The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index
AbstractWe investigated the influence of vitamin D receptor (VDR) polymorphisms and vitamin D level on the blood pressure and the risk of preeclampsia. In a case ‐control study, 200 pregnant women, including 100 individuals with preeclampsia along with 100 healthy pregnant women, were studied for VDR FokI, TaqI, and BmsI polymorphisms and serum 25 (OH)‐D level using polymerase chain reaction‐restriction fragment length polymorphism method and commercia l kit, respectively. The mean level of 25 (OH)‐D in preeclamptic patients was significantly lower (16.6 ± 4.2 ng/mL,P < 0.001) compared with controls ...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Negin Rezavand,
Saba Tabarok,
Ziba Rahimi,
Asad Vaisi ‐Raygani,
Ehsan Mohammadi,
Zohreh Rahimi Tags: RESEARCH ARTICLE Source Type: research
Evaluation of Osteopontin and Pok émon genes expression in hepatitis C virus–associated hepatocellular carcinoma
Osteopontin and Pok émon genes have been hypothesized to be useful as therapeutic targets or diagnostic markers in hepatocellular carcinoma and liver fibrosis due to hepatitis C virus infection. We conducted our study on 50 patients and classified them into three groups—Group I: Patients with HCV‐related HCC; Grou p II: Patients with hepatitis C cirrhosis; and Group III: Patients with hepatitis C fibrosis. We conclude that hepatocellular carcinoma is associated with overexpression of both Osteopontin and Pokémon and that Osteopontin plays a significant role in liver fibrosis due to hepatitis C infection. AbstractOste...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Nashwa El ‐Khazragy,
Mona M. Khalifa,
Ahmed M. Salem,
Menha Swellam,
Marwa Hegazy Tags: RESEARCH ARTICLE Source Type: research
miR ‐129‐5p and ‐3p co‐target WWP1 to suppress gastric cancer proliferation and migration
Gastric cancer (GC) is a worldwide health problem. Here we identified a novel miR ‐129‐5p/‐3p‐WW domain‐containing E3 ubiquitin protein ligase 1 (WWP1) regulatory axis in GC. Both miR‐129‐5p/‐3p can target WWP1 to suppress GC progression. AbstractGastric cancer (GC) is a worldwide health problem. Uncovering the underlining molecular mechanisms of GC is of vital significance. Here, we identified a novel oncogene WW domain ‐containing E3 ubiquitin protein ligase 1 (WWP1) in GC. WWP1 could promote GC cell proliferation and migration in vitro and expedite GC growth in vivo. We also found out two microRNAs (mi...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Xiaorui Chen,
Chang Li,
Rongjie Cheng,
Zhuo Gao,
Xiangbo Meng,
Chen Sun,
Chenxi Liang,
Lianjun Ma,
Yanqing Liu Tags: RESEARCH ARTICLE Source Type: research
Hypermethylated in cancer 1 (HIC1) suppresses bladder cancer progression by targeting yes ‐associated protein (YAP) pathway
ConclusionsOur data unprecedently showed that HIC1 was responsible for the inhibition of proliferation, migration, and invasion of BCa via the YAP signaling pathway. These findings suggested that therapeutic strategies regulating HIC1 expression might provide effective treatments for BCa. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Xiaoguang Zhou,
Peng Zhang,
Hu Han,
Hongen Lei,
Xiaodong Zhang Tags: RESEARCH ARTICLE Source Type: research
IGF ‐1 and BMP‐7 synergistically stimulate articular cartilage repairing in the rabbit knees by improving chondrogenic differentiation of bone‐marrow mesenchymal stem cells
This study aims to explore whether Insulin ‐like growth factor 1 (IGF‐1) and bone morphogenetic protein‐7 (BMP‐7)‐modified bone‐marrow mesenchymal stem cells (BMSCs) affect the repair of cartilage damage found in the knee. Primarily, BMSCs were treated with a series of pEGFP‐C1, IGF‐1, and BMP‐7, followed by determination o f IGF‐1 and BMP‐7 expression. A rabbit cartilage defect model was also established. Afterfward, cell morphology, viability, cartilage damage repair effect, and expression of collagen I and collagen II at the 6th and the 12th week were measured. BMSCs treated with pEGFP‐C1/IGF‐1...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Xian ‐Bo Peng,
Yuan Zhang,
Yue‐Qiu Wang,
Qi He,
Qian Yu Tags: RESEARCH ARTICLE Source Type: research
Crosstalk of mTOR/PKM2 and STAT3/c ‐Myc signaling pathways regulate the energy metabolism and acidic microenvironment of gastric cancer
Our results suggested that c ‐Myc might be considered a potential therapeutic target for gastric cancer and PKM2 combined with c‐Myc could better inhibit the malignant biological behaviors of gastric cancer. AbstractCancer cells consume large amounts of glucose to produce lactate, even in the presence of ample oxygen. This phenomenon is called the Warburg effect. c ‐Myc is an important member of the Myc gene family and is involved in the development of various tumors. It plays an important role in the regulation of tumor energy metabolism, which can regulate glycolysis to promote the Warburg effect in a tumor. Our st...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Sumeng Gao,
Min Chen,
Wei Wei,
Xiaoqi Zhang,
Mingming Zhang,
Yuling Yao,
