Aflatoxin G1 induced TNF ‐α‐dependent lung inflammation to enhance DNA damage in alveolar epithelial cells
In this study, we found increased DNA damage and cytochrome P450 (CYP2A13) expression in AFG1‐induced inflamed lung tissues. Furthermore, we treated the mice with a soluble tumor necrosis factor (TNF)‐α receptor and AFG1 and found that TNF ‐α neutralization inhibited the AFG1‐induced chronic lung inflammation in vivo, and then reversed the CYP2A13 expression and DNA damage in AT‐II cells. The results suggest that AFG1 induces TNF ‐α‐dependent lung inflammation to regulate 2A13 expression and enhance DNA damage in AT‐II cells. Then, we treated the primary mice AT‐II cells and human AT‐II like cells (A...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Peilu Shao,
Ningfei Guo,
Can Wang,
Mei Zhao,
Li Yi,
Chunping Liu,
Lifei Kang,
Lei Cao,
Ping Lv,
Lingxiao Xing,
Xianghong Zhang,
Haitao Shen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Association between miRNAs expression and signaling pathways of oxidative stress in diabetic retinopathy
AbstractDiabetic retinopathy (DR) is a major cause of vision reduction in diabetic patients. Hyperglycemia is a known instigator for the development of DR, even though the role of oxidative stress pathways in the pathogenesis of DR is established. The studies indicate that microRNAs (miRNAs) are significant to the etiology of DR; changes in miRNAs expression levels may be associated with onset and progression of DR. In addition, miRNAs have emerged as a useful disease marker due to their availability and stability in detecting the severity of DR. The relationship between miRNAs expression levels and oxidative stress pathwa...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Mahbobeh Satari,
Esmat Aghadavod,
Moein Mobini,
Zatollah Asemi Tags: REVIEW ARTICLE Source Type: research
MicroRNA ‐145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2
In this study, we report that microRNA ‐145 (miR‐145) and p53 were downregulated in vivo and in vitro, concomitant with the enhanced expression of zinc finger E‐box binding homeobox 2 (ZEB2). In addition, overexpression of miR‐145 and p53 led to upregulation of the number of senescence‐associated β‐galactosidase‐positive H SCs and the expression of senescence markers p16 and p21, along with the reduced abundance of HSC activation markers α‐smooth muscle actin and type I collagen in activated HSCs. Furthermore, silencing of ZEB2 promoted senescence of activated HSCs. Moreover, we also demonstrated that miR...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Junfa Yang,
Yuchen Lu,
Peipei Yang,
Qingfeng Chen,
Yang Wang,
Qi Ding,
Tao Xu,
Xiaofeng Li,
Changyao Li,
Cheng Huang,
Xiaoming Meng,
Jun Li,
Lei Zhang,
Xiao Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The effects of Nutlin ‐3 on morphology, cellular proliferation, and apoptosis in rat primary mesenchymal stem cells
ConclusionHere, we show that rat BMSCs are relatively resistant to Nutlin ‐3; however, further in vivo data with long‐term exposure may help to corroborate our findings. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Babak Bajelan,
Majid Zaki ‐Dizaji,
Shahram Darabi,
Farzad Rajaei Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Human breast cancer decellularized scaffolds promote epithelial ‐to‐mesenchymal transitions and stemness of breast cancer cells in vitro
In our study, human breast cancer biopsies were decellularized by the detergent technique with sodium lauryl ether sulfate (SLES) solution for the first time. Scaffolds seeded with MCF ‐7 cells demonstrated the process of cell recellularization in vitro, with increased cell migration, proliferation, and epithelial‐to‐mesenchymal transition (EMT) process. When treated with 5‐fluorouracil (5‐Fu), the expressions of stem cell markers, including Oct4, Sox2, and CD49F, were m aximally maintained in the recellularized scaffold with decreased apoptosis rates compared with monolayer cells. AbstractBreast cancer, with uns...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Gang Liu,
