circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma
We examined their expression in the sera of 68 patients with HCC, 60 patients with chronic hepatitis C (CHC), and 36 healthy controls using quantitative polymerase chain reaction. circRNAs hsa_circ_00156, hsa_circ_000224, and hsa_circ_00520 are novel potential biomarkers of high sensitivity and specificity, which could potentially be used in the diagnosis of HCC. AbstractCircular RNAs (circRNAs) are a newly validated type of noncoding RNAs recently found to be deregulated in several human cancers. More accurate and specific noninvasive biomarkers are strongly needed for better diagnosis and prognosis of hepatocellular carc...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Marwa Matboli, Ayman E Shafei, Mahmoud A Ali, Ahmed M Ashry, Kamal M Kamal, Mohammed Ali Agag, Ibrahim Reda, Eman Fathy Tash, Marwa Ali Tags: RESEARCH ARTICLE Source Type: research

The determination of the potential anticancer effects of Coriandrum sativum in PC ‐3 and LNCaP prostate cancer cell lines
In conclusion, this data present a valuable addition to the very limited data available out there on the potential use ofC. sativum in prostate cancer treatment. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Levent Elmas, M ücahit Secme, Ramazan Mammadov, Umut Fahrioglu, Yavuz Dodurga Tags: RESEARCH ARTICLE Source Type: research

The diagnostic accuracy of procalcitonin and C ‐reactive protein for sepsis: A systematic review and meta‐analysis
ConclusionIn this meta ‐analysis, our results together indicate a moderate degree of value of PCT and CRP for the diagnosis of sepsis in adult patients. The diagnosis accuracy and specificity of PCT are higher than those of CRP. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Meichun Tan, Yunxia Lu, Hao Jiang, Liandong Zhang Tags: RESEARCH ARTICLE Source Type: research

Lycium barbarum polysaccharides promoted proliferation and differentiation in osteoblasts
We proposed a previously unidentified function ofLycium barbarum polysaccharides (LBP) in osteoblast differentiation, suggesting its potential clinical role in bone disease treatment. PCNA, proliferating cell nuclear antigen AbstractOsteoblasts have the capacity to differentiate into several different cell types, including adipocyte, chondrocyte, and muscle lineages. Therefore, osteoblast can be potentially applied in the treatment of bone diseases. The factors controlling osteoblast differentiation is complex. Recently, it has been reported that some natural products regulate the differentiation in osteoblasts and promote...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Huiying Zhang, Lei Zheng, Zhanpeng Yuan Tags: RESEARCH ARTICLE Source Type: research

Cyadox regulates the transcription of different genes by activation of the PI3K signaling pathway in porcine primary hepatocytes
1. Increased expressions of growth ‐related genes such as an epidermal growth factor (EGF) and insulin‐like growth factor‐1 (IGF‐1) in porcine primary hepatocytes treated with cyadox are mediated mainly through phosphoinositide 3‐kinase (PI3K) signaling pathway, potentially leading to enhanced cell growth.2. EGF might be the early response gene of cyadox, and a primary regulator of other genes expression such as IGF ‐1 and the defender against apoptotic death 1 (DAD1), playing an important role in cell proliferation promoted by cyadox.3. Cyadox may promote transcriptional levels of seven cyadox ‐related gene...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Ju Guo, Luqing Cui, Qirong Lu, Yinfeng Zhang, Qianying Liu, Xu Wang, Yulian Wang, Zhenli Liu, Zonghui Yuan, Menghong Dai Tags: RESEARCH ARTICLE Source Type: research

Mechanically stimulated osteocytes reduce the bone ‐metastatic potential of breast cancer cells in vitro by signaling through endothelial cells
In conclusion, we demonstrated that flow‐stimulated osteocytes downregulate the bone‐metastatic potential of breast cancer cells by signaling through endothelial cells. This provides insights into the capability of bone mechanical regulation in preventing bone metastases; and may assist in prescribing exercise or bone‐loading regimens to patients with breast cancers. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Yu ‐Heng Vivian Ma, Liangcheng Xu, Xueting Mei, Kevin Middleton, Lidan You Tags: RESEARCH ARTICLE Source Type: research

BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML
Acute myeloid leukemia (AML) cells treated with bromodomain and extraterminal domain (BET) inhibitors show defects in oxygen consumption rates (OCRs) and extracellular acidification. The decreased OCR and extracellular acidification rate (ECAR) indicate repression of both mitochondrial dynamics and glycolytic function. AbstractInhibitors of the bromodomain and extraterminal domain family (BETi) offer a new approach to treat hematological malignancies, with leukemias containing mixed lineage leukemia rearrangements being especially sensitive due to a reliance on the regulation of transcription elongation. We explored the me...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Susu Zhang, Yue Zhao, Tiffany M. Heaster, Melissa A. Fischer, Kristy R. Stengel, Xiaofan Zhou, Haley Ramsey, Ming ‐Ming Zhou, Michael R. Savona, Melissa C. Skala, Scott W. Hiebert Tags: RESEARCH ARTICLE Source Type: research

Long noncoding RNA MEG3 inhibits proliferation and migration but induces autophagy by regulation of Sirt7 and PI3K/AKT/mTOR pathway in glioma cells
In our study, human glioblastoma U251 cells were used to explore the roles of MEG3 in glioma in vitro. Herein, the alterations of cell proliferation, migration, apoptosis, and autophagy in cells aberrantly expressing MEG3 were investigated. Moreover, the underlying mechanisms involving in the PI3K/AKT/mTOR pathway were also explored. AbstractGlioma is a common primary brain tumor with high mortality rate and poor prognosis. Long noncoding RNA maternally expressed gene 3 (MEG3) is a tumor suppressor in diverse cancer types. However, the role of MEG3 in glioma remains unclear. We aimed to explore the effects of MEG3 on U251 ...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Dong ‐Hui Xu, Guo‐Nan Chi, Cong‐Hai Zhao, Dong‐Yuan Li Tags: RESEARCH ARTICLE Source Type: research

Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases ‐2/9 expression
In this study, we used MDA ‐MB‐231 and MCF7 breast cancer cell lines to explore the role of LAP3 in the regulation of cancer cell migration and invasion by employing the natural LAP3 inhibitor bestatin and a lentivirus vector that overexpresses or knocks down LAP3. Bestatin inhibited tumor cell migration and invasion in a dose‐dependent manner. Western blot assay showed that bestatin and knockdown of LAP3 upregulated phosphorylation of Hsp27 and downregulated expression of fascin. Phosphorylation of Akt and expression of matrix metalloproteinase‐2/9 can also be downregulated. LAP3 overexpression showed the oppos it...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Chunyan Fang, Jian Zhang, Hanlin Yang, Lili Peng, Kun Wang, Yanjie Wang, Xin Zhao, Huijie Liu, Chunhui Dou, Lihong Shi, Chunling Zhao, Shujuan Liang, Daqi Li, Xuejian Wang Tags: RESEARCH ARTICLE Source Type: research

Wnt/ β‐catenin signaling enhances transcription of the CX43 gene in murine Sertoli cells
In this study, we demonstrate that 42GPA9 Sertoli cells respond to treatments that result in accumulation of β‐catenin within the nucleus and in upregulati on of CX43 gene transcription. β‐Catenin binds to TBEs located both upstream and downstream of the transcriptional start site (TSS). Luciferase reporter experiments revealed that TBEs located upstream of the TSS are necessary for β‐catenin‐mediated upregulation. Our results also indicate tha t the Wnt/β‐catenin‐dependent upregulation of the Cx43 gene in Sertoli cells is accompanied by changes in epigenetic parameters that may be directly contributing to ...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Camila L ópez, Rodrigo Aguilar, Gino Nardocci, Karina Cereceda, Karen Vander Stelt, Juan Carlos Slebe, Martin Montecino, Ilona I. Concha Tags: RESEARCH ARTICLE Source Type: research