Ying Lv,
Tingsheng Ling,
Lei Wang,
Xiaoping Zou Tags: RESEARCH ARTICLE Source Type: research
Decellularized Wharton's jelly extracellular matrix as a promising scaffold for promoting hepatic differentiation of human induced pluripotent stem cells
This study was designed to evaluate hepatic differentiation of human induced pluripotent stem cells (hiPSCs) in decellularized Wharton's jelly (WJ) matrix as an alternative for native liver matrix. WJ matrices were treated with a series of detergents for decellularization. Then hiPSCs were seeded into decellularized WJ scaffold (DWJS) for hepatic differentiation by a defined induction protocol. The DNA quantitative assay and histological evaluation showed that cellular and nuclear materials were efficiently removed and the composition of extracellular matrix was maintained. In DWJS, hiPSCs ‐derived hepatocyte‐like cell...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Mousa Kehtari,
Bahareh Beiki,
Bahman Zeynali,
Fatemeh Sadat Hosseini,
Fatemeh Soleimanifar,
Mohammad Kaabi,
Masoud Soleimani,
Seyed Ehsan Enderami,
Mahboubeh Kabiri,
Hossein Mahboudi Tags: RESEARCH ARTICLE Source Type: research
Rab6A GTPase contributes to phenotypic modulation in pulmonary artery smooth muscle cells under hypoxia
AbstractPrevious studies have demonstrated that hypoxia can induce phenotypic modulation of pulmonary smooth muscle cells; however, the mechanisms remain unclear. The present study aimed to investigate the effect of the GTPase Rab6A ‐mediated phenotypic modulation and other activities of rat pulmonary artery smooth muscle cells (RPASMCs). We revealed that Rab6A was induced by hypoxia (1% O2) and was involved in a hypoxia ‐induced phenotypic switch and endoplasmic reticulum stress (ERS) in RPASMCs. After 48 hours of hypoxia, the expression of the phenotype marker protein smooth muscle actin was downregulated and vimen...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Fang Wang,
Xingxiang Xu,
Weian Tang,
Lingfeng Min,
Junjun Yang Tags: RESEARCH ARTICLE Source Type: research
FtsA as a cidal target for Staphylococcus aureus: Molecular docking and dynamics studies
TheStaphylococcus aureus‐related infections have been a threat to the mankind for a very long time. Over the period of timeS. aureus strains developed resistance to various antibiotics. The present work focused on developing a novel drug against FtsA, which is very much essential for the survival ofS. aureus. Since it is not found in eukaryotes, there could be potentially no side effects. The ZINC74432848 compound was found to be the best inhibitor ofS. aureus FtsA protein based on docking studies. The simulation study emphasizes the fact that ZINC74432848 compound has a stable interaction withS. aureus FtsA protein. Abs...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Adhithya Ragunathan,
Kullappan Malathi,
Sudha Ramaiah,
Anand Anbarasu Tags: RESEARCH ARTICLE Source Type: research
Long noncoding RNA THRIL contributes in lipopolysaccharide ‐induced HK‐2 cells injury by sponging miR‐34a
In conclusion, this study suggested that lncRNA THRIL might be a key regulator participating in LPS‐induced injury in HK‐2 cells. THRIL overexpression aggravated LPS‐induced i njury possibly via sponging miR‐34a, and thus preventing MCP‐1 from degradation by miR‐34a. The THRIL/miR‐34a/MCP‐1 axis might play critical roles in SLE. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 9, 2018 Category: Biochemistry Authors: Yao Deng,
Sen Luan,
Qi Zhang,
Ying Xiao Tags: RESEARCH ARTICLE Source Type: research
Cover Image, Volume 119, Number 12, December 2018
Journal of Cellular Biochemistry,Volume 119, Issue 12, Page i-i, December 2018. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 5, 2018 Category: Biochemistry Authors: M élinée Futel,
Ronan Le Bouffant,
Isabelle Buisson,
Muriel Umbhauer,
Jean‐François Riou Source Type: research
Issue Information
Journal of Cellular Biochemistry,Volume 119, Issue 12, Page 9605-9615, December 2018. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 5, 2018 Category: Biochemistry Source Type: research
Targeting anti ‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis
Journal of Cellular Biochemistry, EarlyView. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 3, 2018 Category: Biochemistry Authors: Sadiya Bi Shaikh,
Ashwini Prabhu,
Yashodhar Prabhakar Bhandary Source Type: research
Optimization of prostate cancer cell detection using multiplex tyramide signal amplification
Journal of Cellular Biochemistry, EarlyView. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 3, 2018 Category: Biochemistry Authors: Sounak Roy,
Haley D. Axelrod,
Kenneth C. Valkenburg,
Sarah Amend,
Kenneth J. Pienta Source Type: research
Inhibitor of growth 4 inhibits cell proliferation, migration, and induces apoptosis of renal cell carcinoma cells
Journal of Cellular Biochemistry, EarlyView. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 3, 2018 Category: Biochemistry Authors: Jiping Sun,
Liyi Xie,
Jing Lv,
Wenjing Zhang,
Jia Lv,
Yu Liang,
Yingzhou Geng,
Xudong Li Source Type: research