Biao Wang,
Shubin Li,
Qin Jin,
Yanfeng Dai Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens
Multiple ‐scale integrative analysis revealed the expression and regulatory networks of PE/PPE family antigens underlying the virulence and pathogenesis of Mtb, providing important clues for the discovery of new anti‐TB measures AbstractPE/PPE family antigens are distributed mainly in pathogenic mycobacteria and serve as potential antituberculosis (TB) vaccine components. Some PE/PPE family antigens can regulate the host innate immune response, interfere with macrophage activation and phagolysosome fusion, and serve as major sources of antigenic variation. PE/PPE antigens have been associated with mycobacteria pathogen...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Wu Li,
Wanyan Deng,
Jianping Xie Tags: MINI ‐REVIEW Source Type: research
Identification of hsa ‐mir‐34a, hsa‐mir‐124, and hsa‐mir‐204 as signatures for cataract
This study aims to explore the key miRNAs underlying the pathogenesis of cataract and find prevention and treatment methods. First, six representative cataract miRNA datasets are selected and the key miRNAs are determined. The target genes of these key miRNAs are predicted using the TargetS can software, and then, the functional enrichment and transcription factor binding analysis of these target genes are completed, respectively. Three signature miRNAs associated with cataract are finally identified. Among them, hsa‐mir‐34a seems to be significantly upregulated, while hsa‐mir‐ 124 and hsa‐mir‐204 are significa...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Ying ‐Li Wei,
Hao Sun Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Comparative study of laparoscopic ‐assisted and open total gastrectomy for Siewert Types II and III adenocarcinoma of the esophagogastric junction
ConclusionsLATG and OTG had no significant difference for Siewert II and III AEJ in terms of radical resection and tumor recurrence, but LATG is worthy to be promoted with less bleeding, less postoperative pain, faster recovery of gastrointestinal function, and shorter hospital stay. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Jianchu Wang,
Jin ‐Cheng Wang,
Bin Song,
Xu‐Dong Dai,
Xiao‐Yu Zhang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
SP1, MYC, CTNNB1, CREB1, JUN genes as potential therapy targets for neuropathic pain of brain
In conclusion, the pathways of immune resp onse and cytokine‐cytokine receptor interaction were determined as the main metabolic pathways of NP affecting the brain, andSP1, MYC, CTNNB1, CREB1, JUN genes were recognized as the most enriched genes in this process, which may provide evidence for the diagnosis and treatment research of neuropathic pain. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Xue ‐Tao Yan,
Yong Xu,
Xiao‐Li Cheng,
Xiang‐Hu He,
Yu Wang,
Wen‐Zhong Zheng,
Ying Zhao,
Hu Chen,
Yan‐Lin Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy
AbstractDiabetic retinopathy is one of the common and serious microvascular complications of diabetes mellitus, as hyperglycemia has metabolic effects on the retina. Hyperglycemia induces increased oxidative stress, which stimulates inflammation pathways and promotes vascular dysfunction of the retina that leads to increased capillary permeability and vascular leakage. One of the main factors involving diabetic retinopathy is the inflammation signaling pathways. In contemporary times, microRNAs (miRNAs) are identified as functional biomarkers for early detection and treatment of numerous diseases specifically diabetic reti...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Rana Shafabakhsh,
Esmat Aghadavod,
Moein Mobini,
Reza Heidari ‐Soureshjani,
Zatollah Asemi Tags: MINI ‐REVIEW Source Type: research
Synergistic anticancer action of quercetin and curcumin against triple ‐negative breast cancer cell lines
