Overexpression of the lncRNA FER1L4 inhibits paclitaxel tolerance of ovarian cancer cells via the regulation of the MAPK signaling pathway
ow the lncRNA FER1L4 in ovarian cancer cells influences paclitaxel (PTX) resistance and its molecular mechanism are determined here. The upregulation of FER1L4 could promote PTX sensitivity of ovarian cancer cells via the regulation of MAPK signaling pathway. The increased level of lncRNA FER1L4 suppressed PTX resistance of ovarian cancer cells through the inhibition of the MAPK signaling pathway. AbstractTo determine how the lncRNA FER1L4 in ovarian cancer cells influences paclitaxel (PTX) resistance, we examined the expression level of FER1L4 in human ovarian epithelial cell lines IOSE80 and HOSEpiC and human ovarian can...
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Siwei Liu,
Bingyu Zou,
Tian Tian,
Xiaohui Luo,
Banyun Mao,
Xun Zhang,
Huajiang Lei Tags: RESEARCH ARTICLE Source Type: research
CDC25A pathway toward tumorigenesis: Molecular targets of CDC25A in cell ‐cycle regulation
In conclusion,CDC25A controls the cell proliferation and tumorigenesis by a change in expression of proteins involved in cyclin D1 regulation and G1/S transition. AbstractThe cell division cycle 25 (CDC25) phosphatases regulate key transitions between cell ‐cycle phases during normal cell division, and in the case of DNA damage, they are key targets of the checkpoint machinery that ensure genetic stability. Little is known about the mechanisms underlying dysregulation and downstream targets of CDC25. To understand these mechanisms, we silenced theCDC25A gene in breast cancer cell line MDA ‐MB‐231 and studied downstre...
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Hossein Sadeghi,
Masoud Golalipour,
Ahad Yamchi,
Touraj Farazmandfar,
Majid Shahbazi Tags: RESEARCH ARTICLE Source Type: research
Translocation and activation of sphingosine kinase 1 by ceramide ‐1‐phosphate
In conclusion, C1P modulates SphK1 functions by interacting with multiple sites in SphK1. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Shohei Nishino,
Hisahiro Yamashita,
Mizuki Tamori,
Masato Mashimo,
Kazuyuki Yamagata,
Hiroyuki Nakamura,
Toshihiko Murayama Tags: RESEARCH ARTICLE Source Type: research
Interaction of gut microbiota with dysregulation of bile acids in the pathogenesis of nonalcoholic fatty liver disease and potential therapeutic implications of probiotics
Nonalcoholic fatty liver disease (NAFLD) is associated with disturbances of gut microbiota that cause dysregulation of bile acids and nuclear receptors. Activation of farnesoid X receptor and Takeda G ‐protein–coupled bile acid protein 5 has been extensively investigated for treating NAFLD with promising outcomes but paradoxical effects are major problems. We propose that modulating gut microbiota could be an alternative novel approach for the treatment of NAFLD. AbstractThe intestinal microbiota is now recognised to play key roles in health due to its involvement in many aspects of human physiology. Disturbance in gut...
Source: Journal of Cellular Biochemistry - November 15, 2018 Category: Biochemistry Authors: Jiezhong Chen,
Michael Thomsen,
Luis Vitetta Tags: VIEW POINTS Source Type: research
Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation
In this study, we investigated the antiproliferative effects and underlying mechanism of the commonly used local anesthetic (lidocaine) on melanoma cells. A375 melanoma cells were treated by lidocaine or vemurafenib. Cell Counting Kit‐8, histological staining, flow cytometric analysis, imm unohistochemical staining, and Western blot analyses were carried out to test the effects of lidocaine and vemurafenib on A375 cells. BALB/C‐nu/nu mice intraperitoneally injected with A375 cells were treated by lidocaine, and then tumor volume and weight were calculated. Lidocaine exhibited vemura fenib‐like effects totally. Lidoca...
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Jun Chen,
Zhihua Jiao,
Aizhong Wang,
Wenhui Zhong Tags: RESEARCH ARTICLE Source Type: research
A dual target of Plasmepsin IX and X: Unveiling the atomistic superiority of a core chemical scaffold in malaria therapy
This study may hasten the search towards the discovery of novel antimalarial drugs amid the current wave of drug resistance. AbstractPlasmepsin IX and X, members of the prominent aspartic family of proteases whose function were hitherto unknown have only recently been established as key mediators of erythrocyte invasion and egress of the virulent malarial parasite. Inhibitor 49c, a potent antimalarial peptidomimetic inhibitor initially developed to target Plasmepsin II has lately been proven to exhibit potent inhibitory activity against Plasmepsin IX and X. However, the molecular and structural dynamics supporting its inhi...