Ameliorative effects of autophagy inducer, simvastatin on alcohol ‐induced liver disease in a rat model
1.Alcoholic liver disease is a worldwide public health issue; however, no available treatment is effective up till now. 2.Increasing number of studies has investigated the pleiotropic effects of statins, mainly its autophagy inducer effect. 3.We aimed to monitor the influence of simvastatin on alcohol ‐induced liver injury and elucidate the underlying mechanisms of its cytoprotective effect. AbstractAlcoholic liver disease (ALD) encompasses a variety of liver injuries with various underlying mechanisms but still no effective treatment. So we aimed to monitor the influence of simvastatin on alcohol ‐induced liver injury...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Marwa Mohamed Atef, Yasser Mostafa Hafez, Hanan Alsaeed Alshenawy, Marwa Nagy Emam Tags: RESEARCH ARTICLE Source Type: research

CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR ‐1252/FOXR2 axis
1.CircABCB10 acted as a tumor promoter. 2.Downregulation of circABCB10 suppressed nonsmall cell lung cancer cell proliferation and migration by promoting microRNA  miR‐1252 expression and suppressing Forkhead box 2. AbstractCircular RNA (circRNA) is a key regulator in the development and progression of human cancers. Previous studies confirmed circRNA ‐0008717 (circABCB10) as an oncogene in osteosarcoma, but the regulatory effect of circABCB10 in nonsmall cell lung cancer (NSCLC) is still unclear. In the current study, we examined the expression of circABCB10 in different NSCLC cell lines. Bioinformatics analysis, Cel...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Xufeng Tian, Lin Zhang, Yan Jiao, Junsheng Chen, Ying Shan, Wenfeng Yang Tags: RESEARCH ARTICLE Source Type: research

Adenosine protects pancreatic beta cells against apoptosis induced by endoplasmic reticulum stress
Adenosine increase MIN6 insulinoma cell survival during endoplasmic reticulum (ER) stress. Thus, adenosine may be considered as a possible pharmacological agent to decrease of ER stress in pancreatic beta cells. AbstractChronic exposure to high glucose induces endoplasmic reticulum (ER) stress in pancreatic beta cells (PBCs). The previous evidence showed that adenosine modulate PBCs viability and insulin secretion. The aim of this study was to evaluate possible involvement of adenosine in protection of MIN6 β‐cells from Tunicamycin (Tu)‐induced ER stress.MIN6 cells were cotreated with Tu and different concentrations o...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Mohammad Keyvanloo Shahrestanaki, Fatemeh Panahi Arasi, Mahmoud Aghaei Tags: RESEARCH ARTICLE Source Type: research

Dppa3 in pluripotency maintenance of ES cells and early embryogenesis
In this review, we first illustrated the important functions of Dppa3 in pluripotency maintenance of ES cells and early embryogenesis. This is the first time,  the function of Dppa3 has been summarized. AbstractEmbryonic development is precisely regulated by a network of signal pathways and specific genes. Dppa3 (also known as Pgc7 or Stella) plays an important role in early embryonic development during the cleavage stage as a maternal effect gene. Dppa3 expresses in many species, and its homologous gene in human and rat genomes is located at the same chromosomal regions and have the same exon ‐intron structure. However...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Shuang Zhao, Jia Xu, Siying Liu, Kaige Cui, Zongjin Li, Na Liu Tags: VIEW POINTS Source Type: research

Epitope ‐based immunoinformatics approach on RNA‐dependent RNA polymerase (RdRp) protein complex of Nipah virus (NiV)
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its molecular mechanisms, we utilized the proteome data of NiV to evaluate the potency of three major proteins (phosphoprotein, polymerase, and nucleocapsid protein RdRp complex) to count as a possible candidate for epitope ‐based vaccine design. AbstractPersistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its m...
Source: Journal of Cellular Biochemistry - November 11, 2018 Category: Biochemistry Authors: Lavanya Ravichandran, Arthi Venkatesan, J. Febin Prabhu Dass Tags: RESEARCH ARTICLE Source Type: research