E TTs have gained interest due to their health benefits in chronic diseases. In particular, TTs were reported to exert significant antitumor activity in a wide range of cancer cells, by counteracting cell growth or proliferation, metastasis and angiogenesis. Recent studies pointed out that TTs exert a synergistic antitumor effect on cancer cells when given in combination with either standard antitumor agents or natural compounds with anticancer activity. These results, together with the safety of TT administration in healthy subjects, suggest that these compounds might represent a new chemopreventive or anticancer ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Marina Montagnani Marelli, Monica Marzagalli, Fabrizio Fontana, Michela Raimondi, Roberta Manuela Moretti, Patrizia Limonta Tags: REVIEW ARTICLE Source Type: research

Stat3 activation is critical for pluripotency maintenance
This study presents an overview of the critical roles of signal transducer and activator of transcription 3 (Stat3) activation in the pluripotency maintenance of embryonic stem (ES) cells, somatic cell reprogramming, and na ïve‐primed pluripotent states conversion of ES cells. AbstractSignal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription with many important functions, including regulation of cell proliferation, differentiation, survival, angiogenesis, and immune response. Besides, it plays critical roles in regulating the pluripotency. With the ability of self ‐renewal and diffe...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yan Zhang, Dan Wang, Jia Xu, Yuebing Wang, Fengxia Ma, Zongjin Li, Na Liu Tags: MINI REVIEW Source Type: research

Regulation of tumor angiogenesis by microRNAs: State of the art
This review focuses on tumor angiogenesis regulation by microRNAs and the mechanism underlying this regulation. MicroRNAs (miRNAs, miRs) are small (21 –25 nucleotides) endogenous and noncoding RNAs involved in many cellular processes such as apoptosis, development, proliferation, and differentiation via binding to the 3′‐untranslated region of the target mRNA and inhibiting its translation. Angiogenesis is a hallmark of cancer, which provide s oxygen and nutrition for tumor growth while removing deposits and wastes from the tumor microenvironment. There are many angiogenesis stimulators, among which vascular ...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Nasser H. Goradel, Nejad Mohammadi, Hamed Haghi ‐Aminjan, Bagher Farhood, Babak Negahdari, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Action mechanisms of n ‐3 polyunsaturated fatty acids on the oocyte maturation and developmental competence: Potential advantages and disadvantages
There is a large body of evidence showing that n ‐3 polyunsaturated fatty acids (PUFAs) have benefits on general health. This review discusses molecular mechanisms by which n‐3 PUFAs affect oocyte maturation and developmental competence. Infertility is a growing problem worldwide. Currently, in vitro fertilization (IVF) is widely performed to treat infertility. However, a high percentage of IVF cycles fails, due to the poor developmental potential of the retrieved oocyte to generate viable embryos. Fatty acid content of the follicular microenvironment can affect oocyte maturation and the subsequent developmental compet...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Reza Zarezadeh, Amir Mehdizadeh, Jo L. M. R. Leroy, Mohammad Nouri, Shabnam Fayezi, Masoud Darabi Tags: MINI REVIEW Source Type: research

The clinical importance of CD4+CD7 − in human diseases
In this review, we first focus on the clinical importance of CD4+CD7− T cells in human disease and also explain the possible function of these cells. Secondly, we also investigate if the CD4+CD7− T cells are resistant to apoptosis. The CD7 antigen is a member of the immunoglobulin superfamily that expresses on the surface of all thymocytes, a majority of mature T cells, and also natural killer cells. Interestingly, under physiological and different pathological conditions, the loss of CD7 antigen occurred in the subset of CD4+ memory T cells. Various functions have been proposed for CD7, including its role in t...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Saeed Mohammadian Haftcheshmeh, Amir Tajbakhsh, Mohaddese Kazemi, Seyed ‐Alireza Esmaeili, Fatemeh Mardani, Mostafa Fazeli, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review
Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti ‐inflammatory, and antibacterial properties; due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer and curcumin has protective effects against skin damage cause d by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability; in this regard, th...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yunes Panahi, Omid Fazlolahzadeh, Stephen L. Atkin, Muhammed Majeed, Alexandra E. Butler, Thomas P. Johnston, Amirhossein Sahebkar Tags: REVIEW ARTICLE Source Type: research

Cover Image, Volume 234, Number 2, February 2019
Cover: The cover image is based on the Original Research ArticleHippo pathway functions as a downstream effector of AKT signaling to regulate the activation of primordial follicles in mice by Liao ‐Liao Hu et al., DOI:10.1002/jcp.27024. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Meng ‐Hao Pan, Fei Wang, Yujie Lu, Feng Tang, Xing Duan, Yu Zhang, Bo Xiong, Shao‐Chen Sun Tags: COVER Source Type: research

Table of Contents, Editor's Choice, Highlights
Journal of Cellular Physiology, Volume 234, Issue 2, Page 987-998, February 2019. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Tags: Issue Information Source Type: research

