Four long noncoding RNAs as potential prognostic biomarkers for hepatocellular carcinoma
In this study, we identified 212 differentially expressed lncRNAs and 7,577 differentially expressed genes between liver HCC tumor tissues and normal tissue samples. And then, combining with clinical information, a total of 11 lncRNAs and 162 genes as HCC biomarkers were identified by comprehensive bioinformatics analysis. Further, through coexpress network analysis, we confirmed four lncRNAs (lncRNA_ANKRD10.IT1, lncRNA_CTD.2583A14.8, lncRNA_RP11.404P21.3, and lncRNA_RP11.488L18.10) that can serve as prognostic biomarkers for HCC. The four lncRNAs identified in this study may serve as a potential therapy target for HCC. Ab...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Jianchu Wang,
Jian Pu,
Tianwei Yao,
Xiaojie Lu,
Yibin Deng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
MicroRNA ‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells
In the current study, microRNA ‐382‐5p was identified as a regulator of mitochondrial biogenesis and dynamics at mRNA levels. Silencing of miRNA‐382‐5p in C2C12 myotubes revealed a collective downregulation of mitochondrial ribosomal proteins and respiratory chain proteins. MiR‐382 silenced C2C12 showed a mitonuclear pr otein imbalance that led to the activation of the mitochondrial unfolded protein response and a reduced basal oxygen consumption rate without affecting mitochondrial content. AbstractProper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are as...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Dennis Dahlmans,
Alexandre Houzelle,
P énélope Andreux,
Xu Wang,
Johanna A. Jörgensen,
Norman Moullan,
Sabine Daemen,
Sander Kersten,
Johan Auwerx,
Joris Hoeks Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Between an ugly truth and a perfect lie: Wiping off fearful memories using beta ‐adrenergic receptors antagonists
This review illustrates the role of propranolol in fear memory with demonstration of studies that support or oppose its beneficial effect. AbstractPsychiatric disorders such as anxiety, phobias, and post ‐traumatic stress disorder are considered of high global prevalence. Currently, a therapeutic approach to treat these disorders using beta‐blockers, which antagonize the beta‐adrenergic receptors (B1, B2, and B3) is being studied. This approach claims that beta‐blockers, such as propranolol, inhibit fear memory reconsolidation. However, there are several studies refuting such claims by discrediting their experiment...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Abdelrahman M. AlOkda,
Mostafa M. Nasr,
Shaimaa N. Amin Tags: REVIEW ARTICLE Source Type: research
miR ‐124 promotes neural differentiation in mouse bulge stem cells by repressing Ptbp1 and Sox9
miR ‐124 andlet ‐7b are upregulated in hair follicle bulge cells after neural differentiation.Upregulation ofmiR ‐124 triggers neural differentiation.Ptbp1 andSox9 mRNAs are directmiR ‐124 targets during neural differentiation of hair follicle stem cells (HFSCs). AbstractHair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR ‐124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicles.miR ‐9,let ‐7b, andmi...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Haleh Mokabber,
Nowruz Najafzadeh,
Mohammad Mohammadzadeh Vardin Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
TMEM206 promotes the malignancy of colorectal cancer cells by interacting with AKT and extracellular signal ‐regulated kinase signaling pathways
ConclusionTMEM206 controlled the progression of CRC by accelerating CRC cell proliferation and promoting CRC cell migration and invasion. The target of TMEM206 may be AKT, which is known to be involved in modulating the biological behaviors of various cancers. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Jinbo Zhao,
Dehua Zhu,
Xiupeng Zhang,
Yong Zhang,
Jianping Zhou,
Ming Dong Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued
In this study, we found that cell proliferation was reduced by CQ treatment in time and dose ‐dependent manners. No obvious cell death was detected; however, what was observed instead was G0/G1 arrest during which primary cilium started to grow in the presence of CQ. Pharmacological inhibition of primary cilium formation led to a reduction of cell viability suggesting that CQ‐induced pr imary cilium protected cells from death. In addition to cell growth, with the CQ treatment the retina pigmented epithelium (RPE) cells less flattened with the spindle‐like protrusion. When checking the microtubule networks, the microt...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Ting ‐Yu Chen,
Wei‐Chih Lien,
Hui‐Ling Cheng,
Ta‐Shen Kuan,
Shi‐Yuan Sheu,
Chia‐Yih Wang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
MicroRNAs and signaling networks involved in epithelial –mesenchymal transition
In nature, MT participates in many physiological and pathological processes including embryonic development, organogenesis, wound healing, and cancer metastasis. Many aspects regulate EMT including: transcription factors, gene expression patterns, and signaling pathway crosstalk. MicroRNAs as noncoding genes play a distinct role in the progression or suppression of EMT. AbstractEpithelial –mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell‐to‐cell connection and are detached from the base membrane. EMT is fundamental for many biological processes such as embryonic development and n...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Mohammad Hossein Musavi Shenas,
Shadi Eghbal ‐Fard,
Vahid Mehrisofiani,
Nima Abd Yazdani,