Women with the breast cancer type 1 susceptibility protein (BRCA1) mutation and loss of BRCA1 expression are reported to have an increased risk of triple ‐negative breast cancer (TNBC). We detected that quercetin and curcumin dose‐dependently enhanced BRCA1 expression. Quercetin and curcumin appeared to induce BRCA1 promoter histone acetylation. Our present study concluded that the combination treatment of quercetin and curcumin acts synergistica lly to induce anticancer activity against TNBC cells by modulating tumor suppressor genes. AbstractWomen with the breast cancer type 1 susceptibility protein (BRCA1) mutation ...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Sai Kundur,
Amrita Prayag,
Priyanga Selvakumar,
Hung Nguyen,
Lloyd McKee,
Clairissa Cruz,
Asha Srinivasan,
Sunday Shoyele,
Ashakumary Lakshmikuttyamma Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Induced pluripotent stem cell ‐derived extracellular vesicles: A novel approach for cell‐free regenerative medicine
This study reviews the physiological functions of extracellular vesicles and discusses their potential therapeutic benefit in regenerative me dicine. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Behnaz Taheri,
Masoud Soleimani,
Sedigheh Fekri Aval,
Elahe Esmaeili,
Zahra Bazi,
Nosratollah Zarghami Tags: REVIEW ARTICLE Source Type: research
Glucagon attenuates lipid accumulation in cow hepatocytes through AMPK signaling pathway activation
The ketotic cows displayed hepatic lipid metabolic disorder and high blood concentration of glucagon. The present study indicates that glucagon activates the AMPK signalling pathway to increase lipid oxidation and VLDL assembly and decrease lipid synthesis in cow hepatocytes, thereby reducing liver fat accumulation. AbstractThe ketotic cows displayed hepatic lipid metabolic disorder and high blood concentration of glucagon. Importantly, adenosine monophosphate ‐activated protein kinase (AMPK) signaling pathway plays an important role in the hepatic lipid homeostasis. Therefore, the aim of this study was to investigate th...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yu Li,
Hongyan Ding,
Jihong Dong,
Sajid Ur Rahman,
Shibin Feng,
Xichun Wang,
Jinjie Wu,
Zhe Wang,
Guowen Liu,
Xiaobing Li,
Xinwei Li Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Comparative transcriptome analysis reveals PERP upregulated during Salmonella Enteritidis challenge in laying ducks
In this study, the ducks were orally inoculated with SE, and the ovarian follicles and stroma were collected to detect SE infection. The immune responses were triggered and the innate and adaptive immune genes (TLR4, NOD1, Av βD7, and IL‐1β) were upregulated significantly during the SE challenge. Moreover, the ovary tissues (small follicle and stroma) of susceptible and resistant–laying ducks were performed by RNA sequencing. We obtained and identified 23 differentially expressed genes (DEGs) between susceptible an d resistant–laying ducks in both small follicle and stroma tissues (p < 0.05). The DEGs were ...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Yu Zhang,
Tian ‐tian Gu,
Yang Chen,
Yu Huang,
Jinping Du,
Lizhi Lu,
Guo‐qiang Zhu,
Qi Xu,
Guo‐hong Chen Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis
AbstractThe interplay between H2S and nitric oxide (NO) is thought to contribute to renal functions. The current study was designed to assess the role of NO in mediating the renoprotective effects of hydrogen sulfide in the 5/6 nephrectomy (5/6 Nx) animal model. Forty rats were randomly assigned to 5 experimental groups: (a) Sham; (b) 5/6 Nx; (c) 5/6Nx+sodium hydrosulfide ‐a donor of H2S, (5/6Nx+sodium hydrosulfide [NaHS]); (d) 5/6Nx+NaHS+L‐NAME (a nonspecific nitric oxide synthase [NOS] inhibitor); (e) 5/6Nx+NaHS+aminoguanidine (a selective inhibitor of inducible NOS [iNOS]). Twelve weeks after 5/6 Nx, we assessed the...
Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Mohammad Khabbaz Shirazi,
Asaad Azarnezhad,
Mohammad Foad Abazari,
Mansour Poorebrahim,
Pegah Ghoraeian,
Nima Sanadgol,
Hanieh Bokharaie,
Sahar Heydari,
Amin Abbasi,
Sahra Kabiri,
Maryam Nouri Aleagha,
Seyed Ehsan Enderami,
Amir Savar Dashtaki Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