Exercise ameliorates high ‐fat diet‐induced impairment of differentiation of adipose‐derived stem cells into neuron‐like cells in rats
In this study, we determined the impact of either a 9‐week high‐fat diet (60% fat; HFD) or 9‐week exercise training on the differentiation potential of ADSCs into neuron‐like cells in male Wistar rats. Rats were randomly assigned to a normal diet‐fed (ND‐SED) group, HFD‐fed (HFD‐SED) group, or exercise‐trained HFD‐fed gro up (HFD‐EX). After a 9‐week intervention, ADSCs from all groups differentiated into neuron‐like cells. Expression of neuronal marker proteins (nestin, βIII‐tubulin, and microtubule‐associated protein 2 [MAP2]) and the average length of cell neurites were lower in cells f...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Hisashi Kato, Hidemasa Minamizato, Hideki Ohno, Yoshinobu Ohira, Tetsuya Izawa Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Carvacrol induces mitochondria ‐mediated apoptosis via disruption of calcium homeostasis in human choriocarcinoma cells
In this study, we demonstrated that carvacrol exertes antiproliferative effects through suppression of phosphoinositide 3 ‐kinase–protein kinase B and mitogen‐activated protein kinase signaling, generating oxidative stress and altering calcium homeostasis mediated by mitochondrial dysfunction in human choriocarcinoma JAR and JEG3 cells. Therefore, carvacrol has a possibility as a novel therapeutic agent or supple ment for the treatment of choriocarcinoma patients. Carvacrol is a monoterpenoid phenol present in the oils of various plants includingOriganum vulgare (oregano) orOriganum majorana (marjoram). For a lon...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Whasun Lim, Jiyeon Ham, Fuller W. Bazer, Gwonhwa Song Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

The predictive value of a preoperative systemic immune ‐inflammation index and prognostic nutritional index in patients with esophageal squamous cell carcinoma
(a)  The preoperative high systemic immune‐inflammation index (SII) and low prognostic nutritional index (PNI) are powerful indicators of aggressive biology and poor prognosis for patients with esophageal squamous cell carcinoma (ESCC). (b) Combination of SII and PNI (coSII–PNI) clearly classified ESCC patients into three independent groups before surgery. (c) The coSII–PNI can enhance the accuracy of prognosis. Growing evidence indicates that systemic inflammation response and malnutrition status are correlated with survival in certain types of solid tumors. The aim of this study is to evaluat...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Hongdian Zhang, Xiaobin Shang, Peng Ren, Lei Gong, Ashique Ahmed, Zhao Ma, Rong Ma, Xianxian Wu, Xiangming Xiao, Hongjing Jiang, Peng Tang, Zhentao Yu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Deletion of Axin1 in condylar chondrocytes leads to osteoarthritis ‐like phenotype in temporomandibular joint via activation of β‐catenin and FGF signaling
We have generated Axin1 conditional knockout (KO) mice by targeting aggrecan ‐expressing condylar cartilage cells in the temporomandibular joint (TMJ). The Axin1 conditional KO mice showed TMJ osteoarthritis (OA)‐like phenotype, probably through activation of β‐catenin and fibroblast growth factor (FGF) signaling. Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a degenerative disease in the adult, which is characterized by the pathological degeneration of condylar cartilage. Axin1 plays a critical role in the regulation of cartilage development and homeostasis. To determine the role of Axin1 in TMJ t...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yachuan Zhou, Bing Shu, Rong Xie, Jian Huang, Liwei Zheng, Xuedong Zhou, Guozhi Xiao, Lan Zhao, Di Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Effects of carnitine palmitoyltransferases on cancer cellular senescence
This study revealed that carnitine palmitoyltransferase 1C (CPT1C) knockdown exhibited the strongest impact on cell growth arrest and senescence, lipid change and accumulation, and mitochondrial dysfunction among all members of the CPT family. In addition, only knocking down CPT1C could downregulate the protein expression of c ‐Myc and cyclin D1 and upregulate the cell cycle inhibitor p27 significantly, which contributes to the potential molecular mechanism of CPT1C knockdown‐induced cellular senescence. The carnitine palmitoyltransferase (CPT) family is essential for fatty acid oxidation. Recently, we found that CPT1C...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Lihuan Guan, Yixin Chen, Yongtao Wang, Huizhen Zhang, Shicheng Fan, Yue Gao, Tingying Jiao, Kaili Fu, Jiahong Sun, Aiming Yu, Min Huang, Huichang Bi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Implication of basal lamina dependency in survival of Nrf2 ‐null muscle stem cells via an antioxidative‐independent mechanism
Muscle regeneration ability of Nrf2 ‐null mice is normal. However, in a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in muscle stem cells Nuclear factor erythroid 2 –related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration have been reported. Here, using aged Nrf2‐null and Nrf2–dystrophic doub...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Yusei Takemoto, Shoya Inaba, Lidan Zhang, Kazutake Tsujikawa, Akiyoshi Uezumi, So ‐ichiro Fukada Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Inhibition of JNK and p38 MAPK ‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy
This study investigated whether ivabradine exerts a therapeutic effect in DCM. C57BL/6J mice were injected intraperitoneally with streptozotocin (STZ) to induce diabetes; then administered with ivabradine or saline (control). After 12 weeks, the surviving mice were analyzed to determine the cardioprotective effect of ivabradine against DCM. Although treatment with ivabradine did not affect blood glucose levels, it attenuated tumor necrosis factor‐α, interleukin‐1β, and interleukin‐6 messenger RNA (mRNA) expression, inhibi ted c‐Jun N‐terminal kinase (JNK) and p38 mitogen‐activated protein kinase (p38...
Source: Journal of Cellular Physiology - November 20, 2018 Category: Cytology Authors: Guangfeng Zuo, Xiaomin Ren, Xuesong Qian, Peng Ye, Jie Luo, Xiaofei Gao, Junjie Zhang, Shaoliang Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research