Omid Rahbar Farzam,
Faroogh Marofi,
Mehdi Yousefi Tags: REVIEW ARTICLE Source Type: research
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR ‐181b/SIRT1/HO‐1 signaling
This study aimed to investigate the role and underlying mechanism of LA in the abdominal aortic aneurysm (AAA). AAA model was established by continuous infusion of 1000 ng/kg/min of angiotensin II (AngII) in ApoE‐/‐ mice for 4 weeks. At 7 days before AngII administration, 5 mg/kg/day or 10 mg/kg/day of LA was intraperitoneally administered to mice and continued for 4 weeks. The characteristics and quantification of AAAs were determined in situ. Real‐time PCR or western blot was used to measure mRNA or protein levels of matrix metalloproteinase 2 and matrix metal loproteinase 9; pro‐inflammatory cytokines tum...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Xuhui Hou,
Songbai Yang,
Yan Zheng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Long ‐term evaluation of corneal sub‐basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy
The aim of the study is to evaluate corneal sub ‐basal nerves (SBN) a mean of 15.6 years after photorefractive keratectomy (PRK) and the effects on them of pars plana vitrectomy (PPV), using in vivo confocal microscopy (IVCM). PRK eyes showed reduced SBN plexus compared with non‐PRK eyes. In addition, SBN density showed a slow but continuous recovery process up to the end of our follow‐up (25 years) after PRK. Both PRK and non‐PRK eyes showed a marked reduction in SBN density 6 months after PPV. AbstractThe corneal sub ‐basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recover...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Gian Marco Tosi,
Gianluca Martone,
Tommaso Bacci,
Antonio Tarantello,
Stefano Baiocchi,
Davide Marigliani,
Gabriele Cevenini,
Flavia Menicacci,
Gianni Virgili,
Giacomina Massaro ‐Giordano Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
A comparison of three strategies for biopanning of phage ‐scFv library against diphtheria toxin
In conclusion, the results of our study indicate that soluble antibody‐capturing method is an efficient method for isolation of specific scFv fragments. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Mostafa Lakzaei,
Mohhamad Javad Rasaee,
Ali Akbar Fazaeli,
Mahdi Aminian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Troxerutin attenuates myocardial cell apoptosis following myocardial ischemia ‐reperfusion injury through inhibition of miR‐146a‐5p expression
In conclusion, troxerutin exerted cardioprotective effects during I/R injury by downregulating miR‐146a‐5p. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Liliang Shu,
Wanzhe Zhang,
Gongcheng Huang,
Chen Huang,
Xiaohua Zhu,
Gang Su,
Jing Xu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Formation and activation induction of primordial follicles using granulosa and cumulus cells conditioned media
In conclusion, the current study showed that condition medium of GCs could enhance in vitro activation of primordial follicles, probably through downregulation of PTEN. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Mohammad Jafari Atrabi,
Vahid Akbarinejad,
Ramazan Khanbabaee,
Azam Dalman,
Christiani Andrade Amorim,
Mustafa Najar ‐Asl,
Mojtaba Rezazadeh Valojerdi,
Rouhollah Fathi Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
The effect of Activin ‐A on periodontal ligament fibroblasts‐mediated osteoclast formation in healthy donors and in patients with fibrodysplasia ossificans progressiva
This study brings new insight on the role of Activin A in osteoclast formation, which may further add to understanding FOP pathophysiology; in addition to the known Activin ‐A‐mediated HO, this study shows that Activin‐A may also inhibit osteoclast formation, thereby further promoting HO formation. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Ton Schoenmaker,
Fenne Wouters,
Dimitra Micha,
Tim Forouzanfar,
Coen Netelenbos,
E. Marelise W. Eekhoff,
Nathalie Bravenboer,
Teun J. de Vries Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Cancer stem cells (CSCs) in cancer progression and therapy
Most of the tumors are occupied with a number of self ‐renewing cells called cancer stem cells (CSCs) that are contributed to the initiation, maintenance, and thriving cancer. The cells have rather similar characteristics to other stem cells located in the niche of body organs, but they have not essentially the same responses to the diverse stimuli. There is evidence for repopulation of CSCs after treatment with chemo/radiotherapy, which is possibly because of their highly plastic feature. Normal stem cells have the proclivity to transform into CSCs when they undergo continuous mutagenesis or receive tumorigenic signals ...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Masoud Najafi,
Bagher Farhood,
Keywan Mortezaee Tags: REVIEW ARTICLE Source Type: research
Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development
We review the genes and mechanisms of clonal hematopoiesis of indeterminate potential (CHIP) and cancer and cardiovascular disease (CVD) development. We discuss targeting mutated genes, receptors and growth factors in hematopoietic stem cells regulation and CHIP to control CVD disease. Also, we suggest novel strategies for treatment of cells and pathways involved in regulation of HSCs can be used to manage CVD treatment AbstractThe clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and he...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Habib Haybar,
Saeid Shahrabi,
Majid Ghanavat,
Elahe Khodadi Tags: REVIEW ARTICLE Source Type: research