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Geraldene Munsamy,
Clement Agoni,
Mahmoud E. S. Soliman Tags: RESEARCH ARTICLE Source Type: research
Identification of key lncRNAs in the carcinogenesis and progression of colon adenocarcinoma by co ‐expression network analysis
In conclusion, through co‐expression analysis, we identified and validated four key lncRNAs in association with the carcinogenesis and progression of COAD, and these lncRNAs might have important clinical implications for improving the risk stratification, therapeutic decision and prognos is prediction in COAD patients. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Shi Jiang,
Biyong Tan,
Xingqiang Zhang Tags: RESEARCH ARTICLE Source Type: research
Effect of microRNA ‐141 on the development of diabetic nephropathy through regulating AKT/AMPK signaling pathway by targeting insulin receptor substrate 2
ConclusionMiR ‐141 promoted DN progression through regulating AKT/AMPK signaling pathway by targeting IRS2. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Yang Li,
Denggao Huang,
Linlin Zheng,
Hui Cao,
Zhongcheng Fan Tags: RESEARCH ARTICLE Source Type: research
Long noncoding RNA HAGLROS regulates apoptosis and autophagy in colorectal cancer cells via sponging miR ‐100 to target ATG5 expression
In conclusion, a highly expression of HAGLROS correlated with shorter survival time of CRC patients . Downregulation of HAGLROS may induce apoptosis and inhibit autophagy in CRC cells by regulation of miR‐100/ATG5 axis and PI3K/AKT/mTOR pathway. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Yansheng Zheng,
Kanglian Tan,
Haipeng Huang Tags: RESEARCH ARTICLE Source Type: research
The effects of particle density in moxa smoke on the ultrastructure of knee cartilage and expressions of TNF ‐α, IL‐1b, BAX, and Bcl‐2 mRNA in a rat model for osteoarthritis
ConclusionsA correlation was found between the particle density in moxa smoke and degree of injury to knee cartilage, favoring higher particle densities. This can be partially related to the suppression of the inflammatory effects of TNF ‐α, IL‐1b, enhancement of the antiapoptotic effects of Bcl‐2, and, nevertheless, suppression of the apoptotic effects of BAX. Finally, the protective effect of antiapoptotic is one of the key mechanisms for an ambient moxa smoking environment. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Jiangtao Zhang,
QiYi Li,
ShouYa Chang Tags: RESEARCH ARTICLE Source Type: research
LncRNA CRNDE promotes the epithelial ‐mesenchymal transition of hepatocellular carcinoma cells via enhancing the Wnt/β‐catenin signaling pathway
In this study, we investigated the expression and function of CRNDE. CRNDE was significantly upregulated in tumor tissues compared with adjacent normal tissues. In vitro, we revealed that knockdown of CRNDE inhibited cell proliferation, migration, and cell invasion capacities in HCC. Animal studies indicated that CRNDE knockdown represses both growth and metastasis of HCC tumors in vivo. Moreover, knockdown of CRNDE suppressed the cell epithelial ‐mesenchymal transition (EMT) process by increasing the expression of E‐cadherin and ZO‐1, whereas, decreasing the expression of N‐cadherin, slug, twist, and vimentin in H...
Source: Journal of Cellular Biochemistry - November 14, 2018 Category: Biochemistry Authors: Liying Zhu,
Nenghong Yang,
Guiqin Du,
Chengcheng Li,
Guoqi Liu,
Shengju Liu,
Yongjie Xu,
Yanan Di,
Wei Pan,
Xing Li Tags: RESEARCH ARTICLE Source Type: research
Tumor ‐suppressive microRNA‐10a inhibits cell proliferation and metastasis by targeting Tiam1 in esophageal squamous cell carcinoma
MicroRNA (miR) ‐10a inhibits esophageal squamous cell carcinoma (ESCC) progression by Tiam1; miR‐10a acts as tumor‐suppression by targeting Tiam1 in ESCC. AbstractAberrant microRNAs (miRNAs) expressions could contribute to the progression of numerous cancers, including esophageal squamous cell carcinoma, while miR ‐10a participates in multiple biological processes on cancers. However, the molecular mechanism of miR‐10a in esophageal squamous cell carcinoma (ESCC) has not been investigated. Herein, miR‐10a was significantly reduced in ESCC clinical tissues and ESCC cell lines (EC109 and TE‐3). In addit ion, im...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Yatian Liu,
Xiaojun Wang,
Xuesong Jiang,
Pengwei Yan,
Liangliang Zhan,
Huanfeng Zhu,
Tingting Wang,
Jing Wen Tags: RESEARCH ARTICLE Source Type: research
Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS ‐sirt1‐NF‐κB signaling
In conclusion, chemerin can seduce inflammatory response and promote nuclear factor ‐κB (NF‐κB) activation through inhibition of sirtuin 1 (sirt1) activity by reactive oxygen species (ROS) production AbstractPsoriasis is a chronic disease which carries the emotional and social burden, promotes joint disability and raises comorbidity possibility in patients. Obesity is closely correlated with the occurrence of psoriasis and adipokines produced by adipose tissues were found to be critical culprits. Chemerin is one of them and its expression was increased in patients with psoriatic arthritis. In our hypothesis, chemerin...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Yuan Wang,
Jia Huo,
Dingwei Zhang,
Gang Hu,
Yanfei Zhang Tags: RESEARCH ARTICLE Source Type: research
FOXD2 ‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma
In conclusion, FOXD2‐AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells. (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Wenqing Ren,
Zirong Zhu,
Lina Wu Tags: RESEARCH ARTICLE Source Type: research
Systematic analysis of multigene predictors in gastric cancer exploiting gene expression signature
In this study, we investigated the top 10% overexpressed genes in GC from five data sets of the Oncomine platform, with 265 GC samples versus 174 normal gastric mucosa samples. Sixteen candidate genes were identified as predictors of GC, of which 14 genes were verified through the comparison of expression levels in specimens from normal (chronic gastritis, 21 samples) and GC groups (38 samples). In addition, unique molecular portraits of diffuse adenocarcinoma (DA), intestinal adenocarcinoma (IA), and mixed adenocarcinoma (MA) were studied through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis, ...
Source: Journal of Cellular Biochemistry - November 13, 2018 Category: Biochemistry Authors: Kuankuan Ai,
Yanli Jia,
Jin Li,
Chong Wang,
Yan Wang Tags: RESEARCH ARTICLE Source Type: research
